{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T07:08:37Z","timestamp":1776323317212,"version":"3.50.1"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T00:00:00Z","timestamp":1440633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0135498","type":"journal-article","created":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T17:58:27Z","timestamp":1440698307000},"page":"e0135498","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Elevated Levels of Asymmetric Dimethylarginine (ADMA) in the Pericardial Fluid of Cardiac Patients Correlate with Cardiac Hypertrophy"],"prefix":"10.1371","volume":"10","author":[{"given":"Zoltan","family":"Nemeth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Cziraki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandor","family":"Szabados","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadett","family":"Biri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandor","family":"Keki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akos","family":"Koller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,8,27]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0003-4975(10)65204-6","article-title":"The pericardium","volume":"14","author":"AE Baue","year":"1972","journal-title":"The Annals of thoracic surgery"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0002-9149(86)90771-X","article-title":"Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings","volume":"57","author":"RB Devereux","year":"1986","journal-title":"Am J Cardiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1113\/jphysiol.1978.sp012277","article-title":"A study of the composition of pericardial fluid, with special reference to the probable mechanism of fluid formation","volume":"277","author":"AT Gibson","year":"1978","journal-title":"The Journal of physiology"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.amjmed.2005.01.066","article-title":"The composition of normal pericardial fluid and its implications for diagnosing pericardial effusions","volume":"118","author":"S Ben-Horin","year":"2005","journal-title":"The American journal of medicine"},{"issue":"Suppl 3","key":"ref5","doi-asserted-by":"crossref","first-page":"S502","DOI":"10.1097\/00005344-199526003-00147","article-title":"Human pericardial fluid contains the highest amount of endothelin-1 of all mammalian biologic fluids thus far tested","volume":"26","author":"F Horkay","year":"1995","journal-title":"Journal of cardiovascular pharmacology"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0024-3205(99)00331-8","article-title":"Enhanced accumulation of pericardial fluid adenosine and inosine in patients with coronary artery disease","volume":"65","author":"L Fazekas","year":"1999","journal-title":"Life Sci"},{"issue":"3","key":"ref7","first-page":"156","article-title":"Angiotensin-converting enzyme in pericardial fluid: comparative study with serum activity","volume":"91","author":"RA Gomes","year":"2008","journal-title":"Arq Bras Cardiol"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0024-3205(97)01105-3","article-title":"Presence of immunoreactive endothelin-1 and atrial natriuretic peptide in human pericardial fluid","volume":"62","author":"F Horkay","year":"1998","journal-title":"Life sciences"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1536\/jhj.44.633","article-title":"Endothelin-1 concentrations in pericardial fluid are more elevated in patients with ischemic heart disease than in patients with nonischemic heart disease","volume":"44","author":"A Namiki","year":"2003","journal-title":"Japanese heart journal"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0163-7258(99)00072-8","article-title":"Paracrine and autocrine effects of nitric oxide on myocardial function","volume":"86","author":"AM Shah","year":"2000","journal-title":"Pharmacol Ther"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1001\/archsurg.1971.01350010030007","article-title":"Electrolyte and acid-base composition of pericardial fluid in man","volume":"102","author":"P Hutchin","year":"1971","journal-title":"Archives of surgery"},{"issue":"11","key":"ref12","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1172\/JCI32024","article-title":"Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice","volume":"117","author":"D Tirziu","year":"2007","journal-title":"J Clin Invest"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.33549\/physiolres.930000.49.37","article-title":"The potential role of nitric oxide in the hypertrophic growth of the left ventricle","volume":"49","author":"F Simko","year":"2000","journal-title":"Physiol Res"},{"issue":"6","key":"ref14","first-page":"409","article-title":"Factors and mechanisms involved in left ventricular hypertrophy and the anti-hypertrophic role of nitric oxide","volume":"90","author":"JA Garcia","year":"2008","journal-title":"Arq Bras Cardiol"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1046\/j.1523-1755.2002.00437.x","article-title":"Left ventricular hypertrophy, cardiac remodeling and asymmetric dimethylarginine (ADMA) in hemodialysis patients","volume":"62","author":"C Zoccali","year":"2002","journal-title":"Kidney Int"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.yjmcc.2009.09.012","article-title":"Nitric oxide inhibits endothelin-1-induced neonatal cardiomyocyte hypertrophy via a RhoA-ROCK-dependent pathway","volume":"47","author":"JC Hunter","year":"2009","journal-title":"J Mol Cell Cardiol"},{"issue":"12","key":"ref17","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1093\/eurjhf\/hfq158","article-title":"The role of asymmetric dimethylarginine and arginine in the failing heart and its vasculature","volume":"12","author":"M Visser","year":"2010","journal-title":"Eur J Heart Fail"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1159\/000337485","article-title":"Asymmetric dimethylarginine reduces nitric oxide donor-mediated dilation of arterioles by activating the vascular renin-angiotensin system and reactive oxygen species","volume":"49","author":"Z Veresh","year":"2012","journal-title":"Journal of vascular research"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1161\/HYPERTENSIONAHA.108.116731","article-title":"ADMA impairs nitric oxide-mediated arteriolar function due to increased superoxide production by angiotensin II-NAD(P)H oxidase pathway","volume":"52","author":"Z Veresh","year":"2008","journal-title":"Hypertension"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1161\/01.HYP.0000256764.86208.3d","article-title":"Asymmetrical dimethylarginine inhibits shear stress-induced nitric oxide release and dilation and elicits superoxide-mediated increase in arteriolar tone","volume":"49","author":"J Toth","year":"2007","journal-title":"Hypertension"},{"issue":"Suppl 1","key":"ref21","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1177\/1358836X0501000111","article-title":"ADMA metabolism and clearance","volume":"10","author":"T Teerlink","year":"2005","journal-title":"Vascular medicine"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.phrs.2009.07.016","article-title":"Role of the PRMT-DDAH-ADMA axis in the regulation of endothelial nitric oxide production","volume":"60","author":"AJ Pope","year":"2009","journal-title":"Pharmacological research: the official journal of the Italian Pharmacological Society"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"82","DOI":"10.2174\/157340310791162659","article-title":"The Role of Asymmetric Dimethylarginine (ADMA) in Endothelial Dysfunction and Cardiovascular Disease","volume":"6","author":"L Sibal","year":"2010","journal-title":"Current cardiology reviews"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ijcard.2010.11.003","article-title":"Urinary asymmetric dimethylarginine (ADMA) is a predictor of mortality risk in patients with coronary artery disease","volume":"156","author":"C Wolf","year":"2012","journal-title":"International journal of cardiology"},{"issue":"8793","key":"ref25","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/0140-6736(92)90865-Z","article-title":"Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure","volume":"339","author":"P Vallance","year":"1992","journal-title":"Lancet"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1681\/ASN.V131170","article-title":"Marked increase of asymmetric dimethylarginine in patients with incipient primary chronic renal disease","volume":"13","author":"JT Kielstein","year":"2002","journal-title":"Journal of the American Society of Nephrology: JASN"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/path.2769","article-title":"Asymmetric dimethylarginine (ADMA) induces chronic kidney disease through a mechanism involving collagen and TGF-beta1 synthesis","volume":"223","author":"F Mihout","year":"2011","journal-title":"The Journal of pathology"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.5301\/jn.5000085","article-title":"Measuring asymmetric dimethylarginine (ADMA) in CKD: a comparison between enzyme-linked immunosorbent assay and liquid chromatography-electrospray tandem mass spectrometry","volume":"25","author":"P Pecchini","year":"2012","journal-title":"Journal of nephrology"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"F149","DOI":"10.1152\/ajprenal.00045.2012","article-title":"Reduced renal plasma clearance does not explain increased plasma asymmetric dimethylarginine in hypertensive subjects with mild to moderate renal insufficiency","volume":"303","author":"RA Ronden","year":"2012","journal-title":"American journal of physiology Renal physiology"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.niox.2006.10.003","article-title":"Aortic stenosis is associated with elevated plasma levels of asymmetric dimethylarginine (ADMA)","volume":"16","author":"DT Ngo","year":"2007","journal-title":"Nitric Oxide"},{"issue":"9299","key":"ref31","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/S0140-6736(01)07184-7","article-title":"Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine","volume":"358","author":"VP Valkonen","year":"2001","journal-title":"Lancet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1749-8090-7-23","article-title":"Early post-operative thrombosis of the prosthetic mitral valve in patient with heparin-induced thrombocytopenia","volume":"7","author":"A Cziraki","year":"2012","journal-title":"J Cardiothorac Surg"},{"issue":"5\u20136","key":"ref33","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1159\/000101461","article-title":"Serum asymmetric dimethylarginine negatively correlates with intima-media thickness in early-onset atherosclerosis","volume":"23","author":"J Zsuga","year":"2007","journal-title":"Cerebrovascular diseases"},{"issue":"1\u20132","key":"ref34","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.chroma.2005.01.052","article-title":"High-performance liquid chromatographic assay of N(G)-monomethyl-L-arginine, N(G),N(G)-dimethyl-L-arginine, and N(G),N(G)'-dimethyl-L-arginine using 4-fluoro-7-nitro-2, 1,3-benzoxadiazole as a fluorescent reagent","volume":"1066","author":"S Nonaka","year":"2005","journal-title":"Journal of chromatography A"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1136\/hrt.82.2.192","article-title":"Echocardiographic assessment of ejection fraction in left ventricular hypertrophy","volume":"82","author":"B Wandt","year":"1999","journal-title":"Heart"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.5603\/CJ.2012.0006","article-title":"The relationship between L-arginine\/ADMA ratio and coronary collateral development in patients with low glomerular filtration rate","volume":"19","author":"M Celik","year":"2012","journal-title":"Cardiology journal"},{"issue":"9","key":"ref37","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1515\/cclm-2012-0033","article-title":"Compensating for the influence of total serum protein in the Schwartz formula","volume":"50","author":"MM Speeckaert","year":"2012","journal-title":"Clinical chemistry and laboratory medicine: CCLM \/ FESCC"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1042\/cs0850165","article-title":"Atrial natriuretic peptide in the pericardial fluid of patients with heart disease","volume":"85","author":"J Amano","year":"1993","journal-title":"Clin Sci (Lond)"},{"issue":"Suppl 1","key":"ref39","doi-asserted-by":"crossref","first-page":"S287","DOI":"10.1097\/00005344-199800001-00080","article-title":"High pericardial fluid levels of endothelin are not caused by altered neutral endopeptidase activity in cardiac patients","volume":"31","author":"P Turbucz","year":"1998","journal-title":"J Cardiovasc Pharmacol"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s10157-007-0471-x","article-title":"Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease","volume":"11","author":"S Ueda","year":"2007","journal-title":"Clinical and experimental nephrology"},{"issue":"1\u20132","key":"ref41","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jchromb.2006.09.023","article-title":"An overview of plasma concentrations of asymmetric dimethylarginine (ADMA) in health and disease and in clinical studies: methodological considerations","volume":"851","author":"JD Horowitz","year":"2007","journal-title":"Journal of chromatography B, Analytical technologies in the biomedical and life sciences"},{"issue":"1\u20132","key":"ref42","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jchromb.2006.07.024","article-title":"HPLC analysis of ADMA and other methylated L-arginine analogs in biological fluids","volume":"851","author":"T Teerlink","year":"2007","journal-title":"Journal of chromatography B, Analytical technologies in the biomedical and life sciences"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000213088","article-title":"Electrolytes and free amino acids in leg skeletal muscle of young and elderly women","volume":"29","author":"P Moller","year":"1983","journal-title":"Gerontology"},{"issue":"4","key":"ref44","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/08037050213763","article-title":"Homocysteine and ADMA\u2014emerging risk factors for cardiovascular disease?","volume":"11","author":"T Hedner","year":"2002","journal-title":"Blood pressure"},{"issue":"5","key":"ref45","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1161\/ATVBAHA.108.162768","article-title":"Impact of asymmetric dimethylarginine on mortality after acute myocardial infarction","volume":"28","author":"M Zeller","year":"2008","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"issue":"11","key":"ref46","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1161\/01.ATV.0000242801.38419.48","article-title":"Asymmetric dimethylarginine predicts major adverse cardiovascular events in patients with advanced peripheral artery disease","volume":"26","author":"F Mittermayer","year":"2006","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"issue":"5","key":"ref47","first-page":"651","article-title":"Stent placement in patients with coronary heart disease decreases plasma levels of the endogenous nitric oxide synthase inhibitor ADMA","volume":"23","author":"F Scalera","year":"2009","journal-title":"International journal of molecular medicine"},{"issue":"10","key":"ref48","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/clc.4960261006","article-title":"Asymmetrical dimethylarginine: a novel risk factor for coronary artery disease","volume":"26","author":"TM Lu","year":"2003","journal-title":"Clin Cardiol"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.pharmthera.2007.03.002","article-title":"The L-arginine paradox: Importance of the L-arginine\/asymmetrical dimethylarginine ratio","volume":"114","author":"SM Bode-Boger","year":"2007","journal-title":"Pharmacology & therapeutics"},{"issue":"3","key":"ref50","doi-asserted-by":"crossref","first-page":"G435","DOI":"10.1152\/ajpgi.00268.2011","article-title":"Nitric oxide and L-arginine metabolism in a devascularized porcine model of acute liver failure","volume":"303","author":"V Sharma","year":"2012","journal-title":"American journal of physiology Gastrointestinal and liver physiology"},{"issue":"8","key":"ref51","doi-asserted-by":"crossref","first-page":"746","DOI":"10.3109\/1354750X.2010.519784","article-title":"Assessment of serum levels of asymmetric dimethylarginine, symmetric dimethylarginine and L-arginine in coronary artery disease","volume":"15","author":"MZ Gad","year":"2010","journal-title":"Biomarkers"},{"issue":"19","key":"ref52","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/j.jacc.2011.11.066","article-title":"Estimated glomerular filtration rate and prognosis in heart failure: value of the Modification of Diet in Renal Disease Study-4, chronic kidney disease epidemiology collaboration, and cockroft-gault formulas","volume":"59","author":"E Zamora","year":"2012","journal-title":"Journal of the American College of Cardiology"},{"issue":"12","key":"ref53","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1681\/ASN.2009010025","article-title":"Change in estimated GFR associates with coronary heart disease and mortality","volume":"20","author":"K Matsushita","year":"2009","journal-title":"Journal of the American Society of Nephrology: JASN"},{"issue":"12","key":"ref54","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.3945\/jn.111.148197","article-title":"Reference intervals for plasma L-arginine and the L-arginine:asymmetric dimethylarginine ratio in the Framingham Offspring Cohort","volume":"141","author":"N Luneburg","year":"2011","journal-title":"The Journal of nutrition"},{"issue":"5","key":"ref55","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1172\/JCI111351","article-title":"Effects of pressure overload, left ventricular hypertrophy on beta-adrenergic receptors, and responsiveness to catecholamines","volume":"73","author":"DE Vatner","year":"1984","journal-title":"The Journal of clinical investigation"},{"issue":"6","key":"ref56","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1161\/CIRCULATIONAHA.107.716647","article-title":"Assessment of left ventricular diastolic function and recognition of diastolic heart failure","volume":"116","author":"WH Gaasch","year":"2007","journal-title":"Circulation"},{"issue":"1","key":"ref57","doi-asserted-by":"crossref","first-page":"i11","DOI":"10.1093\/ejechocard\/jen240","article-title":"Aortic stenosis","volume":"10","author":"JB Chambers","year":"2009","journal-title":"Eur J Echocardiogr"},{"issue":"5","key":"ref58","doi-asserted-by":"crossref","first-page":"226","DOI":"10.20452\/pamw.1222","article-title":"Relationship between serum asymmetric dimethylarginine and left ventricular structure and function in patients with endstage renal disease treated with hemodialysis","volume":"122","author":"M Napora","year":"2012","journal-title":"Pol Arch Med Wewn"},{"issue":"3","key":"ref59","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1161\/HYPERTENSIONAHA.110.152959","article-title":"Angiotensin II and NADPH oxidase increase ADMA in vascular smooth muscle cells","volume":"56","author":"Z Luo","year":"2010","journal-title":"Hypertension"},{"issue":"3","key":"ref60","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1161\/01.RES.73.3.413","article-title":"Molecular characterization of angiotensin II\u2014induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype","volume":"73","author":"J Sadoshima","year":"1993","journal-title":"Circulation research"},{"issue":"3","key":"ref61","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1172\/JCI46399","article-title":"RAS signaling pathway mutations and hypertrophic cardiomyopathy: getting into and out of the thick of it","volume":"121","author":"BD Gelb","year":"2011","journal-title":"The Journal of clinical investigation"},{"issue":"3","key":"ref62","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1510\/icvts.2007.168302","article-title":"Biochemical markers of myocardial injury in the pericardial fluid of patients undergoing heart surgery","volume":"7","author":"AL Fernandez","year":"2008","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3109\/08037051.2014.868629","article-title":"2013 ESH\/ESC Practice Guidelines for the Management of Arterial Hypertension","volume":"23","author":"G Mancia","year":"2014","journal-title":"Blood pressure"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0135498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T06:09:20Z","timestamp":1748585360000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0135498"}},"subtitle":[],"editor":[{"given":"Carlo","family":"Gaetano","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,8,27]]},"references-count":63,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0135498","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,27]]}}}