{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:49:57Z","timestamp":1790012997433,"version":"4.0.1"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T00:00:00Z","timestamp":1435795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0131073","type":"journal-article","created":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T18:19:59Z","timestamp":1435861199000},"page":"e0131073","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Serine Arginine-Rich Splicing Factor 1 (SRSF1) Contributes to the Transcriptional Activation of CD3\u03b6 in Human T Cells"],"prefix":"10.1371","volume":"10","author":[{"given":"Vaishali R.","family":"Moulton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Gillooly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel A.","family":"Perl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Markopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George C.","family":"Tsokos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,7,2]]},"reference":[{"issue":"22","key":"ref1","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1056\/NEJMra1100359","article-title":"Systemic lupus erythematosus","volume":"365","author":"GC Tsokos","year":"2011","journal-title":"N Engl J Med"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/ar3251","article-title":"Abnormalities of T cell signaling in systemic lupus erythematosus","volume":"13","author":"VR Moulton","year":"2011","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1006\/jaut.2000.0475","article-title":"Polymorphisms\/mutations of TCR-zeta-chain promoter and 3&apos; untranslated region and selective expression of TCR zeta-chain with an alternatively spliced 3&apos; untranslated region in patients with systemic lupus erythematosus","volume":"16","author":"MP Nambiar","year":"2001","journal-title":"Journal of autoimmunity"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1002\/1529-0131(199909)42:9<1908::AID-ANR17>3.0.CO;2-7","article-title":"Diminished levels of T cell receptor zeta chains in peripheral blood T lymphocytes from patients with systemic lupus erythematosus","volume":"42","author":"V Brundula","year":"1999","journal-title":"Arthritis and rheumatism"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/08916930903374741","article-title":"Pathogenic mechanisms in systemic lupus erythematosus","volume":"43","author":"A Perl","year":"2010","journal-title":"Autoimmunity"},{"issue":"7","key":"ref6","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1172\/JCI1457","article-title":"Altered pattern of TCR\/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain","volume":"101","author":"SN Liossis","year":"1998","journal-title":"The Journal of clinical investigation"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/1529-0131(200105)44:5<1114::AID-ANR192>3.0.CO;2-B","article-title":"Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus","volume":"44","author":"EJ Enyedy","year":"2001","journal-title":"Arthritis and rheumatism"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/0092-8674(92)90598-7","article-title":"ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain","volume":"71","author":"AC Chan","year":"1992","journal-title":"Cell"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.4049\/jimmunol.171.7.3325","article-title":"T cell rewiring in differentiation and disease","volume":"171","author":"S Krishnan","year":"2003","journal-title":"J Immunol"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1002\/art.11072","article-title":"Reconstitution of deficient T cell receptor zeta chain restores T cell signaling and augments T cell receptor\/CD3-induced interleukin-2 production in patients with systemic lupus erythematosus","volume":"48","author":"MP Nambiar","year":"2003","journal-title":"Arthritis and rheumatism"},{"issue":"19","key":"ref11","doi-asserted-by":"crossref","first-page":"18959","DOI":"10.1074\/jbc.M501048200","article-title":"Decreased stability and translation of T cell receptor zeta mRNA with an alternatively spliced 3&apos;-untranslated region contribute to zeta chain down-regulation in patients with systemic lupus erythematosus","volume":"280","author":"B Chowdhury","year":"2005","journal-title":"The Journal of biological chemistry"},{"issue":"29","key":"ref12","doi-asserted-by":"crossref","first-page":"20037","DOI":"10.1074\/jbc.M710434200","article-title":"The RNA-stabilizing protein HuR regulates the expression of zeta chain of the human T cell receptor-associated CD3 complex","volume":"283","author":"VR Moulton","year":"2008","journal-title":"The Journal of biological chemistry"},{"issue":"17","key":"ref13","doi-asserted-by":"crossref","first-page":"12490","DOI":"10.1074\/jbc.M109.091660","article-title":"Alternative splicing factor\/splicing factor 2 regulates the expression of the zeta subunit of the human T cell receptor-associated CD3 complex","volume":"285","author":"VR Moulton","year":"2010","journal-title":"The Journal of biological chemistry"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1073\/pnas.1214207110","article-title":"Splicing factor SF2\/ASF rescues IL-2 production in T cells from systemic lupus erythematosus patients by activating IL-2 transcription","volume":"110","author":"VR Moulton","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1101\/gad.12.1.55","article-title":"A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm","volume":"12","author":"JF Caceres","year":"1998","journal-title":"Genes & development"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev.biochem.72.121801.161720","article-title":"Mechanisms of alternative pre-messenger RNA splicing","volume":"72","author":"DL Black","year":"2003","journal-title":"Annual review of biochemistry"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1101\/gad.939502","article-title":"Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF\/SF2: a novel function for SR proteins","volume":"16","author":"R Lemaire","year":"2002","journal-title":"Genes & development"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.molcel.2008.03.013","article-title":"The splicing factor SF2\/ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1","volume":"30","author":"G Michlewski","year":"2008","journal-title":"Molecular cell"},{"issue":"8","key":"ref19","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nsmb.1461","article-title":"The splicing factor SC35 has an active role in transcriptional elongation","volume":"15","author":"S Lin","year":"2008","journal-title":"Nature structural & molecular biology"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.cell.2013.04.028","article-title":"SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase","volume":"153","author":"X Ji","year":"2013","journal-title":"Cell"},{"issue":"5","key":"ref21","article-title":"Unique role of SRSF2 in transcription activation and diverse functions of the SR and hnRNP proteins in gene expression regulation","volume":"4","author":"S Mo","year":"2013","journal-title":"Transcription"},{"issue":"15","key":"ref22","doi-asserted-by":"crossref","first-page":"12587","DOI":"10.1074\/jbc.M112010200","article-title":"De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1","volume":"277","author":"CE Chalfant","year":"2002","journal-title":"The Journal of biological chemistry"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/(SICI)1521-4141(199903)29:03<823::AID-IMMU823>3.0.CO;2-C","article-title":"SF2 and SRp55 regulation of CD45 exon 4 skipping during T cell activation","volume":"29","author":"R Lemaire","year":"1999","journal-title":"European journal of immunology"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/art.1780251101","article-title":"The 1982 revised criteria for the classification of systemic lupus erythematosus","volume":"25","author":"EM Tan","year":"1982","journal-title":"Arthritis and rheumatism"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1084\/jem.180.4.1529","article-title":"Transcriptional regulation of the T cell antigen receptor zeta subunit: identification of a tissue-restricted promoter","volume":"180","author":"BL Rellahan","year":"1994","journal-title":"The Journal of experimental medicine"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.4049\/jimmunol.160.6.2794","article-title":"Elf-1 regulates basal expression from the T cell antigen receptor zeta-chain gene promoter","volume":"160","author":"BL Rellahan","year":"1998","journal-title":"J Immunol"},{"issue":"7","key":"ref27","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1093\/nar\/gkt104","article-title":"Linker histone H1.0 interacts with an extensive network of proteins found in the nucleolus","volume":"41","author":"AA Kalashnikova","year":"2013","journal-title":"Nucleic acids research"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.molcel.2009.02.003","article-title":"Chromatin binding of SRp20 and ASF\/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation","volume":"33","author":"RJ Loomis","year":"2009","journal-title":"Molecular cell"},{"issue":"10","key":"ref29","doi-asserted-by":"crossref","first-page":"6048","DOI":"10.4049\/jimmunol.169.10.6048","article-title":"Defective production of functional 98-kDa form of Elf-1 is responsible for the decreased expression of TCR zeta-chain in patients with systemic lupus erythematosus","volume":"169","author":"YT Juang","year":"2002","journal-title":"J Immunol"},{"issue":"9","key":"ref30","doi-asserted-by":"crossref","first-page":"5975","DOI":"10.4049\/jimmunol.175.9.5975","article-title":"The cyclic AMP response element modulator regulates transcription of the TCR zeta-chain","volume":"175","author":"K Tenbrock","year":"2005","journal-title":"J Immunol"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.4049\/jimmunol.175.5.3417","article-title":"Increased caspase-3 expression and activity contribute to reduced CD3zeta expression in systemic lupus erythematosus T cells","volume":"175","author":"S Krishnan","year":"2005","journal-title":"J Immunol"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.4049\/jimmunol.0803600","article-title":"Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1\/Rab4-regulated lysosomal degradation","volume":"182","author":"DR Fernandez","year":"2009","journal-title":"J Immunol"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/1529-0131(200201)46:1<163::AID-ART10065>3.0.CO;2-J","article-title":"Abnormal expression of various molecular forms and distribution of T cell receptor zeta chain in patients with systemic lupus erythematosus","volume":"46","author":"MP Nambiar","year":"2002","journal-title":"Arthritis and rheumatism"},{"issue":"7","key":"ref34","doi-asserted-by":"crossref","first-page":"4126","DOI":"10.1074\/jbc.M113.518662","article-title":"Ubiquitination regulates expression of the serine\/arginine-rich splicing factor 1 (SRSF1) in normal and systemic lupus erythematosus (SLE) T cells","volume":"289","author":"VR Moulton","year":"2014","journal-title":"The Journal of biological chemistry"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0131073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T23:31:10Z","timestamp":1691796670000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0131073"}},"subtitle":[],"editor":[{"given":"Stamatis-Nick","family":"Liossis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,7,2]]},"references-count":34,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,7,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0131073","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,2]]}}}