{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:54:37Z","timestamp":1778586877582,"version":"3.51.4"},"reference-count":18,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2015,10,2]],"date-time":"2015-10-02T00:00:00Z","timestamp":1443744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0138827","type":"journal-article","created":{"date-parts":[[2015,10,2]],"date-time":"2015-10-02T18:11:01Z","timestamp":1443809461000},"page":"e0138827","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Interferon Lambda 4 Genotype Is Not Associated with Recurrence of Oral or Genital Herpes"],"prefix":"10.1371","volume":"10","author":[{"given":"Krystle A.","family":"Lang Kuhs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark H.","family":"Kuniholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth M.","family":"Pfeiffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seema","family":"Desai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian R.","family":"Edlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion G.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Plankey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald B.","family":"Sharp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard D.","family":"Strickler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C.","family":"Villacres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas C.","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Gange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludmila","family":"Prokunina-Olsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth M.","family":"Greenblatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2015,10,2]]},"reference":[{"issue":"7262","key":"ref1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nature08309","article-title":"Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance","volume":"461","author":"D Ge","year":"2009","journal-title":"Nature"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/ng.447","article-title":"IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy","volume":"41","author":"V Suppiah","year":"2009","journal-title":"Nat Genet"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/ng.449","article-title":"Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C","volume":"41","author":"Y Tanaka","year":"2009","journal-title":"Nat Genet"},{"issue":"7265","key":"ref4","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nature08463","article-title":"Genetic variation in IL28B and spontaneous clearance of hepatitis C virus","volume":"461","author":"DL Thomas","year":"2009","journal-title":"Nature"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1053\/j.gastro.2009.12.056","article-title":"Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study","volume":"138","author":"A Rauch","year":"2010","journal-title":"Gastroenterology"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/ng.2521","article-title":"A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus","volume":"45","author":"L Prokunina-Olsson","year":"2013","journal-title":"Nat Genet"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1084\/jem.20130012","article-title":"IL28B expression depends on a novel TT\/-G polymorphism which improves HCV clearance prediction","volume":"210","author":"S Bibert","year":"2013","journal-title":"J Exp Med"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1093\/infdis\/jit433","article-title":"Association of the IFNL4-DeltaG Allele With Impaired Spontaneous Clearance of Hepatitis C Virus","volume":"209","author":"PV Aka","year":"2014","journal-title":"J Infect Dis"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1089\/jir.2013.0136","article-title":"IFN-lambda4: The Paradoxical New Member of the Interferon Lambda Family","volume":"34","author":"TR O'Brien","year":"2014","journal-title":"J Interferon Cytokine Res"},{"issue":"10","key":"ref10","doi-asserted-by":"crossref","first-page":"e1004681","DOI":"10.1371\/journal.pgen.1004681","article-title":"Selection on a variant associated with improved viral clearance drives local, adaptive pseudogenization of interferon lambda 4 (IFNL4)","volume":"10","author":"FM Key","year":"2014","journal-title":"PLoS Genet"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/ni875","article-title":"IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex","volume":"4","author":"SV Kotenko","year":"2003","journal-title":"Nat Immunol"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/ni873","article-title":"IL\u201328, IL\u201329 and their class II cytokine receptor IL-28R","volume":"4","author":"P Sheppard","year":"2003","journal-title":"Nat Immunol"},{"issue":"8","key":"ref13","doi-asserted-by":"crossref","first-page":"e1003514","DOI":"10.1371\/journal.ppat.1003514","article-title":"A systematic analysis of host factors reveals a Med23-interferon-lambda regulatory axis against herpes simplex virus type 1 replication","volume":"9","author":"SJ Griffiths","year":"2013","journal-title":"PLoS Pathog"},{"issue":"9","key":"ref14","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1128\/CDLI.12.9.1013-1019.2005","article-title":"The Women's Interagency HIV Study: an observational cohort brings clinical sciences to the bench","volume":"12","author":"MC Bacon","year":"2005","journal-title":"Clin Diagn Lab Immunol"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/00007435-199903000-00004","article-title":"Lower genital tract infections among HIV-infected and high-risk uninfected women: findings of the Women's Interagency HIV Study (WIHS)","volume":"26","author":"RM Greenblatt","year":"1999","journal-title":"Sex Transm Dis"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1258\/ijsa.2009.009296","article-title":"Quantitative and qualitative correlates of cervicovaginal herpes simplex virus type 2 shedding among HIV-infected women in the Women's Interagency HIV Study","volume":"22","author":"B Aumakhan","year":"2011","journal-title":"Int J STD AIDS"},{"issue":"7","key":"ref17","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1097\/01.aids.0000222078.75867.77","article-title":"Herpes simplex virus infection in women in the WIHS: epidemiology and effect of antiretroviral therapy on clinical manifestations","volume":"20","author":"N Ameli","year":"2006","journal-title":"AIDS"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2307\/2531248","article-title":"Longitudinal data analysis for discrete and continuous outcomes","volume":"42","author":"SL Zeger","year":"1986","journal-title":"Biometrics"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0138827","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T04:19:07Z","timestamp":1599625147000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0138827"}},"subtitle":[],"editor":[{"given":"Ali A.","family":"Ashkar","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2015,10,2]]},"references-count":18,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0138827","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,2]]}}}