{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:02:21Z","timestamp":1790395341648,"version":"4.1.0"},"reference-count":81,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2015,8,21]],"date-time":"2015-08-21T00:00:00Z","timestamp":1440115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0136145","type":"journal-article","created":{"date-parts":[[2015,8,21]],"date-time":"2015-08-21T18:02:21Z","timestamp":1440180141000},"page":"e0136145","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["Amniotic Fluid Derived Stem Cells with a Renal Progenitor Phenotype Inhibit Interstitial Fibrosis in Renal Ischemia and Reperfusion Injury in Rats"],"prefix":"10.1371","volume":"10","author":[{"given":"Marina Gabriela","family":"Monteiro Carvalho Mori da Cunha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Zia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Oliveira Arcolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne Sylvia","family":"Carlon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Vilibaldo","family":"Beckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ney Luis","family":"Pippi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominguita","family":"Luhers Gra\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Levtchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Deprest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaan","family":"Toelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,8,21]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1681\/ASN.2005090934","article-title":"Towards a definition and classification of acute kidney injury","volume":"16","author":"DG Warnock","year":"2005","journal-title":"Journal of the American Society of Nephrology: JASN"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1172\/JCI200422353","article-title":"Acute renal failure: definitions, diagnosis, pathogenesis, and therapy","volume":"114","author":"RW Schrier","year":"2004","journal-title":"The Journal of clinical investigation"},{"issue":"9887","key":"ref3","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0140-6736(13)60647-9","article-title":"Acute kidney injury: an increasing global concern","volume":"382","author":"NH Lameire","year":"2013","journal-title":"Lancet"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/ki.2011.339","article-title":"AKI in the ICU: definition, epidemiology, risk stratification, and outcomes","volume":"81","author":"K Singbartl","year":"2012","journal-title":"Kidney international"},{"issue":"9","key":"ref5","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00109-009-0491-y","article-title":"The interaction between ischemia-reperfusion and immune responses in the kidney","volume":"87","author":"HR Jang","year":"2009","journal-title":"J Mol Med (Berl)"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"532127","DOI":"10.1155\/2011\/532127","article-title":"Contribution of large pig for renal ischemia-reperfusion and transplantation studies: the preclinical model","volume":"2011","author":"S Giraud","year":"2011","journal-title":"J Biomed Biotechnol"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/ki.2011.405","article-title":"Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury","volume":"81","author":"ID Bucaloiu","year":"2012","journal-title":"Kidney international"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.amjmed.2012.01.016","article-title":"Risk of chronic dialysis and death following acute kidney injury","volume":"125","author":"R Wald","year":"2012","journal-title":"Am J Med"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1136\/jim-52-05-27","article-title":"Consequences of cold ischemic injury of kidneys in clinical transplantation","volume":"52","author":"AK Salahudeen","year":"2004","journal-title":"Journal of investigative medicine: the official publication of the American Federation for Clinical Research"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1097\/00007890-199704150-00011","article-title":"Delayed graft function: risk factors and implications for renal allograft survival","volume":"63","author":"AO Ojo","year":"1997","journal-title":"Transplantation"},{"issue":"1\u20132","key":"ref11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0041-1345(00)02207-7","article-title":"The influence of donor brain death on long-term function of renal allotransplants in rats","volume":"33","author":"J Pratschke","year":"2001","journal-title":"Transplant Proc"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/ki.2014.18","article-title":"Delayed kidney graft function: from mechanism to translation","volume":"86","author":"B Schroppel","year":"2014","journal-title":"Kidney international"},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1089\/ars.2007.1801","article-title":"Heme oxygenase-1 ameliorates ischemia\/reperfusion injury by targeting dendritic cell maturation and migration","volume":"9","author":"K Kotsch","year":"2007","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00011-012-0550-7","article-title":"Interleukin-9 release from human kidney grafts and its potential protective role in renal ischemia\/reperfusion injury","volume":"62","author":"KA Kortekaas","year":"2013","journal-title":"Inflammation research: official journal of the European Histamine Research Society"},{"issue":"7","key":"ref15","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/ki.2008.304","article-title":"Kidney-derived mesenchymal stem cells contribute to vasculogenesis, angiogenesis and endothelial repair","volume":"74","author":"J Chen","year":"2008","journal-title":"Kidney international"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"F31","DOI":"10.1152\/ajprenal.00007.2005","article-title":"Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms","volume":"289","author":"F Togel","year":"2005","journal-title":"American journal of physiology Renal physiology"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/ki.2012.105","article-title":"Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia-reperfusion injury by microRNA-dependent reprogramming of resident renal cells","volume":"82","author":"V Cantaluppi","year":"2012","journal-title":"Kidney international"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.transproceed.2007.01.036","article-title":"Mesenchymal stem cells ameliorate tissue damages triggered by renal ischemia and reperfusion injury","volume":"39","author":"P Semedo","year":"2007","journal-title":"Transplantation proceedings"},{"issue":"12","key":"ref19","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.1093\/ndt\/gfq603","article-title":"Fresh and cryopreserved, uncultured adipose tissue-derived stem and regenerative cells ameliorate ischemia-reperfusion-induced acute kidney injury","volume":"25","author":"Z Feng","year":"2010","journal-title":"Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association\u2014European Renal Association"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"e9357","DOI":"10.1371\/journal.pone.0009357","article-title":"Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis","volume":"5","author":"L Perin","year":"2010","journal-title":"PloS one"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"F207","DOI":"10.1152\/ajprenal.00073.2010","article-title":"VEGF-modified human embryonic mesenchymal stem cell implantation enhances protection against cisplatin-induced acute kidney injury","volume":"300","author":"L Yuan","year":"2011","journal-title":"American journal of physiology Renal physiology"},{"issue":"8","key":"ref22","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1634\/stemcells.2007-0795","article-title":"Human bone marrow mesenchymal stem cells accelerate recovery of acute renal injury and prolong survival in mice","volume":"26","author":"M Morigi","year":"2008","journal-title":"Stem cells"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1097\/01.ASN.0000061595.28546.A0","article-title":"Hematopoietic stem cells contribute to the regeneration of renal tubules after renal ischemia-reperfusion injury in mice","volume":"14","author":"F Lin","year":"2003","journal-title":"Journal of the American Society of Nephrology: JASN"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1111\/j.1523-1755.2005.00629.x","article-title":"Kidney tubular epithelium is restored without replacement with bone marrow-derived cells during repair after ischemic injury","volume":"68","author":"JS Duffield","year":"2005","journal-title":"Kidney Int"},{"issue":"9","key":"ref25","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1681\/ASN.2007020140","article-title":"Stromal cells protect against acute tubular injury via an endocrine effect","volume":"18","author":"B Bi","year":"2007","journal-title":"Journal of the American Society of Nephrology: JASN"},{"issue":"6","key":"ref26","first-page":"1035","article-title":"Mesenchymal stem cells contribute to the renal repair of acute tubular epithelial injury","volume":"14","author":"MB Herrera","year":"2004","journal-title":"International journal of molecular medicine"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1111\/j.1432-2277.2011.01328.x","article-title":"In vivo effect of bone marrow-derived mesenchymal stem cells in a rat kidney transplantation model with prolonged cold ischemia","volume":"24","author":"Y Hara","year":"2011","journal-title":"Transplant international: official journal of the European Society for Organ Transplantation"},{"issue":"11","key":"ref28","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1001\/jama.2012.316","article-title":"Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: a randomized controlled trial","volume":"307","author":"J Tan","year":"2012","journal-title":"JAMA"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"107","DOI":"10.5966\/sctm.2012-0114","article-title":"Autologous bone marrow-derived mesenchymal stromal cells for the treatment of allograft rejection after renal transplantation: results of a phase I study","volume":"2","author":"ME Reinders","year":"2013","journal-title":"Stem Cells Transl Med"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/stem.293","article-title":"Life-sparing effect of human cord blood-mesenchymal stem cells in experimental acute kidney injury","volume":"28","author":"M Morigi","year":"2010","journal-title":"Stem Cells"},{"issue":"10","key":"ref31","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.3109\/14653249.2012.711471","article-title":"The alleviation of acute and chronic kidney injury by human Wharton's jelly-derived mesenchymal stromal cells triggered by ischemia-reperfusion injury via an endocrine mechanism","volume":"14","author":"T Du","year":"2012","journal-title":"Cytotherapy"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/scrt215","article-title":"Human Wharton's jelly-derived mesenchymal stromal cells reduce renal fibrosis through induction of native and foreign hepatocyte growth factor synthesis in injured tubular epithelial cells","volume":"4","author":"T Du","year":"2013","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nbt1274","article-title":"Isolation of amniotic stem cell lines with potential for therapy","volume":"25","author":"P De Coppi","year":"2007","journal-title":"Nat Biotechnol"},{"issue":"17","key":"ref34","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1001\/jama.286.17.2083-JMN1107-2-1","article-title":"Amniotic cells show promise for fetal tissue engineering","volume":"286","author":"M Mitka","year":"2001","journal-title":"JAMA: the journal of the American Medical Association"},{"issue":"11","key":"ref35","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1053\/jpsu.2001.27945","article-title":"The amniotic fluid as a source of cells for fetal tissue engineering","volume":"36","author":"A Kaviani","year":"2001","journal-title":"J Pediatr Surg"},{"issue":"7","key":"ref36","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1093\/humrep\/deg279","article-title":"Oct-4-expressing cells in human amniotic fluid: a new source for stem cell research?","volume":"18","author":"AR Prusa","year":"2003","journal-title":"Hum Reprod"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ajog.2003.12.014","article-title":"Neurogenic cells in human amniotic fluid","volume":"191","author":"AR Prusa","year":"2004","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.juro.2009.11.006","article-title":"Human amniotic fluid as a potential new source of organ specific precursor cells for future regenerative medicine applications","volume":"183","author":"S Da Sacco","year":"2010","journal-title":"J Urol"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.2353\/ajpath.2010.091245","article-title":"Stem cells derived from human amniotic fluid contribute to acute kidney injury recovery","volume":"177","author":"PV Hauser","year":"2010","journal-title":"The American journal of pathology"},{"issue":"7","key":"ref40","doi-asserted-by":"crossref","first-page":"809","DOI":"10.5966\/sctm.2013-0186","article-title":"Amniotic fluid-derived mesenchymal stem cells prevent fibrosis and preserve renal function in a preclinical porcine model of kidney transplantation","volume":"3","author":"E Baulier","year":"2014","journal-title":"Stem cells translational medicine"},{"issue":"11","key":"ref41","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1089\/ten.tea.2009.0727","article-title":"Altered gene expression in human adipose stem cells cultured with fetal bovine serum compared to human supplements","volume":"16","author":"K Bieback","year":"2010","journal-title":"Tissue Eng Part A"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/MOT.0b013e3283424f6e","article-title":"Amniotic fluid as a source of pluripotent and multipotent stem cells for organ regeneration","volume":"16","author":"S Da Sacco","year":"2011","journal-title":"Curr Opin Organ Transplant"},{"issue":"12","key":"ref43","doi-asserted-by":"crossref","first-page":"e81812","DOI":"10.1371\/journal.pone.0081812","article-title":"A novel source of cultured podocytes","volume":"8","author":"S Da Sacco","year":"2013","journal-title":"PLoS One"},{"issue":"10","key":"ref44","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/pd.4162","article-title":"Routine clonal expansion of mesenchymal stem cells derived from amniotic fluid for perinatal applications","volume":"33","author":"S Zia","year":"2013","journal-title":"Prenatal diagnosis"},{"issue":"6","key":"ref45","doi-asserted-by":"crossref","first-page":"e64843","DOI":"10.1371\/journal.pone.0064843","article-title":"Kidney specific protein-positive cells derived from embryonic stem cells reproduce tubular structures in vitro and differentiate into renal tubular cells","volume":"8","author":"R Morizane","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"ref46","first-page":"F587","article-title":"Ksp-cadherin gene promoter. I. Characterization and renal epithelial cell-specific activity","volume":"277","author":"DA Whyte","year":"1999","journal-title":"The American journal of physiology"},{"issue":"4","key":"ref47","doi-asserted-by":"crossref","first-page":"F839","DOI":"10.1152\/ajprenal.00128.2002","article-title":"Regulation of kidney-specific Ksp-cadherin gene promoter by hepatocyte nuclear factor-1beta","volume":"283","author":"Y Bai","year":"2002","journal-title":"American journal of physiology Renal physiology"},{"issue":"1\u20132","key":"ref48","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1159\/000354389","article-title":"A surgical technique for homogenous renal distribution of substances in rats","volume":"51","author":"Carvalho Mori da Cunha MG Monteiro","year":"2013","journal-title":"European surgical research Europaische chirurgische Forschung Recherches chirurgicales europeennes"},{"key":"ref49","article-title":"A prospective study of the clinical utility of prenatal chromosomal microarray analysis in fetuses with ultrasound abnormalities and an exploration of a framework for reporting unclassified variants and risk factors","author":"PD Brady","year":"2013","journal-title":"Genetics in medicine: official journal of the American College of Medical Genetics"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1046\/j.1523-1755.2003.00737.x","article-title":"A small molecule C5a receptor antagonist protects kidneys from ischemia\/reperfusion injury in rats","volume":"63","author":"TV Arumugam","year":"2003","journal-title":"Kidney international"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s11255-008-9365-4","article-title":"Antioxidant and protective effects of silymarin on ischemia and reperfusion injury in the kidney tissues of rats","volume":"40","author":"F Turgut","year":"2008","journal-title":"International urology and nephrology"},{"issue":"3","key":"ref52","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00345-008-0253-4","article-title":"Curcumin protects against ischemia\/reperfusion injury in rat kidneys","volume":"26","author":"O Bayrak","year":"2008","journal-title":"World journal of urology"},{"issue":"7","key":"ref53","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1681\/ASN.2007080901","article-title":"Acute kidney injury leads to inflammation and functional changes in the brain","volume":"19","author":"M Liu","year":"2008","journal-title":"Journal of the American Society of Nephrology: JASN"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0021-9673(01)87434-3","article-title":"Characterization of a solvent system for separation of water-insoluble poliovirus proteins by reversed-phase high-performance liquid chromatography","volume":"326","author":"J Heukeshoven","year":"1985","journal-title":"Journal of chromatography"},{"issue":"7","key":"ref55","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1073\/pnas.052716199","article-title":"In vitro cartilage formation by human adult stem cells from bone marrow stroma defines the sequence of cellular and molecular events during chondrogenesis","volume":"99","author":"I Sekiya","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref56","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1634\/stemcells.2006-0395","article-title":"Concise review: embryonic stem cells: a new tool to study osteoblast and osteoclast differentiation","volume":"25","author":"L Duplomb","year":"2007","journal-title":"Stem Cells"},{"issue":"5","key":"ref57","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1387\/ijdb.092935md","article-title":"On the origin of amniotic stem cells: of mice and men","volume":"54","author":"MP Dobreva","year":"2010","journal-title":"The International journal of developmental biology"},{"issue":"2","key":"ref58","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4161\/org.6.2.11928","article-title":"WT1 and kidney progenitor cells","volume":"6","author":"JA Kreidberg","year":"2010","journal-title":"Organogenesis"},{"issue":"3","key":"ref59","first-page":"150","article-title":"Amniotic fluid volume and normal flows to and from the amniotic cavity","volume":"17","author":"WM Gilbert","year":"1993","journal-title":"Seminars in perinatology"},{"issue":"5","key":"ref60","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/sj.jp.7211290","article-title":"Amniotic fluid: not just fetal urine anymore","volume":"25","author":"MA Underwood","year":"2005","journal-title":"Journal of perinatology: official journal of the California Perinatal Association"},{"issue":"2","key":"ref61","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1089\/scd.2012.0357","article-title":"PKH26 can transfer to host cells in vitro and vivo","volume":"22","author":"P Li","year":"2013","journal-title":"Stem Cells Dev"},{"issue":"26","key":"ref62","doi-asserted-by":"crossref","first-page":"5347","DOI":"10.1182\/blood-2009-05-224030","article-title":""Microenvironmental contaminations" induced by fluorescent lipophilic dyes used for noninvasive in vitro and in vivo cell tracking","volume":"115","author":"F Lassailly","year":"2010","journal-title":"Blood"},{"issue":"12","key":"ref63","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1089\/hum.2010.156","article-title":"Immunological aspects of allogeneic mesenchymal stem cell therapies","volume":"21","author":"MD Griffin","year":"2010","journal-title":"Hum Gene Ther"},{"issue":"5","key":"ref64","doi-asserted-by":"crossref","first-page":"526","DOI":"10.4252\/wjsc.v6.i5.526","article-title":"Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapy","volume":"6","author":"JD Glenn","year":"2014","journal-title":"World journal of stem cells"},{"issue":"1","key":"ref65","doi-asserted-by":"crossref","first-page":"F315","DOI":"10.1152\/ajprenal.00098.2008","article-title":"Bioluminescence imaging to monitor the in vivo distribution of administered mesenchymal stem cells in acute kidney injury","volume":"295","author":"F Togel","year":"2008","journal-title":"American journal of physiology Renal physiology"},{"issue":"4","key":"ref66","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.transproceed.2010.03.081","article-title":"Which is the most suitable and effective route of administration for mesenchymal stem cell-based immunomodulation therapy in experimental kidney transplantation: endovenous or arterial?","volume":"42","author":"S Zonta","year":"2010","journal-title":"Transplant Proc"},{"issue":"3","key":"ref67","doi-asserted-by":"crossref","first-page":"e92347","DOI":"10.1371\/journal.pone.0092347","article-title":"Maximum efficacy of mesenchymal stem cells in rat model of renal ischemia-reperfusion injury: renal artery administration with optimal numbers","volume":"9","author":"J Cai","year":"2014","journal-title":"PloS one"},{"issue":"9","key":"ref68","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/ki.2010.10","article-title":"Differential resolution of inflammation and recovery after renal ischemia-reperfusion injury in Brown Norway compared with Sprague Dawley rats","volume":"77","author":"D Saenz-Morales","year":"2010","journal-title":"Kidney international"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev.med.59.061506.154239","article-title":"Mesenchymal stem cells in acute kidney injury","volume":"59","author":"BD Humphreys","year":"2008","journal-title":"Annual review of medicine"},{"issue":"3","key":"ref70","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/scrt469","article-title":"Mesenchymal stem cells ameliorate rhabdomyolysis-induced acute kidney injury via the activation of M2 macrophages","volume":"5","author":"Y Geng","year":"2014","journal-title":"Stem cell research & therapy"},{"issue":"11","key":"ref71","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1172\/JCI36150","article-title":"Macrophage diversity in renal injury and repair","volume":"118","author":"SD Ricardo","year":"2008","journal-title":"The Journal of clinical investigation"},{"issue":"2","key":"ref72","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1681\/ASN.2009060615","article-title":"Distinct macrophage phenotypes contribute to kidney injury and repair","volume":"22","author":"S Lee","year":"2011","journal-title":"Journal of the American Society of Nephrology: JASN"},{"issue":"8","key":"ref73","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/nm.3218","article-title":"Origin and function of myofibroblasts in kidney fibrosis","volume":"19","author":"VS LeBleu","year":"2013","journal-title":"Nat Med"},{"issue":"1","key":"ref74","doi-asserted-by":"crossref","first-page":"226","DOI":"10.2337\/dc13-0985","article-title":"Early progressive renal decline precedes the onset of microalbuminuria and its progression to macroalbuminuria","volume":"37","author":"AS Krolewski","year":"2014","journal-title":"Diabetes care"},{"issue":"12","key":"ref75","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1681\/ASN.2007030284","article-title":"Renal and bone marrow cells fuse after renal ischemic injury","volume":"18","author":"L Li","year":"2007","journal-title":"Journal of the American Society of Nephrology: JASN"},{"issue":"4","key":"ref76","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1096\/fj.11-183194","article-title":"Fusion of bone marrow-derived cells with renal tubules contributes to renal dysfunction in diabetic nephropathy","volume":"26","author":"T Yamashita","year":"2012","journal-title":"FASEB journal: official publication of the Federation of American Societies for Experimental Biology"},{"issue":"6","key":"ref77","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1681\/ASN.2013080831","article-title":"Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers","volume":"25","author":"AQ Lam","year":"2014","journal-title":"Journal of the American Society of Nephrology: JASN"},{"issue":"1","key":"ref78","doi-asserted-by":"crossref","first-page":"F254","DOI":"10.1152\/ajprenal.00594.2010","article-title":"Paracrine effects of mesenchymal stem cells in cisplatin-induced renal injury require heme oxygenase-1","volume":"300","author":"A Zarjou","year":"2011","journal-title":"American journal of physiology Renal physiology"},{"issue":"5","key":"ref79","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1681\/ASN.2009030322","article-title":"Microvesicles from mesenchymal stromal cells protect against acute kidney injury","volume":"20","author":"JV Bonventre","year":"2009","journal-title":"Journal of the American Society of Nephrology: JASN"},{"issue":"9","key":"ref80","doi-asserted-by":"crossref","first-page":"e44092","DOI":"10.1371\/journal.pone.0044092","article-title":"Bone marrow-derived mesenchymal stem cells repaired but did not prevent gentamicin-induced acute kidney injury through paracrine effects in rats","volume":"7","author":"LA Reis","year":"2012","journal-title":"PLoS One"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1749-6632.1997.tb51989.x","article-title":"Nitric oxide in the vasculature: physiology and pathophysiology","volume":"811","author":"S Moncada","year":"1997","journal-title":"Annals of the New York Academy of Sciences"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0136145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T19:45:28Z","timestamp":1653075928000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0136145"}},"subtitle":[],"editor":[{"given":"Benedetta","family":"Bussolati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,8,21]]},"references-count":81,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0136145","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,21]]}}}