{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T07:29:36Z","timestamp":1790321376203,"version":"4.1.0"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T00:00:00Z","timestamp":1444176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0138113","type":"journal-article","created":{"date-parts":[[2015,10,7]],"date-time":"2015-10-07T21:27:28Z","timestamp":1444253248000},"page":"e0138113","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["Heightened Delta Power during Slow-Wave-Sleep in Patients with Rett Syndrome Associated with Poor Sleep Efficiency"],"prefix":"10.1371","volume":"10","author":[{"given":"Simon","family":"Ammanuel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley C.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Adler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balaji M.","family":"Lakshamanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth S.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua B.","family":"Ewen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael V.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole L.","family":"Marcus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakkubai","family":"Naidu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa D.","family":"Kadam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,10,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"7951","DOI":"10.1523\/JNEUROSCI.0169-11.2011","article-title":"Complexities of Rett Syndrome and MeCP2","volume":"31","author":"RC Samaco","year":"2011","journal-title":"The Journal of Neuroscience"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1177\/1073858403260995","article-title":"Rett syndrome: a prototypical neurodevelopmental disorder","volume":"10","author":"JL Neul","year":"2004","journal-title":"Neuroscientist"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3390\/brainsci4010150","article-title":"Sleep, plasticity and the pathophysiology of neurodevelopmental disorders: the potential roles of protein synthesis and other cellular processes","volume":"4","author":"D Picchioni","year":"2014","journal-title":"Brain Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.pediatrneurol.2012.11.001","article-title":"Rett Syndrome and Epilepsy: An Update for Child Neurologists","volume":"48","author":"A Dolce","year":"2013","journal-title":"Pediatric Neurology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1542\/peds.91.2.445","article-title":"Epidemiology of Rett syndrome: a population-based registry","volume":"91","author":"CA Kozinetz","year":"1993","journal-title":"Pediatrics"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.braindev.2007.04.001","article-title":"Sleep problems in Rett syndrome","volume":"29","author":"D Young","year":"2007","journal-title":"Brain Dev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/jsr.12240","article-title":"The trajectories of sleep disturbances in Rett syndrome","volume":"24","author":"K Wong","year":"2015","journal-title":"Journal of Sleep Research"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S0387-7604(12)80213-0","article-title":"Aberrant sleep patterns in children with the Rett syndrome","volume":"12","author":"CC Piazza","year":"1990","journal-title":"Brain Dev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1469-8749.1998.tb15445.x","article-title":"Sleep dysfunction in Rett syndrome: a trial of exogenous melatonin treatment","volume":"40","author":"AJ McArthur","year":"1998","journal-title":"Dev Med Child Neurol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11325-012-0654-x","article-title":"Polysomnographic findings in Rett syndrome: a case-control study","volume":"17","author":"M Carotenuto","year":"2013","journal-title":"Sleep Breath"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0387-7604(12)80178-1","article-title":"The pathophysiology of the Rett syndrome from the standpoint of polysomnography","volume":"12","author":"M Segawa","year":"1990","journal-title":"Brain Dev"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0022-3476(94)70196-2","article-title":"Polysomnographic characteristics of patients with Rett syndrome","volume":"125","author":"CL Marcus","year":"1994","journal-title":"J Pediatr"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/sleep\/27.7.1255","article-title":"Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan","volume":"27","author":"MM Ohayon","year":"2004","journal-title":"Sleep"},{"issue":"Suppl","key":"ref14","first-page":"S46","article-title":"Polysomnography in the Rett syndrome","volume":"14","author":"M Segawa","year":"1992","journal-title":"Brain Dev"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"5740","DOI":"10.1073\/pnas.1120860109","article-title":"Sex, puberty, and the timing of sleep EEG measured adolescent brain maturation","volume":"109","author":"IG Campbell","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S1388-2457(01)00488-6","article-title":"Age and sex effects in the EEG: development of the normal child","volume":"112","author":"AR Clarke","year":"2001","journal-title":"Clin Neurophysiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1365-2869.2011.00930.x","article-title":"Developmental changes in the sleep electroencephalogram of adolescent boys and girls","volume":"21","author":"FC Baker","year":"2012","journal-title":"J Sleep Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0165-1781(81)90010-X","article-title":"Age-related changes in sleep in depressed and normal subjects","volume":"4","author":"JC Gillin","year":"1981","journal-title":"Psychiatry Research"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.31887\/DCNS.2009.11.1\/gstores","article-title":"Aspects of sleep disorders in children and adolescents","volume":"11","author":"G Stores","year":"2009","journal-title":"Dialogues Clin Neurosci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1053\/spen.2001.29042","article-title":"Sleep-wake function in children with neurodevelopmental and psychiatric disorders","volume":"8","author":"G Stores","year":"2001","journal-title":"Semin Pediatr Neurol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1023\/A:1021254914276","article-title":"Sleep patterns of children with pervasive developmental disorders","volume":"32","author":"RD Honomichl","year":"2002","journal-title":"J Autism Dev Disord"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/B978-0-7020-5307-8.00002-8","article-title":"Brain's alpha, beta, gamma, delta, and theta oscillations in neuropsychiatric diseases: proposal for biomarker strategies","volume":"62","author":"E Basar","year":"2013","journal-title":"Suppl Clin Neurophysiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/B978-0-7020-5307-8.00019-3","article-title":"Review of delta, theta, alpha, beta, and gamma response oscillations in neuropsychiatric disorders","volume":"62","author":"E Basar","year":"2013","journal-title":"Suppl Clin Neurophysiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/B978-0-7020-5307-8.00016-8","article-title":"Brain oscillations as biomarkers in neuropsychiatric disorders: following an interactive panel discussion and synopsis","volume":"62","author":"GG Yener","year":"2013","journal-title":"Suppl Clin Neurophysiol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.seizure.2010.09.011","article-title":"Usefulness of video-EEG monitoring in children","volume":"20","author":"A Riquet","year":"2011","journal-title":"Seizure"},{"key":"ref26","doi-asserted-by":"crossref","DOI":"10.3389\/fnsys.2014.00118","article-title":"24h Quantitative-EEG and in-vivo glutamate biosensor detects activity and circadian rhythm dependent biomarkers of pathogenesis in Mecp2 null mice","volume":"8","author":"MV Johnston","year":"2014","journal-title":"Frontiers in Systems Neuroscience"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"283","DOI":"10.5698\/1535-7597-14.5.283","article-title":"What You Seize Is What You Get: Do We Yet Understand Epilepsy in Rett Syndrome?","volume":"14","author":"TA Benke","year":"2014","journal-title":"Epilepsy Currents"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1469-8749.1998.tb15445.x","article-title":"Sleep dysfunction in Rett syndrome: a trial of exogenous melatonin treatment","volume":"40","author":"AJ McArthur","year":"1998","journal-title":"Development medicine and child neurology"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11325-012-0654-x","article-title":"Polysomnographic findings in Rett syndrome: a case-control study","volume":"17","author":"M Carotenuto","year":"2013","journal-title":"Sleep Breath"},{"key":"ref30","first-page":"1125","article-title":"Rett syndrome. Current status and new vistas","volume":"20","author":"AK Percy","year":"2002","journal-title":"Neurol Clin"},{"key":"ref31","unstructured":"ACNS guidelines (2015) ACNS guidelines."},{"key":"ref32","unstructured":"IFCN guidelines (2015) IFCN guidelines."},{"key":"ref33","article-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specification","year":"2007"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1177\/1087054712460087","article-title":"A Decade of EEG Theta\/Beta Ratio Research in ADHD: A Meta-Analysis","volume":"17","author":"M Arns","year":"2013","journal-title":"Journal of Attention Disorders"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"13211","DOI":"10.1523\/JNEUROSCI.2532-10.2010","article-title":"Mapping of cortical activity in the first two decades of life: a high-density sleep electroencephalogram study","volume":"30","author":"S Kurth","year":"2010","journal-title":"J Neurosci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0361-9230(91)90286-S","article-title":"Sigma (12\u201315 Hz) and delta (0.3\u20133 Hz) EEG oscillate reciprocally within NREM sleep","volume":"27","author":"S Uchida","year":"1991","journal-title":"Brain Res Bull"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"R66","DOI":"10.1186\/cc13823","article-title":"Intensive care unit depth of sleep: proof of concept of a simple electroencephalography index in the non-sedated","volume":"18","author":"L Reinke","year":"2014","journal-title":"Crit Care"},{"key":"ref38","first-page":"35","article-title":"Prevalence and correlates of alpha-delta sleep in major depressive disorders","volume":"8","author":"N Jaimchariyatam","year":"2011","journal-title":"Innov Clin Neurosci"},{"issue":"Supplement 1","key":"ref39","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.1016\/S0387-7604(01)00359-X","article-title":"Clinical, neurophysiological and immunological correlations in classical Rett syndrome","volume":"23","author":"VV Gratchev","year":"2001","journal-title":"Brain and Development"},{"issue":"Supplement 1","key":"ref40","doi-asserted-by":"crossref","first-page":"S90","DOI":"10.1016\/S0387-7604(01)00349-7","article-title":"Cerebrolysin therapy in Rett syndrome: clinical and EEG mapping study","volume":"23","author":"N Gorbachevskaya","year":"2001","journal-title":"Brain and Development"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e35396","DOI":"10.1371\/journal.pone.0035396","article-title":"Daily rhythmic behaviors and thermoregulatory patterns are disrupted in adult female MeCP2-deficient mice","volume":"7","author":"RG Wither","year":"2012","journal-title":"PLoS One"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.5664\/jcsm.5.2S.S27","article-title":"Enhancement of slow wave sleep: implications for insomnia","volume":"5","author":"JK Walsh","year":"2009","journal-title":"J Clin Sleep Med"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/mrdd.10024","article-title":"Neurophysiology of Rett Syndrome","volume":"8","author":"D Glaze","year":"2005","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tics.2013.12.005","article-title":"Sleep, synaptic connectivity, and hippocampal memory during early development","volume":"18","author":"R Huber","year":"2014","journal-title":"Trends in Cognitive Sciences"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0013-4694(98)00051-0","article-title":"Electrophysiological correlates of sleep delta waves","volume":"107","author":"F Amzica","year":"1998","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1006\/exnr.1999.7030","article-title":"Altered Development of Glutamate and GABA Receptors in the Basal Ganglia of Girls with Rett Syndrome","volume":"156","author":"ME Blue","year":"1999","journal-title":"Experimental Neurology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1002\/ar.21380","article-title":"Temporal and regional alterations in NMDA receptor expression in Mecp2-null mice","volume":"294","author":"ME Blue","year":"2011","journal-title":"Anat Rec (Hoboken)"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ijdevneu.2014.08.012","article-title":"Longitudinal study of EEG frequency maturation and power changes in children on the Russian North","volume":"38","author":"SI Soroko","year":"2014","journal-title":"International Journal of Developmental Neuroscience"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.3390\/brainsci3041445","article-title":"Development of Brain EEG Connectivity across Early Childhood: Does Sleep Play a Role?","volume":"3","author":"S Kurth","year":"2013","journal-title":"Brain Sci"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1196\/annals.1308.035","article-title":"The Emergence of Collaborative Brain Function: fMRI Studies of the Development of Response Inhibition","volume":"1021","author":"B Luna","year":"2004","journal-title":"Annals of the New York Academy of Sciences"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1523\/JNEUROSCI.5309-07.2008","article-title":"Neurodevelopmental Trajectories of the Human Cerebral Cortex","volume":"28","author":"P Shaw","year":"2008","journal-title":"The Journal of Neuroscience"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1212\/01.wnl.0000291011.54508.aa","article-title":"Specific mutations in Methyl-CpG-Binding Protein 2 confer different severity in Rett syndrome","volume":"70","author":"JL Neul","year":"2008","journal-title":"Neurology"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"10809","DOI":"10.1523\/JNEUROSCI.23-34-10809.2003","article-title":"Theta and gamma oscillations during encoding predict subsequent recall","volume":"23","author":"PB Sederberg","year":"2003","journal-title":"The Journal of Neuroscience"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.yebeh.2008.01.011","article-title":"Gamma, fast, and ultrafast waves of the brain: Their relationships with epilepsy and behavior","volume":"13","author":"J Hughes","year":"2008","journal-title":"Epilepsy & Behavior"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0361-9230(93)90016-5","article-title":"A Model of Human Sleep Homeostasis Based on EEG Slow-Wave Activity: Quantitative Comparision of Data and Simulations","volume":"31","author":"P Achermann","year":"1993","journal-title":"Brain Research Bulletin"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0887-8994(96)00218-4","article-title":"High levels of cerebrospinal fluid glutamate in Rett syndrome","volume":"15","author":"R Lappalainen","year":"1996","journal-title":"Pediatric Neurology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1093\/cercor\/bhs189","article-title":"Sleep Slow-Wave Activity Regulates Cerebral Glycotic Metabolism","volume":"23","author":"JP Wisor","year":"2012","journal-title":"Cerebral Cortex"},{"key":"ref58","article-title":"Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt","author":"AM Weljie","year":"2015","journal-title":"Proceedings of the National Academy of Sciences"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0138113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T20:24:09Z","timestamp":1653251049000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0138113"}},"subtitle":[],"editor":[{"given":"Raffaele","family":"Ferri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,10,7]]},"references-count":58,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0138113","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,7]]}}}