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Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/influenza\/human_animal_interface\/tripartite_notes_H5N1.pdf\" xlink:type=\"simple\">http:\/\/www.who.int\/influenza\/human_animal_interface\/tripartite_notes_H5N1.pdf<\/ext-link>."},{"key":"ref9","doi-asserted-by":"crossref","DOI":"10.2807\/ese.16.32.19941-en","article-title":"Avian influenza A(H5N1) in humans: new insights from a line list of World Health Organization confirmed cases, September 2006 to August 2010","volume":"16","author":"L Fiebig","year":"2011","journal-title":"Euro Surveill"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e3462","DOI":"10.1371\/journal.pone.0003462","article-title":"Evolution of Highly Pathogenic H5N1 Avian Influenza Viruses in Vietnam between 2001 and 2007","volume":"3","author":"X-F Wan","year":"2008","journal-title":"PLoS ONE"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1750-2659.2011.00298.x","article-title":"Continued evolution of highly pathogenic avian influenza A (H5N1): updated nomenclature","volume":"6","year":"2012","journal-title":"Influenza and Other Respiratory Viruses"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.virol.2013.06.005","article-title":"Emergence of multiple clade 2.3.2.1 influenza A (H5N1) virus subgroups in Vietnam and detection of novel reassortants","volume":"444","author":"A Creanga","year":"2013","journal-title":"Virology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.virol.2012.06.021","article-title":"Evolution of highly pathogenic avian influenza (H5N1) virus populations in Vietnam between 2007 and 2010","volume":"432","author":"T Nguyen","year":"2012","journal-title":"Virology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e44097","DOI":"10.1371\/journal.pone.0044097","article-title":"Highly pathogenic avian influenza virus among wild birds in Mongolia","volume":"7","author":"M Gilbert","year":"2012","journal-title":"PLoS One"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e33092","DOI":"10.1371\/journal.pone.0033092","article-title":"A survey of avian influenza in tree sparrows in China in 2011","volume":"7","author":"Y Han","year":"2012","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1865-1682.2011.01297.x","article-title":"New introduction of clade 2.3.2.1 avian influenza virus (H5N1) into Bangladesh","volume":"59","author":"MR Islam","year":"2012","journal-title":"Transbound Emerg Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1099\/vir.0.037572-0","article-title":"Reintroduction of H5N1 highly pathogenic avian influenza virus by migratory water birds, causing poultry outbreaks in the 2010\u20132011 winter season in Japan","volume":"93","author":"Y Sakoda","year":"2012","journal-title":"J Gen Virol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.virusres.2012.09.004","article-title":"Genetics and infectivity of H5N1 highly pathogenic avian influenza viruses isolated from chickens and wild birds in Japan during 2010\u201311","volume":"170","author":"Y Uchida","year":"2012","journal-title":"Virus Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"10691","DOI":"10.1128\/JVI.00786-11","article-title":"Reversion of PB2-627E to -627K during Replication of an H5N1 Clade 2.2 Virus in Mammalian Hosts Depends on the Origin of the Nucleoprotein","volume":"85","author":"J Bogs","year":"2011","journal-title":"Journal of Virology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e31844","DOI":"10.1371\/journal.pone.0031844","article-title":"Avian influenza (H5N1) virus of clade 2.3.2 in domestic poultry in India","volume":"7","author":"S Nagarajan","year":"2012","journal-title":"PLoS One"},{"key":"ref21","unstructured":"OIE (2014) World Organization for Animal Health. 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Dis"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"9950","DOI":"10.1128\/JVI.00468-07","article-title":"An avian influenza H5N1 virus that binds to a human-type receptor","volume":"81","author":"P Auewarakul","year":"2007","journal-title":"J Virol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"8502","DOI":"10.1128\/JVI.74.18.8502-8512.2000","article-title":"Early alterations of the receptor-binding properties of H1, H2, and H3 avian influenza virus hemagglutinins after their introduction into mammals","volume":"74","author":"M Matrosovich","year":"2000","journal-title":"J Virol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"11533","DOI":"10.1128\/JVI.79.17.11533-11536.2005","article-title":"A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity","volume":"79","author":"L Glaser","year":"2005","journal-title":"J Virol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0092-8674(87)90321-7","article-title":"Influenza virus a pathogenicity: The pivotal role of hemagglutinin","volume":"50","author":"R Webster","year":"1987","journal-title":"Cell"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0966-842X(94)90123-6","article-title":"Host cell proteases controlling virus pathogenicity","volume":"2","author":"H-D Klenk","year":"1994","journal-title":"Trends in Microbiology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.cell.2013.05.035","article-title":"Structural determinants for naturally evolving H5N1 hemagglutinin to switch its receptor specificity","volume":"153","author":"K Tharakaraman","year":"2013","journal-title":"Cell"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.jmb.2008.04.016","article-title":"Recent avian H5N1 viruses exhibit increased propensity for 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