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B"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1242\/dev.124.20.4065","article-title":"Expression and interactions of the two closely related homeobox genes <italic>Phox2a<\/italic> and <italic>Phox2b<\/italic> during neurogenesis","volume":"124","author":"A Pattyn","year":"1997","journal-title":"Development"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/20700","article-title":"The homeobox gene <italic>Phox2b<\/italic> is essential for the development of autonomic neural crest derivatives","volume":"399","author":"A Pattyn","year":"1999","journal-title":"Nature"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/ng1130","article-title":"Polyalanine expansion and frameshift mutations of the paired-like homeobox gene <italic>PHOX2B<\/italic> in congenital central hypoventilation syndrome","volume":"33","author":"J Amiel","year":"2003","journal-title":"Nat Genet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.resp.2005.06.010","article-title":"In pursuit (and discovery) of a genetic basis for congenital central hypoventilation syndrome","volume":"149","author":"DE Weese-Mayer","year":"2005","journal-title":"Respir Physiol Neurobiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/(SICI)1099-0496(199810)26:4<273::AID-PPUL7>3.0.CO;2-C","article-title":"Congenital central hypoventilation syndrome: an update","volume":"26","author":"D Gozal","year":"1998","journal-title":"Pediatr Pulmonol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0034-5687(01)00294-8","article-title":"Chemoreceptive mechanisms elucidated by studies of congenital central hypoventilation syndrome","volume":"129","author":"CM Spengler","year":"2001","journal-title":"Respir Physiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0031-9384(96)00176-X","article-title":"Of mice and mazes: similarities between mice and rats on dry land but not water mazes","volume":"60","author":"IQ Whishaw","year":"1996","journal-title":"Physiol Behav"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1037\/a0025133","article-title":"Similarities and differences in spatial learning and object recognition between young male C57Bl\/6J mice and Sprague-Dawley rats","volume":"125","author":"AM Stranahan","year":"2011","journal-title":"Bahav Neurosci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nature02426","article-title":"Rat genome seq project consortium. Genome sequence of the Brown Norway rat yields insights into mammalian evolution","volume":"428","author":"RA Gibbs","year":"2004","journal-title":"Nature"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1006\/bbrc.1997.7124","article-title":"Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains","volume":"237","author":"R Feil","year":"1997","journal-title":"Biochem Biophys Res Comm"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/embo-reports\/kvd049","article-title":"Point mutation of bacterial artificial chromosomes by ET recombination","volume":"1","author":"JPP Muyrers","year":"2000","journal-title":"EMBO Reports"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1538\/expanim.53.311","article-title":"Establishment of an efficient BAC transgenesis protocol and its application to functional characterization of the mouse <italic>Brachyury<\/italic> locus","volume":"53","author":"K Abe","year":"2004","journal-title":"Exp Anim"},{"issue":"2","key":"ref41","first-page":"199","article-title":"Design and construction of 2A peptide-linked multicistronic vectors","author":"AL Szymczak-Workman","year":"2012","journal-title":"Cold Spring Harbor Protoc"},{"key":"ref42","unstructured":"Igarashi H, Koizumi K, Kaneko R, Ikeda K, Onimaru H, Yanagawa Y, et al. Evaluation of a novel reporter rat line which conditionally expresses red fluorescent protein (tdTomato). Program No. 657.18. 2014 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2014. Online."},{"key":"ref43","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1101\/gr.926603","article-title":"LAGAN and Multi-LAGAN: efficient tools for large-scale multiple alignment of genomic DNA","volume":"13","author":"M Brudno","year":"2003","journal-title":"Genome Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"W273","DOI":"10.1093\/nar\/gkh458","article-title":"VISTA: computational tools for comparative genomics","volume":"32","author":"KA Frazer","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.mod.2011.04.001","article-title":"Pax6 regulates boundary-cell specification in the rat hindbrain","volume":"128","author":"M Takahashi","year":"2011","journal-title":"Mech Dev"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ydbio.2007.08.020","article-title":"<italic>Six1<\/italic> is essential for early neurogenesis in the development of olfactory epithelium","volume":"311","author":"K Ikeda","year":"2007","journal-title":"Dev Biol"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Dercksen VJ, Br\u00fc\u00df C, Stalling D, Gubatz S, Seiffert U, Hege H-C. Towards automatic generation of 3D models of biological objects based on serial sections. In: Visualization in Medicine and Life Sciences. Lars Linsen, Hans Hagen, Bernd Hamann, editors. 2008. pp. 3\u201325. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1007\/978-3-540-72630-2\" xlink:type=\"simple\">http:\/\/dx.doi.org\/10.1007\/978-3-540-72630-2<\/ext-link>","DOI":"10.1007\/978-3-540-72630-2"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1101\/gr.6929408","article-title":"Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at <italic>phox2b<\/italic>","volume":"18","author":"DM McGaughey","year":"2008","journal-title":"Genome Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2164-10-8","article-title":"Asymmetrical distribution of non-conserved regulatory sequences at <italic>PHOX2B<\/italic> is reflected at the ENCODE loci and illuminates a possible genome-wide trend","volume":"10","author":"DM McGaughey","year":"2009","journal-title":"BMC Genomics"},{"issue":"12","key":"ref50","doi-asserted-by":"crossref","first-page":"e52118","DOI":"10.1371\/journal.pone.0052118","article-title":"<italic>Phox2b<\/italic> influences the development of a caudal dopaminergic subset","volume":"7","author":"EJ Hoekstra","year":"2012","journal-title":"PLoS One"},{"issue":"10","key":"ref51","doi-asserted-by":"crossref","first-page":"e26543","DOI":"10.1371\/journal.pone.0026543","article-title":"Expression of sympathetic nervous system genes in lamprey suggests their recruitment for specification of a new vertebrate feature","volume":"6","author":"D H\u00e4ming","year":"2011","journal-title":"PLoS One"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/72635","article-title":"Analysis of vertebrate <italic>SCL<\/italic> loci identifies conserved enhancers","volume":"18","author":"B G\u00f6ttgens","year":"2000","journal-title":"Nat Biotechnol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1002\/dvdy.21498","article-title":"A Histone2BCerulean BAC transgene identifies differential expression of <italic>Phox2b<\/italic> in migrating enteric neural crest derivatives and enteric glia","volume":"237","author":"JC Corpening","year":"2008","journal-title":"Dev Dyn"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"20018","DOI":"10.1073\/pnas.1110416108","article-title":"Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways","volume":"108","author":"F D'Autr\u00e9aux","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/dvg.22393","article-title":"A <italic>Phox2b<\/italic>::<italic>FLPo<\/italic> transgenic mouse line suitable for intersectional genetics","volume":"51","author":"R Hirsch M-","year":"2013","journal-title":"Genesis"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.10448","article-title":"Acquisition of Neuronal and glial markers by neural crest-derived cells in the mouse intestine","volume":"456","author":"HM Young","year":"2003","journal-title":"J Comp Neurol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0301-0082(99)00009-X","article-title":"Respiratory network function in the isolated brainstem-spinal cord of newborn rats","volume":"59","author":"K Ballanyi","year":"1999","journal-title":"Prog Neurobiol"},{"issue":"2","key":"ref58","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1113\/jphysiol.2005.102533","article-title":"Mechanisms of CO<sub>2<\/sub>\/H<sup>+<\/sup> chemoreception by respiratory rhythm generator neurons in the medulla from newborn rats <italic>in vitro<\/italic>","volume":"572","author":"A Kawai","year":"2006","journal-title":"J Physiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.resp.2009.03.007","article-title":"Phox2b, RTN\/pFRG neurons and respiratory rhythmogenesis","volume":"168","author":"H Onimaru","year":"2009","journal-title":"Respir Physiol Neurobiol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nn.2354","article-title":"Genetic identification of an embryonic parafacial oscillator coupling to the preB\u00f6tzinger complex","volume":"12","author":"M Thoby-Brisson","year":"2009","journal-title":"Nat Neurosci"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1073\/pnas.0709115105","article-title":"A human mutation in Phox2b causes lack of CO<sub>2<\/sub> chemosensitivity, fatal central apnea, and specific loss of parafacial neurons","volume":"105","author":"V Dubreuil","year":"2008","journal-title":"Proc Natl Acad Sci 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Res"},{"issue":"2","key":"ref65","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1113\/jphysiol.2002.020032","article-title":"Substance P-saporin lesion of neurons with NK1 receptors in one chemoreceptor site in rats decreases ventilation and chemosensitivity","volume":"544","author":"EE Nattie","year":"2002","journal-title":"J Physiol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1099\/0022-1317-82-5-1013","article-title":"Analysis of the aphthovirus 2A\/2B polyprotein &apos;cleavage&apos; mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal &apos;skip&apos;","volume":"82","author":"MLL Donnelly","year":"2001","journal-title":"J Gene Virol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/dvg.20212","article-title":"Temporal regulation of Cre recombinase activity in neural stem cells","volume":"44","author":"I Imayoshi","year":"2006","journal-title":"Genesis"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.neuroscience.2007.09.028","article-title":"Opioid-induced depression in the lamprey respiratory network","volume":"150","author":"D Mutolo","year":"2007","journal-title":"Neuroscience"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.neuroscience.2010.06.004","article-title":"Role of neurokinin receptors and ionic mechanisms within the respiratory network of the lamprey","volume":"169","author":"D Mutolo","year":"2010","journal-title":"Neuroscience"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"13323","DOI":"10.1523\/JNEUROSCI.2764-11.2011","article-title":"Identification of a cholinergic modulatory and rhythmogenic mechanism within the lamprey respiratory network","volume":"31","author":"D Mutolo","year":"2011","journal-title":"J Neurosci"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"9104","DOI":"10.1523\/JNEUROSCI.0299-13.2013","article-title":"Neuronal mechanisms of respiratory pattern generation are evolutionary conserved","volume":"33","author":"E Cinelli","year":"2013","journal-title":"J Neurosci"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.cbpa.2010.08.018","article-title":"Onset and early development of hypoxic ventilatory responses and branchial neuroepithelial cells in <italic>Xenopus laevis<\/italic>","volume":"157","author":"T-CF Pan","year":"2010","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0301-0082(99)00008-8","article-title":"CO<sub>2<\/sub>, brainstem chemoreceptors and breathing","volume":"59","author":"E Nattie","year":"1999","journal-title":"Prog Neurobiol"},{"issue":"3","key":"ref74","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1113\/expphysiol.2005.029843","article-title":"Homing in on the specific phenotype(s) of cenral respiratory chemoreceptors","volume":"90","author":"GB Richerson","year":"2005","journal-title":"Exp Physiol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1152\/japplphysiol.01169.2009","article-title":"CO<sub>2<\/sub> chemoreception in cardiorespiratory control","volume":"108","author":"RW Putnam","year":"2010","journal-title":"J Appl Physiol"},{"issue":"1","key":"ref76","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1113\/jphysiol.1996.sp021308","article-title":"Chemosensitive medullary neurones in the brainstem-spinal cord preparation of the neonatal rat","volume":"492","author":"A Kawai","year":"1996","journal-title":"J Physiol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature03690","article-title":"ATP is a mediator of chemosensory transduction in the central nervous system","volume":"436","author":"AV Gourine","year":"2005","journal-title":"Nature"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1126\/science.1190721","article-title":"Astrocytes control breathing through pH-dependent release of ATP","volume":"329","author":"AV Gourine","year":"2010","journal-title":"Science"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1152\/jn.00544.2010","article-title":"Astrocytes in the retrotrapezoid nucleus sense H<sup>+<\/sup> by inhibition of a Kir4.1-Kir5.1-like current and may contribute to chemoreception by a purinergic mechanism","volume":"104","author":"IC Wenker","year":"2010","journal-title":"J Neurophysiol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/cne.21105","article-title":"Afferent and efferent connections of the rat retrotrapezoid nucleus","volume":"499","author":"DL Rosin","year":"2006","journal-title":"J Comp Neurol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"14836","DOI":"10.1523\/JNEUROSCI.2623-09.2009","article-title":"Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons","volume":"29","author":"V Dubreuil","year":"2009","journal-title":"J Neurosci"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev-physiol-040510-130049","article-title":"Understanding the rhythm of breathing: so near yet so far","volume":"75","author":"JL Feldman","year":"2013","journal-title":"Annu Rev Physiol"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1152\/japplphysiol.00926.2005","article-title":"Response time and sensitivity of the ventilatory response to CO<sub>2<\/sub> in unanesthetized intact dogs: central vs. peripheral chemoreceptors","volume":"100","author":"CA Smith","year":"2006","journal-title":"J Appl Physiol"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1006\/frne.1994.1012","article-title":"The area postrema and vomiting","volume":"15","author":"AD Miller","year":"1994","journal-title":"Frontiers Neuroendcri"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1203\/01.PDR.0000115677.78759.C5","article-title":"Genetics and early disturbances of breathing control","volume":"55","author":"C Gaultier","year":"2004","journal-title":"Pediatr Res"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1073\/pnas.0910059107","article-title":"Task2 potassium channels set central respiratory CO<sub>2<\/sub> and O<sub>2<\/sub> sensitivity","volume":"107","author":"C Gestreau","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s00424-014-1633-9","article-title":"The role of pH-sensitive TASK channels in central respiratory chemoreception","volume":"467","author":"DA Bayliss","year":"2015","journal-title":"Pflugers Arch\u2014Eur J Physiol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/978-3-319-05161-1_3","article-title":"TRPs as chemosensors (ROS, RNS, RCS, Gasotransmitters). Mammalian transient receptor potential (TRP) cation channels","volume":"223","author":"S Shimizu","year":"2014","journal-title":"Handbook of Experimental Pharmacology"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nchembio.640","article-title":"TRPA1 underlies a sensing mechanism for O<sub>2<\/sub>","volume":"7","author":"N Takahashi","year":"2011","journal-title":"Nature Chemical Biology"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.resp.2012.05.026","article-title":"Peripheral-central chemoreceptor interaction and the significance of a critical period in the development of respiratory control","volume":"185","author":"MTT Wong-Riley","year":"2013","journal-title":"Respir Physiol Neurobiol"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"16410","DOI":"10.1523\/JNEUROSCI.3280-11.2011","article-title":"Phox2b-expressing neurons of the parafacial region regulate breathing rate, inspiration, and expiration in conscious rats","volume":"31","author":"SBG Abbott","year":"2011","journal-title":"J Neurosci"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1523\/JNEUROSCI.5338-10.2011","article-title":"Active expiration induced by excitation of ventral medulla in adult anesthetized rats","volume":"31","author":"S Pagliardini","year":"2011","journal-title":"J Neurosci"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0006-8993(88)91194-8","article-title":"Primary respiratory rhythm generator in the medulla of brainstem-spinal cord preparation from newborn rat","volume":"445","author":"H Onimaru","year":"1988","journal-title":"Brain Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0132475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T18:15:38Z","timestamp":1652811338000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0132475"}},"subtitle":[],"editor":[{"given":"Branden","family":"Nelson","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,7,6]]},"references-count":93,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,7,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0132475","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2015,7,6]]}}}