{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:53:01Z","timestamp":1790697181123,"version":"4.1.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0138267","type":"journal-article","created":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T14:45:23Z","timestamp":1442587523000},"page":"e0138267","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":80,"title":["Transcriptomic Analyses of the Biological Effects of Airborne PM2.5 Exposure on Human Bronchial Epithelial Cells"],"prefix":"10.1371","volume":"10","author":[{"given":"Zhixiang","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengkui","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengnan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kebin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1016\/j.atmosenv.2009.01.054","article-title":"Influence of seasons, air mass origin and day of the week on size-segregated chemical composition of aerosol particles at a kerbside","volume":"43","author":"E Br\u00fcggemann","year":"2009","journal-title":"Atmos. Environ."},{"issue":"14","key":"ref2","doi-asserted-by":"crossref","first-page":"802","DOI":"10.3109\/08958378.2013.850127","article-title":"Particulate matter beyond mass: recent health evidence on the role of fractions, chemical constituents and sources of emission","volume":"25","author":"FR Cassee","year":"2013","journal-title":"Inhal Toxicol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.annepidem.2009.01.018","article-title":"Health effects of particulate air pollution","volume":"19","author":"DW Dockery","year":"2009","journal-title":"Aim Epidemiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S0140-6736(02)11274-8","article-title":"Air pollution and health","volume":"360","author":"B Brunekreef","year":"2002","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"300","DOI":"10.2174\/187152810793358787","article-title":"Role of oxidative stresses induced by diesel exhaust particles in airway inflammation, allergy and asthma: their potential as a target of chemoprevention","volume":"9","author":"YJ Li","year":"2010","journal-title":"Inflamm Allergy Drug Targets"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"487074","DOI":"10.1155\/2011\/487074","article-title":"Oxidative stress and air pollution exposure","volume":"2011","author":"M Lodovici","year":"2011","journal-title":"J Toxicol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/jat.1211","article-title":"Role of nuclear factor-kappa B activation in the adverse effects induced by air pollution particulate matter (PM2.5) in human epithelial lung cells (L132) in culture","volume":"27","author":"Z Dagher","year":"2007","journal-title":"J Appl Toxicol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.envint.2013.01.010","article-title":"Systematic review of Chinese studies of short-term exposure to air pollution and daily mortality","volume":"54","author":"Y Shang","year":"2013","journal-title":"Environ Int"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/S0140-6736(13)62064-4","article-title":"China tackles the health effects of air pollution","volume":"382","author":"Z Chen","year":"2013","journal-title":"Lancet"},{"issue":"1","key":"ref10","first-page":"12","article-title":"China wakes up to the crisis of air pollution Lancet Respir","volume":"1","author":"Y Ouyang","year":"2013","journal-title":"Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nmeth.1226","article-title":"Mapping and quantifying mammalian transcriptomes by RNA-Seq","volume":"5","author":"A Mortazavi","year":"2008","journal-title":"Nat Methods"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/BF02631062","article-title":"A transformed human epithelial cell line that retains tight junctions post crisis","volume":"28A","author":"AL Cozens","year":"1992","journal-title":"In Vitro Cell Dev Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1093\/bioinformatics\/btp336","article-title":"SOAP2: an improved ultrafast tool for short read alignment","volume":"25","author":"R Li","year":"2009","journal-title":"Bioinformatics"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nmeth.1226","article-title":"Mapping and quantifying mammalian transcriptomes by RNA-Seq","volume":"5","author":"A Mortazavi","year":"2008","journal-title":"Nat Methods"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1101\/gr.7.10.986","article-title":"The significance of digital gene expression profiles","volume":"7","author":"S Audic","year":"1997","journal-title":"Genome Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1214\/aos\/1013699998","article-title":"The control of the false discovery rate in multiple testing under dependency","volume":"29","author":"Y Benjamini","year":"2001","journal-title":"The Annals of Statistics"},{"key":"ref17","first-page":"194","article-title":"Blast2GO goes grid: developing a grid-enabled prototype for functional genomics analysis","volume":"120","author":"G Aparicio","year":"2006","journal-title":"Stud Health Technol Inform"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"W293","DOI":"10.1093\/nar\/gkl031","article-title":"WEGO: a web tool for plotting GO annotations","volume":"34","author":"J Ye","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"D480","DOI":"10.1093\/nar\/gkm882","article-title":"KEGG for linking genomes to life and the environment","volume":"36","author":"M Kanehisa","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.atmosenv.2012.10.022","article-title":"Characteristics and health impacts of particulate matter pollution in China (2001\u22122011)","volume":"65","author":"Z Cheng","year":"2013","journal-title":"Atmos. Environ."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/484161a","article-title":"Policy: Cleaning China\u2019s air","volume":"484","author":"Q Zhang","year":"2012","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/em.20186","article-title":"Effect of chemical composition on the induction of DNA damage by urban airborne particulate matter","volume":"47","author":"ME Guti\u00e9rrez-Castillo","year":"2006","journal-title":"Environ Mol Mutagen"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10937404.2012.632359","article-title":"Composition of air pollution particles and oxidative stress in cells, tissues, and living systems","volume":"15","author":"AJ Ghio","year":"2012","journal-title":"J Toxicol Environ Health B Crit Rev"},{"key":"ref24","first-page":"1","article-title":"Combustion-derived flame generated ultrafine soot generates reactive oxygen species and activates Nrf2 antioxidants differently in neonatal and adult rat lungs","volume":"10","author":"JK Chan","year":"2013","journal-title":"Part Fibre Toxicol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1289\/ehp.10318","article-title":"Particulate Air Pollution, Oxidative Stress Genes, and Heart Rate Variability in an Elderly Cohort","volume":"115","author":"T Chahine","year":"2007","journal-title":"Environ Health Perspect"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s00204-005-0020-x","article-title":"Induction of oxidative stress and inhibition of plasminogen activator inhibitor-1 production in endothelial cells following exposure to organic extracts of diesel exhaust particles and urban fine particles","volume":"80","author":"A Furuyama","year":"2006","journal-title":"Arch Toxicol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/em.20133","article-title":"Genotoxicity and physicochemical characteristics of traffic-related ambient particulate matter","volume":"46","author":"TM de Kok","year":"2005","journal-title":"Environ Mol Mutagen"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.tiv.2012.10.018","article-title":"Season linked responses to fine and quasi-ultrafine Milan PM in cultured cells","volume":"27","author":"E Longhin","year":"2013","journal-title":"Toxicol In Vitro"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1080\/15287390306409","article-title":"Benzo[a]pyrene diones are produced by photochemical and enzymatic oxidation and induce concentration-dependent decreases in the proliferative state of human pulmonary epithelial cells","volume":"66","author":"M Reed","year":"2003","journal-title":"J Toxicol Environ Health A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.envpol.2014.07.032","article-title":"Chemical and biological characterization of air particulate matter 2.5, collected from five cities in China","volume":"194","author":"PY Leung","year":"2014","journal-title":"Environ Pollut"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.envpol.2013.10.026","article-title":"Proinflammatory effects and oxidative stress within human bronchial epithelial cells exposed to atmospheric particulate matter (PM(2.5) and PM(&gt;2.5)) collected from Cotonou, Benin","volume":"185","author":"BF Cachon","year":"2014","journal-title":"Environ Pollut"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1021\/tx200529v","article-title":"Prooxidant and proinflammatory potency of air pollution particulate matter (PM2.5\u20130.3) produced in rural, urban, or industrial surroundings in human bronchial epithelial cells (BEAS-2B)","volume":"25","author":"M Dergham","year":"2012","journal-title":"Chem Res Toxicol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3109\/08958378.2011.599445","article-title":"Role of size and composition of traffic and agricultural aerosols in the molecular responses triggered in airway epithelial cells","volume":"23","author":"S Val","year":"2011","journal-title":"Inhal Toxicol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.tox.2009.05.007","article-title":"Role of Paris PM2.5 components in the proinflammatory response induced in airway epithelial cells","volume":"261","author":"A Baulig","year":"2009","journal-title":"Toxicology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jaci.2004.11.047","article-title":"Biology of diesel exhaust effects on respiratory function","volume":"115","author":"M Riedl","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1165\/rcmb.2002-0095OC","article-title":"Airway epithelial cells release MIP-3alpha\/CCL20 in response to cytokines and ambient particulate matter","volume":"28","author":"J Reibman","year":"2003","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3109\/1547691X.2010.509289","article-title":"Roles of MAPK pathway activation during cytokine induction in BEAS-2B cells exposed to fine World Trade Center (WTC) dust","volume":"7","author":"S Wang","year":"2010","journal-title":"J Immunotoxicol"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1365-3083.2012.02712.x","article-title":"Association between arachidonate 5-lipoxygenase-activating protein (ALOX5AP) and lung function in a Korean population","volume":"76","author":"M Ro","year":"2012","journal-title":"Scand J Immunol"},{"issue":"5","key":"ref39","doi-asserted-by":"crossref","first-page":"758","DOI":"10.4187\/respcare.01480","article-title":"Effect of diffuse panbronchiolitis critical region 1 polymorphisms on the risk of aspirin-exacerbated respiratory disease in Korean asthmatics","volume":"57","author":"JS Lee","year":"2012","journal-title":"Respir Care"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.tiv.2013.01.008","article-title":"Genotoxic and inflammatory effects of organic extracts from traffic-related particulate matter in human lung epithelial A549 cells: the role of quinones","volume":"27","author":"Y Shang","year":"2013","journal-title":"Toxicol In Vitro"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0300-483X(02)00545-0","article-title":"Inflammatory mediators induced by coarse (PM2.5\u201310) and fine (PM2.5) urban air particles in RAW 264.7 cells","volume":"183","author":"R Pozzi","year":"2003","journal-title":"Toxicology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.envres.2009.02.010","article-title":"Induction of IL-6 and inhibition of IL-8 secretion in the human airway cell line Calu-3 by urban particulate matter collected with a modified method of PM sampling","volume":"109","author":"E Alfaro-Moreno","year":"2009","journal-title":"Environ Res"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"93","DOI":"10.5539\/gjhs.v5n4p93","article-title":"Interleukin-6 via sputum induction as biomarker of inflammation for indoor particulate matter among primary school children in Klang Valley, Malaysia","volume":"5","author":"SS Nazariah","year":"2013","journal-title":"Glob J Health Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0138267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T20:50:42Z","timestamp":1653166242000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0138267"}},"subtitle":[],"editor":[{"given":"Song Guo","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,9,18]]},"references-count":43,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2015,9,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0138267","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,18]]}}}