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Rommen","year":"2014"},{"key":"ref53","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9781139168342","article-title":"Measuring Behaviour: An Introductory Guide","author":"P Martin","year":"1993"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jneumeth.2010.01.035","article-title":"The precision of video and photocell tracking systems and the elimination of tracking errors with infrared backlighting","volume":"188","author":"JD Bailoo","year":"2010","journal-title":"J Neurosci Methods"},{"key":"ref55","unstructured":"Bates D, Maechler M, Bolker B, Walker S (2014) lme4: Linear mixed-effects models using Eigen and S4. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/cran.r-project.org\/web\/packages\/lme4\/citation.html\" xlink:type=\"simple\">http:\/\/cran.r-project.org\/web\/packages\/lme4\/citation.html<\/ext-link>. Accessed 19 August 2014."},{"key":"ref56","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/00008877-199312000-00009","article-title":"The free-exploratory paradigm: an effective method for measuring neophobic behaviour in mice and testing potential neophobia-reducing drugs","volume":"4","author":"G Griebel","year":"1993","journal-title":"Behav Pharmacol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/00008877-199711000-00012","article-title":"Further pharmacological validation of the BALB\/c neophobia in the free exploratory paradigm as an animal model of trait anxiety","volume":"8","author":"C Belzung","year":"1997","journal-title":"Behav Pharmacol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.euroneuro.2014.01.012","article-title":"The effects of acute pharmacological stimulation of the 5-HT, NA and DA systems on the cognitive judgement bias of rats in the ambiguous-cue interpretation 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