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Seroprevalence of hepatitis B and C virus infections: Results from the 2007 to 2009 and 2009 to 2011 Canadian Health Measures Survey. Statistics Canada Health Reports; 2013. Catalogue no. 82-003-X. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.statcan.gc.ca\/pub\/82-003-x\/2013011\/article\/11876-eng.pdf\" xlink:type=\"simple\">http:\/\/www.statcan.gc.ca\/pub\/82-003-x\/2013011\/article\/11876-eng.pdf<\/ext-link>."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1016\/j.ijid.2010.09.005","article-title":"Seroprevalence of markers for hepatitis B viral infection","volume":"15","author":"RM Merrill","year":"2011","journal-title":"Int J Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1155\/2013\/924640","article-title":"Disease burden of chronic hepatitis B among immigrants in Canada","volume":"27","author":"WWL Wong","year":"2013","journal-title":"Can J Gastroenterol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e44611","DOI":"10.1371\/journal.pone.0044611","article-title":"Seroprevalence of chronic hepatitis B virus infection and prior immunity in immigrants and refugees: A systematic review and meta-analysis","volume":"7","author":"C Rossi","year":"2012","journal-title":"PLoS ONE"},{"key":"ref5","unstructured":"Sherman M, Bilodeau M, Cooper C, Mackie D, Depew W, Villeneuve JP, et al. Liver disease in Canada: A crisis in the making. Canadian Liver Foundation Report; 2013. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.liver.ca\/files\/PDF\/Liver_Disease_Report_2013\/Liver_Disease_In_Canada_-_E.pdf\" xlink:type=\"simple\">http:\/\/www.liver.ca\/files\/PDF\/Liver_Disease_Report_2013\/Liver_Disease_In_Canada_-_E.pdf<\/ext-link>."},{"key":"ref6","unstructured":"Statistics Canada. Immigration and ethnocultural diversity in Canada: National Household Survey, 2011. Statistics Canada Report; 2013. Catalogue no. 99-010-X2011001. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www12.statcan.gc.ca\/nhs-enm\/2011\/as-sa\/99-010-x\/99-010-x2011001-eng.pdf\" xlink:type=\"simple\">http:\/\/www12.statcan.gc.ca\/nhs-enm\/2011\/as-sa\/99-010-x\/99-010-x2011001-eng.pdf<\/ext-link>."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e78548","DOI":"10.1371\/journal.pone.0078548","article-title":"Hepatitis B screening and vaccination strategies for newly arrived adult Canadian immigrants and refugees: A cost-effectiveness analysis","volume":"8","author":"C Rossi","year":"2013","journal-title":"PLoS ONE"},{"key":"ref8","unstructured":"Public Health Agency of Canada. Brief Report: Hepatitis B infection in Canada; 2011. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.phac-aspc.gc.ca\/id-mi\/pdf\/hepB-eng.pdf\" xlink:type=\"simple\">http:\/\/www.phac-aspc.gc.ca\/id-mi\/pdf\/hepB-eng.pdf<\/ext-link>."},{"key":"ref9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.biologicals.2009.01.002","article-title":"Transfusion-transmitted infectious diseases","volume":"37","author":"J Allain","year":"2009","journal-title":"Biologicals"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1097\/QCO.0b013e328357f2f8","article-title":"Diagnosis and personalized management of hepatitis B including significance of genotypes","volume":"25","author":"VW Wong","year":"2012","journal-title":"Curr Op Infect Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11894-011-0233-5","article-title":"Is there any value to hepatitis B virus genotype analysis?","volume":"14","author":"S Tanwar","year":"2012","journal-title":"Curr Gastroenterol Rep"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.7150\/ijms.2.143","article-title":"Enhanced surveillance for childhood hepatitis B virus infection in Canada, 1999\u20132003","volume":"2","author":"H Wu","year":"2005","journal-title":"Int J Med Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1128\/JCM.40.7.2566-2571.2002","article-title":"Sensitive detection of HBsAg mutants by a gap ligase chain reaction assay","volume":"40","author":"C Osiowy","year":"2002","journal-title":"J Clin Microbiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1128\/JCM.41.12.5473-5477.2003","article-title":"Evaluation of the INNO-LiPA HBV genotyping assay for determination of hepatitis B virus genotype","volume":"41","author":"C Osiowy","year":"2003","journal-title":"J Clin Microbiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1099\/0022-1317-76-12-3159","article-title":"The precore\/core promoter mutant (T1762A1764) of hepatitis B virus: clinical significance and an easy method for detection","volume":"76","author":"K Takahashi","year":"1995","journal-title":"J Gen Virol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"W654","DOI":"10.1093\/nar\/gkh419","article-title":"A web-based genotyping resource for viral sequences","volume":"1","author":"M Rozanov","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1093\/nar\/25.24.4876","article-title":"The ClustalX windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools","volume":"24","author":"JD Thompson","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"ref18","first-page":"95","article-title":"BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95\/98\/NT","volume":"41","author":"TA Hall","year":"1999","journal-title":"Nucleic Acids Symp Ser"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1093\/molbev\/msr121","article-title":"MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods","volume":"28","author":"K Tamura","year":"2011","journal-title":"Mol Biol Evol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2144\/000113370","article-title":"DIVEIN: a web server to analyze phylogenies, sequence divergence, diversity, and informative sites","volume":"48","author":"W Deng","year":"2010","journal-title":"Biotechniques"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"7653","DOI":"10.3748\/wjg.v20.i24.7653","article-title":"Clinical implications of hepatitis B virus mutations: Recent advances","volume":"20","author":"I Lazarevic","year":"2014","journal-title":"World J Gastroenterol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/lt.23935","article-title":"Frequent incidence of escape mutants after successful hepatitis B vaccine response and stopping of nucleos(t)ide analogues in liver transplant recipients","volume":"20","author":"M Ishigami","year":"2014","journal-title":"Liver Transpl"},{"key":"ref23","first-page":"81","article-title":"Viral Hepatitis","author":"PR Spradling","year":"2014"},{"key":"ref24","unstructured":"Public Health Agency of Canada. Case Definitions for Communicable Diseases Under National Surveillance. Report; 2009. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.phac-aspc.gc.ca\/publicat\/ccdr-rmtc\/09vol35\/35s2\/Hep_B-eng.php\" xlink:type=\"simple\">http:\/\/www.phac-aspc.gc.ca\/publicat\/ccdr-rmtc\/09vol35\/35s2\/Hep_B-eng.php<\/ext-link>."},{"key":"ref25","doi-asserted-by":"crossref","first-page":"266","DOI":"10.14745\/ccdr.v40i13a01","article-title":"Hepatitis B surveillance in Canada: 2005\u20132012","volume":"40","author":"E Payne","year":"2014","journal-title":"Can Commun Dis Rep"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jcv.2003.09.016","article-title":"Incidence and routes of transmission of hepatitis B virus in England and Wales 1995\u20132000: implications for immunisation policy","volume":"29","author":"S Hahn\u00e9","year":"2004","journal-title":"J Clin Virol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/hep.24804","article-title":"Prevalence of chronic hepatitis B among foreign-born persons living in the United States by country of origin","volume":"56","author":"KV Kowdley","year":"2012","journal-title":"Hepatology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1086\/653622","article-title":"The prevalence of hepatitis B infection in the United States in the era of vaccination","volume":"202","author":"A Wasley","year":"2010","journal-title":"J Infect Dis"},{"key":"ref29","unstructured":"Public Health Agency of Canada. Notifiable Diseases On-Line. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dsol-smed.phac-aspc.gc.ca\/dsol-smed\/ndis\/charts.php?c=yl\" xlink:type=\"simple\">http:\/\/dsol-smed.phac-aspc.gc.ca\/dsol-smed\/ndis\/charts.php?c=yl<\/ext-link>."},{"key":"ref30","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1155\/2012\/705094","article-title":"The impact of hepatitis B knowledge and stigma on screening in Canadian Chinese persons","volume":"26","author":"D Li","year":"2012","journal-title":"Can J Gastroenterol"},{"key":"ref31","first-page":"506","article-title":"Viral Hepatitis","author":"M Carballo","year":"2014"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"5C","DOI":"10.1155\/2007\/910831","article-title":"Management of chronic hepatitis B: Consensus guidelines","volume":"21","author":"M Sherman","year":"2007","journal-title":"Can J Gastroenterol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1001\/jama.1995.03530150033030","article-title":"Assessment of a universal school-based hepatitis B vaccination program","volume":"274","author":"S Dobson","year":"1995","journal-title":"JAMA"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/BF03404397","article-title":"Vaccine coverage during a school-based hepatitis B immunization program","volume":"89","author":"S Deeks","year":"1998","journal-title":"Can J Public Health"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/01.inf.0000207468.04665.ad","article-title":"Impact of the Quebec school-based hepatitis B immunization program and potential benefit of the addition of an infant immunization program","volume":"25","author":"V G\u00eelca","year":"2006","journal-title":"Pediatr Infect Dis J"},{"key":"ref36","first-page":"143","article-title":"Viral Hepatitis","author":"YF Liaw","year":"2014"},{"issue":"Suppl 2","key":"ref37","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1093\/cid\/cit300","article-title":"Injection drug use and hepatitis C virus infection in young adult injectors: using evidence to inform comprehensive prevention","volume":"57","author":"K Page","year":"2013","journal-title":"Clin Infect Dis"},{"key":"ref38","unstructured":"Lloyd C. Sinning and sinned against: the stigmatisation of problem drug users. The UK Drug Policy Commission (UKDPC) Report; 2010. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ukdpc.org.uk\/reports.shtml\" xlink:type=\"simple\">www.ukdpc.org.uk\/reports.shtml<\/ext-link>."},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1136\/gut.2008.157149","article-title":"Risk factors for acute hepatitis B and its progression to chronic hepatitis in Shanghai","volume":"57","author":"H Zhang","year":"2008","journal-title":"China. Gut"},{"key":"ref40","unstructured":"Public Health Agency of Canada. The Chief Public Health Officer&apos;s Report on the State of Public Health. Chapter 4. Social and economic factors that influence our health and contribute to health inequalities report; 2008. Catalogue no. HP2-10\/2008E. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.phac-aspc.gc.ca\/cphorsphc-respcacsp\/2008\/fr-rc\/cphorsphc-respcacsp07i-eng.php\" xlink:type=\"simple\">http:\/\/www.phac-aspc.gc.ca\/cphorsphc-respcacsp\/2008\/fr-rc\/cphorsphc-respcacsp07i-eng.php<\/ext-link>."},{"key":"ref41","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jcv.2004.05.004","article-title":"Molecular epidemiology of hepatitis B virus infections in Denmark","volume":"31","author":"N Fisker","year":"2004","journal-title":"J Clin Virol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1002\/jmv.21309","article-title":"Change of hepatitis B virus genotypes in acute and chronic infections in Japan","volume":"80","author":"M Kobayashi","year":"2008","journal-title":"J Med Virol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1002\/jmv.24005","article-title":"Molecular epidemiology of hepatitis B virus genotypes circulating in acute hepatitis B patients in the Campania region","volume":"86","author":"C Sagnelli","year":"2014","journal-title":"J Med Virol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1128\/JCM.02081-08","article-title":"Distribution of hepatitis B virus genotypes among patients with chronic infection in Japan shifting toward an increase of genotype A","volume":"47","author":"K Matsuura","year":"2009","journal-title":"J Clin Microbiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1159\/000252788","article-title":"Dynamic epidemiology of acute viral hepatitis in Japan","volume":"53","author":"K Yano","year":"2010","journal-title":"Intervirology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"13971","DOI":"10.1128\/JVI.01594-14","article-title":"Recent population expansions of hepatitis B virus in the United States","volume":"88","author":"S Ramachandran","year":"2014","journal-title":"J Virol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/hep.21345","article-title":"Influence of hepatitis B virus genotypes on the intra- and extracellular expression of viral DNA and antigens","volume":"44","author":"M Sugiyama","year":"2006","journal-title":"Hepatology"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1093\/cid\/cit348","article-title":"High levels of hepatitis B virus after the onset of disease lead to chronic infection in patients with acute hepatitis B","volume":"57","author":"H Yotsuyanagi","year":"2013","journal-title":"Clin Infect Dis"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/hep.26635","article-title":"Risk factors for long-term persistence of serum hepatitis B surface antigen following acute hepatitis B virus infection in Japanese adults","volume":"59","author":"K 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