{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T13:09:11Z","timestamp":1775135351802,"version":"3.50.1"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0131198","type":"journal-article","created":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T18:23:29Z","timestamp":1435775009000},"page":"e0131198","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Possible Mechanisms of the Impaired Insulin Secretion in Hypothyroid Rats"],"prefix":"10.1371","volume":"10","author":[{"given":"Aliashraf","family":"Godini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asghar","family":"Ghasemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saleh","family":"Zahediasl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,7,1]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1055\/s-2003-40463","article-title":"Expression of thyroid hormone receptor isoform alpha1 in pancreatic islets","volume":"111","author":"A Zinke","year":"2003","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"8","key":"ref2","doi-asserted-by":"crossref","first-page":"e104184","DOI":"10.1371\/journal.pone.0104184","article-title":"MafA is required for postnatal proliferation of pancreatic beta-cells","volume":"9","author":"K Eto","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"ref3","first-page":"263","article-title":"Changes induced by hypothyroidism in insulin secretion and in the properties of islet plasma membranes","volume":"101","author":"GB Diaz","year":"1993","journal-title":"Arch Int Physiol Biochim Biophys"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1159\/000145892","article-title":"Effect of the removal of different endocrine glands upon insulin secretion and B-cell ultrastructure","volume":"119","author":"CL Gomez Dumm","year":"1984","journal-title":"Acta Anat (Basel)"},{"issue":"2","key":"ref5","first-page":"181","article-title":"Effect of thyroid hormone levels upon pancreatic islet function","volume":"35","author":"AM Cortizo","year":"1985","journal-title":"Acta Physiol Pharmacol Latinoam"},{"key":"ref6","article-title":"The Effect of Thyroidectomy and Propylthiouracil-Induced Hypothyroidism on Insulin Secretion in Male Rats","author":"A Godini","year":"2014","journal-title":"Horm Metab Res"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1096\/fj.11-186841","article-title":"Mitochondrial T3 receptor p43 regulates insulin secretion and glucose homeostasis","volume":"26","author":"E Blanchet","year":"2012","journal-title":"FASEB J"},{"issue":"1","key":"ref8","first-page":"RA12","article-title":"High fat diet modulation of glucose sensing in the beta-cell","volume":"13","author":"ME Cerf","year":"2007","journal-title":"Med Sci Monit"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1007\/s004240100583","article-title":"Effects of triiodothyronine and bovine growth hormone on glucose transporter isoform-2 (GLUT-2) and glucokinase (GK) gene expression in pancreatic islets of fetal and adult rats","volume":"442","author":"M Garcia-Flores","year":"2001","journal-title":"Pflugers Arch"},{"issue":"1\u20132","key":"ref10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0303-7207(97)04026-4","article-title":"Glucose transport correlates with GLUT2 abundance in rat liver during altered thyroid status","volume":"128","author":"HF Kemp","year":"1997","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3109\/00365513.2012.743164","article-title":"Comparison of the effect of maternal hypothyroidism on carbohydrate metabolism in young and aged male offspring in rats","volume":"73","author":"N Karbalaei","year":"2013","journal-title":"Scand J Clin Lab Invest"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2337\/diab.16.1.35","article-title":"Method for the isolation of intact islets of Langerhans from the rat pancreas","volume":"16","author":"PE Lacy","year":"1967","journal-title":"Diabetes"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1172\/JCI41541","article-title":"The Gq\/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice","volume":"120","author":"A Sassmann","year":"2010","journal-title":"J Clin Invest"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"E438","DOI":"10.1152\/ajpendo.00057.2003","article-title":"Glibenclamide inhibits islet carnitine palmitoyltransferase 1 activity, leading to PKC-dependent insulin exocytosis","volume":"285","author":"M Lehtihet","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/taap.2001.9185","article-title":"Effects of triphenyltin on cytosolic Na(+) and Ca(2+) response to glucose and acetylcholine in pancreatic beta-cells from hamster","volume":"174","author":"Y Miura","year":"2001","journal-title":"Toxicol Appl Pharmacol"},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1210\/endo.138.7.5234","article-title":"Impaired cytosolic Ca2+ response to glucose and gastric inhibitory polypeptide in pancreatic beta-cells from triphenyltin-induced diabetic hamster","volume":"138","author":"Y Miura","year":"1997","journal-title":"Endocrinology"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/BF01145963","article-title":"Interaction between perchlorate and nifedipine on insulin secretion from mouse pancreatic islets","volume":"13","author":"G Larsson-Nyren","year":"1993","journal-title":"Biosci Rep"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.bbrc.2003.10.189","article-title":"Enhanced expression of neuronal nitric oxide synthase in islets of exercise-trained rats","volume":"312","author":"H Ueda","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1507\/endocrj1954.27.27","article-title":"Effect of propylthiouracil on nycthemeral and sex related variation of plasma TSH in rats","volume":"27","author":"N Tonooka","year":"1980","journal-title":"Endocrinol Jpn"},{"issue":"8","key":"ref20","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.2337\/diab.43.8.1066","article-title":"Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes","volume":"43","author":"CR Kahn","year":"1994","journal-title":"Diabetes"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/BF00550880","article-title":"Widespread synchronous [Ca2+]i oscillations due to bursting electrical activity in single pancreatic islets","volume":"418","author":"RM Santos","year":"1991","journal-title":"Pflugers Arch"},{"issue":"30","key":"ref22","doi-asserted-by":"crossref","first-page":"22265","DOI":"10.1016\/S0021-9258(18)41522-0","article-title":"Oscillations of secretion driven by oscillations of cytoplasmic Ca2+ as evidences in single pancreatic islets","volume":"268","author":"P Gilon","year":"1993","journal-title":"J Biol Chem"},{"issue":"12","key":"ref23","doi-asserted-by":"crossref","first-page":"8749","DOI":"10.1016\/S0021-9258(17)37032-1","article-title":"Synchronous oscillations of cytoplasmic Ca2+ and insulin release in glucose-stimulated pancreatic islets","volume":"269","author":"P Bergsten","year":"1994","journal-title":"J Biol Chem"},{"issue":"Pt 3","key":"ref24","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1113\/jphysiol.1995.sp020999","article-title":"Thyroid status and diabetes modulate regional differences in potassium currents in rat ventricle","volume":"488","author":"Y Shimoni","year":"1995","journal-title":"J Physiol"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s002329900359","article-title":"Hypothyroidism decreases the ATP sensitivity of KATP channels from rat heart","volume":"162","author":"P Light","year":"1998","journal-title":"J Membr Biol"},{"issue":"5","key":"ref26","first-page":"565","article-title":"Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function","volume":"22","author":"P Gilon","year":"2001","journal-title":"Endocr Rev"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1385\/ENDO:8:3:213","article-title":"Neurotransmitters and their receptors in the islets of Langerhans of the pancreas: what messages do acetylcholine, glutamate, and GABA transmit","volume":"8","author":"LS Satin","year":"1998","journal-title":"Endocrine"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s001250051322","article-title":"Autonomic regulation of islet hormone secretion\u2014implications for health and disease","volume":"43","author":"B Ahren","year":"2000","journal-title":"Diabetologia"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.cmet.2006.04.009","article-title":"A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo","volume":"3","author":"D Gautam","year":"2006","journal-title":"Cell Metab"},{"issue":"Suppl 2","key":"ref30","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1463-1326.2007.00781.x","article-title":"Role of the M3 muscarinic acetylcholine receptor in beta-cell function and glucose homeostasis","volume":"9","author":"D Gautam","year":"2007","journal-title":"Diabetes Obes Metab"},{"issue":"1\u20133","key":"ref31","first-page":"49","article-title":"Thyroid hormone increased L-type calcium channel mRNA expression and L-type calcium current of myocytes in rabbits","volume":"22","author":"Z Yu","year":"2012","journal-title":"Biomed Mater Eng"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1089\/105072502760143809","article-title":"Cellular action of thyroid hormone on the heart","volume":"12","author":"WH Dillmann","year":"2002","journal-title":"Thyroid"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"647","DOI":"10.2337\/diab.39.6.647","article-title":"Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes","volume":"39","author":"FM Matschinsky","year":"1990","journal-title":"Diabetes"},{"issue":"Suppl 3","key":"ref34","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.2337\/diabetes.53.suppl_3.S48","article-title":"Pathways in beta-cell stimulus-secretion coupling as targets for therapeutic insulin secretagogues","volume":"53","author":"JC Henquin","year":"2004","journal-title":"Diabetes"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2337\/diab.45.2.223","article-title":"Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm","volume":"45","author":"FM Matschinsky","year":"1996","journal-title":"Diabetes"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1146\/annurev.bi.64.070195.003353","article-title":"Metabolic coupling factors in pancreatic beta-cell signal transduction","volume":"64","author":"CB Newgard","year":"1995","journal-title":"Annu Rev Biochem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"7156","DOI":"10.2741\/3218","article-title":"Pancreas islets in metabolic signaling\u2014focus on the beta-cell","volume":"13","author":"J Suckale","year":"2008","journal-title":"Front Biosci"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1042\/bj2710585","article-title":"Insulin and tri-iodothyronine induce glucokinase mRNA in primary cultures of neonatal rat hepatocytes","volume":"271","author":"MR Narkewicz","year":"1990","journal-title":"Biochem J"},{"issue":"13","key":"ref39","doi-asserted-by":"crossref","first-page":"5744","DOI":"10.1073\/pnas.89.13.5744","article-title":"[Val12] HRAS downregulates GLUT2 in beta cells of transgenic mice without affecting glucose homeostasis","volume":"89","author":"M Tal","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"46","key":"ref40","doi-asserted-by":"crossref","first-page":"28543","DOI":"10.1016\/S0021-9258(19)61937-X","article-title":"Expression of GLUT-2 antisense RNA in beta cells of transgenic mice leads to diabetes","volume":"269","author":"A Valera","year":"1994","journal-title":"J Biol Chem"},{"issue":"20","key":"ref41","doi-asserted-by":"crossref","first-page":"15205","DOI":"10.1016\/S0021-9258(18)82457-7","article-title":"Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion. Relationship to glucose metabolism","volume":"268","author":"SD Hughes","year":"1993","journal-title":"J Biol Chem"},{"issue":"6","key":"ref42","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.2337\/diabetes.50.6.1282","article-title":"Evidence that extrapancreatic GLUT2-dependent glucose sensors control glucagon secretion","volume":"50","author":"R Burcelin","year":"2001","journal-title":"Diabetes"},{"issue":"4","key":"ref43","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/09687680110100995","article-title":"GLUT2 in pancreatic and extra-pancreatic gluco-detection (review)","volume":"18","author":"B Thorens","year":"2001","journal-title":"Mol Membr Biol"},{"issue":"31","key":"ref44","doi-asserted-by":"crossref","first-page":"23751","DOI":"10.1074\/jbc.M002908200","article-title":"Transgenic reexpression of GLUT1 or GLUT2 in pancreatic beta cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion","volume":"275","author":"B Thorens","year":"2000","journal-title":"J Biol Chem"},{"issue":"12","key":"ref45","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1172\/JCI26309","article-title":"Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors","volume":"115","author":"N Marty","year":"2005","journal-title":"J Clin Invest"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/ng1197-327","article-title":"Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2","volume":"17","author":"MT Guillam","year":"1997","journal-title":"Nat Genet"},{"issue":"9","key":"ref47","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.2337\/diabetes.49.9.1485","article-title":"Glucose uptake, utilization, and signaling in GLUT2-null islets","volume":"49","author":"MT Guillam","year":"2000","journal-title":"Diabetes"},{"issue":"4","key":"ref48","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/s00424-002-0954-2","article-title":"A gene knockout approach in mice to identify glucose sensors controlling glucose homeostasis","volume":"445","author":"B Thorens","year":"2003","journal-title":"Pflugers Arch"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1152\/physiol.00010.2007","article-title":"Brain glucose sensing, counterregulation, and energy homeostasis","volume":"22","author":"N Marty","year":"2007","journal-title":"Physiology (Bethesda)"},{"issue":"15","key":"ref50","doi-asserted-by":"crossref","first-page":"11523","DOI":"10.1016\/S0021-9258(19)78155-1","article-title":"GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity","volume":"269","author":"S Ferber","year":"1994","journal-title":"J Biol Chem"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1210\/endo.135.2.8033812","article-title":"Regulation of GLUT2 glucose transporter expression in liver by thyroid hormone: evidence for hormonal regulation of the hepatic glucose transport system","volume":"135","author":"SP Weinstein","year":"1994","journal-title":"Endocrinology"},{"issue":"3","key":"ref52","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00125-010-2026-z","article-title":"Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells","volume":"54","author":"C Aguayo-Mazzucato","year":"2011","journal-title":"Diabetologia"},{"issue":"5","key":"ref53","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.2337\/db12-0849","article-title":"Thyroid hormone promotes postnatal rat pancreatic beta-cell development and glucose-responsive insulin secretion through MAFA","volume":"62","author":"C Aguayo-Mazzucato","year":"2013","journal-title":"Diabetes"},{"issue":"14","key":"ref54","doi-asserted-by":"crossref","first-page":"12263","DOI":"10.1074\/jbc.M210801200","article-title":"The islet beta cell-enriched RIPE3b1\/Maf transcription factor regulates pdx-1 expression","volume":"278","author":"SE Samaras","year":"2003","journal-title":"J Biol Chem"},{"issue":"12","key":"ref55","doi-asserted-by":"crossref","first-page":"4969","DOI":"10.1128\/MCB.25.12.4969-4976.2005","article-title":"MafA is a key regulator of glucose-stimulated insulin secretion","volume":"25","author":"C Zhang","year":"2005","journal-title":"Mol Cell Biol"},{"issue":"13","key":"ref56","doi-asserted-by":"crossref","first-page":"11225","DOI":"10.1074\/jbc.M111272200","article-title":"Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion","volume":"277","author":"M Brissova","year":"2002","journal-title":"J Biol Chem"},{"issue":"51","key":"ref57","doi-asserted-by":"crossref","first-page":"49903","DOI":"10.1074\/jbc.M206796200","article-title":"MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene","volume":"277","author":"K Kataoka","year":"2002","journal-title":"J Biol Chem"},{"issue":"11","key":"ref58","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1002\/j.1460-2075.1993.tb06109.x","article-title":"IPF1, a homeodomain-containing transactivator of the insulin gene","volume":"12","author":"H Ohlsson","year":"1993","journal-title":"EMBO J"},{"issue":"17","key":"ref59","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1128\/MCB.23.17.6049-6062.2003","article-title":"Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells","volume":"23","author":"TA Matsuoka","year":"2003","journal-title":"Mol Cell Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0131198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T15:20:39Z","timestamp":1652714439000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0131198"}},"subtitle":[],"editor":[{"given":"Kathrin","family":"Maedler","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,7,1]]},"references-count":59,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,7,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0131198","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,1]]}}}