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Manual of Operations. Part 2: Data Definitions and Data Forms For Infants Born in 2013. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.vtoxford.org\/tools\/ManualofOperationsPart2.pdf\" xlink:type=\"simple\">http:\/\/www.vtoxford.org\/tools\/ManualofOperationsPart2.pdf<\/ext-link>. Accessed 01 May 2014"},{"issue":"46","key":"ref12","doi-asserted-by":"crossref","first-page":"17994","DOI":"10.1073\/pnas.0807920105","article-title":"The influence of sex, handedness, and washing on the diversity of hand surface bacteria","volume":"105","author":"N Fierer","year":"2008","journal-title":"ProcNatlAcadSciUSA"},{"issue":"3","key":"ref13","first-page":"695","article-title":"Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA","volume":"59","author":"G Muyzer","year":"1993","journal-title":"ApplEnvironMicrobiol"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"e32543","DOI":"10.1371\/journal.pone.0032543","article-title":"Improved detection of bifidobacteria with optimised 16S rRNA-gene based pyrosequencing","volume":"7","author":"K Sim","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/cid\/ciu822","article-title":"Dysbiosis anticipating necrotizing enterocolitis in very premature infants","volume":"60","author":"K Sim","year":"2015","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1471-2105-12-38","article-title":"Removing noise from pyrosequenced amplicons","volume":"12","author":"C Quince","year":"2011","journal-title":"BMC bioinformatics"},{"issue":"5","key":"ref17","first-page":"335","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"JG Caporaso","year":"2010","journal-title":"NatMethods"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1101\/gr.112730.110","article-title":"Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR amplicons","volume":"21","author":"BJ Haas","year":"2011","journal-title":"Genome research"},{"issue":"21","key":"ref19","doi-asserted-by":"crossref","first-page":"7188","DOI":"10.1093\/nar\/gkm864","article-title":"SILVA: a comprehensive online resource for quality checked and aligned ribosomal RNA sequence data compatible with ARB","volume":"35","author":"E Pruesse","year":"2007","journal-title":"Nucleic Acids Res"},{"issue":"19","key":"ref20","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1093\/bioinformatics\/btq461","article-title":"Search and clustering orders of magnitude faster than BLAST","volume":"26","author":"RC Edgar","year":"2010","journal-title":"Bioinformatics"},{"issue":"Database issue","key":"ref21","doi-asserted-by":"crossref","first-page":"D633","DOI":"10.1093\/nar\/gkt1244","article-title":"Ribosomal Database Project: data and tools for high throughput rRNA analysis","volume":"42","author":"JR Cole","year":"2014","journal-title":"Nucleic acids research"},{"key":"ref22","unstructured":"The British Society for Antimicrobial Chemotherapy. BSAC Methods for Antimicrobial Susceptibility Testing 2014. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/bsac.org.uk\/wp-content\/uploads\/2014\/06\/BSAC-disc-susceptibility-testing-method-June-2014.pdf\" xlink:type=\"simple\">http:\/\/bsac.org.uk\/wp-content\/uploads\/2014\/06\/BSAC-disc-susceptibility-testing-method-June-2014.pdf<\/ext-link>. Accessed 01 June 2014"},{"issue":"24","key":"ref23","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1056\/NEJMoa1109910","article-title":"Rapid whole-genome sequencing for investigation of a neonatal MRSA outbreak","volume":"366","author":"CU Koser","year":"2012","journal-title":"The New England journal of medicine"},{"key":"ref24","article-title":"R: A language and environment for statistical computing","year":"2008"},{"key":"ref25","unstructured":"National Center for Biotechnology Information 2014 [02 October 2014]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/<\/ext-link>."},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1600-0463.2010.02688.x","article-title":"Development of gut microbiota in infants not exposed to medical interventions","volume":"119","author":"M Eggesbo","year":"2011","journal-title":"APMIS: acta pathologica, microbiologica, et immunologica Scandinavica"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"e66986","DOI":"10.1371\/journal.pone.0066986","article-title":"Bacterial diversity in meconium of preterm neonates and evolution of their fecal microbiota during the first month of life","volume":"8","author":"L Moles","year":"2013","journal-title":"PloS 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