{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T14:17:22Z","timestamp":1788617842365,"version":"build-2803163510"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T00:00:00Z","timestamp":1439856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0133460","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T18:01:17Z","timestamp":1439920877000},"page":"e0133460","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes Are Strong Determinants of the Serum Triglyceride and Cholesterol Levels of Japanese Alcoholic Men"],"prefix":"10.1371","volume":"10","author":[{"given":"Akira","family":"Yokoyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Matsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Mizukami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachio","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,8,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/BF00197271","article-title":"Distribution of ADH2 and ALDH2 genotypes in different populations","volume":"88","author":"HW Goedde","year":"1992","journal-title":"Hum Genet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1176\/ajp.152.8.1219","article-title":"Alcohol and aldehyde dehydrogenase polymorphism and the risk for alcoholism","volume":"152","author":"S Higuchi","year":"1995","journal-title":"Am J Psychiatry"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1111\/j.1530-0277.2010.01202.x","article-title":"Polymorphisms of alcohol dehydrogenase 1B and aldehyde dehydrogenase-2 and the blood and salivary ethanol and acetaldehyde concentrations of Japanese alcoholic men","volume":"34","author":"A Yokoyama","year":"2010","journal-title":"Alcohol Clin Exp Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/alcalc\/agt136","article-title":"Blood ethanol levels of nonabstinent Japanese alcoholic men in the morning after drinking and their ADH1B and ALDH2 genotypes","volume":"49","author":"A Yokoyama","year":"2014","journal-title":"Alcohol Alcohol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1002\/ijc.26296","article-title":"Development of squamous neoplasia in esophageal iodine-unstained lesions and the alcohol and aldehyde dehydrogenase genotypes of Japanese alcoholic men","volume":"130","author":"A Yokoyama","year":"2012","journal-title":"Int J Cancer"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1111\/acer.12108","article-title":"Genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and liver cirrhosis, chronic calcific pancreatitis, diabetes mellitus, and hypertension among Japanese alcoholic men","volume":"37","author":"A Yokoyama","year":"2013","journal-title":"Alcohol Clin Exp Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1111\/acer.12372","article-title":"Macrocytosis, macrocytic anemia, and genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 in Japanese alcoholic men","volume":"38","author":"A Yokoyama","year":"2014","journal-title":"Alcohol Clin Exp Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/1471-2458-10-258","article-title":"Alcohol consumption and the risk of morbidity and mortality for different stroke types\u2014a systematic review and meta-analysis","volume":"10","author":"J Patra","year":"2010","journal-title":"BMC Public Health"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1161\/STROKEAHA.108.520288","article-title":"Alcohol consumption and mortality from stroke and coronary heart disease among Japanese men and women: the Japan collaborative cohort study","volume":"39","author":"S Ikehara","year":"2008","journal-title":"Stroke"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/01.STR.0000124459.33597.00","article-title":"Alcohol consumption and risk of stroke among middle-aged men: the JPHC Study Cohort I","volume":"35","author":"H Iso","year":"2004","journal-title":"Stroke"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1186\/1471-2458-14-776","article-title":"Risk factors of stroke in Western and Asian countries: a systematic review and meta-analysis of prospective cohort studies","volume":"14","author":"X Chen","year":"2014","journal-title":"BMC Public Health"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/acer.12069","article-title":"Alcohol dehydrogenase-1B genotype (rs1229984) is a strong determinant of the relationship between body weight and alcohol intake in Japanese alcoholic men","volume":"37","author":"A Yokoyama","year":"2013","journal-title":"Alcohol Clin Exp Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0022-2275(20)40613-3","article-title":"Effects of ethanol on lipid metabolism","volume":"20","author":"E Baraona","year":"1979","journal-title":"J Lipid Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1093\/alcalc\/agn005","article-title":"Associations of alcohol drinking and cigarette smoking with serum lipid levels in healthy middle-aged men","volume":"43","author":"I Wakabayashi","year":"2008","journal-title":"Alcohol Alcohol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1161\/CIRCULATIONAHA.106.678375","article-title":"To drink or not to drink? That is the question","volume":"116","author":"RA Kloner","year":"2007","journal-title":"Circulation"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1161\/STROKEAHA.113.001326","article-title":"Cholesterol levels and risk of hemorrhagic stroke: a systematic review and meta-analysis","volume":"44","author":"X Wang","year":"2013","journal-title":"Stroke"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1093\/clinchem\/48.7.1043","article-title":"Relationship between genetic polymorphisms of alcohol-metabolizing enzymes and changes in risk factors for coronary heart disease associated with alcohol consumption","volume":"48","author":"Y Hashimoto","year":"2002","journal-title":"Clin Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1093\/hmg\/ddr587","article-title":"A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population","volume":"21","author":"A Tan","year":"2012","journal-title":"Hum Mol Genet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.atherosclerosis.2010.05.024","article-title":"Association between aldehyde dehydrogenase 2 genetic polymorphism and serum lipids or lipoproteins: a meta-analysis of seven East Asian populations","volume":"212","author":"PP Hao","year":"2010","journal-title":"Atherosclerosis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"g4164","DOI":"10.1136\/bmj.g4164","article-title":"Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data","volume":"349","author":"MV Holmes","year":"2014","journal-title":"BMJ"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"WT Friedewald","year":"1972","journal-title":"Clin Chem"},{"key":"ref22","year":"1994"},{"key":"ref23","year":"2007"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/S0022-2275(20)39917-X","article-title":"Dietary ethanol is associated with reduced lipolysis of intestinally derived lipoproteins","volume":"35","author":"HJ Pownall","year":"1994","journal-title":"J Lipid Res"},{"key":"ref25","article-title":"Alcoholic ketosis: prevalence, determinants, and ketohepatitis in Japanese alcoholic men","author":"A Yokoyama","year":"2014","journal-title":"Alcohol Alcohol pii agu048"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"E10","DOI":"10.1152\/ajpendo.00011.2008","article-title":"Alcohol and lipid metabolism","volume":"295","author":"M Sozio","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1074\/jbc.M008791200","article-title":"The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver","volume":"276","author":"A Galli","year":"2001","journal-title":"J Biol Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"29342","DOI":"10.1074\/jbc.M202411200","article-title":"Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)","volume":"277","author":"M You","year":"2002","journal-title":"J Biol Chem"},{"key":"ref29","first-page":"991","article-title":"Microsomal ethanol-oxidizing system (MEOS): the first 30 years (1968\u20131998)\u2013a review","volume":"23","author":"CS Lieber","year":"1999","journal-title":"Alcohol Clin Exp Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/hep.22222","article-title":"Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice","volume":"47","author":"Y Lu","year":"2008","journal-title":"Hepatology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/hep.27036","article-title":"Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice","volume":"60","author":"HJ Kwon","year":"2014","journal-title":"Hepatology"},{"key":"ref32","first-page":"707","article-title":"Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenase in individual variation of alcohol metabolism","volume":"29","author":"Y Mizoi","year":"1994","journal-title":"Alcohol Alcohol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1161\/01.CIR.102.19.2347","article-title":"Alcohol consumption raises HDL cholesterol levels by increasing the transport rate of apolipoproteins A-I and A-II","volume":"102","author":"ER De Oliveira e Silva","year":"2000","journal-title":"Circulation"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1111\/acer.12406","article-title":"Roles of the ALDH2 and ADH1B genotypes on the Association between alcohol intake and serum adiponectin levels among Japanese male workers","volume":"38","author":"S Maeda","year":"2014","journal-title":"Alcohol Clin Exp Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"953","DOI":"10.5551\/jat.4879","article-title":"Alcohol drinking status is associated with serum high molecular weight adiponectin in community-dwelling Japanese men","volume":"17","author":"R Kawamoto","year":"2010","journal-title":"J Atheroscler Thromb"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"d636","DOI":"10.1136\/bmj.d636","article-title":"Effect of alcohol consumption on biological markers associated with risk of coronary heart disease: systematic review and meta-analysis of interventional studies","volume":"342","author":"SE Brien","year":"2011","journal-title":"BMJ"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1210\/jc.2009-1862","article-title":"Relationship between alcohol consumption and serum adiponectin levels: the Takahata study\u2014a cross-sectional study of a healthy Japanese population","volume":"95","author":"Y Nishise","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00795-007-0366-7","article-title":"Pathophysiological significance of adiponectin","volume":"40","author":"M. Nishida","year":"2007","journal-title":"Med Mol Morphol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e11735","DOI":"10.1371\/journal.pone.0011735","article-title":"The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population","volume":"5","author":"LL Husemoen","year":"2010","journal-title":"PLoS One"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1001\/archinte.1997.00440280120012","article-title":"Serum lipid and lipoprotein patterns in patients with liver cirrhosis and chronic active hepatitis","volume":"157","author":"C Cicognani","year":"1997","journal-title":"Arch Intern Med"},{"key":"ref41","first-page":"4","article-title":"Body mass index nimotozuku himannoteidoto tonyobyo, koketsuatsu, koshikessyono kikeninshitono kanren\u2013tashisetsukyodokenkyu nyoru ekigakutekikento-","volume":"6","author":"N Yoshiike","year":"2000","journal-title":"Himan Kenkyu"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0133460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T16:13:57Z","timestamp":1718036037000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0133460"}},"subtitle":[],"editor":[{"given":"Zhicheng Carl","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,8,18]]},"references-count":41,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0133460","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,18]]}}}