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Biotechnology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/nar\/27.2.573","article-title":"Tandem repeats finder: a program to analyze DNA sequences","volume":"27","author":"G Benson","year":"1999","journal-title":"Nucleic acids research"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0168-9525(00)02024-2","article-title":"EMBOSS: the European Molecular Biology Open Software Suite","volume":"16","author":"P Rice","year":"2000","journal-title":"Trends in Genetics"},{"key":"ref34","unstructured":"Iseli C, Jongeneel C V, Bucher P. ESTScan: a program for detecting, evaluating, and reconstructing potential coding regions in EST sequences. Proceedings \/. International Conference on Intelligent Systems for Molecular Biology ; ISMB International Conference on Intelligent Systems for Molecular Biology. Swiss Institute of Bioinformatics, Epalinges, Switzerland. <email xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:type=\"simple\">Christian.Iseli@isb-sib.ch<\/email>; 1999; 138\u2013148. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/eutils.ncbi.nlm.nih.gov\/entrez\/eutils\/elink.fcgi?dbfrom=pubmed&id=10786296&retmode=ref&cmd=prlinks\" xlink:type=\"simple\">http:\/\/eutils.ncbi.nlm.nih.gov\/entrez\/eutils\/elink.fcgi?dbfrom=pubmed&amp;id=10786296&amp;retmode=ref&amp;cmd=prlinks<\/ext-link>"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"M Ashburner","year":"2000","journal-title":"Nature Genetics"},{"key":"ref36","unstructured":"Bekaert M. SlimIt [Internet]. 2013. p. Creative Commons Attribution 3.0 License. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.isalmon.eu\/slimit\/\" xlink:type=\"simple\">http:\/\/www.isalmon.eu\/slimit\/<\/ext-link>"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e1002195","DOI":"10.1371\/journal.pcbi.1002195","article-title":"Accelerated Profile HMM Searches","volume":"7","author":"SR Eddy","year":"2011","journal-title":"PLoS Comput Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1186\/gb-2004-5-3-r15","article-title":"The ABC transporter gene family of Caenorhabditis elegans has implications for the evolutionary dynamics of multidrug resistance in eukaryotes","volume":"5","author":"JA Sheps","year":"2004","journal-title":"Genome biology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/1471-2164-14-317","article-title":"A burst of ABC genes in the genome of the polyphagous spider mite <italic>Tetranychus urticae<\/italic>","volume":"14","author":"W Dermauw","year":"2013","journal-title":"BMC genomics"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2164-14-6","article-title":"Functional analysis of the ATP-binding cassette (ABC) transporter gene family of <italic>Tribolium castaneum<\/italic>","volume":"14","author":"G Broehan","year":"2013","journal-title":"BMC genomics"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/nar\/gkg046","article-title":"The InterPro Database, 2003 brings increased coverage and new features","volume":"31","author":"NJ Mulder","year":"2003","journal-title":"Nucleic Acids Research"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"RC Edgar","year":"2004","journal-title":"Nucleic acids research"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s13127-011-0056-0","article-title":"raxmlGUI: a graphical front-end for RAxML","volume":"12","author":"D Silvestro","year":"2011","journal-title":"Organisms Diversity & Evolution"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1093\/bioinformatics\/btu033","article-title":"RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies","volume":"30","author":"A Stamatakis","year":"2014","journal-title":"Bioinformatics (Oxford, England)"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.2741\/2305","article-title":"ABC A-subclass proteins: Gatekeepers of cellular phospho- and sphingolipid transport","volume":"12","author":"JJ Wenzel","year":"2007","journal-title":"Frontiers in Bioscience"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.1158\/0008-5472.CAN-14-0582","article-title":"ABCB5 maintains melanoma-initiating cells through a proinflammatory cytokine signaling circuit","volume":"74","author":"BJ Wilson","year":"2014","journal-title":"Cancer research"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.aquaculture.2013.12.015","article-title":"Isolation and characterisation of four partial cDNA sequences encoding multidrug resistance-associated proteins (MRPs) in the salmon louse <italic>Lepeophtheirus salmonis<\/italic> (Kr\u00f8yer, 1837)","volume":"424\u2013425","author":"J Heumann","year":"2014","journal-title":"Aquaculture"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jinsphys.2009.06.005","article-title":"Physiological and molecular characterization of methotrexate transport by Malpighian tubules of adult <italic>Drosophila melanogaster<\/italic>","volume":"55","author":"S Chahine","year":"2009","journal-title":"Journal of insect 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unraveling the molecular basis of pyrethroid resistance in the dengue vector, <italic>Aedes aegypti<\/italic>","volume":"6","author":"V Bariami","year":"2012","journal-title":"PLoS neglected tropical diseases"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1152\/physrev.00035.2005","article-title":"Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins","volume":"86","author":"RG Deeley","year":"2006","journal-title":"Physiological reviews"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.gene.2013.02.050","article-title":"Origin and evolution of the cystic fibrosis transmembrane regulator protein R domain","volume":"523","author":"A Sebastian","year":"2013","journal-title":"Gene"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.0962-1075.2004.00512.x","article-title":"The dMRP\/CG6214 gene of <italic>Drosophila<\/italic> is 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