{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T16:38:00Z","timestamp":1782319080121,"version":"3.54.5"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T00:00:00Z","timestamp":1442880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0138311","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T18:20:03Z","timestamp":1442946003000},"page":"e0138311","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Epidemiology of Tropical Neglected Diseases in Ecuador in the Last 20 Years"],"prefix":"10.1371","volume":"10","author":[{"given":"Monica","family":"Cartelle Gestal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina Maria","family":"Holban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Escalante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Cevallos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2015,9,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"902803","DOI":"10.1155\/2012\/902803","article-title":"Proteomic analysis of Trypanosoma cruzi epimastigotes subjected to heat shock","volume":"2012","author":"D P\u00e9rez-Morales","year":"2012","journal-title":"J Biomed Biotechnol"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1678-9199-19-34","article-title":"Challenges and perspectives of Chagas disease: a review","volume":"19","author":"PC Pereira","year":"2013","journal-title":"J Venom Anim Toxins Incl Trop Dis"},{"key":"ref3","author":"F Abad-Franch","year":"2003"},{"key":"ref4","unstructured":"Organization WH. WHO. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/en\/\" xlink:type=\"simple\">http:\/\/www.who.int\/en\/<\/ext-link>."},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"602","DOI":"10.4269\/ajtmh.2004.71.602","article-title":"The effects of long-term community level treatment with ivermectin (Mectizan) on adult Onchocerca volvulus in Latin America","volume":"71","author":"EW Cupp","year":"2004","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4269\/ajtmh.2003.68.222","article-title":"Entomological evaluation by pool screen polymerase chain reaction of Onchocerca volvulus transmission in Ecuador following mass Mectizan distribution","volume":"68","author":"AG Guevara","year":"2003","journal-title":"Am J Trop Med Hyg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/1756-3305-4-205","article-title":"Onchocerciasis in the Americas: from arrival to (near) elimination","volume":"4","author":"K Gustavsen","year":"2011","journal-title":"Parasit Vectors"},{"issue":"9","key":"ref8","doi-asserted-by":"crossref","first-page":"e293","DOI":"10.1371\/journal.pntd.0000293","article-title":"Impact of long-term treatment with ivermectin on the prevalence and intensity of soil-transmitted helminth infections","volume":"2","author":"AL Moncayo","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1741-7015-5-9","article-title":"Impact of long-term treatment of onchocerciasis with ivermectin in Ecuador: potential for elimination of infection","volume":"5","author":"JC Vieira","year":"2007","journal-title":"BMC Med"},{"issue":"2","key":"ref10","first-page":"189","article-title":"Incidence of canine rabies in Guayas Province and some aspects of its clinical and laboratory diagnosis","volume":"22","author":"Moggia J Bruno","year":"1965","journal-title":"Rev Ecuat Hig Med Trop"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.virusres.2010.07.012","article-title":"Human rabies transmitted by vampire bats: antigenic and genetic characterization of rabies virus isolates from the Amazon region (Brazil and Ecuador)","volume":"153","author":"JG Castilho","year":"2010","journal-title":"Virus Res"},{"issue":"8","key":"ref12","doi-asserted-by":"crossref","first-page":"e42466","DOI":"10.1371\/journal.pone.0042466","article-title":"Present and potential future distribution of common vampire bats in the Americas and the associated risk to cattle","volume":"7","author":"DN Lee","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"ref13","doi-asserted-by":"crossref","first-page":"e2365","DOI":"10.1371\/journal.pntd.0002365","article-title":"Evolutionary history and phylogeography of rabies viruses associated with outbreaks in Trinidad","volume":"7","author":"JF Seetahal","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4321\/S1575-06202014000100004","article-title":"Leptospirosis: case-series report in a prison of the coast in Ecuador","volume":"16","author":"D Valarezo-Sevilla","year":"2014","journal-title":"Rev Esp Sanid Penit"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","DOI":"10.1590\/S1020-49892012000900001","article-title":"Surveillance for leptospirosis in the Americas, 1996\u20132005: a review of data from ministries of health","volume":"32","author":"F Costa","year":"2012","journal-title":"Revista Panamericana de Salud Publica"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1007\/s00284-011-9931-3","article-title":"Interactions of leptospira with environmental bacteria from surface water","volume":"62","author":"VA Barragan","year":"2011","journal-title":"Curr Microbiol"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"e2249","DOI":"10.1371\/journal.pntd.0002249","article-title":"A systematic review of the epidemiology of echinococcosis in domestic and wild animals","volume":"7","author":"B Otero-Abad","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"issue":"8","key":"ref18","doi-asserted-by":"crossref","first-page":"e2386","DOI":"10.1371\/journal.pntd.0002386","article-title":"Synthesising 30 years of mathematical modelling of Echinococcus transmission","volume":"7","author":"JA Atkinson","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"978146","DOI":"10.1155\/2013\/978146","article-title":"Cystic echinococcosis in a single tertiary care center in Rome, Italy","volume":"2013","author":"L Petrone","year":"2013","journal-title":"Biomed Res Int"},{"issue":"5","key":"ref20","first-page":"53","article-title":"112 years of hydatid surgery in Bulgaria (1895\u20132007)","volume":"2007","author":"G Stoianov","journal-title":"Khirurgiia (Sofiia)"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.3201\/eid1907.121405","article-title":"Human alveolar echinococcosis in Kyrgyzstan","volume":"19","author":"J Usubalieva","year":"2013","journal-title":"Emerg Infect Dis"},{"issue":"3","key":"ref22","first-page":"259","article-title":"Hydatidosis in Ecuador","volume":"23","author":"Moggia J Bruno","year":"1966","journal-title":"Rev Ecuat Hig Med Trop"},{"issue":"1\u20132","key":"ref23","first-page":"183","article-title":"Assessing the burden of Taenia solium cysticercosis and echinococcosis","volume":"125","author":"H Carabin","year":"2004","journal-title":"Vet Parasitol"},{"issue":"3","key":"ref24","first-page":"305","article-title":"Hydatidosis: human and medical exposition. 1st seminar on zoonosis","volume":"30","author":"RF Lazo","year":"1977","journal-title":"Rev Ecuat Hig Med Trop"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"524","DOI":"10.4269\/ajtmh.2012.11-0341","article-title":"First report of orchitis in man caused by Brucella abortus biovar 1 in Ecuador","volume":"87","author":"J Ron-Rom\u00e1n","year":"2012","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1089\/vbz.2012.1191","article-title":"Human brucellosis in northwest Ecuador: typifying Brucella spp., seroprevalence, and associated risk factors","volume":"14","author":"J Ron-Rom\u00e1n","year":"2014","journal-title":"Vector Borne Zoonotic Dis"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S1473-3099(13)70270-6","article-title":"Brucella arteritis: clinical manifestations, treatment, and prognosis","volume":"14","author":"JA Herrick","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"ref28","article-title":"Manual De Procedimientos Del Subsistema Alerta Acci\u00f3n Sive\u2013Alerta","year":"2013"},{"issue":"23\u201324","key":"ref29","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00508-011-0100-2","article-title":"Outbreak of leptospirosis among triathlon participants in Langau, Austria, 2010","volume":"123","author":"C Radl","year":"2011","journal-title":"Wien Klin Wochenschr"},{"key":"ref30","author":"J Monroy","year":"2013"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"334","DOI":"10.4269\/ajtmh.2007.77.334","article-title":"Elimination of Onchocercia volvulus transmission in the Santa Rosa focus of aGuatemala","volume":"77","author":"KA Lindblade","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"638429","DOI":"10.1155\/2012\/638429","article-title":"Elimination of Onchocerca volvulus Transmission in the Huehuetenango Focus of Guatemala","volume":"2012","author":"N Cruz-Ortiz","year":"2012","journal-title":"J Parasitol Res"},{"issue":"9","key":"ref33","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.ijpara.2014.04.001","article-title":"Neglected tropical diseases in Central America and Panama: review of their prevalence, populations at risk and impact on regional development","volume":"44","author":"PJ Hotez","year":"2014","journal-title":"Int J Parasitol"},{"issue":"2","key":"ref34","first-page":"319","article-title":"El Camino a la Eliminaci\u00f3n: un Panorama delas Enfermedades Infecciosas Desatendidasen Am\u00e9rica Latina y el Caribe","volume":"31","author":"Aulta S Kenyon","year":"2014","journal-title":"Rev Peru Med Exp Salud Publica"},{"issue":"Suppl 4","key":"ref35","doi-asserted-by":"crossref","first-page":"S672","DOI":"10.1093\/clinids\/10.Supplement_4.S672","article-title":"Domestic animal rabies control: an overview","volume":"10","author":"GW Beran","year":"1988","journal-title":"Rev Infect Dis"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"95","DOI":"10.11599\/germs.2012.1019","article-title":"Epidemiological management of rabies in Romania","volume":"2","author":"H Najar","year":"2012","journal-title":"Germs"},{"issue":"3","key":"ref37","first-page":"473","article-title":"Rabies in Poland in 2011","volume":"67","author":"M Sadkowska-Todys","year":"2013","journal-title":"Przegl Epidemiol"},{"issue":"25","key":"ref38","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES2013.18.25.20509","article-title":"High prevalence of antibodies against Leptospira spp. in male Austrian adults: a cross-sectional survey, April to June 2009","volume":"18","author":"W Poeppl","year":"2013","journal-title":"Euro Surveill"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ijid.2007.09.011","article-title":"The globalization of leptospirosis: worldwide incidence trends","volume":"12","author":"G Pappas","year":"2008","journal-title":"Int J Infect Dis"},{"key":"ref40","unstructured":"datos Pebd. Hidatidosis en el Ecuador: informe del und\u00e9cimo caso echinococcus vogeli \/ Hidatidosis in Ecuador: report of the eleventh case echinococcus vogeli <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/bases.bireme.br\/cgi-bin\/wxislind.exe\/iah\/online\/?IsisScript=iah\/iah.xis&src=google&base=LILACS\u2329=p&nextAction=lnk&exprSearch=235267&indexSearch=ID\" xlink:type=\"simple\">http:\/\/bases.bireme.br\/cgi-bin\/wxislind.exe\/iah\/online\/?IsisScript=iah\/iah.xis&amp;src=google&amp;base=LILACS\u2329=p&amp;nextAction=lnk&amp;exprSearch=235267&amp;indexSearch=ID<\/ext-link> 1993."},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"303","DOI":"10.4269\/ajtmh.1979.28.303","article-title":"Echinococcus vogeli in man, with a review of polycystic hydatid disease in Colombia and neighboring countries","volume":"28","author":"A D'Alessandro","year":"1979","journal-title":"Am J Trop Med Hyg"},{"key":"ref42","article-title":"Determinacion de Hidatidosis en cerdos faenados en el Camal de Azogues Cuenca: Universidad de Cuenca","author":"Allaico G Silverio","year":"2010"},{"key":"ref43","author":"G Zambrano","year":"2011"},{"key":"ref44","author":"Andrade FA Torres","year":"2012"},{"key":"ref45","author":"T Chasiquiza","year":"2010"},{"issue":"1","key":"ref46","first-page":"50","article-title":"Brucella canis endocarditis: first documented case in Argentina","volume":"45","author":"V Manias","year":"2013","journal-title":"Rev Argent Microbiol"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3201\/eid1902.121031","article-title":"Plague outbreak in Libya, 2009, unrelated to plague in Algeria","volume":"19","author":"N Cabanel","year":"2013","journal-title":"Emerg Infect Dis"},{"issue":"8","key":"ref48","doi-asserted-by":"crossref","first-page":"e71501","DOI":"10.1371\/journal.pone.0071501","article-title":"Epidemiology of brucellosis and q Fever in linked human and animal populations in northern togo","volume":"8","author":"AS Dean","year":"2013","journal-title":"PLoS One"},{"issue":"9","key":"ref49","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.3201\/eid1809.120069","article-title":"Brucellosis in takins, China","volume":"18","author":"J Luo","year":"2012","journal-title":"Emerg Infect Dis"},{"issue":"8","key":"ref50","first-page":"475","article-title":"Human brucellosis outbreak acquired through camel milk ingestion in southern Israel","volume":"14","author":"SB Shimol","year":"2012","journal-title":"Isr Med Assoc J"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0138311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T21:21:11Z","timestamp":1567200071000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0138311"}},"subtitle":[],"editor":[{"given":"Herbert B.","family":"Tanowitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,9,22]]},"references-count":50,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2015,9,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0138311","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,22]]}}}