{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T08:11:22Z","timestamp":1782979882718,"version":"3.54.5"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T00:00:00Z","timestamp":1437436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0133552","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T14:19:02Z","timestamp":1437488342000},"page":"e0133552","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":67,"title":["Tumor-Associated Macrophages Provide Significant Prognostic Information in Urothelial Bladder Cancer"],"prefix":"10.1371","volume":"10","author":[{"given":"Minna M.","family":"Bostr\u00f6m","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki","family":"Irjala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuomas","family":"Mirtti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pekka","family":"Taimen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommi","family":"Kauko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"\u00c5lgars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirpa","family":"Jalkanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Bostr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,7,21]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"D Hanahan","year":"2011","journal-title":"Cell"},{"issue":"7203","key":"ref2","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"A Mantovani","year":"2008","journal-title":"Nature"},{"issue":"6917","key":"ref3","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"LM Coussens","year":"2002","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1600-065X.2008.00607.x","article-title":"The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance","volume":"222","author":"P Allavena","year":"2008","journal-title":"Immunol Rev"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.coi.2010.01.009","article-title":"Macrophages, innate immunity and cancer: balance, tolerance, and diversity","volume":"22","author":"A Mantovani","year":"2010","journal-title":"Curr Opin Immunol"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"A Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"ref7","first-page":"29","article-title":"WHO classification of classification of tumours of the urinary system and male genital organs","author":"G Sauter","year":"2004"},{"key":"ref8","first-page":"262","article-title":"TNM classification of malignant tumors UICC International Union Against Cancer","author":"LH Sobin","year":"2009"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1002\/eji.201041376","article-title":"Stabilin-1\/CLEVER-1, a type 2 macrophage marker, is an adhesion and scavenging molecule on human placental macrophages","volume":"41","author":"S Palani","year":"2011","journal-title":"Eur J Immunol"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/eji.200323859","article-title":"The same endothelial receptor controls lymphocyte traffic both in vascular and lymphatic vessels","volume":"33","author":"H Irjala","year":"2003","journal-title":"Eur J Immunol"},{"issue":"5075","key":"ref11","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1126\/science.1529341","article-title":"A 90-kilodalton endothelial cell molecule mediating lymphocyte binding in humans","volume":"257","author":"M Salmi","year":"1992","journal-title":"Science"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/ijc.26457","article-title":"Type and location of tumor-infiltrating macrophages and lymphatic vessels predict survival of colorectal cancer patients","volume":"131","author":"A Algars","year":"2012","journal-title":"Int J Cancer"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"e50946","DOI":"10.1371\/journal.pone.0050946","article-title":"Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature","volume":"7","author":"QW Zhang","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1046\/j.1442-2042.2000.00190.x","article-title":"Prognostic value of tumor-associated macrophage count in human bladder cancer","volume":"7","author":"T Hanada","year":"2000","journal-title":"Int J Urol"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.urolonc.2014.02.007","article-title":"Infiltration of CD3\u207a and CD68\u207a cells in bladder cancer is subtype specific and affects the outcome of patients with muscle-invasive tumors","volume":"32","author":"G Sj\u00f6dahl","year":"2014","journal-title":"Urol Oncol"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/j.juro.2008.11.090","article-title":"Increased infiltration of tumor associated macrophages is associated with poor prognosis of bladder carcinoma in situ after intravesical bacillus Calmette-Guerin instillation","volume":"181","author":"H Takayama","year":"2009","journal-title":"J Urol"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1016\/j.eururo.2009.01.040","article-title":"Bladder tumor infiltrating mature dendritic cells and macrophages as predictors of response to bacillus Calmette-Gu\u00e9rin immunotherapy","volume":"55","author":"C Ayari","year":"2009","journal-title":"Eur Urol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"232609","DOI":"10.1155\/2012\/232609","article-title":"Predictive biomarkers of bacillus calmette-gu\u00e9rin immunotherapy response in bladder cancer: where are we now?","volume":"2012","author":"L Lima","year":"2012","journal-title":"Adv Urol"},{"issue":"3\u20134","key":"ref19","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s10555-009-9195-6","article-title":"The role of neutrophils and TNF-related apoptosis-inducing ligand (TRAIL) in bacillus Calmette-Gu\u00e9rin (BCG) immunotherapy for urothelial carcinoma of the bladder","volume":"28","author":"HM Rosevear","year":"2009","journal-title":"Cancer Metastasis Rev"},{"issue":"18","key":"ref20","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/BF03262330","article-title":"The health economics of bladder cancer: a comprehensive review of the published literature","volume":"21","author":"MF Botteman","year":"2003","journal-title":"Pharmacoeconomics"},{"issue":"7528","key":"ref21","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nature13904","article-title":"MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer","volume":"515","author":"T Powles","year":"2014","journal-title":"Nature"},{"issue":"12","key":"ref22","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1245\/s10434-012-2415-2","article-title":"Elevated levels of proliferating and recently migrated tumor-associated macrophages confer increased aggressiveness and worse outcomes in breast cancer","volume":"19","author":"RA Mukhtar","year":"2012","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/ijc.23527","article-title":"Breast cancer expression of CD163, a macrophage scavenger receptor, is related to early distant recurrence and reduced patient survival","volume":"123","author":"I Shabo","year":"2008","journal-title":"Int J Cancer"},{"issue":"4","key":"ref24","first-page":"597","article-title":"Tissue invasive macrophage density is correlated with prognosis in cholangiocarcinoma","volume":"3","author":"C Subimerb","year":"2010","journal-title":"Mol Med Rep"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1136\/jcp.2006.038802","article-title":"Squamous differentiation in primary urothelial carcinoma of the urinary tract as seen by MAC387 immunohistochemistry","volume":"60","author":"A Lopez-Beltran","year":"2007","journal-title":"J Clin Pathol"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1365-2559.1991.tb00029.x","article-title":"The L1 antigen and squamous metaplasia in the bladder","volume":"19","author":"MF Tungekar","year":"1991","journal-title":"Histopathology"},{"issue":"5","key":"ref27","first-page":"2121","article-title":"Recently infiltrating MAC387(+) monocytes\/macrophages a third macrophage population involved in SIV and HIV encephalitic lesion formation","volume":"178","author":"C Soulas","year":"2011","journal-title":"Am J Pathol"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/jlb.55.2.259","article-title":"The monoclonal antibody MAC387 detects an epitope on the calcium-binding protein MRP14","volume":"55","author":"M Goebeler","year":"1994","journal-title":"J Leukoc Biol"},{"issue":"37","key":"ref29","doi-asserted-by":"crossref","first-page":"34264","DOI":"10.1074\/jbc.M204277200","article-title":"FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities","volume":"277","author":"H Adachi","year":"2002","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1100\/tsw.2010.189","article-title":"Multifunctional receptor stabilin-1 in homeostasis and disease","volume":"10","author":"J Kzhyshkowska","year":"2010","journal-title":"ScientificWorldJournal"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0133552","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T10:57:19Z","timestamp":1566989839000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0133552"}},"subtitle":[],"editor":[{"given":"Hari K","family":"Koul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,7,21]]},"references-count":30,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,7,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0133552","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,21]]}}}