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patients","volume":"62","author":"A Trounson","year":"1994","journal-title":"Fertil Steril"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/S0015-0282(01)02853-9","article-title":"In vitro maturation and fertilization of oocytes from unstimulated normal ovaries, polycystic ovaries, and women with polycystic ovary syndrome","volume":"76","author":"TJ Child","year":"2001","journal-title":"Fertil Steril"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1093\/humrep\/deh768","article-title":"Favourable pregnancy results with insemination of in vitro matured oocytes from unstimulated patients","volume":"20","author":"V Soderstrom-Anttila","year":"2005","journal-title":"Hum Reprod"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/j.fertnstert.2013.01.090","article-title":"In vitro maturation of oocytes: uncommon indications","volume":"99","author":"M 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Rev"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"f2914","DOI":"10.1136\/bmj.f2914","article-title":"Demystifying trial networks and network meta-analysis","volume":"346","author":"EJ Mills","year":"2013","journal-title":"BMJ"},{"issue":"7109","key":"ref29","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"M Egger","year":"1997","journal-title":"BMJ"},{"key":"ref30","unstructured":"Wells GA, Shea B, O&apos;Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp\" xlink:type=\"simple\">http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp<\/ext-link>. Accessed 17 December 2013."},{"issue":"9","key":"ref31","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1002\/sim.1761","article-title":"What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data","volume":"23","author":"MJ Sweeting","year":"2004","journal-title":"Stat Med"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"R DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"ref33","unstructured":"Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0, The Cochrane Collaboration 2011. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cochrane-handbook.org.ed\" xlink:type=\"simple\">http:\/\/www.cochrane-handbook.org.ed<\/ext-link>. 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