{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T11:37:33Z","timestamp":1769341053199,"version":"3.49.0"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T00:00:00Z","timestamp":1436140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0132001","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T18:30:59Z","timestamp":1436207459000},"page":"e0132001","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["Association of DNA Methylation with Acute Mania and Inflammatory Markers"],"prefix":"10.1371","volume":"10","author":[{"given":"Sarven","family":"Sabunciyan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brion","family":"Maher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Bahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faith","family":"Dickerson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Yolken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,7,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"15533","DOI":"10.1073\/pnas.0507666102","article-title":"Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia","volume":"102","author":"SJ Glatt","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.biopsych.2013.09.035","article-title":"Peripheral Biomarkers Revisited: Integrative Profiling of Peripheral Samples for Psychiatric Research","volume":"75","author":"A Hayashi-Takagi","year":"2014","journal-title":"Biol Psychiatry"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/ajmg.c.20013","article-title":"Family, twin, and adoption studies of bipolar disorder","volume":"123C","author":"JW Smoller","year":"2003","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1176\/ajp.140.11.1413","article-title":"Overview: a current perspective on twin studies of schizophrenia","volume":"140","author":"KS Kendler","year":"1983","journal-title":"Am J Psychiatry"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1001\/archpsyc.1992.01820120071010","article-title":"Schizophrenia after prenatal exposure to the Dutch Hunger Winter of 1944\u20131945","volume":"49","author":"ES Susser","year":"1992","journal-title":"Arch Gen Psychiatry"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/oxfordjournals.schbul.a007030","article-title":"A systematic review and meta-analysis of Northern Hemisphere season of birth studies in schizophrenia","volume":"29","author":"G Davies","year":"2003","journal-title":"Schizophr Bull"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.4103\/0974-777X.83536","article-title":"Toxoplasmosis: a global threat","volume":"3","author":"JM Furtado","year":"2011","journal-title":"J Glob Infect Dis"},{"key":"ref8","first-page":"689","article-title":"The long-term consequences of exposure to lead","volume":"11","author":"A Rosin","year":"2009","journal-title":"Isr Med Assoc J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"S180","DOI":"10.1086\/344280","article-title":"Traffic of JC virus from sites of initial infection to the brain: the path to progressive multifocal leukoencephalopathy","volume":"186","author":"BF Sabath","year":"2002","journal-title":"J Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1001\/jamapsychiatry.2013.3730","article-title":"Methylome-wide association study of schizophrenia: identifying blood biomarker signatures of environmental insults","volume":"71","author":"KA Aberg","year":"2014","journal-title":"JAMA Psychiatry"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"e73520","DOI":"10.1371\/journal.pone.0073520","article-title":"A combined marker of inflammation in individuals with mania","volume":"8","author":"F Dickerson","year":"2013","journal-title":"PLoS One"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e321","DOI":"10.1038\/tp.2013.94","article-title":"Gene expression profiling by mRNA sequencing reveals increased expression of immune\/inflammation-related genes in the hippocampus of individuals with schizophrenia","volume":"3","author":"Y Hwang","year":"2013","journal-title":"Transl Psychiatry"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jad.2012.06.010","article-title":"Cytokines in bipolar disorder: a systematic review and meta-analysis","volume":"144","author":"K Munkholm","year":"2013","journal-title":"J Affect Disord"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"142","DOI":"10.4088\/JCP.14r09007","article-title":"C-reactive protein alterations in bipolar disorder: a meta-analysis","volume":"76","author":"AA Dargel","year":"2015","journal-title":"J Clin Psychiatry"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nn.3922","article-title":"Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways","volume":"18","year":"2015","journal-title":"Nat Neurosci"},{"key":"ref16","first-page":"5021","article-title":"Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma","volume":"60","author":"CA Eads","year":"2000","journal-title":"Cancer Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/S0002-9440(10)63511-0","article-title":"Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation","volume":"163","author":"GH Kang","year":"2003","journal-title":"Am J Pathol"},{"key":"ref18","article-title":"User's Guide for the SCID-I, Structured Clinical Interview for DSM IV Axis I Disorders","author":"M First","year":"1996"},{"key":"ref19","article-title":"Structured Clinical interview for DSM-IV Disorders\u2014Non-Patient Edition","author":"M First","year":"1998"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.schres.2012.03.037","article-title":"Antibodies to retroviruses in recent onset psychosis and multi-episode schizophrenia","volume":"138","author":"F Dickerson","year":"2012","journal-title":"Schizophr Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/mp.2011.42","article-title":"Identification of a biological signature for schizophrenia in serum","volume":"17","author":"E Schwarz","year":"2012","journal-title":"Mol Psychiatry"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"4715","DOI":"10.1073\/pnas.83.13.4715","article-title":"Transcriptional regulation of steroid hydroxylase genes by corticotropin","volume":"83","author":"ME John","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref23","article-title":"Novel activities of CYP11A1 and their potential physiological significance","author":"AT Slominski","year":"2014","journal-title":"J Steroid Biochem Mol Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1046\/j.1471-4159.2003.01935.x","article-title":"Cellular distribution and bioactivity of the key steroidogenic enzyme, cytochrome P450side chain cleavage, in sensory neural pathways","volume":"86","author":"C Patte-Mensah","year":"2003","journal-title":"J Neurochem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0028-3908(03)00251-X","article-title":"Phosphorylation influences neurosteroid modulation of synaptic GABAA receptors in rat CA1 and dentate gyrus neurones","volume":"45","author":"SC Harney","year":"2003","journal-title":"Neuropharmacology"},{"key":"ref26","first-page":"57","article-title":"Neuroactive steroid modulation of GABAA receptors","volume":"48","author":"RW Olsen","year":"1995","journal-title":"Adv Biochem Psychopharmacol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jad.2011.04.009","article-title":"AKR1C4 gene variant associated with low euthymic serum progesterone and a history of mood irritability in males with bipolar disorder","volume":"133","author":"AG Johansson","year":"2011","journal-title":"J Affect Disord"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"12599","DOI":"10.1073\/pnas.93.22.12599","article-title":"Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography","volume":"93","author":"DP Uzunov","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref29","first-page":"547","article-title":"Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice","volume":"11","author":"CE Marx","year":"2008","journal-title":"Int J Neuropsychopharmacol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.pbb.2006.07.026","article-title":"Clozapine markedly elevates pregnenolone in rat hippocampus, cerebral cortex, and serum: candidate mechanism for superior efficacy?","volume":"84","author":"CE Marx","year":"2006","journal-title":"Pharmacol Biochem Behav"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.pbb.2006.07.032","article-title":"Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: implications for therapeutic actions","volume":"84","author":"CE Marx","year":"2006","journal-title":"Pharmacol Biochem Behav"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0895-4356(00)00314-0","article-title":"Adjusting for multiple testing\u2014when and how?","volume":"54","author":"R Bender","year":"2001","journal-title":"J Clin Epidemiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen","volume":"276","author":"CJ Phiel","year":"2001","journal-title":"J Biol Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"E1166","DOI":"10.1002\/ijc.27526","article-title":"Serum DNA methylation for monitoring response to neoadjuvant chemotherapy in breast cancer patients","volume":"131","author":"A Avraham","year":"2012","journal-title":"Int J Cancer"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1158\/1078-0432.1219.11.3","article-title":"Identification of epigenetic aberrant promoter methylation in serum DNA is useful for early detection of lung cancer","volume":"11","author":"K Fujiwara","year":"2005","journal-title":"Clin Cancer Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"539","DOI":"10.4161\/epi.5.6.12378","article-title":"Global DNA hypomethylation is associated with in utero exposure to cotinine and perfluorinated alkyl compounds","volume":"5","author":"R Guerrero-Preston","year":"2010","journal-title":"Epigenetics"},{"key":"ref37","first-page":"2313","article-title":"Correlation between serum DNA methylation and prognosis in gastric cancer patients","volume":"26","author":"H Ikoma","year":"2006","journal-title":"Anticancer Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"157","DOI":"10.5230\/jgc.2013.13.3.157","article-title":"Disappearance of Serum Methylated p16 Indicates Longer Survival in Patients with Gastric Cancer","volume":"13","author":"HK Lim","year":"2013","journal-title":"J Gastric Cancer"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/ncomms1180","article-title":"Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences","volume":"2","author":"L Balaj","year":"2011","journal-title":"Nat Commun"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/pros.22853","article-title":"Different gDNA content in the subpopulations of prostate cancer extracellular vesicles: apoptotic bodies, microvesicles, and exosomes","volume":"74","author":"E Lazaro-Ibanez","year":"2014","journal-title":"Prostate"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e34653","DOI":"10.1371\/journal.pone.0034653","article-title":"Cardiomyocyte microvesicles contain DNA\/RNA and convey biological messages to target cells","volume":"7","author":"A Waldenstrom","year":"2012","journal-title":"PLoS One"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/jmcb\/mjt011","article-title":"Extracellular vesicle-mediated transfer of donor genomic DNA to recipient cells is a novel mechanism for genetic influence between cells","volume":"5","author":"J Cai","year":"2013","journal-title":"J Mol Cell Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"H Valadi","year":"2007","journal-title":"Nat Cell Biol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.biopsych.2013.09.037","article-title":"Autoimmunity, inflammation, and psychosis: a search for peripheral markers","volume":"75","author":"V Bergink","year":"2014","journal-title":"Biol Psychiatry"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0132001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,12]],"date-time":"2023-08-12T01:55:43Z","timestamp":1691805343000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0132001"}},"subtitle":[],"editor":[{"given":"Consuelo","family":"Walss-Bass","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,7,6]]},"references-count":44,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,7,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0132001","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,6]]}}}