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Evidence for down-regulation of genes that encode secreted proteins in the stressed cells","volume":"278","author":"TM Pakula","year":"2003","journal-title":"The Journal of biological chemistry"},{"issue":"3","key":"ref74","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.4049\/jimmunol.162.3.1633","article-title":"Role of TNF-alpha in pulmonary host defense in murine invasive aspergillosis","volume":"162","author":"B Mehrad","year":"1999","journal-title":"Journal of immunology"},{"issue":"1","key":"ref75","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/02681219680000081","article-title":"Production of cytokines by alveolar and peritoneal macrophages stimulated by <italic>Aspergillus fumigatus<\/italic> conidia or hyphae","volume":"34","author":"D Taramelli","year":"1996","journal-title":"Journal of medical and veterinary mycology: bi-monthly publication of the International Society for Human and Animal 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albicans<\/italic> via circuitry comprised of Mkc1, calcineurin, and Hsp90","volume":"6","author":"SL LaFayette","year":"2010","journal-title":"PLoS pathogens"},{"issue":"8","key":"ref79","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/(SICI)1097-0061(19960630)12:8<741::AID-YEA967>3.0.CO;2-G","article-title":"The <italic>Candida albicans<\/italic> PKC1 gene encodes a protein kinase C homolog necessary for cellular integrity but not dimorphism","volume":"12","author":"G Paravicini","year":"1996","journal-title":"Yeast"},{"issue":"11","key":"ref80","doi-asserted-by":"crossref","first-page":"e1003716","DOI":"10.1371\/journal.ppat.1003716","article-title":"Deletion of the alpha-(1,3)-glucan synthase genes induces a restructuring of the conidial cell wall responsible for the avirulence of <italic>Aspergillus fumigatus<\/italic>","volume":"9","author":"A Beauvais","year":"2013","journal-title":"PLoS pathogens"},{"key":"ref81","article-title":"<italic>Aspergillus fumigatus 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Cocheme","year":"2008","journal-title":"The Journal of biological chemistry"},{"issue":"37","key":"ref87","doi-asserted-by":"crossref","first-page":"27259","DOI":"10.1074\/jbc.M704298200","article-title":"The thioredoxin system of the filamentous fungus <italic>Aspergillus nidulans<\/italic>: impact on development and oxidative stress response","volume":"282","author":"M Thon","year":"2007","journal-title":"The Journal of biological chemistry"},{"issue":"1","key":"ref88","doi-asserted-by":"crossref","first-page":"e1003160","DOI":"10.1371\/journal.ppat.1003160","article-title":"Dissection of Ire1 functions reveals stress response mechanisms uniquely evolved in <italic>Candida glabrata<\/italic>","volume":"9","author":"T Miyazaki","year":"2013","journal-title":"PLoS pathogens"},{"issue":"5","key":"ref89","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1111\/mmi.12820","article-title":"The <italic>Aspergillus nidulans<\/italic> signalling mucin MsbA regulates starvation responses, adhesion and affects cellulase secretion in response to environmental cues","volume":"94","author":"NA Brown","year":"2014","journal-title":"Molecular microbiology"},{"issue":"5","key":"ref90","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1046\/j.1365-2958.1999.01667.x","article-title":"Genome-wide analysis of gene expression regulated by the yeast cell wall integrity signalling pathway","volume":"34","author":"US Jung","year":"1999","journal-title":"Molecular microbiology"},{"issue":"2","key":"ref91","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.fgb.2004.11.006","article-title":"Expression of agsA, one of five 1,3-alpha-D-glucan synthase-encoding genes in <italic>Aspergillus niger<\/italic>, is induced in response to cell wall stress","volume":"42","author":"RA Damveld","year":"2005","journal-title":"Fungal Genet 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response to cell wall stress","volume":"58","author":"RA Damveld","year":"2005","journal-title":"Molecular microbiology"},{"issue":"3","key":"ref95","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/mmi.12877","article-title":"<italic>Aspergillus fumigatus<\/italic> devoid of cell wall beta-1,3-glucan is viable, massively sheds galactomannan and is killed by septum formation inhibitors","volume":"95","author":"K Dichtl","year":"2015","journal-title":"Molecular microbiology"},{"issue":"3","key":"ref96","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1128\/AAC.05323-11","article-title":"Reshuffling of <italic>Aspergillus fumigatus<\/italic> cell wall components chitin and beta-glucan under the influence of caspofungin or nikkomycin Z alone or in combination","volume":"56","author":"PE Verwer","year":"2012","journal-title":"Antimicrobial agents and 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