{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:27:53Z","timestamp":1792182473596,"version":"4.4.0"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T00:00:00Z","timestamp":1439942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0135236","type":"journal-article","created":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T17:55:57Z","timestamp":1440006957000},"page":"e0135236","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Inhibition of Autophagy Potentiated the Antitumor Effect of Nedaplatin in Cisplatin-Resistant Nasopharyngeal Carcinoma Cells"],"prefix":"10.1371","volume":"10","author":[{"given":"Zhongyu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilei","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianwen","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,8,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.semcancer.2012.01.009","article-title":"Non-viral environmental risk factors for nasopharyngeal carcinoma: a systematic review","volume":"22","author":"WH Jia","year":"2012","journal-title":"Semin Cancer Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.semradonc.2012.03.008","article-title":"Current management of nasopharyngeal cancer","volume":"22","author":"AW Lee","year":"2012","journal-title":"Semin Radiat Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1200\/JCO.1990.8.8.1342","article-title":"Chemo-radiotherapy in patients with locally advanced nasopharyngeal carcinoma: a radiation therapy oncology group study","volume":"8","author":"M Al-Sarraf","year":"1990","journal-title":"J Clin Oncol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1200\/JCO.1998.16.4.1310","article-title":"Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099","volume":"16","author":"M Al-Sarraf","year":"1998","journal-title":"J Clin Oncol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/BF00451649","article-title":"Pharmacokinetics of (glycolate-0,0&apos;)-diammine platinum (II), a new platinum derivative, in comparison with cisplatin and carboplatin","volume":"23","author":"Y Sasaki","year":"1989","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/jjco\/hyp183","article-title":"Induction chemotherapy with nedaplatin with 5-FU followed by intensity-modulated radiotherapy concurrent with chemotherapy for locoregionally advanced nasopharyngeal carcinoma","volume":"40","author":"J Zheng","year":"2010","journal-title":"Jpn J Clin Oncol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1002\/hed.23487","article-title":"Concurrent chemoradiotherapy with nedaplatin plus paclitaxel or fluorouracil for locoregionally advanced nasopharyngeal carcinoma: Survival and toxicity","volume":"36","author":"J Xu","year":"2014","journal-title":"Head Neck"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00280-013-2203-0","article-title":"Multicenter phase II study of capecitabine combined with nedaplatin for recurrent and metastatic nasopharyngeal carcinoma patients after failure of cisplatin-based chemotherapy","volume":"72","author":"PJ Peng","year":"2013","journal-title":"Cancer Chemother Pharmacol"},{"issue":"10","key":"ref9","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/S0959-8049(98)00224-X","article-title":"Clinical development of platinum complexes in cancer therapy: an historical perspective and an update","volume":"34","author":"D Lebwohl","year":"1988","journal-title":"Eur J Cancer"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"830","DOI":"10.4161\/auto.24132","article-title":"Autophagy in stem cells","volume":"9","author":"JL Guan","year":"2013","journal-title":"Autophagy"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2007.12.018","article-title":"Autophagy in the pathogenesis of disease","volume":"132","author":"B Levine","year":"2008","journal-title":"Cell"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/B978-0-12-407173-5.00003-0","article-title":"Autophagy: cancer&apos;s friend or foe","volume":"118","author":"SK Bhutia","year":"2013","journal-title":"Adv Cancer Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrc3262","article-title":"Deconvoluting the context-dependent role for autophagy in cancer","volume":"12","author":"E White","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11010-011-1199-1","article-title":"Long-term cisplatin exposure impairs autophagy and causes cisplatin resistance in human lung cancer cells","volume":"364","author":"B Sirichanchuen","year":"2012","journal-title":"Mol Cell Biochem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.ejca.2011.01.019","article-title":"p62\/SQSTM1 involved in cisplatin resistance in human ovarian cancer cells by clearing ubiquitinated proteins","volume":"47","author":"H Yu","year":"2011","journal-title":"Eur J Cancer"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/onc.2010.441","article-title":"ROS-mediated upregulation of Noxa overcomes chemoresistance in chronic lymphocytic leukemia","volume":"30","author":"SH Tonino","year":"2011","journal-title":"Oncogene"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"699","DOI":"10.4161\/auto.27955","article-title":"NOX4 regulates autophagy during energy deprivation","volume":"10","author":"S Sciarretta","year":"2014","journal-title":"Autophagy"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nrc3599","article-title":"Cancer drug resistance: an evolving paradigm","volume":"13","author":"C Holohan","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"ref19","first-page":"393","article-title":"Evaluation of novel platinum complexes, inhibitors of topoisomerase I and II in non-small cell lung cancer (NSCLC) sublines resistant to cisplatin","volume":"15","author":"M Fukuda","year":"1995","journal-title":"Anticancer Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1038\/sj.leu.2401333","article-title":"Cytotoxic drugs and the CD95 pathway","volume":"13","author":"C Friesen","year":"1999","journal-title":"Leukemia"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1038\/sj.leu.2400827","article-title":"Deficient activation of the CD95 (APO-1\/Fas) system in drug-resistant cells","volume":"11","author":"C Friesen","year":"1997","journal-title":"Leukemia"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nrc3599","article-title":"Cancer drug resistance: an evolving paradigm","volume":"13","author":"C Holohan","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-2184.2012.00845.x","article-title":"Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis","volume":"45","author":"L Ouyang","year":"2012","journal-title":"Cell Prolif"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4161\/auto.19496","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy","volume":"8","author":"DJ Klionsky","year":"2012","journal-title":"Autophagy"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e81162","DOI":"10.1371\/journal.pone.0081162","article-title":"Cisplatin induces a mitochondrial-ROS response that contributes to cytotoxicity depending on mitochondrial redox status and bioenergetic functions","volume":"8","author":"R Marullo","year":"2013","journal-title":"PLOS ONE"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.cell.2009.03.048","article-title":"Autophagy suppresses tumorigenesis through elimination of p62","volume":"137","author":"R Mathew","year":"2009","journal-title":"Cell"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"246","DOI":"10.4161\/auto.5432","article-title":"Is mitochondrial generation of reactive oxygen species a trigger for autophagy?","volume":"4","author":"Y Chen","year":"2008","journal-title":"Autophagy"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"545","DOI":"10.4161\/auto.19012","article-title":"Autophagy: a cyto-protective mechanism which prevents primary human hepatocyte apoptosis during oxidative stress","volume":"8","author":"RH Bhogal","year":"2012","journal-title":"Autophagy"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4161\/auto.7.2.14074","article-title":"Caffeine induces apoptosis by enhancement of autophagy via PI3K\/Akt\/mTOR\/p70S6K inhibition","volume":"7","author":"S Saiki","year":"2011","journal-title":"Autophagy"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1089\/hum.2011.120","article-title":"Inhibition of autophagy enhances the effects of E1A-defective oncolytic adenovirus dl922-947 against glioma cells in vitro and in vivo","volume":"23","author":"G Botta","year":"2012","journal-title":"Hum Gene Ther"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4161\/auto.3424","article-title":"Control of the autophagy maturation step by the MAPK ERK and p38: lessons from environmental carcinogens","volume":"3","author":"E Corcelle","year":"2007","journal-title":"Autophagy"},{"issue":"19","key":"ref32","doi-asserted-by":"crossref","first-page":"8788","DOI":"10.1073\/pnas.1003428107","article-title":"Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity","volume":"107","author":"F Weinberg","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","first-page":"792639","article-title":"Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways","volume":"2011","author":"Y Son","year":"2011","journal-title":"J Signal Transduct"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jaci.2013.03.024","article-title":"Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK\/ERK activation","volume":"132","author":"G Kano","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"14473","DOI":"10.1021\/jp9056835","article-title":"The second-generation anticancer drug Nedaplatin: a theoretical investigation on the hydrolysis mechanism","volume":"113","author":"ME Alberto","year":"2009","journal-title":"J Phys Chem B"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1248\/bpb.28.1385","article-title":"Relationship between cisplatin or nedaplatin-induced nephrotoxicity and renal accumulation","volume":"28","author":"Y Kawai","year":"2005","journal-title":"Biol Pharm Bull"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1172\/JCI28833","article-title":"Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma","volume":"117","author":"RK Amaravadi","year":"2007","journal-title":"J Clin Invest"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1017\/S1462399409001306","article-title":"The role of autophagy in tumour development and cancer therapy","volume":"11","author":"MT Rosenfeldt","year":"2009","journal-title":"Expert Rev Mol Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.canlet.2012.03.002","article-title":"Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells","volume":"320","author":"XL Guo","year":"2012","journal-title":"Cancer Lett"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.biopha.2011.12.002","article-title":"The different regulatory effects of p53 status on multidrug resistance are determined by autophagy in ovarian cancer cells","volume":"66","author":"D Kong","year":"2012","journal-title":"Biomed Pharmacother"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"509","DOI":"10.4161\/auto.7.5.15066","article-title":"Induction of autophagy by drug-resistant esophageal cancer cells promotes their survival and recovery following treatment with chemotherapeutics","volume":"7","author":"TR O'Donovan","year":"2011","journal-title":"Autophagy"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/cancers1010023","article-title":"N&apos;,N&apos;-Dimethyl-N&apos;,N&apos;-bis(phenylcarbonothioyl) Propanedihydrazide (Elesclomol) Selectively Kills Cisplatin Resistant Lung Cancer Cells through Reactive Oxygen Species (ROS)","volume":"1","author":"M Wangpaichitr","year":"2009","journal-title":"Cancers (Basel)"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e844","DOI":"10.1038\/cddis.2013.338","article-title":"Autophagy prevents irradiation injury and maintains stemness through decreasing ROS generation in mesenchymal stem cells","volume":"4","author":"J Hou","year":"2013","journal-title":"Cell Death Dis"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nrd3802","article-title":"Autophagy modulation as a potential therapeutic target for diverse diseases","volume":"11","author":"DC Rubinsztein","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"635","DOI":"10.4161\/auto.4916","article-title":"Roles of the Akt\/mTOR\/p70S6K and ERK1\/2 signaling pathways in curcumin-induced autophagy","volume":"3","author":"N Shinojima","year":"2007","journal-title":"Autophagy"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1172\/JCI70454","article-title":"Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma","volume":"124","author":"XH Ma","year":"2014","journal-title":"J Clin Invest"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"395","DOI":"10.4161\/auto.6.3.11303","article-title":"Elevated Beclin 1 expression is correlated with HIF-1alpha in predicting poor prognosis of nasopharyngeal carcinoma","volume":"6","author":"XB Wan","year":"2010","journal-title":"Autophagy"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0135236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T16:42:19Z","timestamp":1718037739000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0135236"}},"subtitle":[],"editor":[{"given":"Ya","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,8,19]]},"references-count":47,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0135236","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,19]]}}}