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RORgammat+ cells","volume":"305","author":"G Eberl","year":"2004","journal-title":"Science"},{"issue":"1","key":"ref55","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1073\/pnas.88.1.43","article-title":"Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta","volume":"88","author":"A Bandeira","year":"1991","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5361","key":"ref56","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1126\/science.280.5361.275","article-title":"Generation of intestinal T cells from progenitors residing in gut cryptopatches","volume":"280","author":"H Saito","year":"1998","journal-title":"Science"},{"issue":"6 Pt 1","key":"ref57","first-page":"889","article-title":"The etiology of transmissible murine colonic hyperplasia","volume":"26","author":"SW Barthold","year":"1976","journal-title":"Laboratory animal 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Schlenner","year":"2010","journal-title":"Immunity"},{"key":"ref69","article-title":"In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors","author":"LI Ehrlich","year":"2010","journal-title":"Blood"},{"issue":"3","key":"ref70","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1084\/jem.20052444","article-title":"Lineage specification and plasticity in CD19- early B cell precursors","volume":"203","author":"LL Rumfelt","year":"2006","journal-title":"The Journal of experimental medicine"},{"issue":"7188","key":"ref71","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/nature06840","article-title":"The earliest thymic progenitors for T cells possess myeloid lineage potential","volume":"452","author":"JJ Bell","year":"2008","journal-title":"Nature"},{"issue":"6","key":"ref72","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.immuni.2004.05.001","article-title":"Cellular niches controlling B lymphocyte behavior within 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