{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:54:50Z","timestamp":1792677290774,"version":"4.5.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T00:00:00Z","timestamp":1441152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0137179","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T14:02:47Z","timestamp":1441202567000},"page":"e0137179","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Innate Immune Signalling Genetics of Pain, Cognitive Dysfunction and Sickness Symptoms in Cancer Pain Patients Treated with Transdermal Fentanyl"],"prefix":"10.1371","volume":"10","author":[{"given":"Daniel T.","family":"Barratt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e5l","family":"Klepstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Dale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stein","family":"Kaasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A.","family":"Somogyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,9,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1053\/srao.2000.6590","article-title":"Cancer-related symptoms","volume":"10","author":"CS Cleeland","year":"2000","journal-title":"Semin Radiat Oncol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/annonc\/mdm056","article-title":"Prevalence of pain in patients with cancer: a systematic review of the past 40 years","volume":"18","author":"MH van den Beuken-van Everdingen","year":"2007","journal-title":"Ann Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1191\/0269216305pm1054oa","article-title":"Pain and pain treatments in European palliative care units. A cross sectional survey from the European Association for Palliative Care Research Network","volume":"19","author":"P Klepstad","year":"2005","journal-title":"Palliat Med"},{"issue":"Suppl 10","key":"ref4","doi-asserted-by":"crossref","first-page":"x294","DOI":"10.1093\/annonc\/mds360","article-title":"Pain management","volume":"23","author":"CI Ripamonti","year":"2012","journal-title":"Ann Oncol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1177\/0269216311404274","article-title":"Transdermal opioids as front line treatment of moderate to severe cancer pain: a systemic review","volume":"25","author":"D Tassinari","year":"2011","journal-title":"Palliat Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/sj.clpt.6100095","article-title":"Pharmacogenetics of opioids","volume":"81","author":"AA Somogyi","year":"2007","journal-title":"Clin Pharmacol Ther"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.pain.2011.01.040","article-title":"Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients","volume":"152","author":"P Klepstad","year":"2011","journal-title":"Pain"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/bph.12028","article-title":"Pharmacological characterization of LPS and opioid interactions at the toll-like receptor 4","volume":"168","author":"CW Stevens","year":"2013","journal-title":"Br J Pharmacol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1124\/pr.110.004135","article-title":"Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia","volume":"63","author":"MR Hutchinson","year":"2011","journal-title":"Pharmacol Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nri3621","article-title":"Pathological pain and the neuroimmune interface","volume":"14","author":"PM Grace","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.bbi.2009.08.004","article-title":"Evidence that opioids may have toll-like receptor 4 and MD-2 effects","volume":"24","author":"MR Hutchinson","year":"2010","journal-title":"Brain Behav Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nrd4334","article-title":"Emerging targets in neuroinflammation-driven chronic pain","volume":"13","author":"RR Ji","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"R Dantzer","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1159\/000079408","article-title":"A cytokine-based neuroimmunologic mechanism of cancer-related symptoms","volume":"11","author":"BN Lee","year":"2004","journal-title":"Neuroimmunomodulation"},{"key":"ref15","year":"2013"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/FPC.0000000000000032","article-title":"Genetic, pathological and physiological determinants of transdermal fentanyl pharmacokinetics in 620 cancer patients of the EPOS study","volume":"24","author":"DT Barratt","year":"2014","journal-title":"Pharmacogenet Genomics"},{"key":"ref17","first-page":"129","article-title":"Pain assessment: global use of the Brief Pain Inventory","volume":"23","author":"CS Cleeland","year":"1994","journal-title":"Ann Acad Med Singapore"},{"key":"ref18","first-page":"189","article-title":"&quot;Mini-mental state&quot;. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"MF Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/j.1532-5415.1992.tb01992.x","article-title":"The mini-mental state examination: a comprehensive review","volume":"40","author":"TN Tombaugh","year":"1992","journal-title":"J Am Geriatr Soc"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/tpj.2011.27","article-title":"Genetic clustering of European cancer patients indicates that opioid-mediated pain relief is independent of ancestry","volume":"12","author":"A Galvan","year":"2012","journal-title":"Pharmacogenomics J"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000180580","article-title":"Prediction of creatinine clearance from serum creatinine","volume":"16","author":"DW Cockcroft","year":"1976","journal-title":"Nephron"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00228-007-0444-8","article-title":"Early pharmacokinetics of nasal fentanyl: is there a significant arterio-venous difference?","volume":"64","author":"K Moksnes","year":"2008","journal-title":"Eur J Clin Pharmacol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/1097-0142(194811)1:4<634::AID-CNCR2820010410>3.0.CO;2-L","article-title":"The use of nitrogen mustards in the palliative treatment of carcinoma","volume":"1","author":"D Karnofsky","year":"1948","journal-title":"Cancer"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology","volume":"85","author":"NK Aaronson","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s12031-013-0201-7","article-title":"Association of innate immune single-nucleotide polymorphisms with the electroencephalogram during desflurane general anaesthesia","volume":"52","author":"CV Mulholland","year":"2014","journal-title":"J Mol Neurosci"},{"key":"ref26","article-title":"R: A Language and Environment for Statistical Computing","year":"2013"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1191\/0269216303pm835oa","article-title":"Routine drug monitoring of serum concentrations of morphine, morphine-3-glucuronide and morphine-6-glucuronide do not predict clinical observations in cancer patients","volume":"17","author":"P Klepstad","year":"2003","journal-title":"Palliat Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1200\/JCO.2010.32.6884","article-title":"Prevalence and predictors of cognitive dysfunction in opioid-treated patients with cancer: a multinational study","volume":"29","author":"GP Kurita","year":"2011","journal-title":"J Clin Oncol"},{"key":"ref29","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-21706-2","article-title":"Modern Applied Statistics with S","author":"W Venables","year":"2002"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"97","DOI":"10.12703\/P6-97","article-title":"MyD88: a central player in innate immune signaling","volume":"6","author":"J Deguine","year":"2014","journal-title":"F1000Prime Rep"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0968-0004(02)02145-X","article-title":"A universal role for MyD88 in TLR\/IL-1R-mediated signaling","volume":"27","author":"S Janssens","year":"2002","journal-title":"Trends Biochem Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bbi.2014.10.011","article-title":"S100A8 contributes to postoperative cognitive dysfunction in mice undergoing tibial fracture surgery by activating the TLR4\/MyD88 pathway","volume":"44","author":"SM Lu","year":"2015","journal-title":"Brain Behav Immun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.3892\/mmr.2013.1322","article-title":"The role of the TLR4 signaling pathway in cognitive deficits following surgery in aged rats","volume":"7","author":"Y Wang","year":"2013","journal-title":"Mol Med Rep"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1089\/neu.2011.2244","article-title":"Exogenous administration of PACAP alleviates traumatic brain injury in rats through a mechanism involving the TLR4\/MyD88\/NF-kappaB pathway","volume":"29","author":"SS Mao","year":"2012","journal-title":"J Neurotrauma"},{"key":"ref35","unstructured":"Gunma University Hospital, Department of Anesthesiology. Preventive effect of minocycline on postoperative cognitive dysfunction in Japanese elderly patients: A randomized, double-blind, placebo-controlled trial. Unique trial Number: UMIN000014620. Database: UMIN-CTR Clinical Trial Database, University hospital Medical Information Network (UMIN) Center (Japan) [internet]. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/upload.umin.ac.jp\/cgi-open-bin\/ctr\/ctr.cgi?function=brows&action=brows&recptno=R000016796&type=summary&language=E\" xlink:type=\"simple\">https:\/\/upload.umin.ac.jp\/cgi-open-bin\/ctr\/ctr.cgi?function=brows&amp;action=brows&amp;recptno=R000016796&amp;type=summary&amp;language=E<\/ext-link>."},{"key":"ref36","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/gene.2013.48","article-title":"The MyD88 rs6853 and TIRAP rs8177374 polymorphic sites are associated with resistance to human pulmonary tuberculosis","volume":"14","author":"R Capparelli","year":"2013","journal-title":"Genes Immun"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.vaccine.2008.01.017","article-title":"Associations between SNPs in toll-like receptors and related intracellular signaling molecules and immune responses to measles vaccine: preliminary results","volume":"26","author":"N Dhiman","year":"2008","journal-title":"Vaccine"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"495","DOI":"10.2147\/JPR.S36446","article-title":"Dosing considerations with transdermal formulations of fentanyl and buprenorphine for the treatment of cancer pain","volume":"7","author":"TL Skaer","year":"2014","journal-title":"J Pain Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jpainsymman.2005.05.001","article-title":"Which mini-mental state exam items can be used to screen for delirium and cognitive impairment?","volume":"30","author":"PM Fayers","year":"2005","journal-title":"J Pain Symptom Manage"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/pon.1090","article-title":"Brief cognitive assessment of cancer patients: evaluation of the Mini-Mental State Examination (MMSE) psychometric properties","volume":"16","author":"K Mystakidou","year":"2007","journal-title":"Psychooncology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/gps.2293","article-title":"Primary care physicians&apos; attitudes towards cognitive screening: findings from a national postal survey","volume":"25","author":"P Iracleous","year":"2010","journal-title":"Int J Geriatr Psychiatry"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1017\/S1041610208007394","article-title":"Screening for dementia in primary care: a review of the use, efficacy and quality of measures","volume":"20","author":"A Milne","year":"2008","journal-title":"Int Psychogeriatr"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1017\/S1041610205002693","article-title":"IPA survey of brief cognitive screening instruments","volume":"18","author":"KI Shulman","year":"2006","journal-title":"Int Psychogeriatr"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/gps.2306","article-title":"Brief cognitive screening instruments: an update","volume":"25","author":"Z Ismail","year":"2010","journal-title":"Int J Geriatr Psychiatry"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/gps.2208","article-title":"Screening for mild cognitive impairment: a systematic review","volume":"24","author":"JA Lonie","year":"2009","journal-title":"Int J Geriatr Psychiatry"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jpsychires.2008.04.014","article-title":"A meta-analysis of the accuracy of the mini-mental state examination in the detection of dementia and mild cognitive impairment","volume":"43","author":"AJ Mitchell","year":"2009","journal-title":"J Psychiatr Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0137179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T17:59:01Z","timestamp":1718042341000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0137179"}},"subtitle":[],"editor":[{"given":"Chang-Qing","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,9,2]]},"references-count":46,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2015,9,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0137179","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,2]]}}}