{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:10:51Z","timestamp":1778843451947,"version":"3.51.4"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T00:00:00Z","timestamp":1438041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0134357","type":"journal-article","created":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T18:04:27Z","timestamp":1438106667000},"page":"e0134357","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Age-Related Changes in Ocular Blood Velocity in Suspects with Glaucomatous Optic Disc Appearance. Comparison with Healthy Subjects and Glaucoma Patients"],"prefix":"10.1371","volume":"10","author":[{"given":"Magdalena","family":"Asejczyk-Widlicka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrycja","family":"Krzyzanowska-Berkowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata P.","family":"Sander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Robert","family":"Iskander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,7,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1755-3768.2011.02178.x","article-title":"Use of color Doppler imaging in ocular blood flow research","volume":"89","author":"I Stalmans","year":"2011","journal-title":"Acta Ophthalmol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1350-9462(02)00008-3","article-title":"The impact of ocular blood flow in glaucoma","volume":"21","author":"J Flammer","year":"2002","journal-title":"Prog Retin Eye Res"},{"key":"ref3","first-page":"690","article-title":"Color Doppler imaging in untreated high- and normal-pressure open-angle glaucoma","volume":"38","author":"Z Butt","year":"1997","journal-title":"Ophthalmol Vis Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/BF02169780","article-title":"The glaucoma suspect: Differentiation of the future glaucoma eye from the non-glaucomatous suspect eye","volume":"227","author":"IA Chrisholm","year":"1989","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0002-9394(14)70127-8","article-title":"Blood-flow velocities of the extraocular vessels in patients with high-tension and normal-tension primary open\u2014angle glaucoma","volume":"123","author":"HJ Kaiser","year":"1997","journal-title":"Am J Ophthalmol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1111\/j.1600-0420.2005.00567.x","article-title":"Predictive value of color Doppler imaging in a prospective study of visual field progression in primary open-angle glaucoma","volume":"83","author":"A Martinez","year":"2005","journal-title":"Acta Ophthalmol Scand"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1136\/bjo.2006.093633","article-title":"Glaucoma progression is associated with decreased blood flow velocities in the short posterior ciliary artery","volume":"90","author":"O Zeitz","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1167\/iovs.11-8817","article-title":"Predictive Value of Retrobulbar Blood Flow Velocities in Glaucoma Suspects","volume":"53","author":"P Calvo","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/S0002-9394(02)02156-6","article-title":"Rate of progression of glaucoma correlates with retrobulbar circulation and intraocular pressure","volume":"135","author":"M Satilims","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1001\/archopht.121.12.1711","article-title":"Ocular hemodynamics and glaucoma prognosis: a color Doppler imaging study","volume":"121","author":"F Galassi","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"ref11","first-page":"2645","article-title":"Age-related ocular blood flow changes","volume":"37","author":"G Ravalico","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1001\/archopht.118.8.1076","article-title":"Aging affects the retrobulbar circulation differently in women and men","volume":"118","author":"A Harris","year":"2000","journal-title":"Arch Ophthalmol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/00006324-200304000-00008","article-title":"The effect of age on ocular blood supply determined by pulsatile ocular blood flow and color Doppler ultrasonography","volume":"80","author":"AK Lam","year":"2003","journal-title":"Optom Vis Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e102814","DOI":"10.1371\/journal.pone.0102814","article-title":"Glaucomatous and age-related changes in corneal pulsation shape. The ocular dicrotism","volume":"9","author":"ME Danielewska","year":"2014","journal-title":"PLoS ONE"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1167\/iovs.11-9388","article-title":"Ophthalmic artery Doppler waveform changes associated with increased damage in glaucoma patients","volume":"53","author":"LA Pinto","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00061198-199508000-00011","article-title":"Test\/retest reproducibility of color Doppler imaging assessment of blood flow velocity in orbital vessels","volume":"4","author":"A Harris","year":"1995","journal-title":"Journal of Glaucoma"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1167\/iovs.04-0717","article-title":"Comparison of the autoregulatory mechanisms between middle cerebral artery and ophthalmic artery after thigh cuff deflation in healthy subjects","volume":"46","author":"J Kolodjaschna","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1007\/s00417-009-1178-3","article-title":"Reproducibility of color Doppler imaging","volume":"247","author":"I Stalmans","year":"2009","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"463","DOI":"10.7863\/jum.1995.14.6.463","article-title":"Variability in measurement of central retinal artery velocity using color Doppler imaging","volume":"14","author":"KJ Dennis","year":"1995","journal-title":"J Ultrasound Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"6652","DOI":"10.1167\/iovs.10-5490","article-title":"Retrobulbar blood flow velocities in open angle glaucoma and their association with mean arterial blood pressure","volume":"51","author":"G Garh\u00f6fer","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1755-3768.2011.02335.x","article-title":"Disturbed correlation between arterial resistance and pulsatility in glaucoma patients","volume":"90","author":"LA Pinto","year":"2012","journal-title":"Acta Ophthalmol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1167\/iovs.10-6710","article-title":"Systemic vascular dysregulation and retrobulbar hemodynamics in normal-tension glaucoma","volume":"52","author":"F Galassi","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1161\/01.STR.24.11.1686","article-title":"The impact of cardiac index on cerebral hemodynamics","volume":"24","author":"M Saha","year":"1993","journal-title":"Stroke"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/S0735-1097(01)01166-4","article-title":"Comparative effects of aging in men and women on the properties of the arterial tree","volume":"37","author":"H Smulyan","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1161\/hc3101.091158","article-title":"Microcirculation in hypertension: a new target for treatment?","volume":"104","author":"BI Levy","year":"2001","journal-title":"Circulation"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1097\/00004872-200105000-00013","article-title":"Small artery remodeling is the most prevalent (earliest?) form of target organ damage in mild essential hypertension","volume":"19","author":"JB Park","year":"2001","journal-title":"J Hypertens"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S1350-9462(01)00014-3","article-title":"Role of nitric oxide in the control of ocular blood flow","volume":"20","author":"L Schmetterer","year":"2001","journal-title":"Prog Retin Eye Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.ajo.2010.01.018","article-title":"Blood pressure, perfusion pressure, and glaucoma","volume":"149","author":"J Caprioli","year":"2010","journal-title":"Am J Ophthalmol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1167\/iovs.08-2956","article-title":"Blood pressure, perfusion pressure, and open-angle glaucoma: the Los Angeles Latino Eye Study","volume":"51","author":"F Memarzadeh","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/BF00917974","article-title":"Color Doppler imaging in evaluation of optic nerve blood supply in normal and glaucomatous subjects","volume":"16","author":"F Galassi","year":"1992","journal-title":"International Ophthalmology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0002-9394(14)76579-1","article-title":"Color Doppler analysis of ocular vessel blood velocity in normal-tension glaucoma","volume":"118","author":"A Harris","year":"1994","journal-title":"Am J Ophthalmol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S0002-9394(14)75424-8","article-title":"Doppler imaging in patients with asymmetric glaucoma and unilateral visual field loss","volume":"121","author":"MT Nicolela","year":"1996","journal-title":"Am J Ophthalmol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0301-5629(01)00464-1","article-title":"Comparison of visually evoked peak systolic and end diastolic flow velocity using a control system approach","volume":"27","author":"B Rosengarten","year":"2001","journal-title":"Ultrasound Med Biol"},{"key":"ref34","first-page":"199","article-title":"Measurement of retinal blood flow","volume":"96","author":"DW Hill","year":"1976","journal-title":"Trans Ophthalmol Soc UK"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1148\/radiology.211.2.r99ma48411","article-title":"Relationship between the resistive index and vascular compliance and resistance","volume":"211","author":"RO Bude","year":"1999","journal-title":"Radiology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.2214\/ajr.154.6.2110732","article-title":"Intrarenal arterial Doppler sonography in patients with nonobstructive renal disease: correlation of resistive findings with biopsy findings","volume":"154","author":"JF Platt","year":"1990","journal-title":"Am J Roentgenol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0161-6420(96)30662-3","article-title":"Influence of age on retinal and optic nerve head blood circulation","volume":"103","author":"MJ Groh","year":"1996","journal-title":"Ophthalmology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1568-1637(02)00064-8","article-title":"Microvascular plasticity in aging","volume":"2","author":"DR Riddle","year":"2003","journal-title":"Age Res Rev"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1167\/iovs.04-0987","article-title":"The effect of age on optic nerve head blood flow","volume":"46","author":"AG Boehm","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/00061198-199610000-00004","article-title":"Ocualar hypertension and primary open\u2013angle glaucoma: a comperative study of their retrobulbar blood flow velocity","volume":"5","author":"MT Nicolela","year":"1996","journal-title":"J Glaucoma"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1167\/iovs.03-0079","article-title":"Retinal vessel diameters and their associations with age and blood pressure","volume":"44","author":"TY Wong","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e286","DOI":"10.1111\/aos.12314","article-title":"Visual field loss in optic disc drusen patients correlates with central retinal artery blood velocity","volume":"92","author":"LA Pinto","year":"2014","journal-title":"Acta Ophthalmol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1136\/bjo.80.12.1055","article-title":"Acute IOP elevation with scleral suction: effect on retrobulbar haemodynamics","volume":"80","author":"A Harris","year":"1996","journal-title":"Br J Ophthalmol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"H1442","DOI":"10.1152\/ajpheart.2001.280.4.H1442","article-title":"RI in central retinal artery as assessed by CDI does not correspond to retinal vascular resistance","volume":"280","author":"E Polska","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/IJG.0b013e31817d23c7","article-title":"Correlation of intraocular pressure measured with Goldmann and dynamic contour tonometry in normal and glaucomatous eyes","volume":"18","author":"T Realini","year":"2009","journal-title":"J Glaucoma"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/sj.eye.6703102","article-title":"Comparison of Goldmann applanation tonometry and dynamic contour tonometry in healthy and glaucomatous eyes","volume":"23","author":"P Ceruti","year":"2009","journal-title":"Eye"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1186\/1471-2415-14-30","article-title":"Clinical utility of spectral analysis of intraocular pressure pulse wave","volume":"14","author":"M Asejczyk-Widlicka","year":"2014","journal-title":"BMC Ophthalmol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1167\/iovs.08-2955","article-title":"The relationship between diurnal variations in intraocular pressure measurements and central corneal thickness and corneal hysteresis","volume":"50","author":"A Kotecha","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1136\/bjo.2006.108340","article-title":"Pulsatile ocular blood flow: relationship with flow velocities in vessels supplying the retina and choroid","volume":"91","author":"IB Zion","year":"2007","journal-title":"Br J Ophthalmol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0002-9394(14)70820-7","article-title":"The relationship between progression of visual field defects and retrobulbar circulation in patients with glaucoma","volume":"124","author":"Y Yamazaki","year":"1997","journal-title":"Am J Ophthalmol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1001\/archopht.121.12.1711","article-title":"Ocular hemodynamics and glaucoma prognosis: a color doppler imaging study","volume":"121","author":"F Galassi","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/S0002-9394(02)02156-6","article-title":"Rate of progression of glaucoma correlates with retrobulbar circulation and intraocular pressure","volume":"135","author":"M Satilmis","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1136\/bjo.2006.099853","article-title":"Retrobulbar haemodynamics and morphometric optic disc analysis in primary open-angle glaucoma","volume":"90","author":"N Plange","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.ajo.2008.04.034","article-title":"Retinal blood flow and nerve fiber layer measurements in early-stage open-angle glaucoma","volume":"146","author":"F Berisha","year":"2008","journal-title":"Am J Ophthalmol"},{"key":"ref55","unstructured":"Siesky B, Ehrlich R, Moss A. Ocular blood flow correlates with structural changes in glaucoma patients: The Indianapolis Glaucoma Progression Study. AAO Meeting 2009, Abstract 90627."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0134357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T09:32:33Z","timestamp":1589016753000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0134357"}},"subtitle":[],"editor":[{"given":"Bang V","family":"Bui","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,7,28]]},"references-count":55,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,7,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0134357","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,28]]}}}