{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:46:15Z","timestamp":1791179175307,"version":"4.1.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T00:00:00Z","timestamp":1439942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0136193","type":"journal-article","created":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T13:56:35Z","timestamp":1439992595000},"page":"e0136193","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":26,"title":["Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT\/mTOR Signaling"],"prefix":"10.1371","volume":"10","author":[{"given":"Peng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronglin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyuan","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,8,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jamcollsurg.2008.02.031","article-title":"Surgery for gallbladder cancer: a population-based analysis","volume":"207","author":"NG Coburn","year":"2008","journal-title":"J Am Coll Surg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3892\/or.2012.2073","article-title":"SAHA down-regulates the expression of indoleamine 2,3-dioxygenase via inhibition of the JAK\/STAT1 signaling pathway in gallbladder carcinoma cells","volume":"29","author":"P Zhang","year":"2013","journal-title":"Oncol Rep"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1440-1746.2005.03576.x","article-title":"Gallbladder cancer in India: a dismal picture","volume":"20","author":"Y Batra","year":"2005","journal-title":"J Gastroenterol Hepatol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1097\/00000658-199611000-00008","article-title":"Long-term results after resection for gallbladder cancer. Implications for staging and management","volume":"224","author":"DL Bartlett","year":"1996","journal-title":"Ann Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jamcollsurg.2010.09.009","article-title":"Gallbladder cancer: differences in presentation, surgical treatment, and survival in patients treated at centers in three countries","volume":"212","author":"JM Butte","year":"2011","journal-title":"J Am Coll Surg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.ijrobp.2004.12.059","article-title":"Adjuvant external-beam radiotherapy with concurrent chemotherapy after resection of primary gallbladder carcinoma: a 23-year experience","volume":"62","author":"BG Czito","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.canlet.2008.08.016","article-title":"HDAC family: What are the cancer relevant targets?","volume":"277","author":"O Witt","year":"2009","journal-title":"Cancer Lett"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"6693","DOI":"10.1038\/sj.onc.1207893","article-title":"Histone deacetylase inhibitors specifically kill nonproliferating tumour cells","volume":"23","author":"A Burgess","year":"2004","journal-title":"Oncogene"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.canlet.2009.03.013","article-title":"Histone deacetylase inhibitors as anti-neoplastic agents","volume":"280","author":"N Batty","year":"2009","journal-title":"Cancer Lett"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1517\/13543784.17.2.169","article-title":"Histone deacetylase inhibitors: possible implications for neurodegenerative disorders","volume":"17","author":"E Hahnen","year":"2008","journal-title":"Expert Opin Investig Drugs"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.2174\/156802610792232079","article-title":"Macrocyclic histone deacetylase inhibitors","volume":"10","author":"SC Mwakwari","year":"2010","journal-title":"Curr Top Med Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/CAD.0b013e328012a5db","article-title":"Histone deacetylase inhibitors for epigenetic therapy of cancer","volume":"18","author":"C Monneret","year":"2007","journal-title":"Anticancer Drugs"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1200\/JCO.2005.16.600","article-title":"Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies","volume":"23","author":"KN Bhalla","year":"2005","journal-title":"J Clin Oncol"},{"key":"ref14","first-page":"377","article-title":"Update on the treatment of cutaneous T-cell lymphoma (CTCL): Focus on vorinostat","volume":"1","author":"M Duvic","year":"2007","journal-title":"Biologics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.canlet.2011.09.004","article-title":"Vascular endothelial growth factor-D promotes growth, lymphangiogenesis and lymphatic metastasis in gallbladder cancer","volume":"314","author":"W Lin","year":"2012","journal-title":"Cancer Lett"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3892\/or.2012.2073","article-title":"SAHA down-regulates the expression of indoleamine 2, 3-dioxygenase via inhibition of the JAK\/STAT1 signaling pathway in gallbladder carcinoma cells","volume":"29","author":"P Zhang","year":"2013","journal-title":"Oncol Rep"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1182\/blood-2005-11-026344","article-title":"Suberoylanilide hydroxamic acid (SAHA; vorinostat) suppresses translation of cyclin D1 in mantle cell lymphoma cells","volume":"110","author":"N Kawamata","year":"2007","journal-title":"Blood"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/MOG.0000000000000068","article-title":"Aspects on gallbladder cancer in 2014","volume":"30","author":"A \u00c5ndr\u00e9n-Sandberg","year":"2014","journal-title":"Curr Opin Gastroenterol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.1038\/sj.onc.1210620","article-title":"Histone deacetylase inhibitors: molecular mechanisms of action","volume":"26","author":"WS Xu","year":"2007","journal-title":"Oncogene"},{"key":"ref20","article-title":"Synergistic Loss of Prostate Cancer Cell Viability by Co-inhibition of HDAC and PARP","author":"OS Chao","year":"2014","journal-title":"Mol Cancer Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1349-7006.2009.01387.x","article-title":"Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma","volume":"101","author":"J Yamaguchi","year":"2010","journal-title":"Cancer Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s11060-011-0791-2","article-title":"P53-dependent antiproliferative and pro-apoptotic effects of trichostatin A (TSA) in glioblastoma cells","volume":"107","author":"K Bajbouj","year":"2012","journal-title":"J Neurooncol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jhep.2012.01.018","article-title":"The therapeutic effect of histone deacetylase inhibitor PCI-24781 on gallbladder carcinoma in BK5.erbB2 mice","volume":"57","author":"T Kitamura","year":"2012","journal-title":"J Hepatol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S1471-4892(03)00071-7","article-title":"Targeting mTOR signaling for cancer therapy","volume":"3","author":"S Huang","year":"2003","journal-title":"Curr Opin Pharmacol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2012.01.005","article-title":"mTOR inhibitors in cancer therapy","volume":"319","author":"YY Zaytseva","year":"2012","journal-title":"Cancer Lett"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2174\/138161210789941865","article-title":"The PKB\/AKT pathway in cancer","volume":"16","author":"A Carnero","year":"2010","journal-title":"Curr Pharm Des"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1101\/gad.1212704","article-title":"Upstream and downstream of mTOR","volume":"18","author":"N Hay","year":"2004","journal-title":"Genes Dev"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.ccr.2004.05.027","article-title":"Lost in translation: dysregulation of cap-dependent translation and cancer","volume":"5","author":"MA Bjornsti","year":"2004","journal-title":"Cancer Cell"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1038\/leu.2008.243","article-title":"Blockade of mTOR signaling potentiates the ability of histone deacetylase inhibitor to induce growth arrest and differentiation of acute myelogenous leukemia cells","volume":"22","author":"C Nishioka","year":"2008","journal-title":"Leukemia"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jep.2011.04.034","article-title":"NBM-HD-3, a novel histone deacetylase inhibitor with anticancer activity through modulation of PTEN and AKT in brain cancer cells","volume":"136","author":"WJ Huang","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/bjc.2011.495","article-title":"Preclinical evaluation of dual PI3K-mTOR inhibitors and histone deacetylase inhibitors in head and neck squamous cell carcinoma","volume":"106","author":"RB Erlich","year":"2012","journal-title":"Br J Cancer"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.18632\/oncotarget.1314","article-title":"Combinatorial antitumor effect of HDAC and the PI3K-Akt-mTOR pathway inhibition in a Pten defecient model of prostate cancer","volume":"4","author":"L Ellis","year":"2013","journal-title":"Oncotarget"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1182\/blood-2009-05-220889","article-title":"Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2","volume":"114","author":"M Gupta","year":"2009","journal-title":"Blood"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0136193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T11:59:11Z","timestamp":1567079951000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0136193"}},"subtitle":[],"editor":[{"given":"Wei-Guo","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,8,19]]},"references-count":33,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0136193","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,19]]}}}