{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T18:53:10Z","timestamp":1785783190259,"version":"3.56.0"},"reference-count":16,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T00:00:00Z","timestamp":1440547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0136513","type":"journal-article","created":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T18:10:32Z","timestamp":1440612632000},"page":"e0136513","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["The Troy Microneedle: A Rapidly Separating, Dissolving Microneedle Formed by Cyclic Contact and Drying on the Pillar (CCDP)"],"prefix":"10.1371","volume":"10","author":[{"given":"Miroo","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huisuk","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungil","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,8,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3134","DOI":"10.1016\/j.biomaterials.2011.01.014","article-title":"Dissolving microneedles for transdermal drug administration prepared by stepwise controlled drawing of maltose","volume":"32","author":"K Lee","year":"2011","journal-title":"Biomaterials"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"7705","DOI":"10.1016\/j.biomaterials.2011.06.058","article-title":"A high-capacity, hybrid electro-microneedle for in-situ cutaneous gene transfer","volume":"32","author":"K Lee","year":"2011","journal-title":"Biomaterials"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1016\/j.biomaterials.2007.12.048","article-title":"Dissolving microneedles for transdermal drug delivery","volume":"29","author":"JW Lee","year":"2008","journal-title":"Biomaterials"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/ics.12115","article-title":"Novel cosmetic patches for wrinkle improvement: retinyl retinoate-and ascorbic acid-loaded dissolving microneedles","volume":"36","author":"M Kim","year":"2014","journal-title":"Int J Cosmet Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.1016\/j.biomaterials.2011.03.012","article-title":"The viscoelastic, hyperelastic and scale dependent behaviour of freshly excised individual skin layers","volume":"32","author":"ML Crichton","year":"2011","journal-title":"Biomaterials"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.jbiomech.2003.12.010","article-title":"Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force","volume":"37","author":"SP Davis","year":"2004","journal-title":"J Biomech"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1016\/j.tiv.2010.08.012","article-title":"Effects of microneedle length, density, insertion time and multiple applications on human skin barrier function: assessments by transepidermal water loss","volume":"24","author":"YA Gomaa","year":"2010","journal-title":"Toxicol In Vitro"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/01206501-199712000-00010","article-title":"Allergic contact dermatitis from hydrocolloid dressings","volume":"8","author":"D Sasseville","year":"1997","journal-title":"Dermatitis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11095-010-0097-7","article-title":"Two-layered dissolving microneedles for percutaneous delivery of peptide\/protein drugs in rats","volume":"28","author":"K Fukushima","year":"2011","journal-title":"Pharm Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1002\/adma.201300526","article-title":"Rapidly\u2013dissolvable microneedle patches via a highly scalable and reproducible soft lithography approach","volume":"25","author":"KA Moga","year":"2013","journal-title":"Adv Mater"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jconrel.2010.10.033","article-title":"Separable arrowhead microneedles","volume":"149","author":"LY Chu","year":"2011","journal-title":"J Control Release"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1016\/j.biomaterials.2012.12.041","article-title":"Fully embeddable chitosan microneedles as a sustained release depot for intradermal vaccination","volume":"34","author":"M-C Chen","year":"2013","journal-title":"Biomaterials"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"7309","DOI":"10.1016\/j.biomaterials.2012.06.065","article-title":"Drawing lithography for microneedles: a review of fundamentals and biomedical applications","volume":"33","author":"K Lee","year":"2012","journal-title":"Biomaterials"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/adma.200902418","article-title":"Drawing Lithography: Three-Dimensional Fabrication of an Ultrahigh-Aspect-Ratio Microneedle","volume":"22","author":"K Lee","year":"2010","journal-title":"Adv Mater"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jconrel.2013.05.026","article-title":"Droplet-born air blowing: Novel dissolving microneedle fabrication","volume":"170","author":"JD Kim","year":"2013","journal-title":"J Control Release"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.cherd.2008.06.002","article-title":"Transdermal drug delivery by coated microneedles: geometry effects on effective skin thickness and drug permeability","volume":"86","author":"A Davidson","year":"2008","journal-title":"Chem Eng Res Des"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0136513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T09:35:04Z","timestamp":1540287304000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0136513"}},"subtitle":[],"editor":[{"given":"Anne C","family":"Moore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,8,26]]},"references-count":16,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0136513","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,26]]}}}