{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T12:14:16Z","timestamp":1778847256843,"version":"3.51.4"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0130431","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T18:27:04Z","timestamp":1435256824000},"page":"e0130431","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Experimental African Trypanosome Infection by Needle Passage or Natural Tsetse Fly Challenge Thwarts the Development of Collagen-Induced Arthritis in DBA\/1 Prone Mice via an Impairment of Antigen Specific B Cell Autoantibody Titers"],"prefix":"10.1371","volume":"10","author":[{"given":"Carl","family":"De Trez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brunette","family":"Katsandegwaza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Caljon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Magez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,6,25]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2249.2010.04139.x","article-title":"The 'hygiene hypothesis' for autoimmune and allergic diseases: an update","volume":"160","author":"H Okada","year":"2010","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/rr48","article-title":"The coming-of-age of the hygiene hypothesis","volume":"2","author":"FD Martinez","year":"2001","journal-title":"Respir Res"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0092-8674(00)81109-5","article-title":"Rheumatoid arthritis","volume":"85","author":"M Feldmann","year":"1996","journal-title":"Cell"},{"issue":"3","key":"ref4","first-page":"639","article-title":"Incidence of arthritis and autoreactivity of anti-collagen antibodies after immunization of DBA\/1 mice with heterologous and autologous collagen II","volume":"62","author":"R Holmdahl","year":"1985","journal-title":"Clin Exp Immunol"},{"issue":"8251","key":"ref5","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0140-6736(81)91107-7","article-title":"Rheumatoid arthritis: a disease of T-lymphocyte\/macrophage immunoregulation","volume":"2","author":"G Janossy","year":"1981","journal-title":"Lancet"},{"issue":"Suppl 2","key":"ref6","doi-asserted-by":"crossref","first-page":"ii3","DOI":"10.1093\/rheumatology\/keh616","article-title":"B cells: a fundamental role in the pathogenesis of rheumatoid arthritis?","volume":"44","author":"GS Panayi","year":"2005","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1046\/j.1365-2249.1998.00529.x","article-title":"B cell-deficient mice do not develop type II collagen-induced arthritis (CIA)","volume":"111","author":"L Svensson","year":"1998","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.4049\/jimmunol.179.2.1369","article-title":"B cell depletion delays collagen-induced arthritis in mice: arthritis induction requires synergy between humoral and cell-mediated immunity","volume":"179","author":"K Yanaba","year":"2007","journal-title":"J Immunol"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1093\/intimm\/11.7.1065","article-title":"Collagen-induced arthritis development requires alpha beta T cells but not gamma delta T cells: studies with T cell-deficient (TCR mutant) mice","volume":"11","author":"A Corthay","year":"1999","journal-title":"Int Immunol"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/nprot.2007.173","article-title":"Collagen-induced arthritis","volume":"2","author":"DD Brand","year":"2007","journal-title":"Nat Protoc"},{"issue":"11","key":"ref11","doi-asserted-by":"crossref","first-page":"5178","DOI":"10.4049\/jimmunol.157.11.5178","article-title":"Autoantibodies to murine type II collagen in collagen-induced arthritis: a comparison of susceptible and nonsusceptible strains","volume":"157","author":"DD Brand","year":"1996","journal-title":"J Immunol"},{"issue":"8","key":"ref12","first-page":"1075","article-title":"African trypanosomiasis and antibodies: implications for vaccination, therapy and diagnosis. Future Microbiol","volume":"4","author":"S Magez","year":"2009"},{"issue":"9394","key":"ref13","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/S0140-6736(03)14694-6","article-title":"The trypanosomiases","volume":"362","author":"MP Barrett","year":"2003","journal-title":"Lancet"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"e1000078","DOI":"10.1371\/journal.ppat.1000078","article-title":"Trypanosomiasis-induced B cell apoptosis results in loss of protective anti-parasite antibody responses and abolishment of vaccine-induced memory responses","volume":"4","author":"M Radwanska","year":"2008","journal-title":"PLoS Pathog"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.clim.2014.04.014","article-title":"A novel pancreatic beta-cell targeting bispecific-antibody (BsAb) can prevent the development of type 1 diabetes in NOD mice","volume":"153","author":"P Bhattacharya","journal-title":"Clin Immunol"},{"issue":"11","key":"ref16","doi-asserted-by":"crossref","first-page":"e50366","DOI":"10.1371\/journal.pone.0050366","article-title":"Human monoclonal antibodies against highly conserved HR1 and HR2 domains of the SARS-CoV spike protein are more broadly neutralizing","volume":"7","author":"HA Elshabrawy","journal-title":"PLoS One"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"e1002089","DOI":"10.1371\/journal.ppat.1002089","article-title":"T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosis","volume":"7","author":"V Bockstal","year":"2011","journal-title":"PLoS Pathog"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMra020100","article-title":"The effect of infections on susceptibility to autoimmune and allergic diseases","volume":"347","author":"JF Bach","year":"2002","journal-title":"N Engl J Med"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1385\/CRIAI:26:1:35","article-title":"Regulation of allergy and autoimmunity in helminth infection","volume":"26","author":"MS Wilson","year":"2004","journal-title":"Clin Rev Allergy Immunol"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.4049\/jimmunol.175.4.2501","article-title":"The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent","volume":"175","author":"MB Drennan","year":"2005","journal-title":"J Immunol"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/art.22453","article-title":"Interferon-gamma regulates susceptibility to collagen-induced arthritis through suppression of interleukin-17","volume":"56","author":"CQ Chu","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1128\/IAI.26.3.822-826.1979","article-title":"Suppression of antibody response to Leptospira biflexa and Brucella abortus and recovery from immunosuppression after Berenil treatment","volume":"26","author":"FR Rurangirwa","year":"1979","journal-title":"Infect Immun"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1046\/j.1365-2249.2000.01384.x","article-title":"Parasite-mediated down-regulation of collagen-induced arthritis (CIA) in DA rats","volume":"122","author":"L Mattsson","year":"2000","journal-title":"Clin Exp Immunol"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"e48635","DOI":"10.1371\/journal.pone.0048635","article-title":"Type II collagen induces peripheral tolerance in BALB\/c mice via the generation of CD8+ T regulatory cells","volume":"7","author":"SM Farooq","year":"2012","journal-title":"PLoS One"},{"issue":"12","key":"ref25","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1111\/jcmm.12376","article-title":"Eye-mediated immune tolerance to Type II collagen in arthritis-prone strains of mice","volume":"18","author":"SM Farooq","year":"2014","journal-title":"J Cell Mol Med"},{"issue":"7564","key":"ref26","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0140-6736(68)90595-3","article-title":"Autoimmune disease and parasitic infections in Nigerians","volume":"2","author":"BM Greenwood","year":"1968","journal-title":"Lancet"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0130431","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T20:01:17Z","timestamp":1691784077000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0130431"}},"subtitle":[],"editor":[{"given":"Hossam M","family":"Ashour","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,6,25]]},"references-count":26,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,6,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0130431","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,25]]}}}