{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:14:58Z","timestamp":1790072098115,"version":"4.0.1"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T00:00:00Z","timestamp":1438300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0133971","type":"journal-article","created":{"date-parts":[[2015,7,31]],"date-time":"2015-07-31T18:20:50Z","timestamp":1438366850000},"page":"e0133971","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Cardiac Dysregulation and Myocardial Injury in a 6-Hydroxydopamine-Induced Rat Model of Sympathetic Denervation"],"prefix":"10.1371","volume":"10","author":[{"given":"Yue-Hua","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-long","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du-Fang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Qing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-ge","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,7,31]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1172\/JCI26381","article-title":"Mechanisms of sudden cardiac death","volume":"115","author":"M Rubart","year":"2005","journal-title":"J Clinical Invest"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1161\/HYPERTENSIONAHA.109.142042","article-title":"Sympathetic nervous system modulation of inflammation and remodeling in the hypertensive heart","volume":"55","author":"SP Levick","year":"2010","journal-title":"Hypertension"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0046-8177(00)80191-4","article-title":"Cardiac autonomic denervation in congestive heart failure: comparison of Chagas&apos; heart disease with other dilated cardiomyopathy","volume":"31","author":"CR Machado","year":"2000","journal-title":"Hum Pathol"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/CIRCIMAGING.111.963967","article-title":"Cardiac autonomic denervation in diabetes mellitus","volume":"4","author":"FG Hage","year":"2011","journal-title":"Circ Cardiovasc Imaging"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"H2229","DOI":"10.1152\/ajpheart.00768.2003","article-title":"Infarction alters both the distribution and noradrenergic properties of cardiac sympathetic neurons","volume":"286","author":"W Li","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1476-5381.1983.tb10520.x","article-title":"The effect of modification of sympathetic activity on responses to ligation of a coronary artery in the conscious rat","volume":"79","author":"JH Botting","year":"1983","journal-title":"Br J Pharmacol"},{"issue":"12","key":"ref7","first-page":"1581","article-title":"Cardiovascular autonomic neuropathy in spontaneously diabetic rats with and without application of EGb 761","volume":"25","author":"R Schneider","year":"2010","journal-title":"Histol Histopathol"},{"issue":"8","key":"ref8","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.metabol.2010.12.004","article-title":"Abnormal left ventricular torsion and cardiac autonomic dysfunction in subjects with type 1 diabetes mellitus","volume":"60","author":"MK Piya","year":"2011","journal-title":"Metabolism"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1161\/01.RES.57.3.383","article-title":"Adverse effects of chronic cardiac denervation in conscious dogs with myocardial ischemia","volume":"57","author":"M Lavallee","year":"1985","journal-title":"Circ Res"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0031-6997(25)06677-3","article-title":"Pharmacological actions of 6-hydroxydopamine","volume":"26","author":"RM Kostrzewa","year":"1974","journal-title":"Pharmacol Rev"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"e104850","DOI":"10.1371\/journal.pone.0104850","article-title":"Cardiac sympathetic denervation in 6-OHDA-treated nonhuman primates","volume":"9","author":"V Joers","year":"2014","journal-title":"PloS one"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"e35371","DOI":"10.1371\/journal.pone.0035371","article-title":"Nonuniform cardiac denervation observed by 11C-meta-hydroxyephedrine PET in 6-OHDA-treated monkeys","volume":"7","author":"V Joers","year":"2012","journal-title":"PloS one"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0165-1838(96)00121-X","article-title":"Methods of sympathetic degeneration and alteration","volume":"62","author":"MJ Picklo","year":"1997","journal-title":"J Auton Nerv Syst"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1161\/01.RES.31.2.207","article-title":"Acute and chronic cardiovascular effects of 6-hydroxydopamine in dogs","volume":"31","author":"P Gauthier","year":"1972","journal-title":"Circ Res"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.expneurol.2009.12.017","article-title":"Methylcobalamin increases Erk1\/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model","volume":"222","author":"K Okada","year":"2010","journal-title":"Exp Neurol"},{"issue":"11","key":"ref16","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1055\/s-2007-1010925","article-title":"Methylcobalamin improves nerve conduction in streptozotocin-diabetic rats without affecting sorbitol and myo-inositol contents of sciatic nerve","volume":"20","author":"M Sonobe","year":"1988","journal-title":"Horm Metab Res"},{"issue":"2","key":"ref17","first-page":"48","article-title":"Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials","volume":"14","author":"Y Sun","year":"2005","journal-title":"Acta Neurol Taiwan"},{"key":"ref18","year":"1989"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1161\/01.RES.8.1.129","article-title":"The electrocardiogram of the normal and hypertensive rat","volume":"8","author":"MP Sambhi","year":"1960","journal-title":"Circ Res"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1177\/1470320313489061","article-title":"Pioglitazone enhances the blood pressure-lowering effect of losartan via synergistic attenuation of angiotensin II-induced vasoconstriction","volume":"15","author":"X Kong","year":"2014","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1109\/10.979357","article-title":"An advanced detrending method with application to HRV analysis","volume":"49","author":"MP Tarvainen","year":"2002","journal-title":"IEEE Trans Biomed Eng"},{"issue":"8","key":"ref22","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.amjcard.2009.12.022","article-title":"Relation of high heart rate variability to healthy longevity","volume":"105","author":"U Zulfiqar","year":"2010","journal-title":"Am J Cardiol"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.CIR.93.5.1043","article-title":"Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology","volume":"93","year":"1996","journal-title":"Circulation"},{"issue":"8","key":"ref24","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/S0002-9149(99)00066-1","article-title":"Heart rate variability in obesity and the effect of weight loss","volume":"83","author":"K Karason","year":"1999","journal-title":"Am J Cardiol"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0169-2607(99)00017-6","article-title":"The analysis of heart rate variability in unrestrained rats. Validation of method and results","volume":"60","author":"AE Aubert","year":"1999","journal-title":"Comput Methods Programs Biomed"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/cvr\/cvp029","article-title":"Structural and functional cardiac cholinergic deficits in adult neurturin knockout mice","volume":"82","author":"AM Mabe","year":"2009","journal-title":"Cardiovasc Res"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1046\/j.1540-8167.2001.00294.x","article-title":"Interleukin-6 levels are inversely correlated with heart rate variability in patients with decompensated heart failure","volume":"12","author":"D Aronson","year":"2001","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"R264","DOI":"10.1152\/ajpregu.00687.2009","article-title":"Tyrosine hydroxylase immunoreactivity as indicator of sympathetic activity: simultaneous evaluation in different tissues of hypertensive rats","volume":"300","author":"K Burgi","year":"2011","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/(SICI)1096-9861(19970224)378:4<454::AID-CNE2>3.0.CO;2-1","article-title":"Vesicular acetylcholine transporter (VAChT) protein: a novel and unique marker for cholinergic neurons in the central and peripheral nervous systems","volume":"378","author":"U Arvidsson","year":"1997","journal-title":"J Comp Neurol"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0165-3806(85)90106-3","article-title":"Sympathetic neuronal survival factors change after denervation","volume":"352","author":"SJ Kanakis","year":"1985","journal-title":"Brain Res"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1023\/A:1020919828028","article-title":"Differential effects of chemical sympathectomy on expression and activity of tyrosine hydroxylase and levels of catecholamines and DOPA in peripheral tissues of rats","volume":"24","author":"M Kawamura","year":"1999","journal-title":"Neurochem Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1161\/01.RES.9.2.282","article-title":"Electrocardiogram in the normal rat and its alteration with experimental coronary occlusion","volume":"9","author":"SJ Normann","year":"1961","journal-title":"Circ Res"},{"key":"ref33","first-page":"633","article-title":"The electrocardiographic appearances of myocardial infarction in the rat","volume":"41","author":"R Hill","year":"1960","journal-title":"Br J Exp Pathol"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1523\/JNEUROSCI.05-04-01058.1985","article-title":"Treatment with 6-hydroxydopamine and colchicine decreases nerve growth factor levels in sympathetic ganglia and increases them in the corresponding target tissues","volume":"5","author":"S Korsching","year":"1985","journal-title":"J Neurosci"},{"issue":"12","key":"ref35","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1016\/j.clinph.2006.08.009","article-title":"Altered diurnal autonomic variation and reduced vagal information flow in acute schizophrenia","volume":"117","author":"S Boettger","year":"2006","journal-title":"Clinical Neurophysiol"},{"issue":"8","key":"ref36","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1046\/j.1540-8167.2003.03078.x","article-title":"Circadian profile of cardiac autonomic nervous modulation in healthy subjects: differing effects of aging and gender on heart rate variability","volume":"14","author":"H Bonnemeier","year":"2003","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/0002-8703(95)90119-1","article-title":"Stability of index of heart rate variability in patients with congestive heart failure","volume":"129","author":"PK Stein","year":"1995","journal-title":"Am Heart J"},{"issue":"12","key":"ref38","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1016\/j.jacc.2004.01.050","article-title":"Dissection of long-range heart rate variability: controlled induction of prognostic measures by activity in the laboratory","volume":"43","author":"D Roach","year":"2004","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"ref39","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1073\/pnas.79.6.2116","article-title":"Functional significance of coactivation of vagal and sympathetic cardiac nerves","volume":"79","author":"K Koizumi","year":"1982","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"ref40","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1113\/expphysiol.2014.080184","article-title":"Autonomic control of the heart: going beyond the classical neurotransmitters","volume":"100","author":"N Herring","year":"2015","journal-title":"Experimental physiology"},{"issue":"3","key":"ref41","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.yjmcc.2011.11.016","article-title":"The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: implications for neural control of cardiac excitability","volume":"52","author":"N Herring","year":"2012","journal-title":"J Mol Cell Cardiol"},{"issue":"11","key":"ref42","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1139\/y80-209","article-title":"Effect of renal denervation on arterial pressure and renal norepinephrine concentration in Wistar-Kyoto and spontaneously hypertensive rats","volume":"58","author":"RL Kline","year":"1980","journal-title":"Can J Physiol Pharmacol"},{"key":"ref43","first-page":"76","article-title":"Renal functional &amp; haemodynamic changes following acute unilateral renal denervation in Sprague Dawley rats","volume":"131","author":"IM Salman","year":"2010","journal-title":"Indian J Med Res"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"H2302","DOI":"10.1152\/ajpheart.01029.2002","article-title":"Renal denervation chronically lowers arterial pressure independent of dietary sodium intake in normal rats","volume":"284","author":"F Jacob","year":"2003","journal-title":"American J Physiol Heart Circ Physiol"},{"issue":"6","key":"ref45","doi-asserted-by":"crossref","first-page":"F1209","DOI":"10.1152\/ajprenal.00010.2004","article-title":"Effect of renal denervation on dynamic autoregulation of renal blood flow","volume":"286","author":"GF DiBona","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1161\/01.RES.18.4.416","article-title":"Functional distribution of right and left stellate innervation to the ventricles. Production of neurogenic electrocardiographic changes by unilateral alteration of sympathetic tone","volume":"18","author":"F Yanowitz","year":"1966","journal-title":"Circ Res"},{"issue":"5","key":"ref47","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/BF01839386","article-title":"Creatine kinase in the dog: a review","volume":"17","author":"M Aktas","year":"1993","journal-title":"Vet Res Commun"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/jbio.201200012","article-title":"Effect of hydration on assessment of early enamel lesion using swept-source optical coherence tomography","volume":"6","author":"A Nazari","year":"2013","journal-title":"J Biophotonics"},{"issue":"1","key":"ref49","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1590\/S0102-86502009000100008","article-title":"Assessment of serum enzymatic markers of cardiomyocytes injury in female dogs submitted to ketamine S(+), atropin and xylazine association","volume":"24","author":"LG Franco","year":"2009","journal-title":"Acta Cir Bra"},{"issue":"2","key":"ref50","first-page":"133","article-title":"Histochemical study of cardiac mast cells degranulation and collagen deposition: interaction with the cathecolaminergic system in the rat","volume":"50","author":"A Facoetti","year":"2006","journal-title":"Eur J Histochem"},{"issue":"5","key":"ref51","doi-asserted-by":"crossref","first-page":"H1838","DOI":"10.1152\/ajpheart.01063.2001","article-title":"Abnormal cardiac function associated with sympathetic nervous system hyperactivity in mice","volume":"283","author":"PC Brum","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"ref52","first-page":"181","article-title":"6-Hydroxydopamine mediated cardiotoxicity in rabbits","volume":"2","author":"KG Lurie","year":"1988","journal-title":"Am J Cardiovasc Pathol"},{"issue":"12","key":"ref53","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1007\/s002590050343","article-title":"Effects of aldose reductase inhibitor and vitamin B12 on myocardial uptake of iodine-123 metaiodobenzylguanidine in patients with non-insulin-dependent diabetes mellitus","volume":"25","author":"K Utsunomiya","year":"1998","journal-title":"Eur J Nucl Med"},{"issue":"4","key":"ref54","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1365-2362.2010.02430.x","article-title":"Methylcobalamin effects on diabetic neuropathy and nerve protein kinase C in rats","volume":"41","author":"H Mizukami","year":"2011","journal-title":"Eur J Clin Invest"},{"issue":"6","key":"ref55","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1172\/JCI44824","article-title":"Pivotal role of cardiomyocyte TGF-beta signaling in the murine pathological response to sustained pressure overload","volume":"121","author":"N Koitabashi","year":"2011","journal-title":"J Clin Invest"},{"issue":"3","key":"ref56","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.pharmthera.2010.05.002","article-title":"TNFalpha in atherosclerosis, myocardial ischemia\/reperfusion and heart failure","volume":"127","author":"P Kleinbongard","year":"2010","journal-title":"Pharmacol Ther"},{"issue":"5\u20138","key":"ref57","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/BF03402177","article-title":"The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation","volume":"9","author":"VA Pavlov","year":"2003","journal-title":"Mol Med"},{"issue":"6","key":"ref58","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/nri2566","article-title":"Reflex control of immunity","volume":"9","author":"KJ Tracey","year":"2009","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"ref59","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0031-6997(24)01470-4","article-title":"The sympathetic nerve\u2014an integrative interface between two supersystems: the brain and the immune system","volume":"52","author":"IJ Elenkov","year":"2000","journal-title":"Pharmacol Rev"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0133971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T20:54:22Z","timestamp":1748552062000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0133971"}},"subtitle":[],"editor":[{"given":"German E.","family":"Gonzalez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,7,31]]},"references-count":59,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,7,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0133971","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,31]]}}}