{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:07:25Z","timestamp":1759565245491},"reference-count":75,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T00:00:00Z","timestamp":1436140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0131573","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T19:08:08Z","timestamp":1436209688000},"page":"e0131573","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Exploring Genetic Factors Involved in Huntington Disease Age of Onset: E2F2 as a New Potential Modifier Gene"],"prefix":"10.1371","volume":"10","author":[{"given":"Leire","family":"Valc\u00e1rcel-Ocete","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gorka","family":"Alkorta-Aranburu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikel","family":"Iriondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asier","family":"Fullaondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Garc\u00eda-Barcina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Manuel","family":"Fern\u00e1ndez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Lezcano-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Losada-Domingo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Ruiz-Ojeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amaia","family":"\u00c1lvarez de Arcaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"P\u00e9rez-Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymund A. C.","family":"Roos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rgen E.","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Saft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"REGISTRY investigators of the European Huntington's Disease Network","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana M.","family":"Zubiaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Aguirre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,7,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1750-1172-5-40","article-title":"Huntington&apos;s disease: a clinical review","volume":"5","author":"RA Roos","year":"2010","journal-title":"Orphanet J Rare Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1474-4422(10)70245-3","article-title":"Huntington&apos;s disease: from molecular pathogenesis to clinical treatment","volume":"10","author":"CA Ross","year":"2011","journal-title":"Lancet Neurol"},{"key":"ref3","first-page":"RRN1258","article-title":"Age-at-onset in Huntington disease","volume":"3","author":"M Orth","year":"2011","journal-title":"PLOS Currents Huntington Disease"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S1474-4422(09)70170-X","article-title":"Biological and clinical manifestations of Huntington&apos;s disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data","volume":"8","author":"SJ Tabrizi","year":"2009","journal-title":"Lancet Neurol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1136\/jnnp.2007.128728","article-title":"Detection of Huntington&apos;s disease decades before diagnosis: the Predict-HD study","volume":"79","author":"JS Paulsen","year":"2008","journal-title":"Journal of Neurology Neurosurgery and Psychiatry"},{"key":"ref6","first-page":"1202","article-title":"The likelihood of being affected with Huntington disease by a particular age, for a specific CAG size","volume":"60","author":"RR Brinkman","year":"1997","journal-title":"American Journal of Human Genetics"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neulet.2004.10.018","article-title":"Modulation of age at onset of Huntington disease patients by variations in TP53 and human caspase activated DNase (hCAD) genes","volume":"374","author":"B Chattopadhyay","year":"2005","journal-title":"Neurosci Lett"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.nbd.2009.06.009","article-title":"A genetic variation in the ADORA2A gene modifies age at onset in Huntington&apos;s disease","volume":"35","author":"CM Dhaenens","year":"2009","journal-title":"Neurobiol Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1750-1326-4-10","article-title":"PGC-1alpha as modifier of onset age in Huntington disease","volume":"4","author":"E Taherzadeh-Fard","year":"2009","journal-title":"Mol Neurodegener"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0304-3940(03)00436-1","article-title":"Modulation of age at onset in Huntington&apos;s disease and spinocerebellar ataxia type 2 patients originated from eastern India","volume":"345","author":"B Chattopadhyay","year":"2003","journal-title":"Neurosci Lett"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1469-1809.2006.00335.x","article-title":"The relationship between CAG repeat length and age of onset differs for Huntington&apos;s disease patients with juvenile onset or adult onset","volume":"71","author":"JM Andresen","year":"2007","journal-title":"Ann Hum Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1073\/pnas.0308679101","article-title":"Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington&apos;s disease age of onset","volume":"101","author":"NS Wexler","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/ajmg.a.20190","article-title":"Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease","volume":"119A","author":"L Djouss\u00e9","year":"2003","journal-title":"Am J Med Genet A"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1073\/pnas.94.8.3872","article-title":"Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease","volume":"94","author":"DC Rubinsztein","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1471-2202-7-62","article-title":"Genetic analysis of the GRIK2 modifier effect in Huntington&apos;s disease","volume":"7","author":"W Zeng","year":"2006","journal-title":"BMC Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10048-004-0198-8","article-title":"NR2A and NR2B receptor gene variations modify age at onset in Huntington disease","volume":"6","author":"L Arning","year":"2005","journal-title":"Neurogenetics"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00439-007-0393-4","article-title":"NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner","volume":"122","author":"L Arning","year":"2007","journal-title":"Hum Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"RRN1247","DOI":"10.1371\/currents.RRN1247","article-title":"NMDA receptor gene variations as modifiers in Huntington disease: a replication study","volume":"3","author":"C Saft","year":"2011","journal-title":"PLoS Curr"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1073\/pnas.98.4.1811","article-title":"The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: Neuropathologic and genetic evidence for a role in Huntington&apos;s disease pathogenesis","volume":"98","author":"S Holbert","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/hmg\/ddn003","article-title":"Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington&apos;s disease","volume":"17","author":"S Metzger","year":"2008","journal-title":"Hum Mol Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s10048-010-0248-3","article-title":"Age at onset in Huntington&apos;s disease: replication study on the associations of ADORA2A, HAP1 and OGG1","volume":"11","author":"E Taherzadeh-Fard","year":"2010","journal-title":"Neurogenetics"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1750-1326-4-3","article-title":"The gene coding for PGC-1alpha modifies age at onset in Huntington&apos;s Disease","volume":"4","author":"P Weydt","year":"2009","journal-title":"Mol Neurodegener"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-1326-6-1","article-title":"Localization of sequence variations in PGC-1alpha influence their modifying effect in Huntington disease","volume":"6","author":"HV Che","year":"2011","journal-title":"Mol Neurodegener"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00439-010-0873-9","article-title":"Age at onset in Huntington&apos;s disease is modified by the autophagy pathway: implication of the V471A polymorphism in Atg7","volume":"128","author":"S Metzger","year":"2010","journal-title":"Hum Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e68951","DOI":"10.1371\/journal.pone.0068951","article-title":"The V471A polymorphism in autophagy-related gene ATG7 modifies age at onset specifically in Italian Huntington disease patients","volume":"8","author":"S Metzger","year":"2013","journal-title":"PLoS One"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/gm80","article-title":"Huntington&apos;s disease: the case for genetic modifiers","volume":"8","author":"JF Gusella","year":"2009","journal-title":"Genome Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2350-5-7","article-title":"Glutathione S-Transferase Omega 1 variation does not influence age at onset of Huntington\u2019s disease","volume":"5","author":"L Arning","year":"2004","journal-title":"BMC Med Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00109-007-0299-6","article-title":"ASK1 and MAP2K6 as modifiers of age at onset in Huntington&apos;s disease","volume":"86","author":"L Arning","year":"2008","journal-title":"J Mol Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1212\/WNL.0b013e318249f683","article-title":"CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion","volume":"78","author":"JM Lee","year":"2012","journal-title":"Neurology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1007\/s00439-012-1205-z","article-title":"Population stratification may bias analysis of PGC-1\u03b1 as a modifier of age at Huntington disease motor onset","volume":"131","author":"EM Ramos","year":"2012","journal-title":"Hum. Genet"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1212\/01.wnl.0000175977.57661.b1","article-title":"Association between BDNF Val66Met polymorphism and age at onset in Huntington disease","volume":"65","author":"J Alberch","year":"2005","journal-title":"Neurology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.cell.2006.04.026","article-title":"Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin","volume":"125","author":"RK Graham","year":"2006","journal-title":"Cell"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"15019","DOI":"10.1523\/JNEUROSCI.2071-10.2010","article-title":"Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo","volume":"30","author":"RK Graham","year":"2010","journal-title":"J Neurosci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/sj.cdd.4400819","article-title":"Extended polyglutamine selectively interacts with caspase-8 and -10 in nuclear aggregates","volume":"8","author":"M U","year":"2001","journal-title":"Cell Death Differ"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"4860","DOI":"10.1038\/onc.2008.117","article-title":"E2F1 regulates autophagy and the transcription of autophagy genes","volume":"27","author":"S Polager","year":"2008","journal-title":"Oncogene"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.1038\/sj.onc.1204663","article-title":"E2F2 converts reversibly differentiated PC12 cells to an irreversible, neurotrophin-dependent state","volume":"20","author":"SP Persengiev","year":"2001","journal-title":"Oncogene"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1083\/jcb.200412071","article-title":"Davie, JE, Rubinsztein DC. Cdk5 phosphorylation of huntingtin reduces its cleavage by caspases: implications for mutant huntingtin toxicity","volume":"169","author":"S Luo","year":"2005","journal-title":"J Cell Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"7318","DOI":"10.1523\/JNEUROSCI.1831-07.2007","article-title":"Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons","volume":"2","author":"SL Anne","year":"2007","journal-title":"J Neurosci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"E82","DOI":"10.1371\/journal.pgen.0030082","article-title":"Huntingtin interacting proteins are genetic modifiers of neurodegeneration","volume":"3","author":"LS Kaltenbach","year":"2007","journal-title":"PLoS Genet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.0953-816X.2003.03131.x","article-title":"The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin","volume":"19","author":"H Rangone","year":"2004","journal-title":"Eur J Neurosci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ajhg.2009.02.003","article-title":"CAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroup","volume":"84","author":"SC Warby","year":"2009","journal-title":"Am J Hum Genet"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nm.2559","article-title":"Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway","volume":"18","author":"DE Cohen","year":"2011","journal-title":"Nat Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1126\/science.1072613","article-title":"Sp1 and TAFII130 transcriptional activity disrupted in early Huntington&apos;s disease","volume":"296","author":"AW Dunah","year":"2002","journal-title":"Science"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/34112","article-title":"A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD","volume":"391","author":"M Enari","year":"1998","journal-title":"Nature"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"8461","DOI":"10.1073\/pnas.95.15.8461","article-title":"The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis","volume":"95","author":"X Liu","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ncb735","article-title":"Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi","volume":"4","author":"FG Gervais","year":"2002","journal-title":"Nat Cell Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1523\/JNEUROSCI.5175-06.2007","article-title":"NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1","volume":"27","author":"M Metzler","year":"2007","journal-title":"J Neurosci"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1126\/science.1059581","article-title":"Loss of huntingtin-mediated BDNF gene transcription in Huntington&apos;s disease","volume":"293","author":"C Zuccato","year":"2001","journal-title":"Science"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cell.2004.06.018","article-title":"Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules","volume":"118","author":"LR Gauthier","year":"2004","journal-title":"Cell"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1755-5949.2010.00204.x","article-title":"Therapeutic potential of kainate receptors","volume":"17","author":"C Matute","year":"2011","journal-title":"CNS Neurosci Ther"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.pneurobio.2006.11.003","article-title":"N-Methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington\u2019s disease","volume":"81","author":"MYM Fan","year":"2007","journal-title":"Progress in neurology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.nbd.2005.11.001","article-title":"Decreased association of the transcription factor Sp1 with genes downregulated in Huntington\u2019s disease","volume":"22","author":"AS Chen-Plotkin","year":"2006","journal-title":"Neurobiol Dis"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.cell.2006.10.023","article-title":"PGC-1alpha, a new therapeutic target in Huntington\u2019s disease?","volume":"127","author":"JK McGill","year":"2006","journal-title":"Cell"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.cell.2009.03.018","article-title":"Acetylation targets mutant huntingtin to autophagosomes for degradation","volume":"137","author":"H Jeong","year":"2009","journal-title":"Cell"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nm.2558","article-title":"Neuroprotective role of Sirt1 in mammalian models of Huntington&apos;s disease through activation of multiple Sirt1 targets","volume":"18","author":"M Jiang","year":"2011","journal-title":"Nat Med"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4161\/cam.3.1.7511","article-title":"Huntingtin associated protein 1 and its functions","volume":"3","author":"LL Wu","year":"2009","journal-title":"Cell Adh Migr"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.2307\/2408641","article-title":"Estimating F-statistics for the analysis of population structure","volume":"38","author":"BS Weir","year":"1984","journal-title":"Evolution"},{"key":"ref58","unstructured":"Goudet J. FSTAT, a program to estimate and test gene diversities and fixation indices (version 2.9.3). Available from <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.unil.ch\/izea\/softwares\/fstat.html\" xlink:type=\"simple\">http:\/\/www.unil.ch\/izea\/softwares\/fstat.html<\/ext-link>. Updated from Goudet (1995) (2001)."},{"key":"ref59","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview. analysis and visualization of LD and haplotype maps","volume":"2","author":"JC Barrett","year":"2005","journal-title":"Bionformatics"},{"key":"ref60","first-page":"1","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"7","author":"J Vandesompele","year":"2002","journal-title":"Genome Biology"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/nar\/30.9.e36","article-title":"Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR","volume":"30","author":"MW Pffaf","year":"2002","journal-title":"Nucleic Acids Research"},{"issue":"Suppl 1","key":"ref62","doi-asserted-by":"crossref","first-page":"E132","DOI":"10.1002\/mc.21882","article-title":"Combined effects of E2F1 and E2F2 polymorphisms on risk and early onset of squamous cell carcinoma of the head and neck","volume":"51","author":"M Lu","year":"2012","journal-title":"Mol Carcinog"},{"key":"ref63","doi-asserted-by":"crossref","unstructured":"Kobal J, Lovre\u010di\u010d L, Peterlin B. Chapter 4. Biomarkers for Huntington&apos;s Disease. In: Huntington&apos;s Disease\u2014Core Concepts and Current Advances. InTechOpen; 2012.pp. 101\u2013120.","DOI":"10.5772\/32757"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/ng0893-398","article-title":"The relationship between trinucleotide (CAG) repeat length and clinical features of Huntingtons disease","volume":"4","author":"SE Andrew","year":"1993","journal-title":"Nature Genetics"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.4161\/cc.7.24.7379","article-title":"E2F2 represses cell cycle regulators to maintain quiescence","volume":"7","author":"A Infante","year":"2008","journal-title":"Cell Cycle"},{"key":"ref66","first-page":"385","article-title":"Huntington\u2019s disease: the current state of research with peripheral tissues","volume":"2","author":"C Colciago","year":"2009","journal-title":"Exp Neurol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"e46492","DOI":"10.1371\/journal.pone.0046492","article-title":"Downregulation of genes involved in metabolism and oxidative stress in peripheral leukocytes of Huntington\u2019s disease patients","volume":"7","author":"KH Chang","year":"2012","journal-title":"PLoS One"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jns.2013.11.014","article-title":"Gene expression profile in fibroblast of Huntington\u2019s disease patients and controls","volume":"337","author":"E Marchina","year":"2014","journal-title":"J Neurol Sci"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1136\/jmg.2006.045153","article-title":"Replication of twelve association studies for Huntington\u2019s disease residual age of onset in large Venezuelan kindreds","volume":"44","author":"JM Andresen","year":"2007","journal-title":"J Med Genet"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1002\/ajmg.a.36079","article-title":"Interstitial 12p13.1 deletion involving GRIN2B in three patients with intellectual disability","volume":"161","author":"J Andrieux","year":"2013","journal-title":"Am J Med Genet"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.gde.2013.10.009","article-title":"Using chromatin marks to interpret and localize genetic associations to complex human traits and diseases","volume":"23","author":"S Raychaudhuri","year":"2013","journal-title":"Curr Opin Genet Dev"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"41299","DOI":"10.1074\/jbc.M008408200","article-title":"Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain","volume":"275","author":"AS Hackam","year":"2000","journal-title":"J Biol Chem"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.nbd.2005.11.003","article-title":"Bhattacharyya NP: Induction of apoptosis in cells expressing exogenous Hippi, a molecular partner of huntingtin-interacting protein Hip1","volume":"22","author":"P Majumder","year":"2006","journal-title":"Neurobiol Dis"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1016\/j.febslet.2012.07.011","article-title":"Replacement of charged and polar residues in the coiled-coiled interface of huntingtin-interacting protein 1 (HIP1) causes aggregation and cell death","volume":"586","author":"SN Fontaine","year":"2012","journal-title":"FEBS Lett"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0301-0082(03)00122-9","article-title":"Kainate receptors and synaptic transmission","volume":"70","author":"JE Huettner","year":"2003","journal-title":"Prog Neurobiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0131573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T21:41:53Z","timestamp":1717969313000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0131573"}},"subtitle":[],"editor":[{"given":"David","family":"Blum","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,7,6]]},"references-count":75,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,7,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0131573","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2015,7,6]]}}}