{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:49:54Z","timestamp":1788259794136,"version":"build-2803163510"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T00:00:00Z","timestamp":1436313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0131709","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T17:57:05Z","timestamp":1436378225000},"page":"e0131709","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Differential Rearing Alters Forced Swim Test Behavior, Fluoxetine Efficacy, and Post-Test Weight Gain in Male Rats"],"prefix":"10.1371","volume":"10","author":[{"given":"David L.","family":"Arndt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy J.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Cain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,7,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nrd1634","article-title":"Depression, antidepressants and suicidality: a critical appraisal","volume":"4","author":"J Licinio","year":"2005","journal-title":"Nature Reviews Drug Discovery"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/S0140-6736(96)07492-2","article-title":"Alternative projections of mortality and disability by cause 1990\u20132020: Global Burden of Disease Study","volume":"349","author":"CJ Murray","year":"1997","journal-title":"The Lancet"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/nprot.2012.044","article-title":"Using the rat forced swim test to assess antidepressant-like activity in rodents","volume":"7","author":"DA Slattery","year":"2012","journal-title":"Nature Protocols"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0024-3205(74)90345-2","article-title":"A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-Trifluoromethylphenoxy)-n-methyl-3-phenylpropylamine","volume":"15","author":"DT Wong","year":"1974","journal-title":"Life Sciences"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.neubiorev.2005.03.008","article-title":"Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test","volume":"29","author":"JF Cryan","year":"2005","journal-title":"Neuroscience and Biobehavioral Reviews"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1037\/1064-1297.5.2.107","article-title":"Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression","volume":"5","author":"MJ Detke","year":"1997","journal-title":"Experimental and Clinical Psychopharmacology"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S0024-3205(74)80012-3","article-title":"Effect of an uptake inhibitor on serotonin metabolism in rat brain: studies with 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine","volume":"15","author":"RW Fuller","year":"1974","journal-title":"Life Sciences"},{"issue":"2\u20133","key":"ref8","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0014-2999(97)01393-9","article-title":"Pharmacological profile of antidepressants and related compounds at human monoamine transporters","volume":"340","author":"M Tatsumi","year":"1997","journal-title":"European Journal of Pharmacology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.brainres.2006.05.051","article-title":"The influence of sec and social isolation housing on pre- and postsynaptic 5-HT1A receptors","volume":"1103","author":"L Schiller","year":"2006","journal-title":"Brain Research"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.pnpbp.2010.09.013","article-title":"The age-dependent effects of selective serotonin reuptake inhibitors in humans and rodents: A review","volume":"35","author":"JDA Olivier","year":"2011","journal-title":"Progress in Neuro-Psychopharmacology & Biological Psychiatry"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/(SICI)1096-9861(20000207)417:2<181::AID-CNE4>3.0.CO;2-A","article-title":"Somatodendritic localization of 5\u2010HT1A and preterminal axonal localization of 5\u2010HT1B serotonin receptors in adult rat brain","volume":"417","author":"M Riad","year":"2000","journal-title":"Journal of Comparative Neurology"},{"issue":"8","key":"ref12","first-page":"20","article-title":"Mixed depression and anxiety: serotonin1A receptors as a common pharmacologic link","volume":"58","author":"SM Stahl","year":"1997","journal-title":"Journal of Clinical Psychiatry"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1037\/h0032527","article-title":"Cerebral effects of differential experience in hypophysectomized rats","volume":"79","author":"MR Rosenzweig","year":"1972","journal-title":"Journal of Comparative and Physiological Psychology"},{"key":"ref14","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4612-4766-1","article-title":"Enriched and impoverished environments: Effects on brain and behavior","author":"MJ Renner","year":"1987"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.biopsych.2009.06.022","article-title":"Environmental enrichment produces a behavioral phenotype mediated by low cyclic adenosine monophosphate response element binding (CREB) activity in the nucleus accumbens","volume":"67","author":"TA Green","year":"2010","journal-title":"Biological Psychiatry"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0006-8993(85)90105-2","article-title":"Enhancement of hippocampal field potentials in rats exposed to a novel complex environment","volume":"339","author":"PE Sharp","year":"1985","journal-title":"Brain Research"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/jn.1986.55.4.739","article-title":"Altered synaptic transmission in dentate gyrus of rats reared in complex environments: evidence from hippocampal slices maintained in vitro","volume":"55","author":"EJ Green","year":"1986","journal-title":"Journal of Neurophysiology"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/35044558","article-title":"Neural consequences of environmental enrichment","volume":"1","author":"H van Praag","year":"2000","journal-title":"Nature Reviews Neuroscience"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1460-9568.2005.04552.x","article-title":"Long-lasting modulation of the induction of LTD and LTP in rat hippocampal CA1 by behavioural stress and environmental enrichment","volume":"23","author":"A Artola","year":"2006","journal-title":"European Journal of Neuroscience"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.neubiorev.2008.03.003","article-title":"Behavioral and neurochemical effects of post-weaning social isolation in rodents\u2014relevance to developmental neuropsychiatric disorders","volume":"32","author":"KCF Fone","year":"2008","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0169-328X(97)00317-3","article-title":"Environmental enrichment selectively increases 5-HT1A receptor mRNA expression and binding in the rat hippocampus","volume":"53","author":"S Rasmuson","year":"1998","journal-title":"Molecular Brain Research"},{"issue":"6","key":"ref22","first-page":"417","article-title":"The role of the hippocampus in the pathophysiology of major depression","volume":"29","author":"S Campbell","year":"2004","journal-title":"Journal of Psychiatry and Neuroscience"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.pbb.2007.11.004","article-title":"Differential effect of environment enrichment and social isolation on depressive-like behavior, spontaneous activity and serotonin and norepinephrine concentration in prefrontal cortex and ventral striatum","volume":"89","author":"JC Brenes","year":"2008","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pbb.2010.04.007","article-title":"Effects of fluoxetine and PCPA on isolation-induced morphine self-administration and startle reactivity","volume":"96","author":"S Raz","year":"2010","journal-title":"Pharmacology, Biochemistry and Behavior"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.pbb.2011.12.017","article-title":"Effects of sertraline on behavioral alterations caused by environmental enrichment and social isolation","volume":"101","author":"E Yildirim","year":"2012","journal-title":"Pharmacology, Biochemistry, and Behavior"},{"key":"ref26","article-title":"Guide for the care and use of laboratory animals","year":"1996"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"RD Porsolt","year":"1977","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0166-4328(96)00067-8","article-title":"Detection of serotonergic and noradrenergic antidepressants in the rat forced swimming test: the effects of water depth","volume":"73","author":"MJ Detke","year":"1996","journal-title":"Behavioral Brain Research"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00008877-199711000-00010","article-title":"The forced swimming test as a model for core and component behavioral effects of antidepressant drugs","volume":"8","author":"I Lucki","year":"1997","journal-title":"Behavioral Pharmacology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0165-6147(02)02017-5","article-title":"Assessing antidepressant activity in rodents: recent developments and future needs","volume":"23","author":"JF Cryan","year":"2002","journal-title":"Trends in Pharmacological Sciences"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1101\/lm.1670910","article-title":"Social modulation of learning in rats","volume":"17","author":"E Knapska","year":"2009","journal-title":"Learning and Memory"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.bbr.2008.08.014","article-title":"A detailed analysis of open-field habituation and behavioral and neurochemical antidepressant-like effects in postweaning and enriched rats","volume":"197","author":"JC Brenes","year":"2009","journal-title":"Behavioral Brain Research"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.physbeh.2013.05.012","article-title":"Factors influencing behavior in the forced swim test","volume":"118","author":"OV Bogdanova","year":"2013","journal-title":"Physiology & behavior"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00213-011-2565-0","article-title":"Impact of mGluR5 during amphetamine-induced hyperactivity and conditioned hyperactivity in differentially reared rats","volume":"221","author":"MJ Gill","year":"2012","journal-title":"Psychopharmacology"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1037\/a0035273","article-title":"The effects of mGluR2\/3 activation and repeated amphetamine-induced locomotor activity in differentially reared male rats","volume":"22","author":"DL Arndt","year":"2014","journal-title":"Experimental and Clinical Psychopharmacology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neubiorev.2014.11.017","article-title":"Inoculation stress hypothesis of environmental enrichment","volume":"49","author":"EJ Crofton","year":"2015","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"ref37","article-title":"Enduring effects of post-weaning rearing condition on depressive- and anxiety-like behaviors and motor activity in male rats","author":"B Mosaferi","year":"2015","journal-title":"Physiology and Behavior"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.neuropharm.2010.01.006","article-title":"Involvement of \u03b1-MSH in the social isolation induced anxiety and depression-like behaviors in rat","volume":"58","author":"DM Kokare","year":"2010","journal-title":"Neuropharmacology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/syn.21511","article-title":"The comparable effects of environmental enrichment with exercise and serotonin transporter blockade on serotonergic neurons in the dorsal raphe nucleaus","volume":"66","author":"L MacGillivray","year":"2012","journal-title":"Synapse"},{"issue":"23","key":"ref40","doi-asserted-by":"crossref","first-page":"13525","DOI":"10.1073\/pnas.2233056100","article-title":"Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function","volume":"100","author":"F C\u00f4t\u00e9","year":"2003","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"4","key":"ref41","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/sj.npp.1300897","article-title":"Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and medial nuclei: major depression and suicide","volume":"31","author":"H Bach-Mizrachi","year":"2006","journal-title":"Neuropsychopharmacology"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"e97603","DOI":"10.1371\/journal.pone.0097603","article-title":"Effects of chronic fluoxetine treatment on neurogenesis and tryptophan hyodroxylase expression in adolescent and adult rats","volume":"9","author":"A Klomp","year":"2014","journal-title":"PloS One"},{"issue":"9","key":"ref43","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.1523\/JNEUROSCI.12-09-03628.1992","article-title":"A functional anatomical study of unipolar depression","volume":"12","author":"WC Drevets","year":"1992","journal-title":"The Journal of Neuroscience"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/1520-6394(2000)12:1+<2::AID-DA2>3.0.CO;2-4","article-title":"Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders","volume":"12","author":"KJ Ressler","year":"2000","journal-title":"Depression and Anxiety"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.neuroscience.2007.04.054","article-title":"Both increases in immature dentate neuron number and decreases of immobility time in the forced swim test occurred in parallel after environmental enrichment of mice","volume":"147","author":"MV Llorens-Martin","year":"2007","journal-title":"Neuroscience"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neulet.2006.05.048","article-title":"Enriched environment experience overcomes the memory deficits and depressive-like behavior induced by early life stress","volume":"404","author":"M Cui","year":"2006","journal-title":"Neuroscience Letters"},{"key":"ref47","first-page":"427","article-title":"Environmental enrichment-related variations in behavioral, biochemical, and physiologic responses of sprague-dawley and long evans rats","volume":"49","author":"AT Konkle","year":"2010","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/hipo.22134","article-title":"Region-dependent and stage-specific effects of stress, environmental enrichment, and antidepressant treatment on hippocampal neurogenesis","volume":"23","author":"A Tanti","year":"2013","journal-title":"Hippocampus"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/BF02245592","article-title":"Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressant","volume":"121","author":"MJ Detke","year":"1995","journal-title":"Psychopharmacology"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s002130050555","article-title":"Antidepressant behavioral effects by dual inhibition of monoamine reuptake in the rat forced swimming test","volume":"136","author":"JP Reneric","year":"1998","journal-title":"Psychopharmacology"},{"issue":"2","key":"ref51","first-page":"1","article-title":"Effects of antidepressants on behavioral assessment in adolescent rats","volume":"33","author":"HE Refaey","year":"2011","journal-title":"Bahrain Medical Bulletin"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s002130051156","article-title":"Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test","volume":"147","author":"M Page","year":"1999","journal-title":"Psychopharmacology"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.pnpbp.2007.05.002","article-title":"Effect of various classes of antidepressants in behavioral paradigms of despair","volume":"31","author":"SK Kulkarni","year":"2007","journal-title":"Progress in Neuro-Psychopharmacology & Biological Psychiatry"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neulet.2008.12.024","article-title":"Effects of fluoxetine on the rat brain in the forced swimming test: A [F-18] FDG micro-PET imaging study","volume":"451","author":"D Jang","year":"2009","journal-title":"Neuroscience Letters"},{"issue":"4","key":"ref55","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.neuron.2009.04.017","article-title":"Neurogenesis-dependent and-independent effects of fluoxetine in an animal model of anxiety\/depression","volume":"62","author":"DJ David","year":"2009","journal-title":"Neuron"},{"issue":"1","key":"ref56","doi-asserted-by":"crossref","first-page":"e16646","DOI":"10.1371\/journal.pone.0016646","article-title":"Fluoxetine Exerts Age-Dependent Effects on Behavior and Amygdala Neuroplasticity in the Rat","volume":"6","author":"JR Homberg","year":"2011","journal-title":"PlosOne"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ejphar.2008.11.010","article-title":"Differential sensitivity to SSRI and tricyclic antidepressants in juvenile and adult mice of three strains","volume":"602","author":"SS Mason","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.tips.2009.11.003","article-title":"New perspectives on the neurodevelopmental effects of SSRIs","volume":"31","author":"JR Homberg","year":"2009","journal-title":"Trends Pharmacol Sci"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07455","article-title":"The molecular neurobiology of depression","volume":"455","author":"V Krishnan","year":"2008","journal-title":"Nature"},{"issue":"4","key":"ref60","first-page":"e35901","article-title":"Neurogenomic evidence for a shared mechanism of the antidepressant effects of exercise and chronic fluoxetine in mice","volume":"7","author":"GJ Huang","year":"2012"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/ajcn\/55.1.177s","article-title":"Preclinical pharmacology of fluoxetine, a serotonergic drug for weight loss","volume":"55","author":"TT Yen","year":"1992","journal-title":"The American Journal of Clinical Nutrition"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0024-3205(93)90116-K","article-title":"Time course of brain serotonin metabolism after cessation of long-term fluoxetine treatment in the rat","volume":"52","author":"JH Trouvin","year":"1993","journal-title":"Life Sciences"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0028-3908(02)00075-8","article-title":"Treatment of cycling female rats with fluoxetine induces desensitization of hypothalamic 5-HT<sub>1A<\/sub> receptors with no change in 5-HT<sub>2A<\/sub> receptors","volume":"43","author":"LD Van de Kar","year":"2002","journal-title":"Neuropharmacology"},{"issue":"9","key":"ref64","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1093\/carcin\/20.9.1793","article-title":"The promotion effect of anorectic drugs on aflatoxin B<sub>1<\/sub>-induced hepatic preneoplastic foci","volume":"20","author":"X Lin","year":"1999","journal-title":"Carcinogenesis"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s00213-002-1232-x","article-title":"Destruction of serotonergic nerve terminals prevents fluoxetine-induced desensitization of hypothalamic 5-HT<sub>1A<\/sub> receptors","volume":"164","author":"DN D\u2019Souza","year":"2002","journal-title":"Psychopharmacology"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"R390","DOI":"10.1152\/ajpregu.00335.2003","article-title":"Fluoxetine-induced changes in body weight and 5-HT<sub>1A<\/sub> receptor-mediated hormone secretion in rats on a tryptophan-deficient diet","volume":"286","author":"DN D\u2019Souza","year":"2003","journal-title":"Am J Phsyiol Regul Integr Comp Physiol"},{"issue":"10","key":"ref67","first-page":"385","article-title":"Fluoxetine differentially suppresses sucrose solution in free-fed and food-deprived rats\u2014reversal by amantadine","volume":"8","author":"MA Prendergast","year":"2002","journal-title":"Med Sci Monit"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1006\/faat.1994.1098","article-title":"A developmental neurotoxicity evaluation of the effects of prenatal exposure to fluoxetine in rats","volume":"23","author":"CV Vorhees","year":"1994","journal-title":"Fundamental and Applied Toxicology"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.bbr.2011.06.016","article-title":"5-HT<sub>1B<\/sub> mRNA expression after chronic social stress","volume":"224","author":"AR Furay","year":"2011","journal-title":"Behavioral Brain Research"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0131709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T03:01:08Z","timestamp":1566961268000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0131709"}},"subtitle":[],"editor":[{"given":"Judith","family":"Homberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,7,8]]},"references-count":69,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,7,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0131709","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,8]]}}}