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Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/cran.r-project.org\/package=gridExtra\" xlink:type=\"simple\">http:\/\/cran.r-project.org\/package=gridExtra<\/ext-link>"},{"key":"ref28","unstructured":"Jr FEH, Charles Dupont. Hmisc: Harrell Miscellaneous [Internet]. 2015. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/cran.r-project.org\/package=Hmisc\" xlink:type=\"simple\">http:\/\/cran.r-project.org\/package=Hmisc<\/ext-link>"},{"key":"ref29","unstructured":"Gamer M, Lemon, Jim, Ian Fellows PS. irr: Various Coefficients of Interrater Reliability and Agreement [Internet]. 2012. 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