{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:34:33Z","timestamp":1787852073575,"version":"build-2784847793"},"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T00:00:00Z","timestamp":1438732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0134601","type":"journal-article","created":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T14:13:50Z","timestamp":1438784030000},"page":"e0134601","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":64,"title":["Functional Local Renin-Angiotensin System in Human and Rat Periodontal Tissue"],"prefix":"10.1371","volume":"10","author":[{"given":"Carlos F.","family":"Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C.","family":"Morandini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago J.","family":"Dion\u00edsio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1vio A.","family":"Faria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta C.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio M.","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bella L.","family":"Colombini-Ishikiriama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla R.","family":"Sipert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubens P.","family":"Maciel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana P.","family":"Akashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela P.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo P.","family":"Garlet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila O.","family":"Rodini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra L.","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Becari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Salgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo B.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Matus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela N.","family":"Didier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.","family":"Greene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,8,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1902\/jop.2009.080264","article-title":"Characterization of a local renin-angiotensin system in rat gingival tissue","volume":"80","author":"CF Santos","year":"2009","journal-title":"J Periodontol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S1532-0456(02)00098-4","article-title":"Proliferative effects of angiotensin II and endothelin-1 on guinea pig gingival fibroblast cells in culture","volume":"132","author":"N Ohuchi","year":"2002","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cca.2004.02.003","article-title":"Pharmacological properties of angiotensin II receptors in cultured rabbit gingival fibroblasts","volume":"137","author":"N Ohuchi","year":"2004","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/154405910308200108","article-title":"Role of K+ATP channels, endothelin A receptors, and effect of angiotensin II on blood flow in oral tissues","volume":"82","author":"E Berggreen","year":"2003","journal-title":"J Dent Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.regpep.2006.11.008","article-title":"Regulation of angiotensin II receptors levels during rat induced pulpitis","volume":"140","author":"PP Souza","year":"2007","journal-title":"Regul Pept"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1600-0757.2006.00174.x","article-title":"The breadth of bacterial diversity in the human periodontal pocket and other oral sites","volume":"42","author":"BJ Paster","year":"2006","journal-title":"Periodontol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nrmicro2873","article-title":"The keystone-pathogen hypothesis","volume":"10","author":"G Hajishengallis","year":"2012","journal-title":"Nat Rev Microbiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1902\/jop.1996.67.2.109","article-title":"Periodontal status and detection frequency of bacteria at sites of periodontal health and gingivitis","volume":"67","author":"GR Riviere","year":"1996","journal-title":"J Periodontol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1600-0757.2005.00107.x","article-title":"Periodontal microbial ecology","volume":"38","author":"SS Socransky","year":"2005","journal-title":"Periodontol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1399-302X.2008.00467.x","article-title":"The host cytokine response to <italic>Porphyromonas gingivalis<\/italic> is modified by gingipains","volume":"24","author":"PG Stathopoulou","year":"2009","journal-title":"Oral Microbiol Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1159\/000363338","article-title":"<italic>Porphyromonas gingivalis<\/italic> fimbriae dampen P2X7-dependent interleukin-1beta secretion","volume":"6","author":"AC Morandini","year":"2014","journal-title":"J Innate Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1902\/jop.2008.080174","article-title":"Host-response therapeutics for periodontal diseases","volume":"79","author":"WV Giannobile","year":"2008","journal-title":"J Periodontol"},{"key":"ref13","first-page":"60","article-title":"Pathogenesis of periodontitis: role of cytokines in host response","volume":"29","author":"V Deo","year":"2010","journal-title":"Dent Today"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1902\/jop.1996.67.10s.1123","article-title":"Periodontal disease and cardiovascular disease","volume":"67","author":"J Beck","year":"1996","journal-title":"J Periodontol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1146\/annurev.immunol.24.021605.090646","article-title":"Osteoimmunology: interplay between the immune system and bone metabolism","volume":"24","author":"MC Walsh","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1600-051X.1990.tb00035.x","article-title":"Fate of pocket epithelium in an apically positioned flap","volume":"17","author":"DJ Pippin","year":"1990","journal-title":"J Clin Periodontol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1600-0757.1993.tb00215.x","article-title":"Periodontal diseases: a brief historical perspective","volume":"2","author":"H Loe","year":"1993","journal-title":"Periodontol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1600-051X.2004.00545.x","article-title":"Matrix metalloproteinases, their physiological inhibitors and osteoclast factors are differentially regulated by the cytokine profile in human periodontal disease","volume":"31","author":"GP Garlet","year":"2004","journal-title":"J Clin Periodontol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s10735-008-9163-4","article-title":"Morphologic evaluation and expression of matrix metalloproteinases-2 and 9 and nitric oxide during experimental periodontal disease in rat","volume":"39","author":"CO Rodini","year":"2008","journal-title":"J Mol Histol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1902\/jop.2008.070411","article-title":"COX-2 inhibition decreases VEGF expression and alveolar bone loss during the progression of experimental periodontitis in rats","volume":"79","author":"TM Oliveira","year":"2008","journal-title":"J Periodontol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/ID.0b013e3181a44fd8","article-title":"Clinical, histological, and microbiological findings in peri-implant disease: a pilot study","volume":"18","author":"SB Ferreira Jr.","year":"2009","journal-title":"Implant Dent"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1097\/00005344-200205000-00002","article-title":"Molecular cloning and sequencing of the cDNA for rat mesenteric arterial bed elastase-2, an angiotensin II-forming enzyme","volume":"39","author":"CF Santos","year":"2002","journal-title":"J Cardiovasc Pharmacol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0002-9440(10)65284-4","article-title":"Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression","volume":"154","author":"JE Nor","year":"1999","journal-title":"Am J Pathol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1161\/01.HYP.0000081221.36703.01","article-title":"Angiotensin I conversion to angiotensin II stimulates cortical collecting duct sodium transport","volume":"42","author":"P Komlosi","year":"2003","journal-title":"Hypertension"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.ijom.2007.11.021","article-title":"Expression of vascular endothelial growth factor-C does not predict occult lymph-node metastasis in early oral squamous cell carcinoma","volume":"37","author":"SE Faustino","year":"2008","journal-title":"Int J Oral Maxillofac Surg"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1161\/01.HYP.19.6.575","article-title":"Increased vascular formation of angiotensin II in one-kidney, one clip hypertension","volume":"19","author":"R Leite","year":"1992","journal-title":"Hypertension"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1111\/j.1471-4159.1972.tb01298.x","article-title":"Distribution and properties of angiotensin converting enzyme of rat brain","volume":"19","author":"HY Yang","year":"1972","journal-title":"J Neurochem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1139\/y02-004","article-title":"Kinetic characterization and inhibition of the rat MAB elastase-2, an angiotensin I-converting serine protease","volume":"80","author":"CF Santos","year":"2002","journal-title":"Can J Physiol Pharmacol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1902\/jop.2009.090375","article-title":"Differential production of macrophage inflammatory protein-1\u03b1, stromal-derived factor-1, and IL-6 by human cultured periodontal ligament and gingival fibroblasts challenged with lipopolysaccharide from <italic>P<\/italic>. <italic>gingivalis<\/italic>","volume":"81","author":"AC Morandini","year":"2010","journal-title":"J Periodontol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"H1163","DOI":"10.1152\/ajpheart.2001.281.3.H1163","article-title":"Angiotensin II and VEGF are involved in angiogenesis induced by short-term exercise training","volume":"281","author":"SL Amaral","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"353","DOI":"10.33549\/physiolres.9300102","article-title":"Impact of antihypertensive therapy on the skeleton: effects of enalapril and AT1 receptor antagonist losartan in female rats","volume":"50","author":"PD Broulik","year":"2001","journal-title":"Physiol Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.2337\/db08-0805","article-title":"Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis","volume":"57","author":"VP Singh","year":"2008","journal-title":"Diabetes"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1002\/art.27384","article-title":"Involvement of the renin-angiotensin system in the development of vascular damage in a rat model of arthritis: effect of angiotensin receptor blockers","volume":"62","author":"T Sakuta","year":"2010","journal-title":"Arthritis Rheum"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1042\/CS20130414","article-title":"Non-canonical signalling and roles of the vasoactive peptides angiotensins and kinins","volume":"126","author":"CM Costa-Neto","year":"2014","journal-title":"Clin Sci (Lond)"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/jcpe.12097","article-title":"Increased bone loss and amount of osteoclasts in kinin B1 receptor knockout mice","volume":"40","author":"TO Gon\u00e7alves-Zillo","year":"2013","journal-title":"J Clin Periodontol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1042\/BJ20040634","article-title":"Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism","volume":"383","author":"GI Rice","year":"2004","journal-title":"Biochem J"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"H775","DOI":"10.1152\/ajpheart.00818.2002","article-title":"Functional role, cellular source, and tissue distribution of rat elastase-2, an angiotensin II-forming enzyme","volume":"285","author":"CF Santos","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1590\/S0100-879X2011007500093","article-title":"Alternative pathways for angiotensin II generation in the cardiovascular system","volume":"44","author":"C Becari","year":"2011","journal-title":"Braz J Med Biol Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1128\/IAI.00886-12","article-title":"Effect of angiotensin II receptor blocker on experimental periodontitis in a mouse model of Marfan syndrome","volume":"81","author":"N Suda","year":"2013","journal-title":"Infect Immun"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/jcpe.12160","article-title":"Effect of telmisartan on levels of IL-1, TNF-\u03b1, down-regulated COX-2, MMP-2, MMP-9 and RANKL\/RANK in an experimental periodontitis model","volume":"40","author":"AA Ara\u00fajo","year":"2013","journal-title":"J Clin Periodontol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1524-6175.2007.06602.x","article-title":"The pathophysiologic role of the brain renin-angiotensin system in stroke protection: clinical implications","volume":"9","author":"SG Chrysant","year":"2007","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/infdis\/jit499","article-title":"Angiotensin II receptor type 1\u2014a novel target for preventing neonatal meningitis in mice by Escherichia coli K1","volume":"209","author":"S Krishnan","year":"2014","journal-title":"J Infect Dis"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0167-4889(92)90172-8","article-title":"Bradykinin stimulates the production of prostaglandin E2 and interleukin-6 in human osteoblast-like cells","volume":"1135","author":"S Rahman","year":"1992","journal-title":"Biochim Biophys Acta"},{"key":"ref44","article-title":"The role of kinin B1 receptor and the effect of angiotensin I-converting enzyme inhibition on acute gout attacks in rodents","author":"CR Silva","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1161\/HYPERTENSIONAHA.109.144600","article-title":"Angiotensin I-converting enzyme inhibitors are allosteric enhancers of kinin B1 and B2 receptor function","volume":"55","author":"EG Erdos","year":"2010","journal-title":"Hypertension"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.4049\/jimmunol.169.6.3353","article-title":"IL-6, leukemia inhibitory factor, and oncostatin M stimulate bone resorption and regulate the expression of receptor activator of NF-\u03b2B ligand, osteoprotegerin, and receptor activator of NF-\u03b2B in mouse calvariae","volume":"169","author":"P Palmqvist","year":"2002","journal-title":"J Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1006\/bbrc.1998.9723","article-title":"Transforming growth factor-\u03b21 increases mRNA levels of osteoclastogenesis inhibitory factor in osteoblastic\/stromal cells and inhibits the survival of murine osteoclast-like cells","volume":"252","author":"T Murakami","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/36593","article-title":"A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function","volume":"390","author":"DM Anderson","year":"1997","journal-title":"Nature"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S8756-3282(99)00162-3","article-title":"Interleukin-1\u03b2 and tumor necrosis factor-\u03b1, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells","volume":"25","author":"LC Hofbauer","year":"1999","journal-title":"Bone"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.4049\/jimmunol.162.5.2562","article-title":"TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells","volume":"162","author":"R Josien","year":"1999","journal-title":"J Immunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"R59","DOI":"10.1172\/JCI10763","article-title":"Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection","volume":"106","author":"YT Teng","year":"2000","journal-title":"J Clin Invest"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"987","DOI":"10.2353\/ajpath.2006.060180","article-title":"B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease","volume":"169","author":"T Kawai","year":"2006","journal-title":"Am J Pathol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1128\/IAI.70.6.3143-3148.2002","article-title":"Bacteria induce osteoclastogenesis via an osteoblast-independent pathway","volume":"70","author":"Y Jiang","year":"2002","journal-title":"Infect Immun"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/art.38286","article-title":"Reciprocal activation of CD4+ T cells and synovial fibroblasts by stromal cell-derived factor 1 promotes RANKL expression and osteoclastogenesis in rheumatoid arthritis","volume":"66","author":"HR Kim","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1046\/j.1423-0410.1999.7740197.x","article-title":"Efficiency of donor screening for human parvovirus B19 by the receptor-mediated hemagglutination assay method","volume":"77","author":"H Sakata","year":"1999","journal-title":"Vox Sang"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"13613","DOI":"10.1074\/jbc.274.19.13613","article-title":"Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival","volume":"274","author":"L Lum","year":"1999","journal-title":"J Biol Chem"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1006\/bbrc.2000.3379","article-title":"Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-\u043aB ligand: modulation of the expression by osteotropic factors and cytokines","volume":"275","author":"T Nakashima","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s007740200049","article-title":"Transgenic mice overexpressing soluble osteoclast differentiation factor (sODF) exhibit severe osteoporosis","volume":"20","author":"A Mizuno","year":"2002","journal-title":"J Bone Miner Metab"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1177\/154405910808700311","article-title":"Tumor necrosis factor-alpha-converting enzyme (TACE) levels in periodontal diseases","volume":"87","author":"N Bostanci","year":"2008","journal-title":"J Dent Res"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s11010-014-2160-x","article-title":"Role of reactive oxygen species in angiotensin II: induced receptor activator of nuclear factor-\u043aB ligand expression in mouse osteoblastic cells","volume":"396","author":"Y Zhang","year":"2014","journal-title":"Mol Cell Biochem"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1002\/jcp.24887","article-title":"Angiotensin receptor I stimulates osteoprogenitor proliferation through TGF\u03b2-mediated signaling","volume":"230","author":"F Querques","year":"2015","journal-title":"J Cell Physiol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1084\/jem.191.2.275","article-title":"Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF\/RANKL-RANK interaction","volume":"191","author":"K Kobayashi","year":"2000","journal-title":"J Exp Med"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1084\/jem.20050978","article-title":"Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis","volume":"202","author":"N Kim","year":"2005","journal-title":"J Exp Med"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"4857","DOI":"10.1074\/jbc.M807610200","article-title":"Angiotensin II type 2 receptor blockade increases bone mass","volume":"284","author":"Y Izu","year":"2009","journal-title":"J Biol Chem"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/0022034510382118","article-title":"The roles of angiotensin II in stretched periodontal ligament cells","volume":"90","author":"S Monnouchi","year":"2011","journal-title":"J Dent Res"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/jre.12200","article-title":"Mechanical induction of interleukin-11 regulates osteoblastic\/cementoblastic differentiation of human periodontal ligament stem\/progenitor cells","volume":"50","author":"S Monnouchi","year":"2015","journal-title":"J Periodontal Res"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1096\/fj.07-098954","article-title":"Angiotensin II accelerates osteoporosis by activating osteoclasts","volume":"22","author":"H Shimizu","year":"2008","journal-title":"FASEB J"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00210-013-0886-8","article-title":"Olmesartan decreases IL-1\u03b2 and TNF-\u03b1 levels; downregulates MMP-2, MMP-9, COX-2, and RANKL; and upregulates OPG in experimental periodontitis","volume":"386","author":"AA Ara\u00fajo","year":"2013","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1359\/jbmr.081006","article-title":"Activation of renin-angiotensin system induces osteoporosis independently of hypertension","volume":"24","author":"Y Asaba","year":"2009","journal-title":"J Bone Miner Res"},{"key":"ref70","article-title":"Review of osteoimmunology and the host response in endodontic and periodontal lesions","author":"DT Graves","year":"2011","journal-title":"J Oral Microbiol 3"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0134601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T07:22:24Z","timestamp":1718004144000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0134601"}},"subtitle":[],"editor":[{"given":"Michael","family":"Bader","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,8,5]]},"references-count":70,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0134601","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,5]]}}}