{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T21:07:10Z","timestamp":1766869630857},"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T00:00:00Z","timestamp":1436140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0132561","type":"journal-article","created":{"date-parts":[[2015,7,6]],"date-time":"2015-07-06T19:06:50Z","timestamp":1436209610000},"page":"e0132561","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Cytochrome P450 CYP 2C19*2 Associated with Adverse 1-Year Cardiovascular Events in Patients with Acute Coronary Syndrome"],"prefix":"10.1371","volume":"10","author":[{"given":"You-quan","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dian-gang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,7,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1046\/j.1365-2796.2002.01027.x","article-title":"Individual variations of platelet inhibition after loading doses of clopidogrel","volume":"252","author":"P J\u00e4remo","year":"2002","journal-title":"J Intern Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jacc.2004.09.067","article-title":"Variability in platelet responsiveness to clopidogrel among 544 individuals","volume":"45","author":"VL Serebruany","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1124\/dmd.109.029132","article-title":"Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite","volume":"38","author":"M Kazui","year":"2010","journal-title":"Drug Metab Dispos"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1182\/blood-2006-04-013052","article-title":"Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects","volume":"108","author":"JS Hulot","year":"2006","journal-title":"Blood"},{"key":"ref5","first-page":"375A","article-title":"Inhibition of platelet aggregation by clopidogrel is unaffected by the CYP2C19 681G > A polymorphism in patients with coronary artery disease (abstr)","volume":"49","author":"SMG Smith","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1093\/eurheartj\/ehs059","article-title":"The relationship between CYP2C19 polymorphisms and ischaemic and bleeding outcomes in stable outpatients: the CHARISMA genetics study","volume":"33","author":"DL Bhatt","year":"2012","journal-title":"Eur Heart J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1055\/s-0037-1613462","article-title":"Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement","volume":"9","author":"I M\u00fcller","year":"2003","journal-title":"Thromb Haemost"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1479-7364-4-1-59","article-title":"The cytochrome p450 homepage","volume":"4","author":"DR Nelson","year":"2009","journal-title":"Hum Genomics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"E101","DOI":"10.1208\/aapsj080112","article-title":"Cytochrome P450s and other enzymes in drug metabolism and toxicity","volume":"8","author":"FP Guengerich","year":"2006","journal-title":"AAPS J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/tpj.2009.10","article-title":"Global variation in CYP2C8-CYP2C9 functional haplotypes","volume":"9","author":"WC Speed","year":"2009","journal-title":"Pharmacogenomics J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1016\/j.jacc.2007.12.056","article-title":"Cytochrome P450 2C19 681G > A polymorphism and high on clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stents","volume":"51","author":"D Trenk","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0140-6736(08)61845-0","article-title":"Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study","volume":"373","author":"JP Collet","year":"2009","journal-title":"Lancet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1056\/NEJMoa0808227","article-title":"Genetic determinants of response to clopidogrel and cardiovascular events","volume":"360","author":"T Simon","year":"2009","journal-title":"N Engl J Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1001\/jama.2009.1232","article-title":"Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy","volume":"302","author":"AR Shuldiner","year":"2009","journal-title":"JAMA"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1016\/j.jacc.2011.11.068","article-title":"Influence of genetic polymorphisms on the effect of high-and standard-dose clopidogrel after percutaneous coronary intervention: the GIFT (Genotype Information and Functional Testing) study","volume":"59","author":"MJ Price","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jacc.2009.12.071","article-title":"Cardiovascular risk in clopidogrel-treated patients according to cytochrome P450 2C19*2 loss-of-function allele or proton pump inhibitor coadministration: a systematic meta-analysis","volume":"56","author":"JS Hulot","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1161\/CIRCULATIONAHA.111.029165","article-title":"Platelet reactivity and cardiovascular outcomes after percutaneous coronary intervention: a time-dependent analysis of the Gauging Responsiveness with a VerifyNow P2Y12 assay: Impact on Thrombosis and Safety (GRAVITAS) trial","volume":"124","author":"MJ Price","year":"2011","journal-title":"Circulation"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1471-2261-13-61","article-title":"Cytochrome P450 2C19*2 polymorphism in patients with stable coronary heart disease and risk for secondary cardiovascular disease events: results of a long-term follow-up study in routine clinical care","volume":"13","author":"D Rothenbacher","year":"2013","journal-title":"BMC Cardiovasc Disord"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.jacc.2005.01.030","article-title":"The relation of dosing to clopidogrel responsiveness and the incidence of high post-treatment platelet aggregation in patients undergoing coronary stenting","volume":"45","author":"PA Gurbel","year":"2005","journal-title":"J Am Coll Cardiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0132561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T18:05:39Z","timestamp":1599242739000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0132561"}},"subtitle":[],"editor":[{"given":"Carmine","family":"Pizzi","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,7,6]]},"references-count":19,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,7,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0132561","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,6]]}}}