{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:07:21Z","timestamp":1791198441385,"version":"4.1.0"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T00:00:00Z","timestamp":1438905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0134146","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T14:03:07Z","timestamp":1438956187000},"page":"e0134146","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Identification of Region-Specific Myocardial Gene Expression Patterns in a Chronic Swine Model of Repaired Tetralogy of Fallot"],"prefix":"10.1371","volume":"10","author":[{"given":"Sabine","family":"Charron","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Roubertie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Benoist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Dubes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen H.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Constantin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Vieillot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Elbes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Quesson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Bordachar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Haissaguerre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Bernus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Benoit","family":"Thambo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Rooryck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,8,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/S0140-6736(09)60657-7","article-title":"Tetralogy of Fallot","volume":"374","author":"C Apitz","year":"2009","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1161\/CIRCULATIONAHA.107.688770","article-title":"Right ventricular mechanics and QRS duration in patients with repaired tetralogy of Fallot: implications of infundibular disease","volume":"116","author":"A Uebing","year":"2007","journal-title":"Circulation"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1093\/europace\/eun178","article-title":"Presence of ventricular dyssynchrony and haemodynamic impact of right ventricular pacing in adults with repaired Tetralogy of Fallot and right bundle branch block","volume":"10","author":"P Bordachar","year":"2008","journal-title":"Europace"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.jacc.2004.11.049","article-title":"Detection of left ventricular asynchrony in patients with right bundle branch block after repair of tetralogy of Fallot using tissue-Doppler imaging-derived strain","volume":"45","author":"MY Abd El Rahman","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/ejhf.66","article-title":"ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models","volume":"16","author":"AF Leite-Moreira","year":"2014","journal-title":"Eur J Heart Fail"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ijcard.2010.08.063","article-title":"Validation of an animal model of right ventricular dysfunction and right bundle branch block to create close physiology to postoperative tetralogy of Fallot","volume":"154","author":"JB Thambo","year":"2012","journal-title":"Int J Cardiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"D1079","DOI":"10.1093\/nar\/gku1071","article-title":"Genenames.org: the HGNC resources in 2015","volume":"43","author":"KA Gray","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"W Huang da","year":"2009","journal-title":"Nat Protoc"},{"key":"ref9","first-page":"173","article-title":"Role of mitogen-activated protein kinase in cardiac hypertrophy and heart failure","volume":"8","author":"W Zhang","year":"2003","journal-title":"Exp Clin Cardiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1161\/01.RES.0000038488.38975.1A","article-title":"Involvement of extracellular signal-regulated kinases 1\/2 in cardiac hypertrophy and cell death","volume":"91","author":"OF Bueno","year":"2002","journal-title":"Circ Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/dvdy.10418","article-title":"Molecular markers of cardiac endocardial cushion development","volume":"228","author":"AD Gitler","year":"2003","journal-title":"Dev Dyn"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/S0008-6363(99)00376-4","article-title":"Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression","volume":"45","author":"H Schumann","year":"2000","journal-title":"Cardiovasc Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/joim.12175","article-title":"The cardiokine secreted Frizzled-related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure","volume":"275","author":"ET Askevold","year":"2014","journal-title":"J Intern Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1479-5876-10-67","article-title":"Ca(2)+-regulatory proteins in cardiomyocytes from the right ventricle in children with congenital heart disease","volume":"10","author":"Y Wu","year":"2012","journal-title":"J Transl Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.pbiomolbio.2014.06.008","article-title":"Systems approach to the study of stretch and arrhythmias in right ventricular failure induced in rats by monocrotaline","volume":"115","author":"D Benoist","year":"2014","journal-title":"Prog Biophys Mol Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"H1185","DOI":"10.1152\/ajpheart.00916.2003","article-title":"Dynamic changes of gene expression in hypoxia-induced right ventricular hypertrophy","volume":"286","author":"S Sharma","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.yjmcc.2011.02.017","article-title":"Hypoxia and HIF-1 suppress SERCA2a expression in embryonic cardiac myocytes through two interdependent hypoxia response elements","volume":"50","author":"VP Ronkainen","year":"2011","journal-title":"J Mol Cell Cardiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1042\/BJ20050068","article-title":"Sarcolipin and phospholamban mRNA and protein expression in cardiac and skeletal muscle of different species","volume":"389","author":"P Vangheluwe","year":"2005","journal-title":"Biochem J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.yjmcc.2007.03.738","article-title":"Sarcolipin and phospholamban as regulators of cardiac sarcoplasmic reticulum Ca2+ ATPase","volume":"42","author":"P Bhupathy","year":"2007","journal-title":"J Mol Cell Cardiol"},{"key":"ref20","first-page":"373","article-title":"Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block","volume":"117","author":"M Pashmforoush","year":"2004","journal-title":"Cell"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"9199","DOI":"10.1073\/pnas.0402596101","article-title":"Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice","volume":"101","author":"M Asahi","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1253\/circj.CJ-09-0465","article-title":"Global gene expression profiling in the failing myocardium","volume":"73","author":"M Asakura","year":"2009","journal-title":"Circ J"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1253\/circj.CJ-10-0234","article-title":"Reduced ACTC1 expression might play a role in the onset of congenital heart disease by inducing cardiomyocyte apoptosis","volume":"74","author":"HK Jiang","year":"2010","journal-title":"Circ J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1113\/jphysiol.2012.235382","article-title":"Role of the Wnt-Frizzled system in cardiac pathophysiology: a rapidly developing, poorly understood area with enormous potential","volume":"591","author":"K Dawson","year":"2013","journal-title":"J Physiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1161\/CIRCRESAHA.114.302711","article-title":"Role for myosin-V motor proteins in the selective delivery of Kv channel isoforms to the membrane surface of cardiac myocytes","volume":"114","author":"SM Schumacher-Bass","year":"2014","journal-title":"Circ Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.ijcard.2005.07.063","article-title":"Gene expression profiling of human cardiac potassium and sodium channels","volume":"111","author":"B Ordog","year":"2006","journal-title":"Int J Cardiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/sj.bjp.0707403","article-title":"The plateau outward current in canine ventricle, sensitive to 4-aminopyridine, is a constitutive contributor to ventricular repolarization","volume":"152","author":"A Sridhar","year":"2007","journal-title":"Br J Pharmacol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e101838","DOI":"10.1371\/journal.pone.0101838","article-title":"Effects of candesartan on electrical remodeling in the hearts of inherited dilated cardiomyopathy model mice","volume":"9","author":"F Odagiri","year":"2014","journal-title":"PLoS One"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e26524","DOI":"10.1371\/journal.pone.0026524","article-title":"Four and a half LIM protein 1C (FHL1C): a binding partner for voltage-gated potassium channel K(v1.5)","volume":"6","author":"I Poparic","year":"2011","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e7307","DOI":"10.1371\/journal.pone.0007307","article-title":"Characterization of multiple ion channels in cultured human cardiac fibroblasts","volume":"4","author":"GR Li","year":"2009","journal-title":"PLoS One"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"C1109","DOI":"10.1152\/ajpcell.00207.2009","article-title":"Functional ion channels in mouse cardiac c-kit(+) cells","volume":"298","author":"Y Han","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1161\/CIRCRESAHA.109.212787","article-title":"Essential roles of an intercalated disc protein, mXinbeta, in postnatal heart growth and survival","volume":"106","author":"Q Wang","year":"2010","journal-title":"Circ Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/B978-0-12-800180-6.00003-7","article-title":"New insights into the roles of Xin repeat-containing proteins in cardiac development, function, and disease","volume":"310","author":"Q Wang","year":"2014","journal-title":"Int Rev Cell Mol Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1152\/physiolgenomics.00148.2011","article-title":"Identification of hypertrophy- and heart failure-associated genes by combining in vitro and in vivo models","volume":"44","author":"B Lu","year":"2012","journal-title":"Physiol Genomics"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1161\/CIRCRESAHA.109.209007","article-title":"Modulation of angiotensin II-mediated cardiac remodeling by the MEF2A target gene Xirp2","volume":"106","author":"SA McCalmon","year":"2010","journal-title":"Circ Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.yjmcc.2010.07.014","article-title":"Identification of right heart-enriched genes in a murine model of chronic outflow tract obstruction","volume":"49","author":"K Kreymborg","year":"2010","journal-title":"J Mol Cell Cardiol"},{"issue":"Suppl 1","key":"ref37","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/1471-2350-8-S1-S3","article-title":"Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness","volume":"8","author":"D Levy","year":"2007","journal-title":"BMC Med Genet"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0134146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T05:53:33Z","timestamp":1540014813000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0134146"}},"subtitle":[],"editor":[{"given":"Robert W","family":"Dettman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,8,7]]},"references-count":37,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0134146","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,7]]}}}