{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:07:53Z","timestamp":1760346473121,"version":"3.41.0"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T00:00:00Z","timestamp":1439337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0135571","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T18:11:01Z","timestamp":1439403061000},"page":"e0135571","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Assessments of Thioridazine as a Helper Compound to Dicloxacillin against Methicillin-Resistant Staphylococcus aureus: In Vivo Trials in a Mouse Peritonitis Model"],"prefix":"10.1371","volume":"10","author":[{"given":"Michael","family":"Stenger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristoffer","family":"Hendel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bollen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter B.","family":"Licht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans J\u00f8rn","family":"Kolmos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janne K.","family":"Klitgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,8,12]]},"reference":[{"key":"ref1","unstructured":"W. LEMK. Priority Medicines for Europe and the World &quot;A Public Health Approach to Innovation&quot;\u2014Update on 2004 Background Paper. Boston University, 2013."},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1086\/345476","article-title":"Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis","volume":"36","author":"SE Cosgrove","year":"2003","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1128\/CMR.00081-09","article-title":"Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic","volume":"23","author":"MZ David","year":"2010","journal-title":"Clinical microbiology reviews"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nchembio.2007.24","article-title":"Targeting virulence: a new paradigm for antimicrobial therapy","volume":"3","author":"AE Clatworthy","year":"2007","journal-title":"Nature chemical biology"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1574-6968.2011.02255.x","article-title":"Thioridazine affects transcription of genes involved in cell wall biosynthesis in methicillin-resistant Staphylococcus aureus","volume":"318","author":"M Bonde","year":"2011","journal-title":"FEMS microbiology letters"},{"issue":"6","key":"ref6","first-page":"1215","article-title":"Reversal of methicillin resistance in Staphylococcus aureus by thioridazine","volume":"62","author":"JK Klitgaard","year":"2008","journal-title":"JAntimicrobChemother"},{"issue":"3","key":"ref7","first-page":"250","article-title":"Phenothiazines alter resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) to oxacillin in vitro","volume":"22","author":"MM Kristiansen","year":"2003","journal-title":"IntJAntimicrobAgents"},{"issue":"3","key":"ref8","first-page":"361","article-title":"Thioridazine reduces resistance of methicillin-resistant staphylococcus aureus by inhibiting a reserpine-sensitive efflux pump","volume":"20","author":"MM Kristiansen","year":"2006","journal-title":"In Vivo"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.resmic.2012.10.007","article-title":"Thioridazine potentiates the effect of a beta-lactam antibiotic against Staphylococcus aureus independently of mecA expression","volume":"164","author":"MO Poulsen","year":"2013","journal-title":"Research in microbiology"},{"issue":"6","key":"ref10","first-page":"725","article-title":"Antimicrobial activity of phenothiazines","volume":"18","author":"L Amaral","year":"2004","journal-title":"In Vivo"},{"issue":"3","key":"ref11","first-page":"262","article-title":"The in-vitro antimicrobial effect of non-antibiotics and putative inhibitors of efflux pumps on Pseudomonas aeruginosa and Staphylococcus aureus","volume":"22","author":"O Hendricks","year":"2003","journal-title":"IntJAntimicrobAgents"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"e64518","DOI":"10.1371\/journal.pone.0064518","article-title":"Thioridazine induces major changes in global gene expression and cell wall composition in methicillin-resistant Staphylococcus aureus USA300","volume":"8","author":"M Thorsing","year":"2013","journal-title":"PloS one"},{"issue":"1","key":"ref13","first-page":"33","article-title":"Effect of thioridazine on experimental cutaneous staphylococcal infections","volume":"28","author":"BL Hahn","year":"2014","journal-title":"In Vivo"},{"key":"ref14","article-title":"Combination of thioridazine and dicloxacillin combats Methicillin-resistant Staphylococcus aureus infections in Caenorhabditis elegans","author":"MO Poulsen","year":"2014","journal-title":"Journal of medical microbiology"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1093\/jac\/dks142","article-title":"Efficacy of linezolid versus a pharmacodynamically optimized vancomycin therapy in an experimental pneumonia model caused by methicillin-resistant Staphylococcus aureus","volume":"67","author":"F Docobo-Perez","year":"2012","journal-title":"The Journal of antimicrobial chemotherapy"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1128\/AAC.00205-10","article-title":"Intra- and extracellular activities of dicloxacillin and linezolid against a clinical Staphylococcus aureus strain with a small-colony-variant phenotype in an in vitro model of THP-1 macrophages and an in vivo mouse peritonitis model","volume":"55","author":"A Sandberg","year":"2011","journal-title":"Antimicrobial agents and chemotherapy"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"e57493","DOI":"10.1371\/journal.pone.0057493","article-title":"A comparative analysis of in vitro and in vivo efficacies of the enantiomers of thioridazine and its racemate","volume":"8","author":"JB Christensen","year":"2013","journal-title":"PloS one"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1093\/jac\/dkt037","article-title":"Thioridazine lacks bactericidal activity in an animal model of extracellular tuberculosis","volume":"68","author":"NK Dutta","year":"2013","journal-title":"The Journal of antimicrobial chemotherapy"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1093\/jac\/dkl222","article-title":"Efficacy of telavancin in a murine model of bacteraemia induced by methicillin-resistant Staphylococcus aureus","volume":"58","author":"N Reyes","year":"2006","journal-title":"The Journal of antimicrobial chemotherapy"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nprot.2007.521","article-title":"Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances","volume":"3","author":"I Wiegand","year":"2008","journal-title":"Nature protocols"},{"issue":"Suppl D","key":"ref21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/jac\/31.suppl_D.55","article-title":"The mouse peritonitis model: present and future use","volume":"31","author":"N Frimodt-Moller","year":"1993","journal-title":"The Journal of antimicrobial chemotherapy"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1128\/AAC.01605-07","article-title":"Intracellular activity of antibiotics against Staphylococcus aureus in a mouse peritonitis model","volume":"53","author":"A Sandberg","year":"2009","journal-title":"Antimicrobial agents and chemotherapy"},{"key":"ref23","first-page":"268","article-title":"Anesthesia and Analgesia in Laboratory Animals","author":"R Fish","year":"2008"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1093\/ilar.41.2.99","article-title":"Humane endpoints for infectious disease animal models","volume":"41","author":"ED Olfert","year":"2000","journal-title":"ILAR journal \/ National Research Council, Institute of Laboratory Animal Resources"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF00495864","article-title":"Binding of thioridazine and thioridazine metabolites to serum proteins. An in vitro study","volume":"319","author":"G Nyberg","year":"1982","journal-title":"Naunyn-Schmiedeberg's archives of pharmacology"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1006\/taap.1999.8688","article-title":"The role of lysosomes in the cellular distribution of thioridazine and potential drug interactions","volume":"158","author":"WA Daniel","year":"1999","journal-title":"Toxicology and applied pharmacology"},{"issue":"6","key":"ref27","first-page":"787","article-title":"Clinical concentrations of thioridazine enhance the killing of intracellular methicillin-resistant Staphylococcus aureus: an in vivo, ex vivo and electron microscopy study","volume":"18","author":"M Martins","year":"2004","journal-title":"In Vivo"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/S0022-3565(25)21884-5","article-title":"Greater potency of mesoridazine and sulforidazine compared with the parent compound, thioridazine, on striatal dopamine autoreceptors","volume":"228","author":"DM Niedzwiecki","year":"1984","journal-title":"The Journal of pharmacology and experimental therapeutics"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ijantimicag.2009.09.027","article-title":"Thioridazine protects the mouse from a virulent infection by Salmonella enterica serovar Typhimurium 74","volume":"35","author":"A Dasgupta","year":"2010","journal-title":"International journal of antimicrobial agents"},{"issue":"12","key":"ref30","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/j.1699-0463.1988.tb00984.x","article-title":"Synergy between a non-neuroleptic thioxanthene stereo-isomer and penicillin in vivo","volume":"96","author":"JE Kristiansen","year":"1988","journal-title":"APMIS"},{"issue":"5","key":"ref31","first-page":"771","article-title":"The curative activity of thioridazine on mice infected with Mycobacterium tuberculosis","volume":"21","author":"M Martins","year":"2007","journal-title":"In Vivo"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0135571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T23:54:13Z","timestamp":1748562853000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0135571"}},"subtitle":[],"editor":[{"given":"Paul J","family":"Planet","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,8,12]]},"references-count":31,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0135571","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2015,8,12]]}}}