{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T09:02:41Z","timestamp":1769850161731,"version":"3.49.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T00:00:00Z","timestamp":1440460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0135775","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T18:00:51Z","timestamp":1440525651000},"page":"e0135775","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Prenatal Paracetamol Exposure and Wheezing in Childhood: Causation or Confounding?"],"prefix":"10.1371","volume":"10","author":[{"given":"Enrica","family":"Migliore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Zugna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Galassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Merletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Gagliardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Rasero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morena","family":"Trevisan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franca","family":"Rusconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Richiardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,8,25]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S1081-1206(10)63127-4","article-title":"Hypothesis: decreased use of pediatric aspirin has contributed to the increasing prevalence of childhood asthma","volume":"81","author":"AE Varner","year":"1998","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s00228-012-1463-7","article-title":"The case of drug causation of childhood asthma: antibiotics and paracetamol","volume":"69","author":"K Heintze","year":"2013","journal-title":"Eur J Clin Pharmacol"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/archdischild-2012-303043","article-title":"Paracetamol exposure in pregnancy and early childhood and development of childhood asthma: a systematic review and meta-analysis","volume":"100","author":"M Cheelo","year":"2014","journal-title":"Arch Dis Child"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/cea.12410","article-title":"The association between paracetamol use and asthma: causation or coincidence?","volume":"45","author":"M Weatherall","year":"2015","journal-title":"Clin Exp Allergy"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jaci.2014.07.065","article-title":"Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children","volume":"135","author":"JE Sordillo","year":"2015","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.jaci.2010.08.023","article-title":"Respiratory tract infections and not paracetamol medication during infancy are associated with asthma development in childhood","volume":"126","author":"E Schnabel","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"c4616","DOI":"10.1136\/bmj.c4616","article-title":"Paracetamol use in early life and asthma: prospective birth cohort study","volume":"341","author":"AJ Lowe","year":"2010","journal-title":"BMJ"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.reprotox.2010.09.005","article-title":"Childhood asthma and use during pregnancy of acetaminophen. A critical review","volume":"30","author":"AR Scialli","year":"2010","journal-title":"Reprod Toxicol"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1111\/j.1651-2227.2011.02403.x","article-title":"Prenatal paracetamol exposure and risk of wheeze at preschool age","volume":"100","author":"E Goksor","year":"2011","journal-title":"Acta Paediatr"},{"issue":"10","key":"ref10","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1046\/j.1365-2222.1999.00662.x","article-title":"A retrospective study of the relationship between childhood asthma and respiratory infection during gestation","volume":"29","author":"CH Hughes","year":"1999","journal-title":"Clin Exp Allergy"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1097\/AOG.0b013e3181c225c0","article-title":"Prenatal exposure to acetaminophen and asthma in children","volume":"114","author":"EM Kang","year":"2009","journal-title":"Obstet Gynecol"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1651-2227.2010.01942.x","article-title":"Paracetamol in early infancy: the risk of childhood allergy and asthma","volume":"100","author":"E Bakkeheim","year":"2011","journal-title":"Acta Paediatr"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.jaci.2012.09.017","article-title":"Infant acetaminophen use associates with early asthmatic symptoms independently of respiratory tract infections: the Copenhagen Prospective Study on Asthma in Childhood 2000 (COPSAC(2000)) cohort","volume":"130","author":"E Kreiner-Moller","year":"2012","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/pai.12034","article-title":"Maternal drug use during pregnancy and asthma risk among children","volume":"24","author":"B Kallen","year":"2013","journal-title":"Pediatr Allergy Immunol"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s10654-007-9194-2","article-title":"Feasibility of recruiting a birth cohort through the Internet: the experience of the NINFEA cohort","volume":"22","author":"L Richiardi","year":"2007","journal-title":"Eur J Epidemiol"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1093\/ije\/dys223","article-title":"Why representativeness should be avoided","volume":"42","author":"KJ Rothman","journal-title":"Int J Epidemiol"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1093\/ije\/dyt103","article-title":"Commentary: Representativeness is usually not necessary and often should be avoided","volume":"42","author":"L Richiardi","year":"2013","journal-title":"Int J Epidemiol"},{"issue":"11","key":"ref18","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1136\/jech-2011-200065","article-title":"Selection bias and patterns of confounding in cohort studies: the case of the NINFEA web-based birth cohort","volume":"66","author":"C Pizzi","year":"2012","journal-title":"J Epidemiol Community Health"},{"key":"ref19","article-title":"International Study on Asthma and Allergies in Childhood","year":"1993"},{"issue":"9928","key":"ref20","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1016\/S0140-6736(14)60615-2","article-title":"Diagnosis, management, and prognosis of preschool wheeze","volume":"383","author":"FM Ducharme","year":"2014","journal-title":"Lancet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/biomet\/70.1.41","article-title":"The central role of the propensity score in observational studies for causal effects","volume":"70","author":"P Rosenbaum","year":"1983","journal-title":"Biometrika"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1365-2222.2005.02151.x","article-title":"Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood","volume":"35","author":"SO Shaheen","year":"2005","journal-title":"Clin Exp Allergy"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S1081-1206(10)60492-9","article-title":"Prenatal exposure to acetaminophen and respiratory symptoms in the first year of life","volume":"101","author":"V Persky","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1136\/thx.2009.121459","article-title":"Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohort","volume":"65","author":"MS Perzanowski","year":"2009","journal-title":"Thorax"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1136\/thorax.57.11.958","article-title":"Paracetamol use in pregnancy and wheezing in early childhood","volume":"57","author":"SO Shaheen","year":"2002","journal-title":"Thorax"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/ije\/dyn070","article-title":"Pre-natal exposure to paracetamol and risk of wheezing and asthma in children: a birth cohort study","volume":"37","author":"C Rebordosa","year":"2008","journal-title":"Int J Epidemiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2147\/CLEP.S28312","article-title":"Use of prescription paracetamol during pregnancy and risk of asthma in children: a population-based Danish cohort study","volume":"4","author":"AB Andersen","year":"2012","journal-title":"Clin Epidemiol"},{"issue":"Suppl 9","key":"ref28","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1289\/ehp.94102s963","article-title":"Effect of acetaminophen on glutathione levels in rat testis and lung","volume":"102","author":"L Micheli","year":"1994","journal-title":"Environ Health Perspect"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1183\/09031936.00002108","article-title":"Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach","volume":"32","author":"PL Brand","year":"2008","journal-title":"Eur Respir J"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0135775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T12:20:12Z","timestamp":1540038012000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0135775"}},"subtitle":[],"editor":[{"given":"Sreeram V.","family":"Ramagopalan","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,8,25]]},"references-count":29,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0135775","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,25]]}}}