{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:26:24Z","timestamp":1771489584971,"version":"3.50.1"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T00:00:00Z","timestamp":1444694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0138069","type":"journal-article","created":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T00:21:20Z","timestamp":1444782080000},"page":"e0138069","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Oseltamivir Population Pharmacokinetics in the Ferret: Model Application for Pharmacokinetic\/Pharmacodynamic Study Design"],"prefix":"10.1371","volume":"10","author":[{"given":"Micaela B.","family":"Reddy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo-Hsiung","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gauri","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig R.","family":"Rayner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandrasena","family":"Pamulapati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bindumadhav M.","family":"Marathe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Forrest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena A.","family":"Govorkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,10,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"E30","DOI":"10.1097\/CCM.0b013e3181d10522","article-title":"Practical lessons from the first outbreaks: clinical presentation, obstacles, and management strategies for severe pandemic (pH1N1) 2009 influenza pneumonitis","volume":"38","author":"DJ Funk","year":"2010","journal-title":"Crit Care Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1001\/jama.2009.1496","article-title":"Critically ill patients with 2009 influenza A(H1N1) infection in Canada","volume":"17","author":"A Kumar","year":"2009","journal-title":"JAMA"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1056\/NEJMra050740","article-title":"Neuraminidase inhibitors for influenza","volume":"353","author":"A Moscona","year":"2005","journal-title":"N Engl J Med"},{"issue":"Suppl 4","key":"ref4","doi-asserted-by":"crossref","first-page":"E43","DOI":"10.1097\/CCM.0b013e3181c85229","article-title":"The use of antiviral agents for the management of severe influenza","volume":"38","author":"JR Smith","year":"2010","journal-title":"Crit Care Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s12325-011-0072-7","article-title":"Oseltamivir in seasonal, pandemic, and avian influenza: a comprehensive review of 10-years clinical experience","volume":"28","author":"JR Smith","year":"2011","journal-title":"Adv Ther"},{"key":"ref6","unstructured":"Tamiflu: EPAR\u2013Product Information. Annex I\u2014European Summary of Product Characteristics. Available at: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.medicines.org.uk\/emc\/\" xlink:type=\"simple\">http:\/\/www.medicines.org.uk\/emc\/<\/ext-link> (Accessed 10 August 2015)."},{"key":"ref7","unstructured":"Tamiflu: Highlights of Prescribing Information. Available at: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2014\/021087s060,021246s043lbl.pdf\" xlink:type=\"simple\">http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2014\/021087s060,021246s043lbl.pdf<\/ext-link> (Accessed 10 August 2015)."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1001\/jama.283.8.1016","article-title":"Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial. US Oral Neuraminidase Study Group","volume":"283","author":"JJ Treanor","year":"2000","journal-title":"JAMA"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/S0140-6736(00)02288-1","article-title":"Efficacy and safety of oseltamivir in treatment of acute influenza: a randomised controlled trial. Neuraminidase Inhibitor Flu Treatment Investigator Group","volume":"355","author":"KG Nicholson","year":"2000","journal-title":"Lancet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00006454-200102000-00002","article-title":"Oral oseltamivir treatment of influenza in children","volume":"20","author":"RJ Whitley","year":"2001","journal-title":"Pediatr Infect Dis J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1001\/jama.285.6.748","article-title":"Effectiveness of oseltamivir in preventing influenza in household contacts: a randomized controlled trial","volume":"285","author":"R Welliver","year":"2001","journal-title":"JAMA"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1086\/381128","article-title":"Management of influenza in households: a prospective, randomized comparison of oseltamivir treatment with or without postexposure prophylaxis","volume":"189","author":"FG Hayden","year":"2004","journal-title":"J Infect Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/01.inf.0000154322.38267.ce","article-title":"Oral oseltamivir improves pulmonary function and reduces exacerbation frequency for influenza-infected children with asthma","volume":"24","author":"SL Johnston","year":"2005","journal-title":"Pediatr Infect Dis J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"955","DOI":"10.3851\/IMP2192","article-title":"Efficacy and safety of oral oseltamivir for influenza prophylaxis in transplant recipients","volume":"17","author":"MG Ison","year":"2012","journal-title":"Antivir Ther"},{"key":"ref15","article-title":"Safety, virology and pharmacokinetics of oseltamivir in infants with laboratory-confirmed influenza infection: a phase I\/II, prospective, open-label, multi-center clinical trial","author":"B Rath","year":"2015","journal-title":"Antivir Ther"},{"issue":"Suppl 2","key":"ref16","first-page":"ii5","article-title":"Pharmacokinetics of oseltamivir: an oral antiviral for the treatment and prophylaxis of influenza in diverse populations","volume":"65","author":"BE Davies","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2165\/00003088-199937060-00003","article-title":"Clinical pharmacokinetics of the prodrug oseltamivir and its active metabolite Ro 64\u20130802","volume":"37","author":"G He","year":"1999","journal-title":"Clin Pharmacokinet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"787","DOI":"10.2165\/00002018-200326110-00004","article-title":"Safety and pharmacology of oseltamivir in clinical use","volume":"26","author":"R Dutkowski","year":"2003","journal-title":"Drug Saf"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.ijantimicag.2009.12.023","article-title":"Safety and pharmacokinetics of oseltamivir at standard and high dosages","volume":"35","author":"R Dutkowski","year":"2010","journal-title":"Int J Antimicrob Agents"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1128\/AAC.42.3.647","article-title":"Identification of GS 4104 as an orally bioavailable prodrug of the influenza virus neuraminidase inhibitor GS 4071","volume":"42","author":"W Li","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1177\/0091270008320317","article-title":"Population pharmacokinetics of oseltamivir when coadministered with probenecid","volume":"48","author":"CR Rayner","year":"2008","journal-title":"J Clin Pharmacol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"613","DOI":"10.2165\/11592640-000000000-00000","article-title":"Development of a physiologically based model for oseltamivir and simulation of pharmacokinetics in neonates and infants","volume":"50","author":"N Parrott","year":"2011","journal-title":"Clin Pharmacokinet"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Wattanagoon Y, Stepniewska K, Lindeg\u00e5rdh N, Pukrittayakamee S, Silachamroon U, Piyaphanee W, et al. Pharmacokinetics of high-dose oseltamivir in healthy volunteers. 2009;53: 945\u2013952.","DOI":"10.1128\/AAC.00588-08"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"7572","DOI":"10.1128\/JVI.00512-11","article-title":"Comparative pathology in ferrets infected with H1N1 influenza A viruses isolated from different hosts","volume":"85","author":"JH Smith","year":"2011","journal-title":"J Virol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.1177127","article-title":"Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets","volume":"325","author":"VJ Munster","year":"2009","journal-title":"Science"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1126\/science.1177238","article-title":"Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice","volume":"325","author":"TR Maines","year":"2009","journal-title":"Science"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"11139","DOI":"10.1128\/JVI.01235-07","article-title":"Pathogenesis of avian influenza (H7) virus infection in mice and ferrets: enhanced virulence of Eurasian H7N7 viruses isolated from humans","volume":"81","author":"JA Belser","year":"2007","journal-title":"J Virol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.antiviral.2011.05.008","article-title":"Assessment of the efficacy of the neuraminidase inhibitor oseltamivir against 2009 pandemic H1N1 influenza virus in ferrets","volume":"91","author":"EA Govorkova","year":"2011","journal-title":"Antiviral Res"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Govorkova EA, Ilyushina NA, Boltz DA, Douglas A, Yilmaz N, Webster RG. Efficacy of oseltamivir therapy in ferrets inoculated with different clades of H5N1 influenza virus. 2007;51: 1414\u20131424.","DOI":"10.1128\/AAC.01312-06"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1128\/AAC.42.3.640","article-title":"Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection","volume":"42","author":"DB Mendel","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1086\/586711","article-title":"Oseltamivir prophylactic regimens prevent H5N1 influenza morbidity and mortality in a ferret model","volume":"197","author":"DA Boltz","year":"2008","journal-title":"J Infect Dis"},{"key":"ref32","first-page":"27","article-title":"Assessment of signs of influenza illness in the ferret model","volume":"24","author":"PD Reuman","year":"1989","journal-title":"Methods"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0378-4347(00)00300-5","article-title":"Development of a high-performance liquid chromatographic\u2013mass spectrometric assay for the specific and sensitive quantification of Ro 64\u20130802, an anti-influenza drug, and its pro-drug, oseltamivir, in human and animal plasma and urine","volume":"745","author":"H Wiltshire","year":"2000","journal-title":"J Chromatogr B Biomed Sci Appl"},{"key":"ref34","article-title":"Applied Biopharmaceutics &amp; Pharmacokinetics","author":"L Shargel","year":"2012"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/0049124104268644","article-title":"Multimodel Inference. Understanding AIC and BIC in Model Selection","volume":"33","author":"KP Burnham","year":"2004","journal-title":"Sociol Methods Res"},{"key":"ref36","article-title":"ADAPT 5 User\u2019s Guide: Pharmacokinetic\/Pharmacodynamic Systems Analysis Software","author":"DZ D\u2019Argenio","year":"2009"},{"key":"ref37","article-title":"Impact of different oseltamivir regimens on treating influenza A virus infection and resistance emergence: insights from a modelling study","author":"L Canini","year":"2014","journal-title":"PLoS Comput Biol"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"e57088","DOI":"10.1371\/journal.pone.0057088","article-title":"Assessing mathematical models of influenza infections using features of the immune response","volume":"8","author":"HM Dobrovolny","year":"2013","journal-title":"PLoS ONE"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1128\/JVI.01318-10","article-title":"Population modeling of influenza A\/H1N1 virus kinetics and symptom dynamics","volume":"85","author":"L Canini","year":"2011","journal-title":"J Virol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0138069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,31]],"date-time":"2019-08-31T14:29:50Z","timestamp":1567261790000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0138069"}},"subtitle":[],"editor":[{"given":"Nicole M.","family":"Bouvier","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,10,13]]},"references-count":39,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0138069","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,13]]}}}