{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:44:53Z","timestamp":1774140293588,"version":"3.50.1"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T00:00:00Z","timestamp":1437350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0133502","type":"journal-article","created":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T17:55:43Z","timestamp":1437414943000},"page":"e0133502","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Pyrimidinergic Receptor Activation Controls Toxoplasma gondii Infection in Macrophages"],"prefix":"10.1371","volume":"10","author":[{"given":"Aline Cristina Abreu","family":"Moreira-Souza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ygor","family":"Marinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gladys","family":"Correa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giani Fran\u00e7a","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Mara Lara Melo","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossiane Claudia","family":"Vommaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robson","family":"Coutinho-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,7,20]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1034\/j.1600-0854.2003.00117.x","article-title":"Toxoplasma gondii: perfecting an intracellular life style","volume":"4","author":"LD Sibley","year":"2003","journal-title":"Traffic"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1086\/315494","article-title":"Discrimination between patients with acquired toxoplasmosis and congenital toxoplasmosis on the basis of the immune response to parasite antigens","volume":"181","author":"JH Yamamoto","year":"2000","journal-title":"J Infect Dis"},{"issue":"7","key":"ref3","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0020-7519(98)00023-X","article-title":"Advances in the life cycle of Toxoplasma gondii","volume":"28","author":"JP Dubey","year":"1998","journal-title":"Int J Parasitol"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nrmicro2128","article-title":"Antimicrobial mechanisms of phagocytes and bacterial evasion strategies","volume":"7","author":"RS Flannagan","year":"2009","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1046\/j.1365-2958.2003.03823.x","article-title":"The antioxidant systems in Toxoplasma gondii and the role of cytosolic catalase in defence against oxidative injury","volume":"51","author":"M Ding","year":"2004","journal-title":"Mol Microbiol"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1074\/jbc.M406367200","article-title":"Peroxiredoxin-linked detoxification of hydroperoxides in Toxoplasma gondii","volume":"280","author":"SE Akerman","year":"2005","journal-title":"J Biol Chem"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.4049\/jimmunol.159.9.4452","article-title":"Intracellular fate of vacuoles containing Toxoplasma gondii is determined at the time of formation and depends on the mechanism of entry","volume":"159","author":"DG Mordue","year":"1997","journal-title":"J Immunol"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0928-8244(03)00279-7","article-title":"From cells to signaling cascades: manipulation of innate immunity by Toxoplasma gondii","volume":"39","author":"EY Denkers","year":"2003","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.pt.2011.03.009","article-title":"Innate responses to Toxoplasma gondii in mice and humans","volume":"27","author":"R Pifer","year":"2011","journal-title":"Trends Parasitol"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.chom.2009.05.017","article-title":"Calcium-dependent signaling and kinases in apicomplexan parasites","volume":"5","author":"O Billker","year":"2009","journal-title":"Cell Host Microbe"},{"issue":"3\u20134","key":"ref11","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.vetpar.2007.05.012","article-title":"Calcium ionophore-induced egress of Toxoplasma gondii shortly after host cell invasion","volume":"147","author":"LA Caldas","year":"2007","journal-title":"Vet Parasitol"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.pharmthera.2005.04.013","article-title":"Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation","volume":"112","author":"MJ Bours","year":"2006","journal-title":"Pharmacol Ther"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0031-6997(24)01373-5","article-title":"Receptors for purines and pyrimidines","volume":"50","author":"V Ralevic","year":"1998","journal-title":"Pharmacol Rev"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1124\/pr.58.3.3","article-title":"International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy","volume":"58","author":"MP Abbracchio","year":"2006","journal-title":"Pharmacol Rev"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.bcp.2004.11.012","article-title":"Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and peritoneal macrophages","volume":"69","author":"R Coutinho-Silva","year":"2005","journal-title":"Biochem Pharmacol"},{"issue":"4","key":"ref16","first-page":"287","article-title":"Involvement of UTP in protection of cardiomyocytes from hypoxic stress","volume":"87","author":"A Shainberg","year":"2009","journal-title":"Can J Physiol Pharmacol"},{"key":"ref17","first-page":"1","article-title":"UTP as an extracellular signaling molecule","volume":"16","author":"ER Lazarowski","year":"2001","journal-title":"News Physiol Sci"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1182\/blood-2006-01-035634","article-title":"The extracellular nucleotide UTP is a potent inducer of hematopoietic stem cell migration","volume":"109","author":"L Rossi","year":"2007","journal-title":"Blood"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","first-page":"5376","DOI":"10.4049\/jimmunol.1002946","article-title":"P2Y(6) agonist uridine 5'-diphosphate promotes host defense against bacterial infection via monocyte chemoattractant protein-1-mediated monocytes\/macrophages recruitment","volume":"186","author":"Z Zhang","year":"2011","journal-title":"J Immunol"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1111\/j.1462-5822.2011.01630.x","article-title":"Infection with Leishmania amazonensis upregulates purinergic receptor expression and induces host-cell susceptibility to UTP-mediated apoptosis","volume":"13","author":"C Marques-da-Silva","year":"2011","journal-title":"Cell Microbiol"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.vetpar.2009.09.051","article-title":"Microscopic analysis of calcium ionophore activated egress of Toxoplasma gondii from the host cell","volume":"167","author":"LA Caldas","year":"2010","journal-title":"Vet Parasitol"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/jemt.20182","article-title":"Intravacuolar network may act as a mechanical support for Toxoplasma gondii inside the parasitophorous vacuole","volume":"67","author":"RC Magno","year":"2005","journal-title":"Microsc Res Tech"},{"issue":"7296","key":"ref23","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nature09022","article-title":"Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma","volume":"465","author":"S Lourido","year":"2010","journal-title":"Nature"},{"issue":"Pt 14","key":"ref24","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1242\/jcs.00596","article-title":"Intracellular calcium stores in Toxoplasma gondii govern invasion of host cells","volume":"116","author":"JL Lovett","year":"2003","journal-title":"J Cell Sci"},{"issue":"11\u201312","key":"ref25","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1111\/j.1365-3024.2008.01064.x","article-title":"Apoptotic pulsed dendritic cells induce a protective immune response against Toxoplasma gondii","volume":"30","author":"L Bertaux","year":"2008","journal-title":"Parasite Immunol"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1046\/j.1462-5822.2003.00258.x","article-title":"In the belly of the beast: subversion of macrophage proinflammatory signalling cascades during Toxoplasma gondii infection","volume":"5","author":"EY Denkers","year":"2003","journal-title":"Cell Microbiol"},{"issue":"12","key":"ref27","doi-asserted-by":"crossref","first-page":"6319","DOI":"10.1016\/j.bmc.2008.05.013","article-title":"Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists","volume":"16","author":"H Ko","year":"2008","journal-title":"Bioorg Med Chem"},{"issue":"1\u20132","key":"ref28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11302-006-9039-6","article-title":"The role of P2 receptors in controlling infections by intracellular pathogens","volume":"3","author":"R Coutinho-Silva","year":"2007","journal-title":"Purinergic Signal"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.micinf.2010.03.004","article-title":"Activation of the P2X(7) receptor triggers the elimination of Toxoplasma gondii tachyzoites from infected macrophages","volume":"12","author":"G Correa","year":"2010","journal-title":"Microbes Infect"},{"issue":"12","key":"ref30","doi-asserted-by":"crossref","first-page":"8485","DOI":"10.4049\/jimmunol.181.12.8485","article-title":"Dendritic cells expressing plasmacytoid marker PDCA-1 are Trojan horses during Toxoplasma gondii infection","volume":"181","author":"AL Bierly","year":"2008","journal-title":"J Immunol"},{"key":"ref31","first-page":"219","article-title":"Apoptosis and its modulation during infection with Toxoplasma gondii: molecular mechanisms and role in pathogenesis","volume":"289","author":"CG Luder","year":"2005","journal-title":"Curr Top Microbiol Immunol"},{"issue":"12\u201313","key":"ref32","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0161-5890(02)00015-9","article-title":"Positive and negative regulation of pathogen induced dendritic cell function by G-protein coupled receptors","volume":"38","author":"J Aliberti","year":"2002","journal-title":"Mol Immunol"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s10495-011-0586-0","article-title":"Toxoplasma gondii Dense Granule Antigen 1 stimulates apoptosis of monocytes through autocrine TGF-beta signaling","volume":"16","author":"A D'Angelillo","year":"2011","journal-title":"Apoptosis"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s11302-009-9130-x","article-title":"The P2X(7) receptor and intracellular pathogens: a continuing struggle","volume":"5","author":"R Coutinho-Silva","year":"2009","journal-title":"Purinergic Signal"},{"issue":"29","key":"ref35","doi-asserted-by":"crossref","first-page":"25870","DOI":"10.1074\/jbc.M202553200","article-title":"Toxoplasma gondii microneme secretion involves intracellular Ca(2+) release from inositol 1,4,5-triphosphate (IP(3))\/ryanodine-sensitive stores","volume":"277","author":"JL Lovett","year":"2002","journal-title":"J Biol Chem"},{"issue":"44","key":"ref36","doi-asserted-by":"crossref","first-page":"41492","DOI":"10.1074\/jbc.M106154200","article-title":"The loss of cytoplasmic potassium upon host cell breakdown triggers egress of Toxoplasma gondii","volume":"276","author":"R Moudy","year":"2001","journal-title":"J Biol Chem"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1128\/EC.00301-07","article-title":"Exit from host cells by the pathogenic parasite Toxoplasma gondii does not require motility","volume":"7","author":"MD Lavine","year":"2008","journal-title":"Eukaryot Cell"},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4103\/2319-4170.127803","article-title":"The role of P2X7 receptor in infectious inflammatory diseases and the influence of ectonucleotidases","volume":"37","author":"AC Morandini","year":"2014","journal-title":"Biomed J"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0133502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T13:11:26Z","timestamp":1748524286000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0133502"}},"subtitle":[],"editor":[{"given":"Ira J","family":"Blader","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,7,20]]},"references-count":38,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,7,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0133502","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,20]]}}}