{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:02:55Z","timestamp":1789124575851,"version":"build-2803163510"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T00:00:00Z","timestamp":1436918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0132704","type":"journal-article","created":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T18:43:33Z","timestamp":1436985813000},"page":"e0132704","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Association between MEFV Mutations M694V and M680I and Beh\u00e7et\u2019s Disease: A Meta-Analysis"],"prefix":"10.1371","volume":"10","author":[{"given":"Ziyan","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,7,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1056\/NEJM199910213411707","article-title":"Behcet&apos;s disease","volume":"341","author":"T Sakane","year":"1999","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1002\/art.1780401023","article-title":"Criteria for the diagnosis of familial Mediterranean fever","volume":"40","author":"A Livneh","year":"1997","journal-title":"Arthritis and Rheumatism"},{"key":"ref3","first-page":"530","article-title":"Familial Mediterranean fever and Behcet&apos;s disease\u2014Are they associated?","volume":"29","author":"E Ben-Chetrit","year":"2002","journal-title":"Journal of Rheumatology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0049-0172(00)80015-3","article-title":"Behcet&apos;s disease in Familial Mediterranean Fever: Characterization of the association between the two diseases","volume":"29","author":"T Schwartz","year":"2000","journal-title":"Seminars in Arthritis and Rheumatism"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1046\/j.1365-4362.2003.01893.x","article-title":"Prevalence of Behcet&apos;s disease in Istanbul, Turkey","volume":"42","author":"G Azizlerli","year":"2003","journal-title":"International Journal of Dermatology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/sj.ejhg.5200672","article-title":"Familial Mediterranean fever: prevalence, penetrance and genetic drift","volume":"9","author":"R Gershoni-Baruch","year":"2001","journal-title":"European Journal of Human Genetics"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10067-009-1279-8","article-title":"Anti-IL-1 treatment for secondary amyloidosis in an adolescent with FMF and Behcet&apos;s disease","volume":"29","author":"Y Bilginer","year":"2010","journal-title":"Clinical Rheumatology"},{"key":"ref8","first-page":"344","article-title":"Familial mediterranean fever in an Iranian patient with behcet disease","volume":"2","author":"M Mobini","year":"2011","journal-title":"Caspian J Intern Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2169\/internalmedicine.45.1560","article-title":"Coexistence of familial mediterranean fever and Behcet&apos;s disease in Japanese patient","volume":"45","author":"M Matsuda","year":"2006","journal-title":"Internal Medicine"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1136\/ard.2009.108571","article-title":"Genetics of Behcet disease inside and outside the MHC","volume":"69","author":"A Meguro","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/ng.625","article-title":"Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behcet&apos;s disease","volume":"42","author":"EF Remmers","year":"2010","journal-title":"Nat Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/ng.624","article-title":"Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet&apos;s disease susceptibility loci","volume":"42","author":"N Mizuki","year":"2010","journal-title":"Nat Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.1002\/art.37708","article-title":"Identification of a susceptibility locus in STAT4 for Behcet&apos;s disease in Han Chinese in a genome-wide association study","volume":"64","author":"S Hou","year":"2012","journal-title":"Arthritis Rheum"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1136\/annrheumdis-2011-200288","article-title":"Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet&apos;s disease","volume":"72","author":"YJ Lee","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/ng.2520","article-title":"Genome-wide association analysis identifies new susceptibility loci for Behcet&apos;s disease and epistasis between HLA-B*51 and ERAP1","volume":"45","author":"Y Kirino","year":"2013","journal-title":"Nat Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1136\/ard.2009.119420","article-title":"IL-23R gene confers susceptibility to Behcet&apos;s disease in a Chinese Han population","volume":"69","author":"Z Jiang","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1136\/annrheumdis-2012-201627","article-title":"MicroRNA-146a and Ets-1 gene polymorphisms in ocular Behcet&apos;s disease and Vogt-Koyanagi-Harada syndrome","volume":"73","author":"Q Zhou","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s00109-014-1159-9","article-title":"Predisposition to Behcet&apos;s disease and VKH syndrome by genetic variants of miR-182","volume":"92","author":"H Yu","year":"2014","journal-title":"J Mol Med (Berl)"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nature08494","article-title":"Finding the missing heritability of complex diseases","volume":"461","author":"TA Manolio","year":"2009","journal-title":"Nature"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.1182\/blood.V95.10.3223","article-title":"The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators","volume":"95","author":"M Centola","year":"2000","journal-title":"Blood"},{"key":"ref21","first-page":"1428","article-title":"Production of TNF-alpha and IL-1 in active Behcet&apos;s disease","volume":"17","author":"K Hamzaoui","year":"1990","journal-title":"J Rheumatol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ng0997-25","article-title":"A candidate gene for familial Mediterranean fever","volume":"17","author":"A Bernot","year":"1997","journal-title":"Nature Genetics"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0092-8674(00)80539-5","article-title":"Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever. The International FMF Consortium","volume":"90","year":"1997","journal-title":"Cell"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/1098-1004(200009)16:3<271::AID-HUMU16>3.0.CO;2-A","article-title":"MEFV mutations in Behcet&apos;s disease","volume":"16","author":"I Touitou","year":"2000","journal-title":"Hum Mutat"},{"key":"ref25","first-page":"S35","article-title":"MEFV mutations are increased in Behcet&apos;s disease (BD) and are associated with vascular involvement","volume":"21","author":"P Atagunduz","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/03009740510017931","article-title":"MEFV gene is a probable susceptibility gene for Behcet&apos;s disease","volume":"34","author":"N Imirzalioglu","year":"2005","journal-title":"Scand J Rheumatol"},{"key":"ref27","first-page":"S24","article-title":"MEFV, TNFRSF1A and CARD15 mutation analysis in Behcet&apos;s disease","volume":"29","author":"Y Baruch","year":"2011","journal-title":"Clin Exp Rheumatol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3109\/03009742.2011.562532","article-title":"Common MEFV mutations in Iranian Azeri Turkish patients with Behcet&apos;s disease","volume":"40","author":"M Esmaeili","year":"2011","journal-title":"Scand J Rheumatol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1007\/s00296-011-2011-y","article-title":"The frequency of MEFV gene mutations in Behcet&apos;s disease and their relation with clinical findings","volume":"32","author":"A Yazici","year":"2012","journal-title":"Rheumatol Int"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"28","DOI":"10.7727\/wimj.2011.041","article-title":"Mediterranean fever gene mutations in Greek patients with Behcet&apos;s disease","volume":"61","author":"K Konstantopoulos","year":"2012","journal-title":"West Indian Med J"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.gene.2013.08.026","article-title":"Common MEFV gene mutations in Turkish patients with Behcet&apos;s disease","volume":"530","author":"T Tasliyurt","year":"2013","journal-title":"Gene"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"8134","DOI":"10.1073\/pnas.1306352110","article-title":"Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in Behcet disease","volume":"110","author":"Y Kirino","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","first-page":"S64","article-title":"Behcet&apos;s disease and hereditary periodic fever syndromes: casual association or causal relationship?","volume":"23","author":"G Espinosa","year":"2005","journal-title":"Clin Exp Rheumatol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1471-2288-14-45","article-title":"Newcastle-Ottawa Scale: comparing reviewers&apos; to authors&apos; assessments","volume":"14","author":"CK Lo","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"JP Higgins","year":"2002","journal-title":"Stat Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"M Egger","year":"1997","journal-title":"BMJ"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"CB Begg","year":"1994","journal-title":"Biometrics"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0197-2456(90)90005-M","article-title":"Power and sample size calculations. A review and computer program","volume":"11","author":"WD Dupont","year":"1990","journal-title":"Control Clin Trials"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s12016-012-8319-x","article-title":"Behcet syndrome: is it one condition?","volume":"43","author":"H Yazici","year":"2012","journal-title":"Clin Rev Allergy Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1056\/NEJMoa021933","article-title":"Development of autoantibodies before the clinical onset of systemic lupus erythematosus","volume":"349","author":"MR Arbuckle","year":"2003","journal-title":"New England Journal of Medicine"},{"key":"ref41","article-title":"Serum Cytokine Levels in Behcet&apos;s Disease","author":"ZM Akkurt","year":"2014","journal-title":"J Clin Lab Anal"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.clindermatol.2013.11.012","article-title":"Behcet&apos;s disease as a systemic disease","volume":"32","author":"MC Mat","year":"2014","journal-title":"Clin Dermatol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/sj.ejhg.5200658","article-title":"The spectrum of Familial Mediterranean Fever (FMF) mutations","volume":"9","author":"I Touitou","year":"2001","journal-title":"Eur J Hum Genet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/BOR.0000000000000003","article-title":"Genetics of Behcet&apos;s disease: Lessons learned from genomewide association studies","volume":"26","author":"A Gul","year":"2014","journal-title":"Current Opinion in Rheumatology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0197-2456(98)00037-3","article-title":"Power and sample size calculations for studies involving linear regression","volume":"19","author":"WD Dupont","year":"1998","journal-title":"Control Clin Trials"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/humu.20080","article-title":"Infevers: an evolving mutation database for auto-inflammatory syndromes","volume":"24","author":"I Touitou","year":"2004","journal-title":"Hum Mutat"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1002\/art.27683","article-title":"Association of familial Mediterranean fever-related MEFV variations with ankylosing spondylitis","volume":"62","author":"F Cosan","year":"2010","journal-title":"Arthritis Rheum"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1097\/MCG.0b013e3182597992","article-title":"Association of the MEFV gene variations with inflammatory bowel disease in Turkey","volume":"47","author":"F Akyuz","year":"2013","journal-title":"J Clin Gastroenterol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1146\/annurev.immunol.25.022106.141627","article-title":"Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*)","volume":"27","author":"SL Masters","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"9982","DOI":"10.1073\/pnas.0602081103","article-title":"The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production","volume":"103","author":"JJ Chae","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.4049\/jimmunol.179.2.1274","article-title":"Pyrin levels in human monocytes and monocyte-derived macrophages regulate IL-1beta processing and release","volume":"179","author":"S Seshadri","year":"2007","journal-title":"J Immunol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/art.22320","article-title":"Association between reduced levels of MEFV messenger RNA in peripheral blood leukocytes and acute inflammation","volume":"56","author":"D Ustek","year":"2007","journal-title":"Arthritis Rheum"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/art.10575","article-title":"Reduced MEFV messenger RNA expression in patients with familial Mediterranean fever","volume":"46","author":"C Notarnicola","year":"2002","journal-title":"Arthritis Rheum"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1136\/annrheumdis-2012-202774","article-title":"Increased NLRP3-dependent interleukin 1beta secretion in patients with familial Mediterranean fever: correlation with MEFV genotype","volume":"73","author":"A Omenetti","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.immuni.2011.02.020","article-title":"Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1beta activation and severe autoinflammation in mice","volume":"34","author":"JJ Chae","year":"2011","journal-title":"Immunity"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/01.GIM.0000151839.12032.1A","article-title":"Obstacles and opportunities in meta-analysis of genetic association studies","volume":"7","author":"G Salanti","year":"2005","journal-title":"Genet Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0132704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T02:13:40Z","timestamp":1599272020000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0132704"}},"subtitle":[],"editor":[{"given":"Graham R.","family":"Wallace","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,7,15]]},"references-count":56,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,7,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0132704","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,15]]}}}