{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:40:40Z","timestamp":1791232840346,"version":"4.1.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T00:00:00Z","timestamp":1440633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0136633","type":"journal-article","created":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T14:06:59Z","timestamp":1440684419000},"page":"e0136633","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Activation of p38 Mitogen-Activated Protein Kinase in Gaucher\u2019s Disease"],"prefix":"10.1371","volume":"10","author":[{"given":"Kazuyuki","family":"Kitatani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinori","family":"Usui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina M.","family":"Obeid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Yaegashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Grabowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf A.","family":"Hannun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,8,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1146\/annurev.bi.47.070178.003351","article-title":"Sphingolipidoses","volume":"47","author":"RO Brady","year":"1978","journal-title":"Annu Rev Biochem"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1073\/pnas.83.6.1660","article-title":"Human acid beta-glucosidase: isolation and amino acid sequence of a peptide containing the catalytic site","volume":"83","author":"T Dinur","year":"1986","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref3","first-page":"377","article-title":"Gaucher disease. Enzymology, genetics, and treatment","volume":"21","author":"GA Grabowski","year":"1993","journal-title":"Adv Hum Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nrm1423","article-title":"The cell biology of lysosomal storage disorders","volume":"5","author":"AH Futerman","year":"2004","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1136\/jmg.30.11.889","article-title":"The glucocerebrosidase locus in Gaucher's disease: molecular analysis of a lysosomal enzyme","volume":"30","author":"PK Mistry","year":"1993","journal-title":"Journal of medical genetics"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev.genom.4.070802.110415","article-title":"Enzyme therapy for lysosomal storage disease: principles, practice, and prospects","volume":"4","author":"GA Grabowski","year":"2003","journal-title":"Annual review of genomics and human genetics"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1365-2141.2004.05351.x","article-title":"Gaucher disease: pathological mechanisms and modern management","volume":"129","author":"M Jmoudiak","year":"2005","journal-title":"British journal of haematology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1093\/brain\/aws095","article-title":"Contribution of brain inflammation to neuronal cell death in neuronopathic forms of Gaucher's disease","volume":"135","author":"EB Vitner","year":"2012","journal-title":"Brain"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ymgme.2012.04.020","article-title":"Immunological cell type characterization and Th1-Th17 cytokine production in a mouse model of Gaucher disease","volume":"106","author":"MK Pandey","year":"2012","journal-title":"Molecular genetics and metabolism"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1006\/bcmd.1997.0137","article-title":"Elevated levels of M-CSF, sCD14 and IL8 in type 1 Gaucher disease","volume":"23","author":"CE Hollak","year":"1997","journal-title":"Blood Cells Mol Dis"},{"key":"ref11","first-page":"205","article-title":"Cytokines in Gaucher's disease","volume":"10","author":"V Barak","year":"1999","journal-title":"Eur Cytokine Netw"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/qjmed\/90.1.19","article-title":"Pro-inflammatory cytokines and the pathogenesis of Gaucher's disease: increased release of interleukin-6 and interleukin-10","volume":"90","author":"MJ Allen","year":"1997","journal-title":"QJM"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1172\/JCI0214530","article-title":"Systemic inflammation in glucocerebrosidase-deficient mice with minimal glucosylceramide storage","volume":"109","author":"H Mizukami","year":"2002","journal-title":"J Clin Invest"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/ana.20242","article-title":"NSAIDs increase survival in the Sandhoff disease mouse: synergy with N-butyldeoxynojirimycin","volume":"56","author":"M Jeyakumar","year":"2004","journal-title":"Annals of neurology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.nbd.2009.07.010","article-title":"Beneficial effects of anti-inflammatory therapy in a mouse model of Niemann-Pick disease type C1","volume":"36","author":"D Smith","year":"2009","journal-title":"Neurobiology of disease"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"12979","DOI":"10.1074\/jbc.M809500200","article-title":"Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid","volume":"284","author":"K Kitatani","year":"2009","journal-title":"The Journal of biological chemistry"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"12972","DOI":"10.1074\/jbc.M802790200","article-title":"Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation","volume":"284","author":"K Kitatani","year":"2009","journal-title":"The Journal of biological chemistry"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.bbamcr.2007.03.010","article-title":"p38 MAP-kinases pathway regulation, function and role in human diseases","volume":"1773","author":"A Cuenda","year":"2007","journal-title":"Biochimica et biophysica acta"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.molmed.2009.06.005","article-title":"p38(MAPK): stress responses from molecular mechanisms to therapeutics","volume":"15","author":"LR Coulthard","year":"2009","journal-title":"Trends in molecular medicine"},{"key":"ref20","first-page":"199","article-title":"The p38 MAP Kinase Family as Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS","volume":"1","author":"AD Bachstetter","year":"2010","journal-title":"Aging and disease"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1016\/S0002-9440(10)63566-3","article-title":"Viable mouse models of acid beta-glucosidase deficiency: the defect in Gaucher disease","volume":"163","author":"YH Xu","year":"2003","journal-title":"Am J Pathol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1194\/jlr.M500202-JLR200","article-title":"Gaucher disease mouse models: point mutations at the acid beta-glucosidase locus combined with low-level prosaposin expression lead to disease variants","volume":"46","author":"Y Sun","year":"2005","journal-title":"J Lipid Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"PK Smith","year":"1985","journal-title":"Analytical biochemistry"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"10061","DOI":"10.1073\/pnas.90.21.10061","article-title":"Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6","volume":"90","author":"IL Campbell","year":"1993","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"36793","DOI":"10.1074\/jbc.M608137200","article-title":"Protein kinase C-induced activation of a ceramide\/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK","volume":"281","author":"K Kitatani","year":"2006","journal-title":"The Journal of biological chemistry"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e19037","DOI":"10.1371\/journal.pone.0019037","article-title":"Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse","volume":"6","author":"Y Sun","year":"2011","journal-title":"PLoS One"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nrd1177","article-title":"p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases","volume":"2","author":"S Kumar","year":"2003","journal-title":"Nat Rev Drug Discov"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1042\/BJ20100323","article-title":"Mechanisms and functions of p38 MAPK signalling","volume":"429","author":"A Cuadrado","year":"2010","journal-title":"The Biochemical journal"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.cellsig.2004.04.006","article-title":"The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation","volume":"16","author":"JL Dean","year":"2004","journal-title":"Cellular signalling"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.molmed.2004.01.007","article-title":"p38 MAP kinase: a convergence point in cancer therapy","volume":"10","author":"JM Olson","year":"2004","journal-title":"Trends in molecular medicine"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0165-5728(96)00184-1","article-title":"TNF-alpha transgenic and knockout models of CNS inflammation and degeneration","volume":"72","author":"L Probert","year":"1997","journal-title":"Journal of neuroimmunology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"11294","DOI":"10.1073\/pnas.92.24.11294","article-title":"Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha","volume":"92","author":"L Probert","year":"1995","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0301-0082(98)00045-8","article-title":"The role of tumour necrosis factor, interleukin 6, interferon-gamma and inducible nitric oxide synthase in the development and pathology of the nervous system","volume":"56","author":"MA Munoz-Fernandez","year":"1998","journal-title":"Progress in neurobiology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0136633","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T11:34:36Z","timestamp":1540208076000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0136633"}},"subtitle":[],"editor":[{"given":"Rasheed","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,8,27]]},"references-count":33,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0136633","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,27]]}}}