{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:30:35Z","timestamp":1791927035927,"version":"4.3.4"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T00:00:00Z","timestamp":1441324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0137262","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T17:50:59Z","timestamp":1441389059000},"page":"e0137262","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Decreased Risk of Ventilator-Associated Pneumonia in Sepsis Due to Intra-Abdominal Infection"],"prefix":"10.1371","volume":"10","author":[{"given":"Fran\u00e7ois","family":"Philippart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Bouroche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Timsit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mait\u00e9","family":"Garrouste-Orgeas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Azoulay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Darmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Adrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Allaouchiche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Ara-Somohano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Ruckly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sylvie","family":"Dumenil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Souweine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dany","family":"Goldgran-Toledano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lila","family":"Bouadma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Misset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Outcomerea study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,9,4]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1097\/CCM.0b013e3182227d52","article-title":"Reducing ventilator-associated pneumonia in intensive care: impact of implementing a care bundle","volume":"39","author":"AC Morris","year":"2011","journal-title":"Crit Care Med"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1164\/rccm.201105-0867OC","article-title":"Attributable mortality of ventilator-associated pneumonia: a reappraisal using causal analysis","volume":"184","author":"M Bekaert","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S1473-3099(07)70265-7","article-title":"Host-pathogen interactions in sepsis","volume":"8","author":"T van der Poll","year":"2008","journal-title":"Lancet Infect Dis"},{"issue":"23","key":"ref4","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1001\/jama.2011.1829","article-title":"Immunosuppression in patients who die of sepsis and multiple organ failure","volume":"306","author":"JS Boomer","year":"2011","journal-title":"Jama"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1086\/345675","article-title":"Diminished interferon-gamma production and responsiveness after endotoxin administration to healthy humans","volume":"186","author":"S Weijer","year":"2002","journal-title":"J Infect Dis"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/cc5055","article-title":"Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis","volume":"10","author":"JM Cavaillon","year":"2006","journal-title":"Crit Care"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/00024382-200304000-00005","article-title":"Evidence for a CD14- and serum-independent pathway in the induction of endotoxin-tolerance in human monocytes and THP-1 monocytic cells","volume":"19","author":"W Heagy","year":"2003","journal-title":"Shock"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1172\/JCI115493","article-title":"Dysregulation of in vitro cytokine production by monocytes during sepsis","volume":"88","author":"C Munoz","year":"1991","journal-title":"J Clin Invest"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/jlb.54.5.444","article-title":"Lipopolysaccharide structure-function relationship in activation versus reprogramming of mouse peritoneal macrophages","volume":"54","author":"X Zhang","year":"1993","journal-title":"J Leukoc Biol"},{"issue":"10","key":"ref10","doi-asserted-by":"crossref","first-page":"6494","DOI":"10.4049\/jimmunol.0803350","article-title":"Potent phagocytic activity with impaired antigen presentation identifying lipopolysaccharide-tolerant human monocytes: demonstration in isolated monocytes from cystic fibrosis patients","volume":"182","author":"C del Fresno","year":"2009","journal-title":"J Immunol"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000049698","article-title":"Cecal ligation and puncture as a model of sepsis in the rat: influence of the puncture size on mortality, bacteremia, endotoxemia and tumor necrosis factor alpha levels","volume":"33","author":"E Otero-Anton","year":"2001","journal-title":"Eur Surg Res"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1097\/SHK.0b013e318150776f","article-title":"Endotoxin pretreatment improves bacterial clearance and decreases mortality in mice challenged with Staphylococcus aureus","volume":"29","author":"ED Murphey","year":"2008","journal-title":"Shock"},{"issue":"11","key":"ref13","doi-asserted-by":"crossref","first-page":"7340","DOI":"10.1128\/IAI.73.11.7340-7347.2005","article-title":"Endotoxin priming improves clearance of Pseudomonas aeruginosa in wild-type and interleukin-10 knockout mice","volume":"73","author":"TK Varma","year":"2005","journal-title":"Infect Immun"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/SHK.0b013e318162c190","article-title":"Induction of endotoxin tolerance enhances bacterial clearance and survival in murine polymicrobial sepsis","volume":"30","author":"DS Wheeler","year":"2008","journal-title":"Shock"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1164\/ajrccm\/138.6.1439","article-title":"Endotoxin-induced suppression of pulmonary antibacterial defenses against Staphylococcus aureus","volume":"138","author":"SE Harris","year":"1988","journal-title":"Am Rev Respir Dis"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/infdis\/153.2.202","article-title":"Impairment of antibacterial defense mechanisms of the lung by extrapulmonary infection","volume":"153","author":"JC White","year":"1986","journal-title":"J Infect Dis"},{"issue":"21","key":"ref17","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1001\/jama.2009.1754","article-title":"International study of the prevalence and outcomes of infection in intensive care units","volume":"302","author":"JL Vincent","year":"2009","journal-title":"Jama"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: a severity of disease classification system","volume":"13","author":"WA Knaus","year":"1985","journal-title":"Crit Care Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1001\/archinte.1962.03620240029006","article-title":"Gram negative bacteremia: etiology and ecology","volume":"110","author":"W McCabe","year":"1962","journal-title":"Arch Intern Med"},{"issue":"24","key":"ref20","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1001\/jama.1993.03510240069035","article-title":"A new Simplified Acute Physiology Score (SAPS II) based on a European\/North American multicenter study","volume":"270","author":"JR Le Gall","year":"1993","journal-title":"Jama"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/BF01709751","article-title":"The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction\/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine","volume":"22","author":"JL Vincent","year":"1996","journal-title":"Intensive Care Med"},{"issue":"7","key":"ref22","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1164\/ajrccm.165.7.2105078","article-title":"Ventilator-associated pneumonia","volume":"165","author":"J Chastre","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression Models and Life Tables","volume":"B34","author":"DR Cox","year":"1972","journal-title":"J Royal Stat Soc"},{"issue":"9","key":"ref24","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1073\/pnas.1222878110","article-title":"Genomic responses in mouse models poorly mimic human inflammatory diseases","volume":"110","author":"J Seok","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"ref25","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/nrd1854","article-title":"Animal models of sepsis: setting the stage","volume":"4","author":"JA Buras","year":"2005","journal-title":"Nat Rev Drug Discov"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/nm0712-998a","article-title":"Rodent models of sepsis found shockingly lacking","volume":"18","author":"K Raven","year":"2012","journal-title":"Nat Med"},{"issue":"1 Suppl","key":"ref27","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1097\/CCM.0b013e3181922bd3","article-title":"Animal models of sepsis: why does preclinical efficacy fail to translate to the clinical setting?","volume":"37","author":"A Dyson","year":"2009","journal-title":"Crit Care Med"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1128\/IAI.01213-09","article-title":"Characterization and modulation of the immunosuppressive phase of sepsis","volume":"78","author":"JT Muenzer","year":"2010","journal-title":"Infect Immun"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/01.sla.0000207097.38963.3b","article-title":"Clinical and economic outcomes of hospital acquired pneumonia in intra-abdominal surgery patients","volume":"243","author":"DA Thompson","year":"2006","journal-title":"Ann Surg"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.amjsurg.2003.07.012","article-title":"A novel model of pneumonia from intraperitoneal injection of bacteria","volume":"186","author":"GA Franklin","year":"2003","journal-title":"Am J Surg"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/shk.0b013e318063e6ca","article-title":"The innate immune response to secondary peritonitis","volume":"28","author":"JW van Till","year":"2007","journal-title":"Shock"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1179\/096805106X102246","article-title":"Compartmentalization of the inflammatory response in sepsis and SIRS","volume":"12","author":"JM Cavaillon","year":"2006","journal-title":"J Endotoxin Res"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF01772577","article-title":"Endotoxaemia in septic shock: clinical and post mortem correlations","volume":"9","author":"AC McCartney","year":"1983","journal-title":"Intensive Care Med"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.chom.2008.06.009","article-title":"Host inactivation of bacterial lipopolysaccharide prevents prolonged tolerance following gram-negative bacterial infection","volume":"4","author":"M Lu","year":"2008","journal-title":"Cell Host Microbe"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1177\/1753425912442431","article-title":"Hepatic uptake and deacylation of the LPS in bloodborne LPS-lipoprotein complexes","volume":"18","author":"B Shao","year":"2012","journal-title":"Innate Immun"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1465-9921-7-30","article-title":"Endotoxin induced peritonitis elicits monocyte immigration into the lung: implications on alveolar space inflammatory responsiveness","volume":"7","author":"M Steinmuller","year":"2006","journal-title":"Respir Res"},{"issue":"6","key":"ref37","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1186\/cc2881","article-title":"Bench-to-bedside review: acute respiratory distress syndrome\u2014how neutrophils migrate into the lung","volume":"8","author":"J Reutershan","year":"2004","journal-title":"Crit Care"},{"issue":"5","key":"ref38","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1165\/rcmb.2011-0392TR","article-title":"Role of chemokines in the pathogenesis of acute lung injury","volume":"46","author":"M Bhatia","year":"2012","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/intimm\/11.2.217","article-title":"Mechanisms of acute inflammatory lung injury induced by abdominal sepsis","volume":"11","author":"B Neumann","year":"1999","journal-title":"Int Immunol"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1189\/jlb.0405236","article-title":"Endotoxin tolerance induces selective alterations in neutrophil function","volume":"78","author":"LC Parker","year":"2005","journal-title":"J Leukoc Biol"},{"issue":"14\u201315","key":"ref41","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.micinf.2011.07.011","article-title":"Innate immune responses to Pseudomonas aeruginosa infection","volume":"13","author":"EG Lavoie","year":"2011","journal-title":"Microbes Infect"},{"issue":"3","key":"ref42","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1165\/rcmb.2008-0362OC","article-title":"Priming of alveolar macrophages upon instillation of lipopolysaccharide in the human lung","volume":"42","author":"JJ Hoogerwerf","year":"2010","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"7","key":"ref43","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1086\/382657","article-title":"Compartmentalization of tolerance to endotoxin","volume":"189","author":"C Fitting","year":"2004","journal-title":"J Infect Dis"},{"issue":"5","key":"ref44","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s00134-010-1824-6","article-title":"Attributable mortality of ventilator-associated pneumonia: respective impact of main characteristics at ICU admission and VAP onset using conditional logistic regression and multi-state models","volume":"36","author":"M Nguile-Makao","year":"2010","journal-title":"Intensive Care Med"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1164\/rccm.200405-644ST","article-title":"Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia","volume":"171","year":"2005","journal-title":"Am J Respir Crit Care Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0137262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T23:16:33Z","timestamp":1718061393000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0137262"}},"subtitle":[],"editor":[{"given":"Sachin","family":"Yende","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,9,4]]},"references-count":45,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2015,9,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0137262","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,4]]}}}