{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:40:20Z","timestamp":1792658420468,"version":"4.5.0"},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T00:00:00Z","timestamp":1436140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0131447","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T15:03:12Z","timestamp":1436194992000},"page":"e0131447","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Dysregulation of Autonomic Nervous System in Chagas\u2019 Heart Disease Is Associated with Altered Adipocytokines Levels"],"prefix":"10.1371","volume":"10","author":[{"given":"Jo\u00e3o Marcos","family":"Barbosa-Ferreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Mady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara Maria","family":"Ianni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heno Ferreira","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix Jos\u00e9 Alvarez","family":"Ramires","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera Maria Cury","family":"Salemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar Jos\u00e9","family":"Grupi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Tessariol","family":"Hachul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,7,6]]},"reference":[{"key":"ref1","year":"2012"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.actatropica.2009.07.019","article-title":"Chagas disease in Spain, the United States and other non-endemic countries","volume":"115","author":"J Gascon","year":"2010","journal-title":"Acta Tropica"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S1473-3099(01)00065-2","article-title":"Clinical and epidemiological aspects of Chagas\u2019disease","volume":"1","author":"A Prata","year":"2001","journal-title":"Lancet Infect Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1590\/S0066-782X2001000700006","article-title":"Chagas\u2019 heart disease: Evolutive evaluation of eletrocardiographic and echocardiographic parameters in patients with the indeterminate form","volume":"77","author":"BM Ianni","year":"2001","journal-title":"Arq Bras Cardiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1161\/CIRCULATIONAHA.106.624296","article-title":"Pathogenesis of chronic Chagas Heart Disease","volume":"115","author":"JA Marin-Neto","year":"2007","journal-title":"Circulation"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0167-5273(98)00212-5","article-title":"Chagas\u2019 heart disease and the autonomic nervous system","volume":"66","author":"DF D\u00e1vila","year":"1998","journal-title":"Int J Cardiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1067\/mhj.2001.111406","article-title":"Parasympathetic dysautonomia precedes left ventricular systolic dysfunction in Chagas disease","volume":"141","author":"ALP Ribeiro","year":"2001","journal-title":"Am Heart J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ijcard.2005.11.010","article-title":"Dysautonomia and ventricular dysfunction in the indeterminate form of Chagas disease","volume":"113","author":"RBG Molina","year":"2006","journal-title":"Int J Cardiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.jacc.2014.04.083","article-title":"Metabolic impairment in heart failure: the myocardial and systemic perspective","volume":"64","author":"W Doehner","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"ref10","first-page":"538","article-title":"Autonomic dysregulation and the metabolic syndrome: Pathologic partners in an emerging global pandemic","volume":"87","author":"HF Lopes","year":"2006"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1590\/S0004-27302009000200005","article-title":"Adipose tissue at the crossroads in the development of the metabolic syndrom, inflammation and atherosclerosis","volume":"53","author":"BL Wajchenberg","year":"2009","journal-title":"Arq Bras Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1467-789X.2009.00571.x","article-title":"Adiponectin: from obesity to cardiovascular disease","volume":"10","author":"C Antoniades","year":"2009","journal-title":"Obesity Reviews"},{"key":"ref13","first-page":"505","article-title":"Adipocytokines- Novel link between inflamation and vascular function?","volume":"57","author":"TJ Guzik","year":"2006","journal-title":"J Physiol and Pharmacol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1161\/01.RES.0000163635.62927.34","article-title":"Adipose tissue, inflamation and cardiovascular disease","volume":"96","author":"AH Berg","year":"2005","journal-title":"Circulation Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1136\/hrt.2005.083345","article-title":"Circulating adiponectin concentrations in patients with congestive heart failure","volume":"92","author":"J George","year":"2006","journal-title":"Heart"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.clinbiochem.2009.02.023","article-title":"Prognostic value of increased adiponectin plasma concentrations in patients with acute destabilized heart failure","volume":"42","author":"B Dieplinger","year":"2009","journal-title":"Clin Biochem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1388-9842(02)00177-0","article-title":"Elevated serum levels of leptin and soluble leptin receptor in patients with chronic heart failure","volume":"5","author":"PC Schulze","year":"2003","journal-title":"Eur J Heart Fail"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0167-5273(00)00397-1","article-title":"Leptin serum levels in cachetic heart failure patients. Relationship with tumor necrosis factor-alpha system","volume":"76","author":"GS Filippatos","year":"2000","journal-title":"Int J Cardiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1590\/S0100-879X2006005000152","article-title":"Leptin levels in different forms of Chagas\u2019 disease","volume":"40","author":"F Fernandes","year":"2007","journal-title":"Braz J Med Biol Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.CIR.93.5.1043","article-title":"Task force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: standards of measurement, physiological, interpretation and clinical use","volume":"93","year":"1996","journal-title":"Circulation"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"24085","DOI":"10.1074\/jbc.M412802200","article-title":"The adipocyte as an important target cell for infection with <italic>Trypanosoma cruzi<\/italic>","volume":"280","author":"TP Coombs","year":"2005","journal-title":"J Biol Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1038\/oby.2008.331","article-title":"<italic>Trypanosoma cruzi<\/italic> infection of cultured adipocytes results in an inflamattory phenotype","volume":"16","author":"F Nagajyothi","year":"2008","journal-title":"Obesity"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.micinf.2011.06.002","article-title":"Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas disease","volume":"13","author":"AVM Ferreira","year":"2011","journal-title":"Microbes Infect"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/1476-511X-11-106","article-title":"Adiponectin through its biphasic serum is a useful biomarker during transition from diastolic dysfunction to systolic dysfunction- an experimental study","volume":"11","author":"M Fu","year":"2012","journal-title":"Lipids Health Dis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/eurheartj\/ehm033","article-title":"Increase in serum adiponectin concentration in patients with heart failure and cachexia: relationship with leptin, other cytokines, and B-type natriuretic peptide","volume":"28","author":"MB McEntegart","year":"2007","journal-title":"Eur Heart J"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/eurjhf\/hfp046","article-title":"Adiponectin is increased in cardiac cachexia irrespective of body mass index","volume":"11","author":"JP Ara\u00fajo","year":"2009","journal-title":"Eur J Heart Fail"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1161\/CIRCULATIONAHA.112.123612","article-title":"Ten years incidence of Chagas cardiomyopathy among asymptomatic Trypanosoma cruzi-seropositive former blood donors","volume":"127","author":"EC Sabino","year":"2013","journal-title":"Circulation"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1016\/j.jacc.2009.02.038","article-title":"Natriuretic peptides enhance the production of adiponectin in human adipocytes and in patients with chronic heart failure","volume":"53","author":"O Tsukamoto","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1161\/CIRCHEARTFAILURE.111.964031","article-title":"Adipose tissue inflammation and adiponectin resistance in patients with advanced heart failure: Correction after ventricular assist device implantation","volume":"5","author":"RS Khan","year":"2012","journal-title":"Circ Heart Fail"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1093\/eurheartj\/ehn136","article-title":"Description of a local cardiac adiponectin system and its deregulation in dilated cardiomyopathy","volume":"29","author":"C Skurk","year":"2008","journal-title":"Eur Heart J"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ijcard.2007.11.040","article-title":"Adipnectin is released from the heart in patients with heart failure","volume":"132","author":"H Takano","year":"2009","journal-title":"Int J Cardiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e3118","DOI":"10.1371\/journal.pntd.0003118","article-title":"High fat diet modulates <italic>Trypanosoma cruzi<\/italic> infection associated myocarditis","volume":"8","author":"F Nagajhioti","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1093\/eurheartj\/ehq498","article-title":"Adiponectin expression in patients with inflammatory cardiomyopathy indicates favourable outcome and inflammation control","volume":"32","author":"P Bobbert","year":"2011","journal-title":"Eur Heart J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s11897-011-0056-6","article-title":"Functional adiponectin resistance and exercise intolerance in heart failure","volume":"8","author":"AMV Berendoncks","year":"2011","journal-title":"Curr Heart Fail Rep"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/oby.2006.130","article-title":"Cold exposure supresses serum adiponectin levels through sympathetic nerve activation in mice","volume":"14","author":"J Imai","year":"2006","journal-title":"Obesity"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.metabol.2010.03.011","article-title":"Cold-induced alteration of adipokine profile in humans","volume":"60","author":"KA Iwen","year":"2011","journal-title":"Metabolism"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.2337\/diacare.27.10.2392","article-title":"Adiponectin concentrations in sera from patients with type 2 diabetes are negatively associated with sympathovagal balance as evaluated by power spectral analysis of heart rate variation","volume":"27","author":"S Wakabayashi","year":"2004","journal-title":"Diabetes Care"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.metabol.2007.02.005","article-title":"Hypoadiponectinemia in type 2 diabetes mellitus in men is associated with overactity as evaluated by cardiac 123I-metaiodobenzylguanidine scintigraphy","volume":"56","author":"N Takahashi","year":"2007","journal-title":"Metabolism"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/878760","article-title":"Cardiac autonomic imbalance in newly diagonsed and established diabetes is associated with markers of adipose tissue inflammation","volume":"2012","author":"DC Lieb","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1093\/sleep\/31.12.1721","article-title":"Hypoadiponectinemia is related to sympathetic activation and severity of obstructive sleep apnea","volume":"31","author":"JC Lam","year":"2008","journal-title":"Sleep"},{"key":"ref41","first-page":"390","article-title":"Effects of adiponectin on the renal sympathetic nerve acitivity and blood pressure in rats","volume":"232","author":"MT Tanida","year":"2007","journal-title":"Exp Biol Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0014-5793(01)02960-X","article-title":"Adiponectin gene expression is inhibited by \u00df-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes","volume":"507","author":"M Fasshauer","year":"2001","journal-title":"FEBS"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1042\/bj20020610","article-title":"Pre- and post-translational negative effect of \u00df-adrenoreceptor agonists on adiponectin secretion: in vitro and in vivo studies","volume":"367","author":"ML Delporte","year":"2002","journal-title":"Biochem J"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1194\/jlr.R700006-JLR200","article-title":"Sympathetic and sensory innervation of white adipose tissue","volume":"48","author":"TJ Bartness","year":"2007","journal-title":"J Lipid Res"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Bartness TJ, Shrestha YB, Vaughan CH, Schwartz GJ, Song CK (2010) Sensory and sympathetic nervous system control of white adipose tissue. Mol Cell Endocrinol 318\u2013343.","DOI":"10.1016\/j.mce.2009.08.031"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e28146","DOI":"10.1371\/journal.pone.0028146","article-title":"The multi-level action of fatty acids on adiponectin production by fat cells","volume":"6","author":"S Karki","year":"2011","journal-title":"PloS One"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1007\/s00125-007-0614-3","article-title":"Atrial natriuretic peptides inhibits the production of adipokines and citokines linked to inflammation and insulin resistance in human subcutaneous adipose tissue","volume":"50","author":"C Moro","year":"2007","journal-title":"Diabetologia"},{"key":"ref48","first-page":"1187","article-title":"Blood glucose and insulin response to intravenous glucose by patients with chronic Chagas\u2019Disease and alcoholism","volume":"26","author":"LCM Oliveira","year":"1993","journal-title":"Braz J Med Biol Res"},{"key":"ref49","first-page":"491","article-title":"Heterogeneous insulin response to an oral glucose load by patients with indeterminate clinical form of Chagas\u2019 disease","volume":"26","author":"ME Guariento","year":"1993","journal-title":"Braz J Med Biol Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.ajpath.2012.11.027","article-title":"Alterations in glucose homeostasis in a murine model of Chagas disease","volume":"182","author":"F Nagajyothi","year":"2013","journal-title":"Am J Pathol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.cardfail.2011.08.010","article-title":"Dynamics in insulin resistance and plasma levels of adipokines in patients with acute descompensated and chronic stable heart failure","volume":"17","author":"PC Schulze","year":"2011","journal-title":"J Cardiac Fail"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1136\/hrt.82.3.352","article-title":"Inappropriately low plasma leptin concentration in the cachexia associated with chronic heart failure","volume":"82","author":"DR Murdoch","year":"1999","journal-title":"Heart"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1517\/17530059.2013.735229","article-title":"Leptin in heart failure","volume":"7","author":"JM Barbosa-Ferreira","year":"2013","journal-title":"Expert Opin Med Diagn"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1079\/PNS19980060","article-title":"Regulation of leptin production: a dominant role for the sympathetic nervous system?","volume":"57","author":"P Trayburn","year":"1998","journal-title":"Proc Nutr Soc"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1210\/jcem.85.5.6511","article-title":"Plasma Leptin concentrations and cardiac autonomic nervous system in healthy subjects with different body weights","volume":"85","author":"G Paolisso","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1097\/00004872-200208000-00008","article-title":"Leptin, sympathetic and baroreflex function: another step on the road to sympathetic differention","volume":"20","author":"G Grassi","year":"2002","journal-title":"J Hypertens"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1097\/00004872-200208000-00027","article-title":"Differential modulation of leptin-induced sympathoexcitation by baroreflex activation","volume":"20","author":"M Hausberg","year":"2002","journal-title":"J Hypertens"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0002-9149(00)01133-4","article-title":"Relation of regional sympathetic denervation and myocardial perfusion disturbance to wall motion impairment in Chagas\u2019 cardiomyopathy","volume":"86","author":"MV Sim\u00f5es","year":"2000","journal-title":"Am J Cardiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"15","DOI":"10.5301\/HEART.2014.12496","article-title":"Differential effects of adrenergic antagonists (carvedilol vs metoprolol) on parasympathetic and sympathetic activity: a comparison of clinical results","volume":"9","author":"HL Bloom","year":"2014","journal-title":"Heart Int"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1113\/expphysiol.2010.056259","article-title":"LF power of heart rate variability is not a measure of cardiac sympathetic but may be a measure of modulations of cardiac autonomic outflows by baroreflexes","volume":"96","author":"DS Goldstein","year":"2011","journal-title":"Exp Phisiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0131447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T21:19:34Z","timestamp":1566940774000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0131447"}},"subtitle":[],"editor":[{"given":"Herbert B.","family":"Tanowitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,7,6]]},"references-count":60,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,7,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0131447","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,6]]}}}