{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:56:25Z","timestamp":1773330985398,"version":"3.50.1"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2015,9,17]],"date-time":"2015-09-17T00:00:00Z","timestamp":1442448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0135983","type":"journal-article","created":{"date-parts":[[2015,9,17]],"date-time":"2015-09-17T18:29:57Z","timestamp":1442514597000},"page":"e0135983","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["No Major Host Genetic Risk Factor Contributed to A(H1N1)2009 Influenza Severity"],"prefix":"10.1371","volume":"10","author":[{"given":"Koldo","family":"Garcia-Etxebarria","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Alma","family":"Bracho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Gal\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e0s","family":"Pumarola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Castilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal","family":"Ortiz de Lejarazu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Rodr\u00edguez-Dominguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00e9s","family":"Quintela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00faria","family":"Bonet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Garcia-Garcer\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Dom\u00ednguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Gonz\u00e1lez-Candelas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesc","family":"Calafell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"CIBERESP Cases and Controls in Pandemic Influenza Working Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,9,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e33139","DOI":"10.1371\/journal.pone.0033139","article-title":"Sociodemographic factors and clinical conditions associated to hospitalization in influenza A (H1N1) 2009 virus infected patients in Spain, 2009\u20132010","volume":"7","author":"F Gonzalez-Candelas","year":"2012","journal-title":"PLoS One"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e33180","DOI":"10.1371\/journal.pone.0033180","article-title":"The role of host genetics in susceptibility to influenza: a systematic review","volume":"7","author":"P Horby","year":"2012","journal-title":"PLoS One"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1086\/524064","article-title":"Evidence for a heritable predisposition to death due to influenza","volume":"197","author":"FS Albright","year":"2008","journal-title":"J Infect Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1073\/pnas.0707659105","article-title":"Lessons from the past: familial aggregation analysis of fatal pandemic influenza (Spanish flu) in Iceland in 1918","volume":"105","author":"M Gottfredsson","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1186\/1471-2334-12-299","article-title":"Pandemic influenza A\/H1N1 virus infection and TNF, LTA, IL1B, IL6, IL8, and CCL polymorphisms in Mexican population: a case-control study","volume":"12","author":"G Morales-Garcia","year":"2012","journal-title":"BMC Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e204","DOI":"10.1016\/j.ijid.2011.11.012","article-title":"Role of tumor necrosis factor gene single nucleotide polymorphisms in the natural course of 2009 influenza A H1N1 virus infection","volume":"16","author":"A Antonopoulou","year":"2012","journal-title":"Int J Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.3201\/eid1712.111002","article-title":"A pilot study of host genetic variants associated with influenza-associated deaths among children and young adults","volume":"17","author":"JM Ferdinands","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature10921","article-title":"IFITM3 restricts the morbidity and mortality associated with influenza","volume":"484","author":"AR Everitt","year":"2012","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/infdis\/jis378","article-title":"A functional variation in CD55 increases the severity of 2009 pandemic H1N1 influenza A virus infection","volume":"206","author":"J Zhou","year":"2012","journal-title":"J Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1183\/09031936.00020611","article-title":"Genetic variants associated with severe pneumonia in A\/H1N1 influenza infection","volume":"39","author":"J Z\u00fa\u00f1iga","year":"2012","journal-title":"Eur Respir J"},{"key":"ref11"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1186\/1471-2164-11-724","article-title":"Accounting for multiple comparisons in a genome-wide association study (GWAS)","volume":"11","author":"RC Johnson","year":"2010","journal-title":"BMC Genomics"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1101\/gr.094052.109","article-title":"Fast model-based estimation of ancestry in unrelated individuals","volume":"19","author":"DH Alexander","year":"2009","journal-title":"Genome Res"},{"key":"ref15","article-title":"R: A Language and Environment for Statistical Computing","year":"2012"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e1001323","DOI":"10.1371\/journal.pgen.1001323","article-title":"Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production","volume":"7","author":"SA Chung","year":"2011","journal-title":"PLoS Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e1000319","DOI":"10.1371\/journal.pgen.1000319","article-title":"A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease","volume":"5","author":"D Burgner","year":"2009","journal-title":"PLoS Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1164\/rccm.200812-1860OC","article-title":"Assessing the reproducibility of asthma candidate gene associations, using genome-wide data","volume":"179","author":"AJ Rogers","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.bbrc.2011.05.019","article-title":"TNF\u03b1 enhances the motility and invasiveness of prostatic cancer cells by stimulating the expression of selective glycosyl- and sulfotransferase genes involved in the synthesis of selectin ligands","volume":"409","author":"P Radhakrishnan","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"10355","DOI":"10.1074\/jbc.M511314200","article-title":"Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity","volume":"281","author":"H Tanaka","year":"2006","journal-title":"J Biol Chem"},{"issue":"Suppl 1","key":"ref21","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1471-2350-8-S1-S4","article-title":"Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI\u2019s Framingham Heart Study","volume":"8","author":"CJ O\u2019Donnell","year":"2007","journal-title":"BMC Med Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1093\/eurpub\/ckr171","article-title":"Pandemic influenza A (H1N1) 2009 in Madrid, Spain: incidence and characteristics in immigrant and native population","volume":"22","author":"MD Esteban-Vasallo","year":"2012","journal-title":"Eur J Public Health"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/bioinformatics\/19.1.149","article-title":"Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits","volume":"19","author":"S Purcell","year":"2003","journal-title":"Bioinformatics"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0141661","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T00:00:00Z","timestamp":1446163200000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0135983","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T22:41:29Z","timestamp":1588977689000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0135983"}},"subtitle":[],"editor":[{"given":"Hiroshi","family":"Nishiura","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,9,17]]},"references-count":23,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2015,9,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0135983","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0141661","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,17]]}}}