{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:05:36Z","timestamp":1791266736533,"version":"4.1.0"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T00:00:00Z","timestamp":1437350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0132903","type":"journal-article","created":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T17:52:09Z","timestamp":1437414729000},"page":"e0132903","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":46,"title":["The Crosstalk between Osteoclasts and Osteoblasts Is Dependent upon the Composition and Structure of Biphasic Calcium Phosphates"],"prefix":"10.1371","volume":"10","author":[{"given":"Yukari","family":"Shiwaku","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Neff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-Ichi","family":"Takeyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"de Bruijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Dard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Gori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Baron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,7,20]]},"reference":[{"issue":"Suppl 2","key":"ref1","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1016\/j.injury.2011.06.008","article-title":"Bioresorbability, porosity and mechanical strength of bone substitutes: what is optimal for bone regeneration?","volume":"42","author":"G Hannink","year":"2011","journal-title":"Injury"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.actbio.2011.11.017","article-title":"Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: a review","volume":"8","author":"S Bose","year":"2012","journal-title":"Acta biomaterialia"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1902\/annals.2003.8.1.227","article-title":"The efficacy of bone replacement grafts in the treatment of periodontal osseous defects. A systematic review","volume":"8","author":"MA Reynolds","year":"2003","journal-title":"Annals of periodontology \/ the American Academy of Periodontology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1016\/j.biomaterials.2007.06.023","article-title":"A tissue engineering approach to bone repair in large animal models and in clinical practice","volume":"28","author":"R Cancedda","year":"2007","journal-title":"Biomaterials"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1021\/cr800427g","article-title":"Calcium phosphate-based osteoinductive materials","volume":"108","author":"RZ LeGeros","year":"2008","journal-title":"Chemical reviews"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0142-9612(97)00036-7","article-title":"Osteoclastic resorption of calcium phosphate ceramics with different hydroxyapatite\/beta-tricalcium phosphate ratios","volume":"18","author":"S Yamada","year":"1997","journal-title":"Biomaterials"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1016\/j.biomaterials.2003.10.079","article-title":"Resorbability of bone substitute biomaterials by human osteoclasts","volume":"25","author":"AF Schilling","year":"2004","journal-title":"Biomaterials"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1177\/44.10.8813078","article-title":"Ultrastructural study of degradation of calcium phosphate ceramic by human monocytes and modulation of this activity by HILDA\/LIF cytokine","volume":"44","author":"MD Benahmed","year":"1996","journal-title":"The journal of histochemistry and cytochemistry: official journal of the Histochemistry Society"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1389-0344(02)00023-0","article-title":"In vitro studies of human and rat osteoclast activity on hydroxyapatite, beta-tricalcium phosphate, calcium carbonate","volume":"19","author":"F Monchau","year":"2002","journal-title":"Biomolecular engineering"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0142-9612(93)90216-O","article-title":"Resorption of sintered synthetic hydroxyapatite by osteoclasts in vitro","volume":"14","author":"K Gomi","year":"1993","journal-title":"Biomaterials"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.actbio.2011.11.032","article-title":"Hydroxyapatite surface roughness: complex modulation of the osteoclastogenesis of human precursor cells","volume":"8","author":"J Costa-Rodrigues","year":"2012","journal-title":"Acta biomaterialia"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/1097-4636(200108)56:2<250::AID-JBM1092>3.0.CO;2-S","article-title":"Dissolution of poorly crystalline apatite crystals by osteoclasts determined on artificial thin-film apatite","volume":"56","author":"HM Kim","year":"2001","journal-title":"Journal of biomedical materials research"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/(SICI)1097-4636(19991205)47:3<424::AID-JBM19>3.0.CO;2-0","article-title":"Osteoclastic responses to various calcium phosphates in cell cultures","volume":"47","author":"Y Doi","year":"1999","journal-title":"Journal of biomedical materials research"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"7441","DOI":"10.1016\/j.biomaterials.2014.05.048","article-title":"Osteoclast resorption of beta-tricalcium phosphate controlled by surface architecture","volume":"35","author":"NL Davison","year":"2014","journal-title":"Biomaterials"},{"key":"ref15","first-page":"481","article-title":"Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit","volume":"3","author":"NA Sims","year":"2014","journal-title":"BoneKEy reports"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s00223-013-9741-7","article-title":"Osteoclast-derived coupling factors in bone remodeling","volume":"94","author":"K Henriksen","year":"2014","journal-title":"Calcified tissue international"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF02058664","article-title":"Tetracycline-based histological analysis of bone remodeling","volume":"3","author":"HM Frost","year":"1969","journal-title":"Calcified tissue research"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.molmed.2004.12.004","article-title":"Osteoclast-derived activity in the coupling of bone formation to resorption","volume":"11","author":"TJ Martin","year":"2005","journal-title":"Trends in molecular medicine"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5840","DOI":"10.1038\/sj.emboj.7601430","article-title":"Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling","volume":"25","author":"J Ryu","year":"2006","journal-title":"The EMBO journal"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"20764","DOI":"10.1073\/pnas.0805133106","article-title":"Regulation of bone formation by osteoclasts involves Wnt\/BMP signaling and the chemokine sphingosine-1-phosphate","volume":"105","author":"L Pederson","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref21","first-page":"666","article-title":"Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation","volume":"123","author":"S Lotinun","year":"2013","journal-title":"The Journal of clinical investigation"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1172\/JCI69493","article-title":"Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation","volume":"123","author":"S Takeshita","year":"2013","journal-title":"The Journal of clinical investigation"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1002\/jbmr.2187","article-title":"Osteoclast-derived complement component 3a stimulates osteoblast differentiation","volume":"29","author":"K Matsuoka","year":"2014","journal-title":"Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cmet.2006.05.012","article-title":"Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis","volume":"4","author":"C Zhao","year":"2006","journal-title":"Cell metabolism"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/nm.2489","article-title":"Suppression of bone formation by osteoclastic expression of semaphorin 4D","volume":"17","author":"T Negishi-Koga","year":"2011","journal-title":"Nature medicine"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.biomaterials.2006.10.001","article-title":"Engineering of bone using bone marrow stromal cells and a silicon-stabilized tricalcium phosphate bioceramic: evidence for a coupling between bone formation and scaffold resorption","volume":"28","author":"M Mastrogiacomo","year":"2007","journal-title":"Biomaterials"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1002\/jbm.a.34621","article-title":"Characterization of bone mineral-resembling biomaterials for optimizing human osteoclast differentiation and resorption","volume":"101","author":"M Nakamura","year":"2013","journal-title":"Journal of biomedical materials research Part A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S0142-9612(01)00218-6","article-title":"Calcium phosphate apatites with variable Ca\/P atomic ratio I. Synthesis, characterisation and thermal stability of powders","volume":"23","author":"S Raynaud","year":"2002","journal-title":"Biomaterials"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ejcb.2005.09.008","article-title":"Podosome and sealing zone: specificity of the osteoclast model","volume":"85","author":"P Jurdic","year":"2006","journal-title":"European journal of cell biology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ejcb.2008.01.001","article-title":"Actin cytoskeletal organisation in osteoclasts: a model to decipher transmigration and matrix degradation","volume":"87","author":"F Saltel","year":"2008","journal-title":"European journal of cell biology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1242\/jcs.052704","article-title":"Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions","volume":"122","author":"C Albiges-Rizo","year":"2009","journal-title":"Journal of cell science"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e179","DOI":"10.1371\/journal.pone.0000179","article-title":"The architecture of the adhesive apparatus of cultured osteoclasts: from podosome formation to sealing zone assembly","volume":"2","author":"C Luxenburg","year":"2007","journal-title":"PloS one"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1242\/jcs.052704","article-title":"Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions","volume":"122","author":"C Albiges-Rizo","year":"2009","journal-title":"Journal of cell science"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1128\/MCB.00851-08","article-title":"Dynamin reduces Pyk2 Y402 phosphorylation and SRC binding in osteoclasts","volume":"29","author":"A Bruzzaniti","year":"2009","journal-title":"Molecular and cellular biology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"7484","DOI":"10.1074\/jbc.M008368200","article-title":"Inhibition of osteoclast function by adenovirus expressing antisense protein-tyrosine kinase 2","volume":"276","author":"LT Duong","year":"2001","journal-title":"The Journal of biological chemistry"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"5231","DOI":"10.1091\/mbc.E04-06-0522","article-title":"Apatite-mediated actin dynamics in resorbing osteoclasts","volume":"15","author":"F Saltel","year":"2004","journal-title":"Molecular biology of the cell"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/cphc.200301014","article-title":"Activation of integrin function by nanopatterned adhesive interfaces","volume":"5","author":"M Arnold","year":"2004","journal-title":"Chemphyschem: a European journal of chemical physics and physical chemistry"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1242\/jcs.060954","article-title":"Nano-topography sensing by osteoclasts","volume":"123","author":"D Geblinger","year":"2010","journal-title":"Journal of cell science"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1016\/j.biomaterials.2007.01.040","article-title":"The effect of the microstructure of beta-tricalcium phosphate on the metabolism of subsequently formed bone tissue","volume":"28","author":"T Okuda","year":"2007","journal-title":"Biomaterials"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1016\/j.biomaterials.2009.05.002","article-title":"Stimulatory effect of hydrothermally synthesized biodegradable hydroxyapatite granules on osteogenesis and direct association with osteoclasts","volume":"30","author":"Y Gonda","year":"2009","journal-title":"Biomaterials"},{"key":"ref41","first-page":"115","article-title":"Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis","volume":"21","author":"SC Manolagas","year":"2000","journal-title":"Endocrine reviews"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1016\/j.biomaterials.2004.09.035","article-title":"A comparative study of biphasic calcium phosphate ceramics for human mesenchymal stem-cell-induced bone formation","volume":"26","author":"TL Arinzeh","year":"2005","journal-title":"Biomaterials"},{"key":"ref43","doi-asserted-by":"crossref","DOI":"10.1088\/1748-6041\/7\/1\/015005","article-title":"The chemical composition of synthetic bone substitutes influences tissue reactions in vivo: histological and histomorphometrical analysis of the cellular inflammatory response to hydroxyapatite, beta-tricalcium phosphate and biphasic calcium phosphate ceramics","volume":"7","author":"S Ghanaati","year":"2012","journal-title":"Biomedical materials"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"6400","DOI":"10.1016\/j.biomaterials.2010.04.037","article-title":"Synergistic induction of bone formation by hOP-1, hTGF-beta3 and inhibition by zoledronate in macroporous coral-derived hydroxyapatites","volume":"31","author":"U Ripamonti","year":"2010","journal-title":"Biomaterials"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/jbm.a.32560","article-title":"Effects of alendronate on bone formation and osteoclastic resorption after implantation of beta-tricalcium phosphate","volume":"93","author":"T Tanaka","year":"2010","journal-title":"Journal of biomedical materials research Part A"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.1038\/ncomms6215","article-title":"Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts","volume":"5","author":"J Keller","year":"2014","journal-title":"Nature communications"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"5398","DOI":"10.1074\/jbc.M112.413583","article-title":"Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathways","volume":"288","author":"P Quint","year":"2013","journal-title":"The Journal of biological chemistry"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bone.2013.04.008","article-title":"Sphingosine-1-phosphate promotes the nuclear translocation of beta-catenin and thereby induces osteoprotegerin gene expression in osteoblast-like cell lines","volume":"55","author":"E Matsuzaki","year":"2013","journal-title":"Bone"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bbrc.2012.05.130","article-title":"Sphingosine 1-phosphate receptor activation enhances BMP-2-induced osteoblast differentiation","volume":"423","author":"C Sato","year":"2012","journal-title":"Biochemical and biophysical research communications"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0132903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T02:57:41Z","timestamp":1717988261000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0132903"}},"subtitle":[],"editor":[{"given":"Luc","family":"Malaval","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,7,20]]},"references-count":49,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,7,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0132903","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,20]]}}}