{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:59:17Z","timestamp":1787021957908,"version":"build-2736575974"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T00:00:00Z","timestamp":1437436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0133500","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T14:09:37Z","timestamp":1437487777000},"page":"e0133500","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Moderate Perinatal Choline Deficiency Elicits Altered Physiology and Metabolomic Profiles in the Piglet"],"prefix":"10.1371","volume":"10","author":[{"given":"Caitlyn M.","family":"Getty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan N.","family":"Dilger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,7,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev.nu.14.070194.001413","article-title":"Choline and human nutrition","volume":"14","author":"SH Zeisel","year":"1994","journal-title":"Annu Rev Nutr"},{"key":"ref2","year":"1998"},{"key":"ref3","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.21.6.LB46-c","article-title":"Choline in the diets of the US population: NHANES, 2003\u20132004","volume":"21","author":"HH Jensen","year":"2007","journal-title":"FASEB J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1093\/aje\/kws395","article-title":"Choline intake during pregnancy and child cognition at age 7 years","volume":"177","author":"CE Boeke","year":"2013","journal-title":"Am J Epidemiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.3945\/ajcn.112.037184","article-title":"Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial","volume":"96","author":"CL Cheatham","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.3945\/ajcn.111.022772","article-title":"Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans","volume":"95","author":"J Yan","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.3945\/ajcn.113.066092","article-title":"Pregnancy alters choline dynamics: results of a randomized trial using stable isotope methodology in pregnant and nonpregnant women","volume":"98","author":"J Yan","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev.nu.14.070194.001413","article-title":"Choline and human nutrition","volume":"14","author":"SH Zeisel","year":"1994","journal-title":"Annu Rev Nutr"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1096\/fasebj.5.7.2010061","article-title":"Choline, an essential nutrient for humans","volume":"5","author":"SH Zeisel","year":"1991","journal-title":"FASEB J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1096\/fj.09-154054","article-title":"Metabolomic profiling can predict which humans will develop liver dysfunction when deprived if dietary choline","volume":"24","author":"W Sha","year":"2010","journal-title":"FASEB J"},{"key":"ref11","author":"WGaXGL Pond","year":"2001"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000419461","article-title":"The piglet as a model for studying aspects of digestion and absorption in milk-fed human infants","volume":"67","author":"PJ Moughan","year":"1992","journal-title":"World Rev Nutr Diet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev.nu.07.070187.002045","article-title":"The pig as a model for human nutrition","volume":"7","author":"ER Miller","year":"1987","journal-title":"Annu Rev Nutr"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-3782(79)90022-7","article-title":"Comparative aspects of the brain growth spurt","volume":"3","author":"J Dobbing","year":"1979","journal-title":"Early Hum Dev"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.bbi.2010.05.008","article-title":"Behavioral assessment of cognitive function using a translational neonatal piglet model","volume":"24","author":"RN Dilger","year":"2010","journal-title":"Brain Behav Immun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.3945\/jn.112.165522","article-title":"Early life iron deficiency impairs spatial cognition in neonatal piglets","volume":"142","author":"JL Rytych","year":"2012","journal-title":"J Nutr"},{"key":"ref17","article-title":"Place and direction learning in a spatial T-maze task by neonatal piglets","author":"MR Elmore","year":"2012","journal-title":"Anim Cogn"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"506","DOI":"10.2527\/jas1973.372506x","article-title":"Evaluation of supplemental choline for reproducing sows housed in total confinement on concrete or in dirt lots","volume":"37","author":"ET Kornegay","year":"1973","journal-title":"J Anim Sci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.2527\/jas1974.3961113x","article-title":"Choline requirement of pregnant sows and gilts under restricted feeding conditions","volume":"39","author":"WL Stockland","year":"1974","journal-title":"J Anim Sci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1152\/jn.1998.79.4.1790","article-title":"Prenatal dietary choline supplementation decreases the threshold for induction of long-term potentiation in young adult rats","volume":"79","author":"GK Pyapali","year":"1998","journal-title":"J Neurophysiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1097\/00001756-199709290-00009","article-title":"Simultaneous temporal processing is sensitive to prenatal choline availability in mature and aged rats","volume":"8","author":"WH Meck","year":"1997","journal-title":"Neuroreport"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1037\/0735-7044.103.6.1234","article-title":"Organizational changes in cholinergic activity and enhanced visuospatial memory as a function of choline administered prenatally or postnatally or both","volume":"103","author":"WH Meck","year":"1989","journal-title":"Behav Neurosci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s003940050036","article-title":"Diurnal pattern of choline concentrations in serum of pigs as influenced by dietary choline or lecithin intake","volume":"37","author":"S Jakob","year":"1998","journal-title":"Z Ernahrungswiss"},{"key":"ref24","year":"2012"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0955-2863(97)00115-0","article-title":"Choline and choline ester concentrations in porcine milk throughout lactation","volume":"8","author":"SM Donovan","year":"1997","journal-title":"J Nutr Biochem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"6656","DOI":"10.1021\/ac901536h","article-title":"Integrated, nontargeted ultrahigh performance liquid chromatography\/electrospray ionization tandem mass spectroscopy platform for the identification and relative quantification of the small-molecule complement of biological systems","volume":"81","author":"AM Evans","year":"2009","journal-title":"Anal Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1177\/0192623309336152","article-title":"Untargeted metabolomic profiling as an evaluative tool of fenofibrate-induced toxicology in Fischer 344 male rats","volume":"37","author":"T Ohta","year":"2009","journal-title":"Toxicol Pathol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1159\/000339311","article-title":"Brain growth of the domestic pig (Sus scrofa) from 2 to 24 weeks of age: a longitudinal MRI study","volume":"34","author":"MS Conrad","year":"2012","journal-title":"Dev Neurosci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/pr.2011.21","article-title":"Magnetic resonance imaging of the neonatal piglet brain","volume":"71","author":"MS Conrad","year":"2012","journal-title":"Pediatr Res"},{"key":"ref30","first-page":"2683","article-title":"Morphological and functional characterization of non-alcoholic fatty liver disease induced by a methionine-choline-deficient diet in C57BL\/6 mice","volume":"6","author":"H Itagaki","year":"2013","journal-title":"Int J Clin Exp Pathol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1039\/C0FO00069H","article-title":"The impact of choline availability on muscle lipid metabolism","volume":"2","author":"V Michel","year":"2011","journal-title":"Food Funct"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1093\/jn\/108.11.1748","article-title":"The relationship of choline and carnitine in the choline-deficient rat","volume":"108","author":"AL Carter","year":"1978","journal-title":"J Nutr"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/0005-2760(67)90165-8","article-title":"Carnitine depletion in the choline-deficient state","volume":"144","author":"C Corredor","year":"1967","journal-title":"Biochim Biophys Acta"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"968","DOI":"10.3945\/ajcn.110.011064","article-title":"Docosahexaenoic acid in plasma phosphatidylcholine may be a potential marker for in vivo phosphatidylethanolamine N-methyltransferase activity in humans","volume":"93","author":"KA da Costa","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.3945\/jn.109.116673","article-title":"Dietary choline deprivation impairs rat brain mitochondrial function and behavioral phenotype","volume":"140","author":"C Pacelli","year":"2010","journal-title":"J Nutr"},{"key":"ref36","first-page":"319172","article-title":"Choline deficiency attenuates body weight gain and improves glucose tolerance in <italic>ob\/ob<\/italic> mice","volume":"2012","author":"G Wu","year":"2012","journal-title":"J Obes"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1177\/0269881104040215","article-title":"Simultaneous depletion of serotonin and catecholamines impairs sustained attention in healthy female subjects without affecting learning and memory","volume":"18","author":"C Matrenza","year":"2004","journal-title":"J Psychopharmacol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0133500","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T13:59:01Z","timestamp":1652882341000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0133500"}},"subtitle":[],"editor":[{"given":"Pascale","family":"Chavatte-Palmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,7,21]]},"references-count":37,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,7,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0133500","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,21]]}}}