{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:57:47Z","timestamp":1780549067433,"version":"3.54.1"},"reference-count":89,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T00:00:00Z","timestamp":1440979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0136707","type":"journal-article","created":{"date-parts":[[2015,8,31]],"date-time":"2015-08-31T17:47:52Z","timestamp":1441043272000},"page":"e0136707","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Absence of sodA Increases the Levels of Oxidation of Key Metabolic Determinants of Borrelia burgdorferi"],"prefix":"10.1371","volume":"10","author":[{"given":"Maria D.","family":"Esteve-Gassent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trever C.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina M.","family":"Small","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek P.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Seshu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,8,31]]},"reference":[{"issue":"8","key":"ref1","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1172\/JCI21681","article-title":"The emergence of Lyme disease","volume":"113","author":"AC Steere","year":"2004","journal-title":"J Clin Invest"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1172\/JCI2325","article-title":"A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state","volume":"101","author":"DR Akins","year":"1998","journal-title":"J Clin Invest"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1046\/j.1365-2958.2003.03537.x","article-title":"Transcriptional regulation of the ospAB and ospC promoters from Borrelia burgdorferi","volume":"48","author":"J Alverson","year":"2003","journal-title":"Mol Microbiol"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1128\/IAI.72.4.2035-2044.2004","article-title":"Whole-genome DNA array analysis of the response of Borrelia burgdorferi to a bactericidal monoclonal antibody","volume":"72","author":"JM Anderton","year":"2004","journal-title":"Infect Immun"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0168-6445(03)00036-6","article-title":"Adaptation of Borrelia burgdorferi in the tick and the mammalian host","volume":"27","author":"J Anguita","year":"2003","journal-title":"FEMS Microbiol Rev"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1128\/IAI.71.6.3371-3383.2003","article-title":"Global analysis of Borrelia burgdorferi genes regulated by mammalian host-specific signals","volume":"71","author":"CS Brooks","year":"2003","journal-title":"Infect Immun"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","first-page":"6677","DOI":"10.1128\/IAI.68.12.6677-6684.2000","article-title":"Identification of 11 pH-regulated genes in Borrelia burgdorferi localizing to linear plasmids","volume":"68","author":"JA Carroll","year":"2000","journal-title":"Infect Immun"},{"issue":"7","key":"ref8","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1128\/IAI.67.7.3181-3187.1999","article-title":"Effects of environmental pH on membrane proteins in Borrelia burgdorferi","volume":"67","author":"JA Carroll","year":"1999","journal-title":"Infect Immun"},{"issue":"22","key":"ref9","doi-asserted-by":"crossref","first-page":"7845","DOI":"10.1128\/JB.187.22.7845-7852.2005","article-title":"Alternate sigma factor RpoS is required for the in vivo-specific repression of Borrelia burgdorferi plasmid lp54-borne ospA and lp6.6 genes","volume":"187","author":"MJ Caimano","year":"2005","journal-title":"J Bacteriol"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"6433","DOI":"10.1128\/IAI.72.11.6433-6445.2004","article-title":"RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants","volume":"72","author":"MJ Caimano","year":"2004","journal-title":"Infect Immun"},{"key":"ref11","article-title":"Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle","author":"MJ Caimano","year":"2007","journal-title":"Mol Microbiol"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1365-2958.2007.05813.x","article-title":"Insights into the complex regulation of rpoS in Borrelia burgdorferi","volume":"65","author":"MN Burtnick","year":"2007","journal-title":"Mol Microbiol"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1128\/IAI.71.4.1689-1705.2003","article-title":"Profiling of temperature-induced changes in Borrelia burgdorferi gene expression by using whole genome arrays","volume":"71","author":"C Ojaimi","year":"2003","journal-title":"Infect Immun"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1073\/pnas.032667699","article-title":"DNA microarray analysis of differential gene expression in Borrelia burgdorferi, the Lyme disease spirochete","volume":"99","author":"AT Revel","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1046\/j.1365-2958.2000.02104.x","article-title":"Interdependence of environmental factors influencing reciprocal patterns of gene expression in virulent Borrelia burgdorferi","volume":"37","author":"X Yang","year":"2000","journal-title":"Mol Microbiol"},{"issue":"19","key":"ref16","doi-asserted-by":"crossref","first-page":"11001","DOI":"10.1073\/pnas.1834315100","article-title":"The response regulator Rrp2 is essential for the expression of major membrane lipoproteins in Borrelia burgdorferi","volume":"100","author":"XF Yang","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7050","key":"ref17","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nature03812","article-title":"The Lyme disease agent exploits a tick protein to infect the mammalian host","volume":"436","author":"N Ramamoorthi","year":"2005","journal-title":"Nature"},{"issue":"22","key":"ref18","doi-asserted-by":"crossref","first-page":"12724","DOI":"10.1073\/pnas.231442498","article-title":"Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway","volume":"98","author":"A Hubner","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/j.1365-2958.2008.06549.x","article-title":"sodA is essential for virulence of Borrelia burgdorferi in the murine model of Lyme disease","volume":"71","author":"MD Esteve-Gassent","year":"2009","journal-title":"Mol Microbiol"},{"issue":"12","key":"ref20","doi-asserted-by":"crossref","first-page":"8468","DOI":"10.1074\/jbc.M112.433540","article-title":"A manganese-rich environment supports superoxide dismutase activity in a Lyme disease pathogen, Borrelia burgdorferi","volume":"288","author":"JD Aguirre","year":"2013","journal-title":"J Biol Chem"},{"issue":"23","key":"ref21","doi-asserted-by":"crossref","first-page":"19284","DOI":"10.1074\/jbc.M112.344903","article-title":"Borrelia burgdorferi, a pathogen that lacks iron, encodes manganese-dependent superoxide dismutase essential for resistance to streptonigrin","volume":"287","author":"B Troxell","year":"2012","journal-title":"J Biol Chem"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"e451","DOI":"10.1371\/journal.pone.0000451","article-title":"Immunity against Ixodes scapularis salivary proteins expressed within 24 hours of attachment thwarts tick feeding and impairs Borrelia transmission","volume":"2","author":"S Narasimhan","year":"2007","journal-title":"PloS one"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1046\/j.1365-2583.2002.00375.x","article-title":"A novel family of anticoagulants from the saliva of Ixodes scapularis","volume":"11","author":"S Narasimhan","year":"2002","journal-title":"Insect Mol Biol"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1073\/pnas.0307669100","article-title":"Disruption of Ixodes scapularis anticoagulation by using RNA interference","volume":"101","author":"S Narasimhan","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5471","key":"ref25","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1126\/science.288.5471.1651","article-title":"Lack of a role for iron in the Lyme disease pathogen","volume":"288","author":"JE Posey","year":"2000","journal-title":"Science"},{"key":"ref26","first-page":"213","article-title":"Determining the cellular targets of reactive oxygen species in Borrelia burgdorferi","volume":"431","author":"JA Boylan","year":"2008","journal-title":"Methods Mol Biol"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.1365-2958.2008.06204.x","article-title":"Borrelia burgdorferi membranes are the primary targets of reactive oxygen species","volume":"68","author":"JA Boylan","year":"2008","journal-title":"Mol Microbiol"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1365-2958.2011.07691.x","article-title":"Nitrosative damage to free and zinc-bound cysteine thiols underlies nitric oxide toxicity in wild-type Borrelia burgdorferi","volume":"81","author":"TJ Bourret","year":"2011","journal-title":"Mol Microbiol"},{"issue":"10","key":"ref29","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S1286-4579(00)01278-8","article-title":"Expression and role of superoxide dismutases (SOD) in pathogenic bacteria","volume":"2","author":"M Lynch","year":"2000","journal-title":"Microbes Infect"},{"issue":"11","key":"ref30","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1128\/IAI.65.11.4705-4710.1997","article-title":"Contribution of the Mn-cofactored superoxide dismutase (SodA) to the virulence of Yersinia enterocolitica serotype O8","volume":"65","author":"A Roggenkamp","year":"1997","journal-title":"Infect Immun"},{"issue":"14","key":"ref31","doi-asserted-by":"crossref","first-page":"7993","DOI":"10.1073\/pnas.95.14.7993","article-title":"Gp91(phox) is the heme binding subunit of the superoxide-generating NADPH oxidase","volume":"95","author":"L Yu","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.immunol.15.1.323","article-title":"Nitric oxide and macrophage function","volume":"15","author":"J MacMicking","year":"1997","journal-title":"Annu Rev Immunol"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0092-8674(95)90085-3","article-title":"Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase","volume":"81","author":"JD MacMicking","year":"1995","journal-title":"Cell"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/gb-2006-7-3-209","article-title":"The dynamic proteome of Lyme disease Borrelia","volume":"7","author":"SJ Norris","year":"2006","journal-title":"Genome Biol"},{"issue":"7","key":"ref35","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1128\/IAI.00189-06","article-title":"Serologic proteome analysis of Borrelia burgdorferi membrane-associated proteins","volume":"74","author":"AJ Nowalk","year":"2006","journal-title":"Infect Immun"},{"issue":"7","key":"ref36","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1002\/pmic.200500187","article-title":"Comparative proteome analysis of subcellular fractions from Borrelia burgdorferi by NEPHGE and IPG","volume":"6","author":"AJ Nowalk","year":"2006","journal-title":"Proteomics"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1111\/j.1365-2958.2005.05042.x","article-title":"Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi","volume":"59","author":"J Seshu","year":"2006","journal-title":"Mol Microbiol"},{"issue":"8","key":"ref38","doi-asserted-by":"crossref","first-page":"4608","DOI":"10.1128\/IAI.71.8.4608-4613.2003","article-title":"The absence of linear plasmid 25 or 28\u20131 of Borrelia burgdorferi dramatically alters the kinetics of experimental infection via distinct mechanisms","volume":"71","author":"M Labandeira-Rey","year":"2003","journal-title":"Infect Immun"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1128\/IAI.69.1.446-455.2001","article-title":"Decreased infectivity in Borrelia burgdorferi strain B31 is associated with loss of linear plasmid 25 or 28\u20131","volume":"69","author":"M Labandeira-Rey","year":"2001","journal-title":"Infect Immun"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1006\/abbi.1999.1680","article-title":"Adaptation of protein carbonyl detection to the requirements of proteome analysis demonstrated for hypoxia\/reoxygenation in isolated rat liver mitochondria","volume":"376","author":"T Reinheckel","year":"2000","journal-title":"Arch Biochem Biophys"},{"issue":"5","key":"ref41","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1021\/ac950914h","article-title":"Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels","volume":"68","author":"A Shevchenko","year":"1996","journal-title":"Anal Chem"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jprot.2009.10.003","article-title":"A proteomic analysis of secretory proteins of a pre-vacuolar mutant of Candida albicans","volume":"73","author":"DP Thomas","year":"2009","journal-title":"J Proteomics"},{"issue":"4","key":"ref43","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2174\/187152606779025815","article-title":"Proteomics to study Candida albicans biology and pathogenicity","volume":"6","author":"DP Thomas","year":"2006","journal-title":"Infect Disord Drug Targets"},{"issue":"9","key":"ref44","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1002\/pmic.200800713","article-title":"A proteomic-based approach for the identification of immunodominant Cryptococcus neoformans proteins","volume":"9","author":"M Young","year":"2009","journal-title":"Proteomics"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1128\/IAI.01118-07","article-title":"Role of the BBA64 locus of Borrelia burgdorferi in early stages of infectivity in a murine model of Lyme disease","volume":"76","author":"M Maruskova","year":"2008","journal-title":"Infect Immun"},{"key":"ref46","article-title":"Deletion of bba64, bba65 and bba66 loci does not alter the infectivity of Borrelia burgdorferi in the murine model of Lyme disease","author":"M Maruskova","year":"2008","journal-title":"Infect Immun"},{"key":"ref47","article-title":"Overexpression of BbCsrA (BB0184) alters morphology and antigen profiles of Borrelia burgdorferi","author":"E Sanjuan","year":"2009","journal-title":"Infect Immun"},{"issue":"4","key":"ref48","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cell.2004.10.027","article-title":"TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi","volume":"119","author":"U Pal","year":"2004","journal-title":"Cell"},{"issue":"7","key":"ref49","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1080\/10715760802209639","article-title":"An SOD mimic protects NADP+-dependent isocitrate dehydrogenase against oxidative inactivation","volume":"42","author":"I Batinic-Haberle","year":"2008","journal-title":"Free Radic Res"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/sj.embor.embor799","article-title":"Differential oxidative damage and expression of stress defence regulons in culturable and non-culturable Escherichia coli cells","volume":"4","author":"B Desnues","year":"2003","journal-title":"EMBO Rep"},{"issue":"Pt 4","key":"ref51","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1099\/mic.0.28612-0","article-title":"Glucose-6-phosphate dehydrogenase and ferredoxin-NADP(H) reductase contribute to damage repair during the soxRS response of Escherichia coli","volume":"152","author":"M Giro","year":"2006","journal-title":"Microbiology"},{"issue":"4","key":"ref52","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1128\/AAC.01087-08","article-title":"Contribution of oxidative damage to antimicrobial lethality","volume":"53","author":"X Wang","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"ref53","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.bbadis.2006.01.012","article-title":"GAPDH as a sensor of NO stress","volume":"1762","author":"MR Hara","year":"2006","journal-title":"Biochim Biophys Acta"},{"issue":"36","key":"ref54","doi-asserted-by":"crossref","first-page":"26562","DOI":"10.1074\/jbc.M704199200","article-title":"The active site cysteine of the proapoptotic protein glyceraldehyde-3-phosphate dehydrogenase is essential in oxidative stress-induced aggregation and cell death","volume":"282","author":"H Nakajima","year":"2007","journal-title":"J Biol Chem"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev.micro.112408.134040","article-title":"Gene regulation in Borrelia burgdorferi","volume":"65","author":"DS Samuels","year":"2011","journal-title":"Annu Rev Microbiol"},{"issue":"5","key":"ref56","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1111\/j.1365-2958.2007.05860.x","article-title":"Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle","volume":"65","author":"MJ Caimano","year":"2007","journal-title":"Mol Microbiol"},{"issue":"2","key":"ref57","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nrmicro2714","article-title":"Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes","volume":"10","author":"JD Radolf","year":"2012","journal-title":"Nat Rev Microbiol"},{"issue":"4","key":"ref58","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1046\/j.1365-2958.1998.01103.x","article-title":"Decorin-binding adhesins from Borrelia burgdorferi","volume":"30","author":"BP Guo","year":"1998","journal-title":"Mol Microbiol"},{"issue":"5","key":"ref59","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1046\/j.1365-2958.1998.01127.x","article-title":"Identification of a 47 kDa fibronectin-binding protein expressed by Borrelia burgdorferi isolate B31","volume":"30","author":"WS Probert","year":"1998","journal-title":"Mol Microbiol"},{"issue":"9","key":"ref60","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1073\/pnas.0306845101","article-title":"Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals","volume":"101","author":"D Grimm","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref61","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1172\/JCI200419894","article-title":"OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands","volume":"113","author":"U Pal","year":"2004","journal-title":"J Clin Invest"},{"issue":"11","key":"ref62","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1128\/IAI.63.11.4535-4539.1995","article-title":"Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi","volume":"63","author":"B Stevenson","year":"1995","journal-title":"Infect Immun"},{"issue":"5","key":"ref63","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.micinf.2005.12.022","article-title":"Borrelia burgdorferi\u2014traveling incognito?","volume":"8","author":"E Fikrig","year":"2006","journal-title":"Microbes Infect"},{"issue":"6660","key":"ref64","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/37551","article-title":"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi","volume":"390","author":"CM Fraser","year":"1997","journal-title":"Nature"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2174\/1874205X01206010119","article-title":"How do lyme borrelia organisms cause disease? The quest for virulence determinants()","volume":"6","author":"SJ Norris","year":"2012","journal-title":"The open neurology journal"},{"issue":"4","key":"ref66","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1042\/bst0040671","article-title":"A study of the permeability of the cytoplasmic membrane of Escherichia coli to reduced and oxidized benzyl viologen and methyl viologen cations: complications in the use of viologens as redox mediators for membrane-bound enzymes","volume":"4","author":"RW Jones","year":"1976","journal-title":"Biochemical Society transactions"},{"issue":"6","key":"ref67","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.resmic.2007.05.004","article-title":"The ompW (porin) gene mediates methyl viologen (paraquat) efflux in Salmonella enterica serovar typhimurium","volume":"158","author":"F Gil","year":"2007","journal-title":"Research in microbiology"},{"issue":"3","key":"ref68","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1046\/j.1365-2958.2002.03204.x","article-title":"The Salmonella enterica sv. Typhimurium smvA, yddG and ompD (porin) genes are required for the efficient efflux of methyl viologen","volume":"46","author":"CA Santiviago","year":"2002","journal-title":"Mol Microbiol"},{"issue":"20","key":"ref69","doi-asserted-by":"crossref","first-page":"11684","DOI":"10.1073\/pnas.2032956100","article-title":"Borrelia oxidative stress response regulator, BosR: a distinctive Zn-dependent transcriptional activator","volume":"100","author":"JA Boylan","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Pt 9","key":"ref70","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1099\/mic.0.28996-0","article-title":"Transcriptional profiling of Borrelia burgdorferi containing a unique bosR allele identifies a putative oxidative stress regulon","volume":"152","author":"JA Hyde","year":"2006","journal-title":"Microbiology"},{"issue":"2","key":"ref71","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1128\/JB.01109-06","article-title":"Borrelia burgdorferi alters its gene expression and antigenic profile in response to CO2 levels","volume":"189","author":"JA Hyde","year":"2007","journal-title":"J Bacteriol"},{"issue":"3","key":"ref72","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1128\/IAI.72.3.1580-1586.2004","article-title":"Dissolved oxygen levels alter gene expression and antigen profiles in Borrelia burgdorferi","volume":"72","author":"J Seshu","year":"2004","journal-title":"Infect Immun"},{"issue":"5","key":"ref73","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1111\/j.1365-2958.2004.04352.x","article-title":"A conservative amino acid change alters the function of BosR, the redox regulator of Borrelia burgdorferi","volume":"54","author":"J Seshu","year":"2004","journal-title":"Mol Microbiol"},{"issue":"7","key":"ref74","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1128\/JB.180.7.1741-1749.1998","article-title":"Cloning and characterization of the Pseudomonas aeruginosa zwf gene encoding glucose-6-phosphate dehydrogenase, an enzyme important in resistance to methyl viologen (paraquat)","volume":"180","author":"JF Ma","year":"1998","journal-title":"J Bacteriol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.micro.57.030502.090938","article-title":"Pathways of oxidative damage","volume":"57","author":"JA Imlay","year":"2003","journal-title":"Annu Rev Microbiol"},{"issue":"1","key":"ref76","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1046\/j.1365-2958.2002.02719.x","article-title":"A potential role for periplasmic superoxide dismutase in blocking the penetration of external superoxide into the cytosol of Gram-negative bacteria","volume":"43","author":"SS Korshunov","year":"2002","journal-title":"Mol Microbiol"},{"issue":"3","key":"ref77","doi-asserted-by":"crossref","first-page":"e93141","DOI":"10.1371\/journal.pone.0093141","article-title":"Global repression of host-associated genes of the Lyme disease spirochete through post-transcriptional modulation of the alternative sigma factor RpoS","volume":"9","author":"DP Dulebohn","year":"2014","journal-title":"PloS one"},{"issue":"2","key":"ref78","doi-asserted-by":"crossref","first-page":"e01017","DOI":"10.1128\/mBio.01017-14","article-title":"Regulatory protein BBD18 of the lyme disease spirochete: essential role during tick acquisition?","volume":"5","author":"BM Hayes","year":"2014","journal-title":"MBio"},{"issue":"11","key":"ref79","doi-asserted-by":"crossref","first-page":"e1000676","DOI":"10.1371\/journal.ppat.1000676","article-title":"Evidence that two ATP-dependent (Lon) proteases in Borrelia burgdorferi serve different functions","volume":"5","author":"JL Coleman","year":"2009","journal-title":"PLoS Pathog"},{"issue":"6","key":"ref80","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1101\/gad.183517.111","article-title":"RpoS proteolysis is controlled directly by ATP levels in Escherichia coli","volume":"26","author":"CN Peterson","year":"2012","journal-title":"Genes Dev"},{"issue":"8","key":"ref81","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1128\/IAI.00494-13","article-title":"Contributions of environmental signals and conserved residues to the functions of carbon storage regulator A of Borrelia burgdorferi","volume":"81","author":"SL Karna","year":"2013","journal-title":"Infect Immun"},{"issue":"2","key":"ref82","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1128\/IAI.00882-10","article-title":"CsrA modulates levels of lipoproteins and key regulators of gene expression critical for pathogenic mechanisms of Borrelia burgdorferi","volume":"79","author":"SL Karna","year":"2011","journal-title":"Infect Immun"},{"issue":"1","key":"ref83","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/mmi.12171","article-title":"Borrelia host adaptation Regulator (BadR) regulates rpoS to modulate host adaptation and virulence factors in Borrelia burgdorferi","volume":"88","author":"CL Miller","year":"2013","journal-title":"Mol Microbiol"},{"issue":"8","key":"ref84","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1128\/IAI.05234-11","article-title":"Oligopeptide permease A5 modulates vertebrate host-specific adaptation of Borrelia burgdorferi","volume":"79","author":"BV Raju","year":"2011","journal-title":"Infect Immun"},{"issue":"11","key":"ref85","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.1128\/IAI.00673-09","article-title":"Overexpression of CsrA (BB0184) alters the morphology and antigen profiles of Borrelia burgdorferi","volume":"77","author":"E Sanjuan","year":"2009","journal-title":"Infect Immun"},{"issue":"5","key":"ref86","doi-asserted-by":"crossref","first-page":"e38171","DOI":"10.1371\/journal.pone.0038171","article-title":"Effect of levels of acetate on the mevalonate pathway of Borrelia burgdorferi","volume":"7","author":"TA Van Laar","year":"2012","journal-title":"PloS one"},{"issue":"10","key":"ref87","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.tibs.2005.08.007","article-title":"Structural proteomics of macromolecular assemblies using oxidative footprinting and mass spectrometry","volume":"30","author":"JQ Guan","year":"2005","journal-title":"Trends in biochemical sciences"},{"issue":"3\u20134","key":"ref88","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00726-003-0011-2","article-title":"Free radical-mediated oxidation of free amino acids and amino acid residues in proteins","volume":"25","author":"ER Stadtman","year":"2003","journal-title":"Amino acids"},{"issue":"8","key":"ref89","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.1021\/cr0682047","article-title":"Hydroxyl radical-mediated modification of proteins as probes for structural proteomics","volume":"107","author":"G Xu","year":"2007","journal-title":"Chemical reviews"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0136707","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T21:01:03Z","timestamp":1718053263000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0136707"}},"subtitle":[],"editor":[{"given":"Brian","family":"Stevenson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,8,31]]},"references-count":89,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,8,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0136707","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,31]]}}}