{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:15:50Z","timestamp":1784009750333,"version":"3.55.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2015,9,17]],"date-time":"2015-09-17T00:00:00Z","timestamp":1442448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0137518","type":"journal-article","created":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T05:50:00Z","timestamp":1442555400000},"page":"e0137518","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Integrated Source Case Investigation for Tuberculosis (TB) and HIV in the Caregivers and Household Contacts of Hospitalised Young Children Diagnosed with TB in South Africa: An Observational Study"],"prefix":"10.1371","volume":"10","author":[{"given":"Sanjay G.","family":"Lala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen M.","family":"Little","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nkeko","family":"Tshabangu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reginah","family":"Msandiwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"van der Watt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Chaisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil A.","family":"Martinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,9,17]]},"reference":[{"key":"ref1","article-title":"Guidelines for intensified tuberculosis case-finding and isoniazid preventive therapy for people living with HIV in resource-constrained settings","year":"2011"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1183\/09031936.00070812","article-title":"Contact investigation for tuberculosis: a systematic review and meta-analysis","volume":"41","author":"GJ Fox","year":"2013","journal-title":"Eur Respir J"},{"key":"ref3","first-page":"457","article-title":"Will DOTS do it? A reappraisal of tuberculosis control in countries with high rates of HIV infection","volume":"3","author":"KM De Cock","year":"1999","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref4","first-page":"819","article-title":"Adult contacts in children with tuberculosis","volume":"34","author":"N Somu","year":"1997","journal-title":"Indian Pediatr"},{"key":"ref5","first-page":"1143","article-title":"Evaluation of a clinical index among adult contacts of children with tuberculosis in rural Haiti","volume":"4","author":"CT Eckhoff","year":"2000","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s13312-011-0081-2","article-title":"Significance of family survey of index case for detection of tuberculosis","volume":"48","author":"N Dahiwale","year":"2011","journal-title":"Indian Pediatr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.5588\/ijtld.12.0933","article-title":"Yield of contact tracing from pediatric tuberculosis index cases in Gaborone, Botswana","volume":"17","author":"S Puryear","year":"2013","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref8","first-page":"182836","article-title":"Source Case Investigation for Children with TB Disease in Pune, India","volume":"2014","author":"D De","year":"2014","journal-title":"Tuberc Res Treat"},{"key":"ref9","article-title":"Guidance for national tuberculosis programmes on the management of tuberculosis in children","year":"2014"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/S1473-3099(08)70182-8","article-title":"Paediatric tuberculosis","volume":"8","author":"SM Newton","year":"2008","journal-title":"Lancet Infect Dis"},{"issue":"Suppl 3","key":"ref11","doi-asserted-by":"crossref","first-page":"S184","DOI":"10.1086\/651490","article-title":"Pediatric tuberculosis: global overview and challenges","volume":"50","author":"S Swaminathan","year":"2010","journal-title":"Clin Infect Dis"},{"key":"ref12","first-page":"153","article-title":"Epidemiology and disease burden of tuberculosis in children: a global perspective","volume":"7","author":"JA Seddon","year":"2014","journal-title":"Infect Drug Resist"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1086\/655129","article-title":"Tuberculosis transmission to young children in a South African community: modeling household and community infection risks","volume":"51","author":"R Wood","year":"2010","journal-title":"Clin Infect Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/1471-2334-7-140","article-title":"Culture-confirmed childhood tuberculosis in Cape Town, South Africa: a review of 596 cases","volume":"7","author":"HS Schaaf","year":"2007","journal-title":"BMC Infect Dis"},{"key":"ref15","first-page":"672","article-title":"Impact of HIV-1 co-infection on presentation and hospital-related mortality in children with culture proven pulmonary tuberculosis in Durban, South Africa","volume":"6","author":"PM Jeena","year":"2002","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref16","first-page":"738","article-title":"Childhood tuberculosis infection and disease: a spatial and temporal transmission analysis in a South African township","volume":"99","author":"K Middelkoop","year":"2009","journal-title":"S Afr Med J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-2458-8-15","article-title":"A systematic review of delay in the diagnosis and treatment of tuberculosis","volume":"8","author":"DG Storla","year":"2008","journal-title":"BMC Public Health"},{"key":"ref18","first-page":"281","article-title":"Patient Reported Delays in Seeking Treatment for Tuberculosis among Adult and Pediatric TB Patients and TB Patients Co-Infected with HIV in Lima, Peru: A Qualitative Study","volume":"2","author":"VA Paz-Soldan","year":"2014","journal-title":"Front Public Health"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1471-2334-8-72","article-title":"Patient and provider delay in tuberculosis suspects from communities with a high HIV prevalence in South Africa: a cross-sectional study","volume":"8","author":"G Meintjes","year":"2008","journal-title":"BMC Infect Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1097\/INF.0b013e3181eaefff","article-title":"Role of Streptococcus pneumoniae in hospitalization for acute community-acquired pneumonia associated with culture-confirmed Mycobacterium tuberculosis in children: a pneumococcal conjugate vaccine probe study","volume":"29","author":"DP Moore","year":"2010","journal-title":"Pediatr Infect Dis J"},{"key":"ref21","unstructured":"The South African Antiretroviral Treatment Guidelines 2013. Department of Health (South Africa); 2013."},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.2471\/BLT.12.106807","article-title":"Eliminating mother-to-child HIV transmission in South Africa","volume":"91","author":"P Barron","year":"2013","journal-title":"Bull World Health Organ"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1186\/1471-2458-9-406","article-title":"Improving the coverage of the PMTCT programme through a participatory quality improvement intervention in South Africa","volume":"9","author":"T Doherty","year":"2009","journal-title":"BMC Public Health"},{"key":"ref24","unstructured":"Goga A, Dinh T, Jackson D, for the SAPMTCTE study group. Evaluation of the Effectiveness of the National Prevention of Mother-to-Child Transmission (PMTCT) Programme Measured at Six Weeks Postpartum in South Africa, 2010. South African Medical Research Council, National Department of Health of South Africa and PEPFAR\/US Centers for Disease Control and Prevention; 2012."},{"key":"ref25","doi-asserted-by":"crossref","first-page":"19266","DOI":"10.3402\/gha.v6i0.19266","article-title":"The contribution of spatial analysis to understanding HIV\/TB mortality in children: a structural equation modelling approach","volume":"6","author":"E Musenge","year":"2013","journal-title":"Glob Health Action"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e47337","DOI":"10.1371\/journal.pone.0047337","article-title":"Mortality and health outcomes of HIV-exposed and unexposed children in a PMTCT cohort in Malawi","volume":"7","author":"M Landes","year":"2012","journal-title":"PLoS One"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1473-3099(09)70326-3","article-title":"Yield of HIV-associated tuberculosis during intensified case finding in resource-limited settings: a systematic review and meta-analysis","volume":"10","author":"K Kranzer","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"ref28","article-title":"District Health Barometer 2012\/13","author":"N Massyn","year":"2013"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"312","DOI":"10.2471\/BLT.09.062893","article-title":"Structured approaches for the screening and diagnosis of childhood tuberculosis in a high prevalence region of South Africa","volume":"88","author":"M Hatherill","year":"2010","journal-title":"Bull World Health Organ"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0137518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T12:28:27Z","timestamp":1540038507000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0137518"}},"subtitle":[],"editor":[{"given":"Mary-Ann","family":"Davies","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,9,17]]},"references-count":29,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2015,9,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0137518","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,17]]}}}