{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:20:01Z","timestamp":1773303601389,"version":"3.50.1"},"reference-count":61,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T00:00:00Z","timestamp":1440374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0136151","type":"journal-article","created":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T17:54:01Z","timestamp":1440438841000},"page":"e0136151","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Changes in Diffusion Kurtosis Imaging and Magnetic Resonance Spectroscopy in a Direct Cranial Blast Traumatic Brain Injury (dc-bTBI) Model"],"prefix":"10.1371","volume":"10","author":[{"given":"Jiachen","family":"Zhuo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaspar","family":"Keledjian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Pampori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volodymyr","family":"Gerzanich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Marc","family":"Simard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rao P.","family":"Gullapalli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,8,24]]},"reference":[{"issue":"6","key":"ref1","first-page":"536","article-title":"The pathogenesis of blast injury and its management","volume":"39","author":"SG Mellor","year":"1988","journal-title":"Br J Hosp Med"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/msj.20104","article-title":"Pathophysiology of traumatic brain injury","volume":"76","author":"MW Greve","year":"2009","journal-title":"Mt Sinai J Med"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.neuron.2012.11.021","article-title":"The neuropathology and neurobiology of traumatic brain injury","volume":"76","author":"K Blennow","year":"2012","journal-title":"Neuron"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s11682-011-9145-0","article-title":"Neuropathology of mild traumatic brain injury: relationship to neuroimaging findings","volume":"6","author":"ED Bigler","year":"2012","journal-title":"Brain Imaging Behav"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1089\/neu.2010.1532","article-title":"Rodent model of direct cranial blast injury","volume":"28","author":"R Kuehn","year":"2011","journal-title":"J Neurotrauma"},{"issue":"14","key":"ref6","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1089\/neu.2013.3016","article-title":"Exposure of the thorax to a sublethal blast wave causes a hydrodynamic pulse that leads to perivenular inflammation in the brain","volume":"31","author":"JM Simard","year":"2014","journal-title":"J Neurotrauma"},{"issue":"44","key":"ref7","doi-asserted-by":"crossref","first-page":"11869","DOI":"10.1523\/JNEUROSCI.3647-07.2007","article-title":"Diffusion tensor imaging reliably detects experimental traumatic axonal injury and indicates approximate time of injury","volume":"27","author":"CL Mac Donald","year":"2007","journal-title":"J Neurosci"},{"issue":"8","key":"ref8","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1212\/WNL.0b013e3181d0ccdd","article-title":"A prospective diffusion tensor imaging study in mild traumatic brain injury","volume":"74","author":"AR Mayer","year":"2010","journal-title":"Neurology"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1212\/01.wnl.0000305961.68029.54","article-title":"Diffusion tensor imaging of acute mild traumatic brain injury in adolescents","volume":"70","author":"EA Wilde","year":"2008","journal-title":"Neurology"},{"issue":"4","key":"ref10","first-page":"539","article-title":"Whole-brain apparent diffusion coefficient in traumatic brain injury: correlation with Glasgow Coma Scale score","volume":"25","author":"K Shanmuganathan","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"issue":"9","key":"ref11","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1089\/neu.2007.0241","article-title":"Diffusion tensor imaging detects clinically important axonal damage after mild traumatic brain injury: a pilot study","volume":"24","author":"JJ Bazarian","year":"2007","journal-title":"J Neurotrauma"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1089\/neu.2010.1739","article-title":"Early microstructural and metabolic changes following controlled cortical impact injury in rat: a magnetic resonance imaging and spectroscopy study","volume":"28","author":"S Xu","year":"2011","journal-title":"J Neurotrauma"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neuroimage.2005.07.012","article-title":"Diffusion tensor imaging in chronic head injury survivors: correlations with learning and memory indices","volume":"29","author":"CH Salmond","year":"2006","journal-title":"Neuroimage"},{"issue":"Pt 10","key":"ref14","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1093\/brain\/awm216","article-title":"White matter integrity and cognition in chronic traumatic brain injury: a diffusion tensor imaging study","volume":"130","author":"MF Kraus","year":"2007","journal-title":"Brain"},{"issue":"10","key":"ref15","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1089\/neu.2006.23.1412","article-title":"Diffusion tensor imaging in the corpus callosum in children after moderate to severe traumatic brain injury","volume":"23","author":"EA Wilde","year":"2006","journal-title":"J Neurotrauma"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1089\/neu.2009.1073","article-title":"Diffusion tensor imaging of mild to moderate blast-related traumatic brain injury and its sequelae","volume":"27","author":"HS Levin","year":"2010","journal-title":"J Neurotrauma"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.expneurol.2011.09.018","article-title":"A mouse model of blast-induced mild traumatic brain injury","volume":"232","author":"V Rubovitch","year":"2011","journal-title":"Exp Neurol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3389\/fneur.2013.00154","article-title":"Primary blast traumatic brain injury in the rat: relating diffusion tensor imaging and behavior","volume":"4","author":"MD Budde","year":"2013","journal-title":"Front Neurol"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1002\/mrm.20508","article-title":"Diffusional kurtosis imaging: the quantification of non-gaussian water diffusion by means of magnetic resonance imaging","volume":"53","author":"JH Jensen","year":"2005","journal-title":"Magn Reson Med"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.neuroimage.2011.07.050","article-title":"Diffusion kurtosis as an in vivo imaging marker for reactive astrogliosis in traumatic brain injury","volume":"59","author":"J Zhuo","year":"2012","journal-title":"Neuroimage"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1148\/radiol.12110927","article-title":"Gliomas: diffusion kurtosis MR imaging in grading","volume":"263","author":"S Van Cauter","year":"2012","journal-title":"Radiology"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/jmri.22397","article-title":"Preliminary evidence of altered gray and white matter microstructural development in the frontal lobe of adolescents with attention-deficit hyperactivity disorder: a diffusional kurtosis imaging study","volume":"33","author":"JA Helpern","year":"2011","journal-title":"J Magn Reson Imaging"},{"issue":"8","key":"ref23","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1161\/STROKEAHA.112.661926","article-title":"Stratification of heterogeneous diffusion MRI ischemic lesion with kurtosis imaging: evaluation of mean diffusion and kurtosis MRI mismatch in an animal model of transient focal ischemia","volume":"43","author":"JS Cheung","year":"2012","journal-title":"Stroke"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/jmri.1880080412","article-title":"1H MRS in acute traumatic brain injury","volume":"8","author":"BD Ross","year":"1998","journal-title":"J Magn Reson Imaging"},{"issue":"7","key":"ref25","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1212\/WNL.52.7.1384","article-title":"Quantitative proton MRS predicts outcome after traumatic brain injury","volume":"52","author":"SD Friedman","year":"1999","journal-title":"Neurology"},{"issue":"8","key":"ref26","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1089\/089771500415382","article-title":"Metabolic and cognitive response to human traumatic brain injury: a quantitative proton magnetic resonance study","volume":"17","author":"WM Brooks","year":"2000","journal-title":"J Neurotrauma"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/00001199-200104000-00005","article-title":"Magnetic resonance spectroscopy in traumatic brain injury","volume":"16","author":"WM Brooks","year":"2001","journal-title":"J Head Trauma Rehabil"},{"issue":"Pt 10","key":"ref28","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1093\/brain\/123.10.2046","article-title":"Early proton magnetic resonance spectroscopy in normal-appearing brain correlates with outcome in patients following traumatic brain injury","volume":"123","author":"MR Garnett","year":"2000","journal-title":"Brain"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/jmri.20696","article-title":"MR spectroscopy: predicting long-term neuropsychological outcome following pediatric TBI","volume":"24","author":"T Babikian","year":"2006","journal-title":"J Magn Reson Imaging"},{"issue":"12","key":"ref30","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1089\/neu.2004.21.1693","article-title":"Proton MRS in acute traumatic brain injury: role for glutamate\/glutamine and choline for outcome prediction","volume":"21","author":"L Shutter","year":"2004","journal-title":"J Neurotrauma"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/jmri.20607","article-title":"Prospective longitudinal proton magnetic resonance spectroscopic imaging in adult traumatic brain injury","volume":"24","author":"BA Holshouser","year":"2006","journal-title":"J Magn Reson Imaging"},{"issue":"10","key":"ref32","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1089\/neu.2009.0896","article-title":"Neurometabolite concentrations in gray and white matter in mild traumatic brain injury: an 1H-magnetic resonance spectroscopy study","volume":"26","author":"C Gasparovic","year":"2009","journal-title":"J Neurotrauma"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1089\/neu.2009.1159","article-title":"Whole-brain proton MR spectroscopic imaging of mild-to-moderate traumatic brain injury and correlation with neuropsychological deficits","volume":"27","author":"V Govind","year":"2010","journal-title":"J Neurotrauma"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12028-010-9406-6","article-title":"1H-MR spectroscopy in traumatic brain injury","volume":"14","author":"S Marino","year":"2011","journal-title":"Neurocrit Care"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1227\/01.NEU.0000163413.90259.85","article-title":"Hypothesis of the postconcussive vulnerable brain: experimental evidence of its metabolic occurrence","volume":"57","author":"R Vagnozzi","year":"2005","journal-title":"Neurosurgery"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1227\/01.NEU.0000280002.41696.D8","article-title":"Temporal window of metabolic brain vulnerability to concussions: mitochondrial-related impairment\u2014part I","volume":"61","author":"R Vagnozzi","year":"2007","journal-title":"Neurosurgery"},{"issue":"11","key":"ref37","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1089\/neu.2013.3224","article-title":"Longitudinal and prognostic evaluation of mild traumatic brain injury: A 1H-magnetic resonance spectroscopy study","volume":"31","author":"EO George","year":"2014","journal-title":"J Neurotrauma"},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/nbm.698","article-title":"Automatic quantitation of localized in vivo 1H spectra with LCModel","volume":"14","author":"SW Provencher","year":"2001","journal-title":"NMR Biomed"},{"issue":"13","key":"ref39","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0024-3205(99)00038-7","article-title":"Model development and behavioral assessment of focal cerebral ischemia in rats","volume":"64","author":"D Petullo","year":"1999","journal-title":"Life Sci"},{"issue":"11","key":"ref40","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1089\/089771501317095241","article-title":"Neurobehavioral assessment of outcome following traumatic brain injury in rats: an evaluation of selected measures","volume":"18","author":"RJ Hamm","year":"2001","journal-title":"J Neurotrauma"},{"key":"ref41","author":"SK Salzman","year":"1994"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/0006-8993(92)90085-N","article-title":"Sensorimotor and cognitive consequences of middle cerebral artery occlusion in rats","volume":"575","author":"CG Markgraf","year":"1992","journal-title":"Brain Res"},{"issue":"5","key":"ref43","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1161\/01.STR.31.5.1144","article-title":"Early exclusive use of the affected forelimb after moderate transient focal ischemia in rats: functional and anatomic outcome","volume":"31","author":"ST Bland","year":"2000","journal-title":"Stroke"},{"issue":"5","key":"ref44","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0028-3908(00)00005-8","article-title":"CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury","volume":"39","author":"T Schallert","year":"2000","journal-title":"Neuropharmacology"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","DOI":"10.1186\/2040-7378-2-13","article-title":"Functional assessments in the rodent stroke model","volume":"2","author":"KL Schaar","year":"2010","journal-title":"Exp Transl Stroke Med"},{"issue":"12","key":"ref46","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1097\/NEN.0b013e3181fbf6d6","article-title":"Glibenclamide reduces hippocampal injury and preserves rapid spatial learning in a model of traumatic brain injury","volume":"69","author":"AD Patel","year":"2010","journal-title":"J Neuropathol Exp Neurol"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3390\/brainsci3010215","article-title":"The protective effect of glibenclamide in a model of hemorrhagic encephalopathy of prematurity","volume":"3","author":"C Tosun","year":"2013","journal-title":"Brain Sci"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0165-0173(01)00067-4","article-title":"Applications of the Morris water maze in the study of learning and memory","volume":"36","author":"R D'Hooge","year":"2001","journal-title":"Brain Res Brain Res Rev"},{"issue":"5867","key":"ref49","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1126\/science.1151120","article-title":"Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning","volume":"319","author":"T Nakashiba","year":"2008","journal-title":"Science"},{"issue":"5834","key":"ref50","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1126\/science.1140263","article-title":"Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network","volume":"317","author":"TJ McHugh","year":"2007","journal-title":"Science"},{"issue":"1","key":"ref51","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.brainres.2004.11.054","article-title":"Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons","volume":"1035","author":"LC Schmued","year":"2005","journal-title":"Brain Res"},{"issue":"9","key":"ref52","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1161\/01.RES.0000097872.69043.A0","article-title":"Alternative splicing of cGMP-dependent protein kinase I in angiotensin-hypertension: novel mechanism for nitrate tolerance in vascular smooth muscle","volume":"93","author":"V Gerzanich","year":"2003","journal-title":"Circ Res"},{"issue":"5","key":"ref53","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.neuron.2004.05.010","article-title":"A double dissociation between hippocampal subfields: differential time course of CA3 and CA1 place cells for processing changed environments","volume":"42","author":"I Lee","year":"2004","journal-title":"Neuron"},{"issue":"5814","key":"ref54","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1126\/science.1135801","article-title":"Pattern separation in the dentate gyrus and CA3 of the hippocampus","volume":"315","author":"JK Leutgeb","year":"2007","journal-title":"Science"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fneur.2012.00030","article-title":"Experimental animal models for studies on the mechanisms of blast-induced neurotrauma","volume":"3","author":"M Risling","year":"2012","journal-title":"Front Neurol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3389\/fneur.2012.00015","article-title":"Neuro-glial and systemic mechanisms of pathological responses in rat models of primary blast overpressure compared to "composite" blast","volume":"3","author":"SI Svetlov","year":"2012","journal-title":"Front Neurol"},{"issue":"2","key":"ref57","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0006-8993(79)90071-4","article-title":"Fine structural localization of glutamine synthetase in astrocytes of rat brain","volume":"161","author":"MD Norenberg","year":"1979","journal-title":"Brain Res"},{"issue":"2","key":"ref58","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jmr.2006.07.003","article-title":"In vivo dynamic turnover of cerebral 13C isotopomers from [U-13C]glucose","volume":"182","author":"S Xu","year":"2006","journal-title":"J Magn Reson"},{"issue":"4","key":"ref59","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/hep.21357","article-title":"Glutamine: a Trojan horse in ammonia neurotoxicity","volume":"44","author":"J Albrecht","year":"2006","journal-title":"Hepatology"},{"issue":"5\u20136","key":"ref60","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1159\/000017476","article-title":"Effects of ammonia exposition on glioma cells: changes in cell volume and organic osmolytes studied by diffusion-weighted and high-resolution NMR spectroscopy","volume":"22","author":"C Zwingmann","year":"2000","journal-title":"Dev Neurosci"},{"issue":"2","key":"ref61","doi-asserted-by":"crossref","first-page":"96","DOI":"10.2340\/16501977-0130","article-title":"Impact of internal capsule lesions on outcome of motor hand function at one year post-stroke","volume":"40","author":"SK Schiemanck","year":"2008","journal-title":"J Rehabil Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0136151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T15:56:15Z","timestamp":1540310175000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0136151"}},"subtitle":[],"editor":[{"given":"Kimberly R.","family":"Byrnes","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,8,24]]},"references-count":61,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0136151","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,24]]}}}