{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:44:59Z","timestamp":1790631899558,"version":"4.1.0"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T00:00:00Z","timestamp":1441929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0137751","type":"journal-article","created":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T17:50:53Z","timestamp":1441993853000},"page":"e0137751","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":35,"title":["Synergistic Effect of Oleanolic Acid on Aminoglycoside Antibiotics against Acinetobacter baumannii"],"prefix":"10.1371","volume":"10","author":[{"given":"Bora","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woojun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,9,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/nrmicro1789","article-title":"An increasing threat in hospitals: multidrug-resistant <italic>Acinetobacter baumannii<\/italic>","volume":"5","author":"L Dijkshoorn","year":"2007","journal-title":"Nat Rev Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0025-7125(05)70303-5","article-title":"Antipseudomonal antibiotics","volume":"85","author":"H Giamarellou","year":"2001","journal-title":"Med Clin N Am"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2217\/17460913.3.6.649","article-title":"Drug treatment for multidrug-resistant <italic>Acinetobacter baumannii<\/italic> infections","volume":"3","author":"M Bassetti","year":"2008","journal-title":"Future Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1128\/CMR.9.2.148","article-title":"<italic>Acinetobacter<\/italic> spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features","volume":"9","author":"E Bergogne-Berezin","year":"1996","journal-title":"Clin Microbiol Rev"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1128\/CMR.00058-07","article-title":"<italic>Acinetobacter baumannii<\/italic>: emergence of a successful pathogen","volume":"21","author":"AY Peleg","year":"2008","journal-title":"Clin Microbiol Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1128\/AAC.45.12.3375-3380.2001","article-title":"Resistance-nodulation-cell division-type efflux pump involved in aminoglycoside resistance in <italic>Acinetobacter baumannii<\/italic> strain BM4454","volume":"45","author":"S Magnet","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1007\/s00018-007-7034-x","article-title":"Aminoglycoside antibiotics: old drugs and new therapeutic approaches","volume":"64","author":"T Hermann","year":"2007","journal-title":"Cell Mol Life Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11373-007-9194-y","article-title":"Aminoglycosides versus bacteria: a description of the action, resistance mechanism, and nosocomial battleground","volume":"15","author":"S Shakil","year":"2008","journal-title":"J Biomed. Sci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1056\/NEJM200003093421007","article-title":"Vancomycin-resistant enterococcal infections","volume":"342","author":"BE Murray","year":"2000","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"192ra85","DOI":"10.1126\/scitranslmed.3006055","article-title":"Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in Mammalian cells","volume":"5","author":"S Kalghatgi","year":"2013","journal-title":"Sci Transl Med"},{"key":"ref11","first-page":"534084","article-title":"Oleanolic acid diminishes liquid fructose-induced fatty liver in rats: role of modulation of hepatic sterol regulatory element-binding protein-1c-mediated expression of genes responsible for de novo fatty acid synthesis","volume":"2013","author":"C Liu","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1021\/jm301910a","article-title":"Development of oleanane-type triterpenes as a new class of HCV entry inhibitors","volume":"56","author":"F Yu","year":"2013","journal-title":"J Med Chem"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1078\/094471103321659807","article-title":"Cardiovascular, antihyperlipidemic and antioxidant effects of oleanolic and ursolic acids in experimental hypertension","volume":"10","author":"LO Somova","year":"2003","journal-title":"Phytomedicine"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.mrfmmm.2006.03.008","article-title":"Protective effects of ursolic acid and oleanolic acid in leukemic cells","volume":"600","author":"Z Ovesn\u00e1","year":"2006","journal-title":"Mutat Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0955-2863(00)00137-6","article-title":"Characterization of antioxidants present in hawthorn fruits","volume":"12","author":"Z Zhang","year":"2001","journal-title":"J Nutr Biochem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1248\/cpb.49.780","article-title":"Antioxidative glucosides from the fruits of <italic>Ligustrum lucidum<\/italic>","volume":"49","author":"ZD He","year":"2001","journal-title":"Chem Pharm Bull"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"7177","DOI":"10.1021\/jf071242m","article-title":"Nonenzymatic antioxidative and antiglycative effects of oleanolic acid and ursolic acid","volume":"55","author":"MC Yin","year":"2007","journal-title":"J Agric Food Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.2337\/db12-1215","article-title":"Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes","volume":"62","author":"JM Castellano","year":"2013","journal-title":"Diabetes"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cbi.2010.02.028","article-title":"Oleanolic acid, a natural triterpenoid improves blood glucose tolerance in normal mice and ameliorates visceral obesity in mice fed a high-fat diet","volume":"185","author":"CL de Melo","year":"2010","journal-title":"Chem Biol Interact"},{"key":"ref20","first-page":"12","article-title":"Delayed treatment with oleanolic acid attenuates tubulointerstitial fibrosis in chronic cyclosporine nephropathy through Nrf2\/HO-1 signaling","volume":"21","author":"YA Hong","year":"2014","journal-title":"J Transl Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1021\/np000267b","article-title":"Antitubercular activity of triterpenoids from <italic>Lippia turbinate<\/italic>","volume":"64","author":"GA W\u00e4chter","year":"2001","journal-title":"J Nat Prod"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jep.2006.11.033","article-title":"Antimycobacterial triterpenoids from <italic>Lantana hispida<\/italic> (Verbenaceae)","volume":"111","author":"A Jim\u00e9nez-Arellanes","year":"2007","journal-title":"J Ethnopharmacol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s10482-009-9388-6","article-title":"Oleanolic acid and ursolic acid affect peptidoglycan metabolism in <italic>Listeria monocytogenes<\/italic>","volume":"97","author":"A Kurek","year":"2010","journal-title":"Antonie van Leeuwenhoek"},{"key":"ref24","first-page":"981","article-title":"Protective effect of oleanolic acid and ursolic acid against lipid peroxidation","volume":"24","author":"S Balanehru","year":"1991","journal-title":"Biochem Int"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1128\/AAC.37.3.613","article-title":"Reproducibility of the microdilution checkerboard method for antibiotic synergy","volume":"37","author":"KH Rand","year":"1993","journal-title":"Antimicrob Agents Chemother"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1093\/jac\/dkg238","article-title":"<italic>In vitro<\/italic> activity of gatifloxacin alone in combination with cefepime, meropenem, piperacillin and gentamicin against multidrug-resistant organisms","volume":"51","author":"MA Dawis","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1128\/AAC.02109-12","article-title":"Antimicrobial activity of nanoemulsion in combination with cetylpyridinium chloride in multidrug-resistant <italic>Acinetobacter baumannii<\/italic>","volume":"57","author":"YY Hwang","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1128\/AAC.02473-13","article-title":"Synergistic effects and antibiofilm properties of chimeric peptides against multidrug-resistant <italic>Acinetobacter baumannii<\/italic> strains","volume":"58","author":"R Gopal","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.femsle.2004.10.013","article-title":"Expression of glutathione S-transferase and peptide methionine sulphoxide reductase in <italic>Ochrobactrum anthropi<\/italic> is correlated to the production of reactive oxygen species caused by aromatic substrates","volume":"241","author":"A Tamburro","year":"2004","journal-title":"FEMS Microbio Lett"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/1574-6968.12135","article-title":"Indole toxicity involves the inhibition of adenosine triphosphate production and protein folding in <italic>Pseudomonas putida<\/italic>","volume":"343","author":"J Kim","year":"2013","journal-title":"FEMS Microbiol Lett"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e60666","DOI":"10.1371\/journal.pone.0060666","article-title":"The efflux inhibitor phenylalanine-arginine beta-naphthylamide (PA\u03b2N) permeabilizes the outer membrane of gram-negative bacteria","volume":"8","author":"RP Lamers","year":"2013","journal-title":"PLoS ONE"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature10069","article-title":"Metabolite-enabled eradication of bacterial persisters by aminoglycosides","volume":"473","author":"KR Allison","year":"2011","journal-title":"Nature"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.resmic.2012.01.008","article-title":"Effects of non-ionic solute stresses on biofilm formation and lipopolysaccharide production in <italic>Escherichia coli<\/italic> O157:H7","volume":"164","author":"J Yeom","year":"2012","journal-title":"Res Microbiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1007\/s00253-012-4669-9","article-title":"The effect of toxic malachite green on the bacterial community in Antarctic soil and the physiology of malachite green-degrading <italic>Pseudomonas<\/italic> sp. MGO","volume":"97","author":"J Jung","year":"2013","journal-title":"Appl Microbiol Biotechnol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/dkg301","article-title":"Synergy, antagonism, and what the chequerboard puts between them","volume":"52","author":"FC Odds","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"11570","DOI":"10.1074\/jbc.M300252200","article-title":"Organic hydroperoxide resistance gene encodes a thiol-dependent peroxidase","volume":"278","author":"JR Cussiol","year":"2003","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"21943","DOI":"10.1074\/jbc.M110.117283","article-title":"Ohr (organic hydroperoxide resistance protein) possesses a previously undescribed activity, lipoyl-dependent peroxidase","volume":"285","author":"JR Cssiol","year":"2010","journal-title":"J Biol Chem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev.biochem.76.061005.092322","article-title":"Glycosyltransferases: structures, functions, and mechanisms","volume":"77","author":"LL Lairson","year":"2008","journal-title":"Annu Rev Biochem"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1021\/pr101299j","article-title":"Proteomic and functional analyses reveal a unique lifestyle for <italic>Acinetobacter baumannii<\/italic> biofilms and a key role for histidine metabolism","volume":"10","author":"MP Cabral","year":"2011","journal-title":"J Proteome Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1099\/mic.0.045161-0","article-title":"Role of DLP12 lysis genes in <italic>Escherichia coli<\/italic> biofilm formation","volume":"157","author":"FA Toba","year":"2011","journal-title":"Microbiology"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.3390\/ijms10041729","article-title":"Adenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensing","volume":"10","author":"P Dzeja","year":"2009","journal-title":"Int J Mol Sci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"516","DOI":"10.4014\/jmb.1109.09012","article-title":"Proteomic analysis of proteins increased or reduced by ethanol of <italic>Lactobacillus plantarum<\/italic> ST4 isolated from <italic>Makgeolli<\/italic>, traditional Korean rice wine","volume":"22","author":"SG Lee","year":"2012","journal-title":"J Microbiol Biotechnol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.4014\/jmb.1203.03066","article-title":"Proteomic analysis of proteins of <italic>Weissella confusa<\/italic> 31 affected by bile salts","volume":"22","author":"KW Lee","year":"2012","journal-title":"J Microbiol Biotechnol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00284-010-9698-y","article-title":"Phenotypic and physiological changes in <italic>Acinetobacter<\/italic> sp. strain DR1 with exogenous plasmid","volume":"62","author":"J Park","year":"2011","journal-title":"Curr Microbiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e107716","DOI":"10.1371\/journal.pone.0107716","article-title":"Plasmid-encoded tetracycline efflux pump protein alters bacterial stress responses and ecological fitness of <italic>Acinetobacter oleivorans<\/italic>","volume":"9","author":"H Hong","year":"2014","journal-title":"PLoS ONE"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4062\/biomolther.2014.008","article-title":"Enhancement of platelet aggregation by ursolic acid and oleanolic acid","volume":"22","author":"M Kim","year":"2014","journal-title":"Biomol Ther (Seoul)"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF00014936","article-title":"Isolation of a delta 6-desaturase gene from the cyanobacterium <italic>Synechocystis<\/italic> sp. strain PCC 6803 by gain-of-function expression in <italic>Anabaena<\/italic> sp. strain PCC 7120","volume":"22","author":"AS Reddy","year":"1993","journal-title":"Plant Mol Biol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1128\/AAC.02293-13","article-title":"Energy metabolism and drug efflux in <italic>Mycobacterium tuberculosis<\/italic>","volume":"58","author":"PA Black","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.fct.2014.01.020","article-title":"Ameliorative effects of oleanolic acid on fluoride induced metabolic and oxidative dysfunctions in rat brain: experimental and biochemical studies","volume":"66","author":"C Sarkar","year":"2014","journal-title":"Food Chem Toxicol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1007\/s00284-010-9866-0","article-title":"Oleanolic and ursolic acids influence affect the expression of the cysteine regulon and the stress response in <italic>Escherichia coli<\/italic>","volume":"62","author":"AM Grudniak","year":"2011","journal-title":"Curr Microbiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"7200","DOI":"10.1128\/AEM.70.12.7200-7209.2004","article-title":"Bile-mediated aminoglycoside sensitivity in <italic>Lactobacillus<\/italic> species likely results from increased membrane permeability attributable to cholic acid","volume":"70","author":"CA Elkins","year":"2004","journal-title":"Appl Environ Microbiol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1242\/jcs.023705","article-title":"TRPV4 enhances cellular uptake of aminoglycoside antibiotics","volume":"121","author":"T Karasawa","year":"2008","journal-title":"J Cell Sci"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/odi.12031","article-title":"The <italic>in vitro<\/italic> study of ursolic acid and oleanolic acid inhibiting cariogenic microorganisms as well as biofilm","volume":"19","author":"L Zhou","year":"2013","journal-title":"Oral Dis"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1099\/mic.0.049791-0","article-title":"Genetic analysis of surface motility in <italic>Acinetobacter baumannii<\/italic>","volume":"157","author":"KM Clemmer","year":"2011","journal-title":"Microbiology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0137751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T03:07:21Z","timestamp":1588993641000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0137751"}},"subtitle":[],"editor":[{"given":"Massimiliano","family":"Galdiero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,9,11]]},"references-count":54,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2015,9,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0137751","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,11]]}}}