{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:19:29Z","timestamp":1785151169333,"version":"3.55.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T00:00:00Z","timestamp":1439251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0133317","type":"journal-article","created":{"date-parts":[[2015,8,11]],"date-time":"2015-08-11T17:59:45Z","timestamp":1439315985000},"page":"e0133317","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Prothrombin Time and Activated Partial Thromboplastin Time Testing: A Comparative Effectiveness Study in a Million-Patient Sample"],"prefix":"10.1371","volume":"10","author":[{"given":"Manu N.","family":"Capoor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry L.","family":"Stonemetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Baird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad S.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahsan","family":"Awan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christof","family":"Birkenmaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario A.","family":"Inchiosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven K.","family":"Magid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"McGoldrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Molmenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajjad","family":"Naqvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"Pothula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aryeh","family":"Shander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Grant","family":"Steen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"Urban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Wall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent A.","family":"Fischetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,8,11]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1001\/jama.2011.1136","article-title":"The role of physicians in controlling medical care costs and reducing waste","volume":"306","author":"RH Brook","year":"2011","journal-title":"Jama"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1001\/jama.2011.1927","article-title":"Where are the health care cost savings?","volume":"307","author":"EJ Emanuel","year":"2012","journal-title":"Jama"},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1001\/jama.2012.136","article-title":"Health care cost and value: the way forward","volume":"307","author":"LF McMahon Jr.","year":"2012","journal-title":"Jama"},{"issue":"14","key":"ref4","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1001\/jama.2012.362","article-title":"Eliminating waste in US health care","volume":"307","author":"DM Berwick","year":"2012","journal-title":"Jama"},{"issue":"15","key":"ref5","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1001\/archinternmed.2012.3319","article-title":"Overdiagnosis of disease: a modern epidemic","volume":"172","author":"JR Hoffman","year":"2012","journal-title":"Archives of internal medicine"},{"issue":"8","key":"ref6","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.mayocp.2013.05.012","article-title":"A decade of reversal: an analysis of 146 contradicted medical practices","volume":"88","author":"V Prasad","year":"2013","journal-title":"Mayo Clinic proceedings"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"e1001655","DOI":"10.1371\/journal.pmed.1001655","article-title":"Using evidence to combat overdiagnosis and overtreatment: evaluating treatments, tests, and disease definitions in the time of too much","volume":"11","author":"R Moynihan","year":"2014","journal-title":"PLoS medicine"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"f4247","DOI":"10.1136\/bmj.f4247","article-title":"Too much medicine; too little care","volume":"347","author":"P Glasziou","year":"2013","journal-title":"Bmj"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1046\/j.1525-1497.1999.00308.x","article-title":"Impact of new guidelines on physicians&apos; ordering of preoperative tests","volume":"14","author":"CA Mancuso","year":"1999","journal-title":"Journal of general internal medicine"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.hrtlng.2005.07.004","article-title":"Overuse of prothrombin and partial thromboplastin coagulation tests in medical inpatients","volume":"34","author":"FH Pilsczek","year":"2005","journal-title":"Heart & lung: the journal of critical care"},{"issue":"Suppl 4","key":"ref11","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.3949\/ccjm.76.s4.07","article-title":"Perioperative management of warfarin and antiplatelet therapy","volume":"76","author":"AK Jaffer","year":"2009","journal-title":"Cleveland Clinic journal of medicine"},{"key":"ref12","unstructured":"Dugdale, DC. Prothrombin time (PT). Medline Plus. US National Library of Medicine, National Institutes of Health. 2013. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.nlm.nih.gov\/medlineplus\/ency\/article\/003652.htm\" xlink:type=\"simple\">http:\/\/www.nlm.nih.gov\/medlineplus\/ency\/article\/003652.htm<\/ext-link>."},{"key":"ref13","unstructured":"Dugdale, DC. Partial thromboplastin time (PTT), Medline Plus. US National Library of Medicine, National Institutes of Health. 2013. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.nlm.nih.gov\/medlineplus\/ency\/article\/003653.htm\" xlink:type=\"simple\">http:\/\/www.nlm.nih.gov\/medlineplus\/ency\/article\/003653.htm<\/ext-link>."},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"W15","DOI":"10.7326\/0003-4819-138-3-200302040-00011-w1","article-title":"Screening for the risk for bleeding or thrombosis","volume":"138","author":"MH Eckman","year":"2003","journal-title":"Annals of internal medicine"},{"issue":"11","key":"ref15","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1056\/NEJMp1000096","article-title":"Five next steps for a new national program for comparative-effectiveness research","volume":"362","author":"JM VanLare","year":"2010","journal-title":"The New England journal of medicine"},{"key":"ref16","unstructured":"Hirsch R, Deixler H. HIPAA Business Associates and Health-Care Big Data: Big Promise, Little Guidance. Bureau of National Affairs. 17 February 2014. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.bna.com\/hipaa-business-associates-and-health-care-big-data-big-promise-little-guidance\/\" xlink:type=\"simple\">http:\/\/www.bna.com\/hipaa-business-associates-and-health-care-big-data-big-promise-little-guidance\/<\/ext-link>. Accessed 15 August 2014."},{"key":"ref17","article-title":"2015 Hospital Accreditation Standards","year":"2014"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/ALN.0b013e31823c1067","article-title":"Practice advisory for preanesthesia evaluation: an updated report by the American Society of Anesthesiologists Task Force on Preanesthesia Evaluation","volume":"116","author":"JL Apfelbaum","year":"2012","journal-title":"Anesthesiology"},{"issue":"7","key":"ref19","doi-asserted-by":"crossref","first-page":"864","DOI":"10.4065\/82.7.864","article-title":"How to interpret and pursue an abnormal prothrombin time, activated partial thromboplastin time, and bleeding time in adults","volume":"82","author":"AH amal","year":"2007","journal-title":"Mayo Clinic proceedings"},{"issue":"29","key":"ref20","first-page":"1","article-title":"National Hospital Discharge Survey: 2007 summary","author":"MJ Hall","year":"2010","journal-title":"National health statistics reports"},{"issue":"11","key":"ref21","first-page":"1","article-title":"Ambulatory surgery in the United States, 2006","author":"KA Cullen","year":"2009","journal-title":"National health statistics reports"},{"key":"ref22","first-page":"723","article-title":"Perioperative medicine: managing for outcome","volume":"xix","author":"MF Newman","year":"2008"},{"key":"ref23","first-page":"73","article-title":"The prothrombin time in hemophilia and in obstructive jaundice","volume":"109","author":"AJ Quick","year":"1935","journal-title":"J Biol Chem"},{"key":"ref24","first-page":"521","article-title":"The coagulation of blood. Investigations on a new clotting factor","volume":"194","author":"PA Owren","year":"1947","journal-title":"Acta Med Scand"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00004311-200101000-00003","article-title":"Preoperative assessment of coagulation disorders","volume":"39","author":"M Cobas","year":"2001","journal-title":"International anesthesiology clinics"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1538-7836.2003.t01-1-00553.x","article-title":"North American Rare Bleeding Disorder Study G. Rare Bleeding Disorder Registry: deficiencies of factors II, V, VII, X, XIII, fibrinogen and dysfibrinogenemias","volume":"2","author":"SS Acharya","year":"2004","journal-title":"Journal of thrombosis and haemostasis: JTH"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"499","DOI":"10.5858\/2002-126-0499-LDOD","article-title":"Laboratory diagnosis of dysfibrinogenemia","volume":"126","author":"MT Cunningham","year":"2002","journal-title":"Archives of pathology & laboratory medicine"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.thromres.2004.10.013","article-title":"Historical perspective of factor XI","volume":"115","author":"K Fujikawa","year":"2005","journal-title":"Thrombosis research"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1055\/s-0038-1646162","article-title":"Factor XI deficiency","volume":"70","author":"U Seligsohn","year":"1993","journal-title":"Thrombosis and haemostasis"},{"issue":"7","key":"ref30","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1056\/NEJMra040403","article-title":"Treatment of von Willebrand&apos;s Disease","volume":"351","author":"PM Mannucci","year":"2004","journal-title":"The New England journal of medicine"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0952-8180(00)00164-1","article-title":"Relationship between clinical history, coagulation tests, and perioperative bleeding during tonsillectomies in pediatrics","volume":"12","author":"P Gabriel","year":"2000","journal-title":"Journal of clinical anesthesia"},{"issue":"3","key":"ref32","first-page":"312","article-title":"Risk of hemorrhage after adenoidectomy and tonsillectomy. Value of the preoperative determination of partial thromboplastin time, prothrombin time and platelet count","volume":"56","author":"K Scheckenbach","year":"2008","journal-title":"Hno"},{"issue":"5","key":"ref33","first-page":"324","article-title":"Predicting hemorrhage using preoperative coagulation screening assays","volume":"3","author":"WH Dzik","year":"2004","journal-title":"Current hematology reports"},{"issue":"2","key":"ref34","first-page":"100","article-title":"Significance of blood tests prior to adenoidectomy","volume":"87","author":"M Schwaab","year":"2008","journal-title":"Laryngo- rhino- otologie"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0165-5876(01)00574-2","article-title":"The need for routine pre-operative coagulation screening tests (prothrombin time PT\/partial thromboplastin time PTT) for healthy children undergoing elective tonsillectomy and\/or adenoidectomy","volume":"61","author":"T Asaf","year":"2001","journal-title":"International journal of pediatric otorhinolaryngology"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/sj.thj.6200306","article-title":"Role of coagulation testing in predicting bleeding risk","volume":"4","author":"YL Chee","year":"2003","journal-title":"The hematology journal: the official journal of the European Haematology Association \/ EHA"},{"issue":"6","key":"ref37","first-page":"473","article-title":"Usefulness of preoperative coagulation tests in the prevention of post-tonsillectomy hemorrhage in children","volume":"48","author":"FJ Garcia Callejo","year":"1997","journal-title":"Acta otorrinolaringologica espanola"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1001\/archsurg.133.2.134","article-title":"The preoperative bleeding time test lacks clinical benefit: College of American Pathologists&apos; and American Society of Clinical Pathologists&apos; position article","volume":"133","author":"P Peterson","year":"1998","journal-title":"Archives of surgery"},{"issue":"5","key":"ref39","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/00000658-198811000-00002","article-title":"A prospective evaluation of the efficacy of preoperative coagulation testing","volume":"208","author":"MJ Rohrer","year":"1988","journal-title":"Annals of surgery"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"810","DOI":"10.7326\/0003-4819-104-6-810","article-title":"Diagnostic uses of the activated partial thromboplastin time and prothrombin time","volume":"104","author":"AL Suchman","year":"1986","journal-title":"Annals of internal medicine"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1001\/archsurg.1982.01380250030007","article-title":"Prothrombin and partial thromboplastin times as preoperative screening tests","volume":"117","author":"JM Eisenberg","year":"1982","journal-title":"Archives of surgery"},{"issue":"8","key":"ref42","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1182\/blood.V80.8.1998.1998","article-title":"Maturation of the hemostatic system during childhood","volume":"80","author":"M Andrew","year":"1992","journal-title":"Blood"},{"issue":"5","key":"ref43","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/ajcp\/109.5.595","article-title":"Minimum specimen volume requirements for routine coagulation testing: dependence on citrate concentration","volume":"109","author":"DM Adcock","year":"1998","journal-title":"American journal of clinical pathology"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/ajcp\/107.1.105","article-title":"Effect of 3.2% vs 3.8% sodium citrate concentration on routine coagulation testing","volume":"107","author":"DM Adcock","year":"1997","journal-title":"American journal of clinical pathology"},{"issue":"2","key":"ref45","first-page":"165","article-title":"Biochemistry and physiology of blood coagulation","volume":"82","author":"KG Mann","year":"1999","journal-title":"Thrombosis and haemostasis"},{"issue":"6","key":"ref46","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/00001721-199809000-00002","article-title":"The effect of time and temperature variables on routine coagulation tests","volume":"9","author":"D Adcock","year":"1998","journal-title":"Blood coagulation & fibrinolysis: an international journal in haemostasis and thrombosis"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0133317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T05:52:17Z","timestamp":1653025937000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0133317"}},"subtitle":[],"editor":[{"given":"Sinuhe","family":"Hahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,8,11]]},"references-count":46,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0133317","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,11]]}}}