{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:12:59Z","timestamp":1792725179502,"version":"4.5.0"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T00:00:00Z","timestamp":1438128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0133877","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T14:10:39Z","timestamp":1438179039000},"page":"e0133877","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":69,"title":["Repurposing Clinical Molecule Ebselen to Combat Drug Resistant Pathogens"],"prefix":"10.1371","volume":"10","author":[{"given":"Shankar","family":"Thangamani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Younis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed N.","family":"Seleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,7,29]]},"reference":[{"key":"ref1","article-title":"Anti-biofilm activity and synergism of novel thiazole compounds with glycopeptide antibiotics against multidrug-resistant Staphylococci","author":"H Mohammad","year":"2014","journal-title":"The Journal of antibiotics"},{"key":"ref2","article-title":"Drug Repurposing for the Treatment of Staphylococcal Infections","author":"S Thangamani","year":"2015","journal-title":"Current pharmaceutical design"},{"key":"ref3","article-title":"Repurposing Non-antimicrobial Drugs and Clinical Molecules to Treat Bacterial Infections","author":"W Younis","year":"2015","journal-title":"Current pharmaceutical design"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"11596","DOI":"10.1038\/srep11596","article-title":"Repurposing ebselen for treatment of multidrug-resistant staphylococcal infections","volume":"5","author":"S Thangamani","year":"2015","journal-title":"Scientific reports"},{"issue":"5699","key":"ref5","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1126\/science.1105511","article-title":"NIH Molecular Libraries Initiative","volume":"306","author":"CP Austin","year":"2004","journal-title":"Science"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/0306-3623(95)00003-J","article-title":"Molecular actions of ebselen\u2014an antiinflammatory antioxidant","volume":"26","author":"T Schewe","year":"1995","journal-title":"General pharmacology"},{"issue":"8","key":"ref7","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1128\/AAC.33.8.1388","article-title":"Susceptibility of methicillin-resistant Staphylococcus aureus to the selenium-containing compound 2-phenyl-1,2-benzoisoselenazol-3(2H)-one (PZ51)","volume":"33","author":"R Nozawa","year":"1989","journal-title":"Antimicrobial agents and chemotherapy"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1096\/fj.12-223305","article-title":"Inhibition of bacterial thioredoxin reductase: an antibiotic mechanism targeting bacteria lacking glutathione","volume":"27","author":"J Lu","year":"2013","journal-title":"FASEB journal: official publication of the Federation of American Societies for Experimental Biology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1038\/ncomms3748","article-title":"Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen","volume":"4","author":"L Favrot","year":"2013","journal-title":"Nature communications"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/jbt.20189","article-title":"Evaluation of the antimicrobial activity of ebselen: role of the yeast plasma membrane H+-ATPase","volume":"21","author":"G Chan","year":"2007","journal-title":"Journal of biochemical and molecular toxicology"},{"key":"ref11","year":"2007"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1128\/AAC.47.7.2283-2292.2003","article-title":"Quantitative analysis of gentamicin, azithromycin, telithromycin, ciprofloxacin, moxifloxacin, and oritavancin (LY333328) activities against intracellular Staphylococcus aureus in mouse J774 macrophages","volume":"47","author":"C Seral","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1089\/nat.2013.0426","article-title":"Targeting listeria monocytogenes rpoA and rpoD genes using peptide nucleic acids","volume":"23","author":"RA Alajlouni","year":"2013","journal-title":"Nucleic acid therapeutics"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1245\/s10434-011-1940-8","article-title":"Postoperative intraperitoneal 5-fluoro-2&apos;-deoxyuridine added to chemoradiation in patients curatively resected (R0) for locally advanced gastric and gastroesophageal junction adenocarcinoma","volume":"19","author":"DJ Cohen","year":"2012","journal-title":"Annals of surgical oncology"},{"issue":"190","key":"ref15","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3006276","article-title":"Silver enhances antibiotic activity against gram-negative bacteria","volume":"5","author":"JR Morones-Ramirez","year":"2013","journal-title":"Science translational medicine"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.bbapap.2008.11.005","article-title":"Outer membrane permeability and antibiotic resistance","volume":"1794","author":"AH Delcour","year":"2009","journal-title":"Biochimica et biophysica acta"},{"issue":"2\u20133","key":"ref17","first-page":"115","article-title":"The problems in the outer membrane permeability and the antibiotic resistance of Pseudomonas aeruginosa","volume":"64","author":"T Nakae","year":"1991","journal-title":"The Kitasato archives of experimental medicine"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1128\/CMR.00117-14","article-title":"The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria","volume":"28","author":"XZ Li","year":"2015","journal-title":"Clinical microbiology reviews"},{"issue":"7","key":"ref19","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1592\/phco.23.7.916.32722","article-title":"The role of multidrug efflux pumps in the antibiotic resistance of Pseudomonas aeruginosa and other gram-negative bacteria. Insights from the Society of Infectious Diseases Pharmacists","volume":"23","author":"JR Aeschlimann","year":"2003","journal-title":"Pharmacotherapy"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/jac\/dkp241","article-title":"Methicillin-resistant Staphylococcus aureus strain USA300: origin and epidemiology","volume":"64","author":"FC Tenover","year":"2009","journal-title":"The Journal of antimicrobial chemotherapy"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.tim.2008.11.005","article-title":"Staphylococcus aureus: new evidence for intracellular persistence","volume":"17","author":"C Garzoni","year":"2009","journal-title":"Trends in microbiology"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1302\/0301-620X.85B6.13509","article-title":"Intracellular Staphylococcus aureus. A mechanism for the indolence of osteomyelitis","volume":"85","author":"JK Ellington","year":"2003","journal-title":"The Journal of bone and joint surgery British volume"},{"issue":"24","key":"ref23","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1001\/jama.293.24.3012","article-title":"Staphylococcus aureus endocarditis: a consequence of medical progress","volume":"293","author":"VG Fowler Jr.","year":"2005","journal-title":"Jama"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/jor.20003","article-title":"Intracellular Staphylococcus aureus and antibiotic resistance: implications for treatment of staphylococcal osteomyelitis","volume":"24","author":"JK Ellington","year":"2006","journal-title":"Journal of orthopaedic research: official publication of the Orthopaedic Research Society"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1574-6968.2009.01530.x","article-title":"Targeting Brucella melitensis with polymeric nanoparticles containing streptomycin and doxycycline","volume":"294","author":"MN Seleem","year":"2009","journal-title":"FEMS microbiology letters"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"4270","DOI":"10.1128\/AAC.00815-09","article-title":"Silica-antibiotic hybrid nanoparticles for targeting intracellular pathogens","volume":"53","author":"MN Seleem","year":"2009","journal-title":"Antimicrobial agents and chemotherapy"},{"issue":"12","key":"ref27","doi-asserted-by":"crossref","first-page":"6407","DOI":"10.1128\/AAC.01437-12","article-title":"Targeting essential genes in Salmonella enterica serovar typhimurium with antisense peptide nucleic acid","volume":"56","author":"MA Soofi","year":"2012","journal-title":"Antimicrobial agents and chemotherapy"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1093\/jac\/38.5.865","article-title":"Penetration of vancomycin into human lung tissue","volume":"38","author":"M Cruciani","year":"1996","journal-title":"J Antimicrob Chemoth"},{"issue":"6","key":"ref29","first-page":"993","article-title":"Bad Bugs, No Drugs: No ESCAPE Revisited Reply","volume":"49","author":"H Peltola","year":"2009","journal-title":"Clinical Infectious Diseases"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1086\/510396","article-title":"Impact of antibiotics on expression of virulence-associated exotoxin genes in methicillin-sensitive and methicillin-resistant Staphylococcus aureus","volume":"195","author":"DL Stevens","year":"2007","journal-title":"J Infect Dis"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/infdis\/jit129","article-title":"Effects of Linezolid on Suppressing In Vivo Production of Staphylococcal Toxins and Improving Survival Outcomes in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Necrotizing Pneumonia","volume":"208","author":"BA Diep","year":"2013","journal-title":"J Infect Dis"},{"issue":"7","key":"ref32","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1093\/jac\/dkt073","article-title":"Effects of subinhibitory concentrations of antibiotics on virulence factor expression by community-acquired methicillin-resistant Staphylococcus aureus","volume":"68","author":"MP Otto","year":"2013","journal-title":"J Antimicrob Chemoth"},{"issue":"10","key":"ref33","doi-asserted-by":"crossref","first-page":"5401","DOI":"10.1128\/AAC.01080-12","article-title":"Linezolid Is Superior to Vancomycin in Experimental Pneumonia Caused by Superantigen-Producing Staphylococcus aureus in HLA Class II Transgenic Mice","volume":"56","author":"MJ Karau","year":"2012","journal-title":"Antimicrobial agents and chemotherapy"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1128\/CMR.15.1.95-110.2002","article-title":"Modulation of release of proinflammatory bacterial compounds by antibacterials: potential impact on course of inflammation and outcome in sepsis and meningitis","volume":"15","author":"R Nau","year":"2002","journal-title":"Clinical microbiology reviews"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.curtheres.2012.04.002","article-title":"Linezolid effects on bacterial toxin production and host immune response: review of the evidence","volume":"73","author":"BA Diep","year":"2012","journal-title":"Current therapeutic research, clinical and experimental"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1128\/AAC.01411-05","article-title":"Inhibition of mammalian mitochondrial protein synthesis by oxazolidinones","volume":"50","author":"EE McKee","year":"2006","journal-title":"Antimicrobial agents and chemotherapy"},{"issue":"8","key":"ref37","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1128\/AAC.46.8.2723-2726.2002","article-title":"Hematologic effects of linezolid: Summary of clinical experience","volume":"46","author":"SL Gerson","year":"2002","journal-title":"Antimicrobial agents and chemotherapy"},{"issue":"8","key":"ref38","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1592\/phco.21.11.1010.34517","article-title":"Hematologic effects of antimicrobials: Focus on the oxazolidinone linezolid","volume":"21","author":"DJ Kuter","year":"2001","journal-title":"Pharmacotherapy"},{"issue":"6","key":"ref39","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1128\/AAC.01411-05","article-title":"Inhibition of mammalian mitochondrial protein synthesis by oxazolidinones","volume":"50","author":"EE McKee","year":"2006","journal-title":"Antimicrobial agents and chemotherapy"},{"issue":"1","key":"ref40","first-page":"137","article-title":"Chloramphenicol-induced erythroid suppression and bone marrow ferrochelatase activity in dogs","volume":"79","author":"DR Manyan","year":"1972","journal-title":"The Journal of laboratory and clinical medicine"},{"issue":"2","key":"ref41","first-page":"90","article-title":"Chloramphenicol induced reversible bone marrow suppression. A case report","volume":"18","author":"S Parashar","year":"1972","journal-title":"Journal of postgraduate medicine"},{"issue":"3","key":"ref42","first-page":"225","article-title":"Chloramphenicol-induced bone marrow suppression","volume":"10","author":"AA Yunis","year":"1973","journal-title":"Seminars in hematology"},{"issue":"10","key":"ref43","doi-asserted-by":"crossref","first-page":"3550","DOI":"10.1128\/AAC.01193-07","article-title":"R chi-01, a new family of oxazolidinones that overcome ribosome-based linezolid resistance","volume":"52","author":"E Skripkin","year":"2008","journal-title":"Antimicrobial agents and chemotherapy"},{"issue":"11","key":"ref44","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1128\/AAC.00184-06","article-title":"Biochemical characterization of the interactions of the novel pleuromutilin derivative retapamulin with bacterial ribosomes","volume":"50","author":"K Yan","year":"2006","journal-title":"Antimicrobial agents and chemotherapy"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"e0124595","DOI":"10.1371\/journal.pone.0124595","article-title":"Repurposing Salicylanilide Anthelmintic Drugs to Combat Drug Resistant Staphylococcus aureus","volume":"10","author":"R Rajamuthiah","year":"2015","journal-title":"PloS one"},{"issue":"7","key":"ref46","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1086\/605572","article-title":"Vancomycin in combination with other antibiotics for the treatment of serious methicillin-resistant Staphylococcus aureus infections","volume":"49","author":"S Deresinski","year":"2009","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"issue":"Suppl 3","key":"ref47","doi-asserted-by":"crossref","first-page":"S165","DOI":"10.1086\/519474","article-title":"Microbiology of antibiotic resistance in Staphylococcus aureus","volume":"45","author":"PC Appelbaum","year":"2007","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1128\/AAC.49.1.302-308.2005","article-title":"Pharmacodynamics of cefepime alone and in combination with various antimicrobials against methicillin-resistant Staphylococcus aureus in an in vitro pharmacodynamic infection model","volume":"49","author":"V Huang","year":"2005","journal-title":"Antimicrobial agents and chemotherapy"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/1471-2334-7-111","article-title":"In vitro evaluation of antibiotics&apos; combinations for empirical therapy of suspected methicillin resistant Staphylococcus aureus severe respiratory infections","volume":"7","author":"L Drago","year":"2007","journal-title":"BMC infectious diseases"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0133877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T22:32:30Z","timestamp":1588977150000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0133877"}},"subtitle":[],"editor":[{"given":"Yung-Fu","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,7,29]]},"references-count":49,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,7,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0133877","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,29]]}}}